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Anderson Cindy M - - 2013
Background: Preeclampsia contributes significantly to pregnancy-associated morbidity and mortality as well as future risk of cardiovascular disease in mother and offspring, and preeclampsia in offspring. The lack of reliable methods for early detection limits the opportunities for prevention, diagnosis, and timely treatment.Purpose: The purpose of this study was to explore ...
Hayes Emily K - - 2013
Maternal obesity is associated with an increased risk of a number of pregnancy complications, including fetal demise, which may be linked to impaired placental development as a result of altered trophoblast invasion and vessel remodeling. Therefore, we examined these parameters in pregnant rats fed a control (normal weight) or high ...
Avi Harlev - - 2013
Abstract OBJECTIVE: To examine if, as in obesity, pregnancies complicated by gestational diabetes mellitus (GDM) exhibit increased macrophage infiltration and activated MAP-kinases in omental adipose tissue. Paired omental (OM) and abdominal subcutaneous (SC) fat samples were collected from 11 GDM and 20 normal pregnancies during cesarean delivery. Tissues were stained ...
Nanovskaya Tatiana N TN Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, - - 2013
The objective of the study was to determine the bidirectional transfer of pravastatin across the dually perfused term human placental lobule and its distribution between the tissue and maternal and fetal circuits. The transfer of pravastatin was determined in the maternal-to-fetal (n = 11) and fetal-to-maternal (n = 10) directions. Pravastatin was ...
Zajicek Michal - - 2013
To evaluate fetal secondary palate in fetuses at 12 to 16 weeks' gestation by three-dimensional ultrasound (3DUS). Between June 2006 and July 2008, volumes of palate were prospectively acquired in fetuses at gestational age of 12-16 weeks. Acquisition was performed when the fetus was facing the transducer with head extended at an ...
Kwon Eun Ji - - 2013
: Polymorphic eruption of pregnancy (PEP), formerly known as pruritic urticarial papules and plaques of pregnancy, is a dermatosis of pregnancy that must be distinguished from pemphigoid gestationis (PG). Although this differential diagnosis may be possible on routine histology, an additional biopsy for direct immunofluorescence (DIF) is often needed. Recent ...
Torricelli Michela - - 2013
Abstract Objective: The aim of this study was to investigate the rate of the different Histological Chorioamnionitis (HCA) grade in relation to the gestational age in term and preterm delivery. Methods: 392 women with singleton pregnancy with spontaneous onset of labor either prematurely or at term, with histologic diagnosis of ...
Kivelio A - - 2013
Iatrogenic preterm prelabour rupture of fetal membranes (iPPROM) remains the main complication after invasive interventions into the intrauterine cavity. The aim of this study was to evaluate the sealing capability and tissue interaction of mussel-mimetic tissue adhesive (mussel glue) in comparison to fibrin glue on punctured fetal membranes in vivo. ...
Sakamoto Mineshi - - 2013
The role of the placenta was assessed by comparing the profiles of methylmercury (MeHg), inorganic mercury (I-Hg), lead (Pb), cadmium (Cd), selenium (Se), zinc (Zn), and copper (Cu) in freeze-dried chorionic tissue of the placenta and umbilical cord tissue. The significance of the placenta and cord tissue as predictors of ...
George R B RB Department of Women's and Obstetric Anesthesia, IWK Health Centre, Halifax, Nova Scotia, Canada; Department of Anesthesiology, Pain Management, and Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address: - - 2013
The microcirculation is responsible for distribution of blood within tissues, delivery of oxygen and other nutrients, and regulation of blood pressure. The objective of this study was to compare the sublingual microcirculation of pregnant participants to that of comparable non-pregnant volunteers. Two groups of participants were recruited: a group of ...
Stern C J - - 2013
Ovarian tissue cryopreservation and transplantation is a form of fertility preservation offered to young women at high risk of losing ovarian function after cancer treatment. While there have been successful births resulting from orthotopic site grafts, we report the first case of an ongoing pregnancy from a heterotopic graft in ...
Taweevisit Mana - - 2013
Abstract The distribution of lipid in the fetal adrenal cortex is reported to correlate with the duration of hypoxia and degree of fetal stress. The original studies were based on Oil Red O staining, requiring frozen tissue that is often not available. To investigate the reliability of these observations, the ...
Garrod A - - 2013
We assessed whether placental morphology is affected by placental storage before fixation. Fresh tissue from uncomplicated pregnancies (n = 10) was fixed immediately and further samples were stored dry, in PBS or culture medium for 24, 48 or 72 h at 4 °C. Placental morphology quantified using image analysis software found no difference in ...
Sivakumar K K Dphil, MRCOG, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford OX3 9DU, United Kingdom. - - 2013
Obesity in pregnancy is associated with increased risks of obesity in the offspring. We investigated the relationship between obesity in pregnancy and circulating maternal and fetal levels of adipose tissue-derived factors adipsin and acylation stimulating protein (ASP) in lean and obese mothers. Paired peripheral and cord blood samples were taken. ...
Osol George - - 2013
Remodeling of the maternal uterine vasculature during pregnancy is a unique cardiovascular process that occurs in the adult and results in significant structural and functional changes in large and small arteries and veins, and in the creation of the placenta - a new fetomaternal vascular organ. This expansive, hypertrophic process ...
Sinai Talaulikar Vikram - - 2013
The human embryo-maternal interface in the first trimester of pregnancy is an area of extensive tissue remodeling. Because collagen is the most abundant constituent of the extracellular matrix of the placental bed, successful invasion must involve its rapid turnover. We compared the nature and distribution of collagen fibrils in decidua ...
Dang Yiping - - 2013
Pregnancy is associated with uteroplacental and vascular remodeling in order to adapt for the growing fetus and the hemodynamic changes in the maternal circulation. We have previously shown upregulation of uterine matrix metalloproteinases (MMPs) during pregnancy. Whether pregnancy-associated changes in MMPs are localized to the uterus or are generalized in ...
Li Qingchun - - 2013
The extracellular matrix (ECM) is characterized by not only well-preserved scaffolds of organs and vascularized tissues, but also by extremely low immunogenicity during allo- or xeno-implantation. This study aimed to establish a model of a composite microvasculature network scaffold with a small-caliber-dominant vascular pedicle by decellularizing fetal porcine aorta and ...
Register Karen B - - 2013
The current study describes a fatal Mycoplasma bovis infection in a North American bison (Bison bison) cow and her aborted fetus in a herd suffering unusual mortality associated with dystocia and abortion. Postmortem evaluation of the subject case found severe caseonecrotic bronchopneumonia, chronic fibrinous pleuritis and pulmonary sequestra, foci of ...
Etemadi Mozziyar - - 2013
Preterm birth is the leading cause of worldwide neonatal mortality. It follows a pathologically accelerated form of the normal processes that govern cervical softening and dilation. Softening and dilation occur due to changes in cervical collagen crosslinking, which can be measured non-invasively by changes in tissue fluorescence and impedance. We ...
Rabotti Chiara - - 2013
During pregnancy, analysis of the electrohysterogram (EHG), which measures the uterine electrical activity, can provide a fundamental contribution for the assessment of uterine contractions and the diagnosis of preterm labor. However, several aspects concerning uterine physiology and its link with EHG measurements are still unclear. As a consequence, the EHG ...
Guedes-Martins Luis - - 2013
Abstract Glycation of proteins or other biomolecules and their further long-term degradation results in the formation of advanced glycation end products, AGEs. AGEs and other ligands interact with their receptors, RAGEs, localized to a variety of tissues, but mainly in endothelium and vascular wall cells. This interaction triggers diverse signalling ...
Schwartz Joel - - 2013
OBJECTIVE: While chronic hypoxia has been recognized as the principal causative factor for decreasing birth weight at high altitude, unknown is whether fetal fat accretion and vascular function are affected. METHODS: Colorado women with normal singleton pregnancies (18 Denver residents, 1,600 m; 24 Leadville residents, 3,100 m) were studied longitudinally ...
Huppertz Berthold - - 2013
Invasion of extravillous trophoblast into maternal tissues has a profound effect on the oxygenation of the placenta and hence the fetus. The main route of trophoblast invasion is interstitial invasion into the tissues of the decidua and myometrium. From this main route side branches reach the spiral arteries (endovascular trophoblast) ...
Awad M - - 2013
INTRODUCTION: Secreted protein of Ly-6 domain 1 (SOLD1), a novel member of the Ly-6 superfamily, is present in the extracellular matrix of the mesenchyme in placental cotyledonary villi and is possibly involved in placental construction. OBJECTIVES: We investigated bovine SOLD1 expression in uteroplacental tissues with temporo-spatial patterning throughout gestation. METHODS: ...
Garabedian C - - 2013
OBJECTIVES: This study aimed to determine whether antenatal ultrasound measurements of fetal soft-tissues and liver can predict macrosomia in women with pregestational diabetes. METHODS: Fetal biometry, soft-tissue thickness (anterior abdominal wall [STAW], thigh [STT], upper arm [STA], scapular [STS]) and liver size were measured sonographically at 23, 28, 31 and ...
Donnez Jacques - - 2013
Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure >90% of girls and young women affected by disorders requiring such treatment. However, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Several options are currently available to preserve fertility in cancer patients. The present review reports the results ...
Fayers S - - 2013
To determine early haemodynamic changes in preeclampsia (PE) using tissue Doppler echocardiography and brain natriuretic peptide (BNP), and to relate these changes to obstetric outcomes. Consenting primigravidae patients in the third trimester of pregnancy were included in the study, which was carried out in a large regional hospital in Durban, ...
Piroth Tobias - - 2013
Restorative cell therapy concepts in neurodegenerative diseases are aimed at replacing lostneurons. Despite advances in research on pluripotent stem cells, fetal tissue from routineelective abortions is still regarded as the only safe cell source. Progenitor cells isolated fromdistinct first-trimester fetal CNS regions have already been used in clinical trials, and ...
van Egmond A - - 2013
Our standard procedure for phenotypic and functional analysis of immune cells present in the placenta is to isolate leukocytes from the decidua within five hours of the delivery. However, this results in logistical problems with deliveries at night, weekends or in other medical centers. Collecting placentas after complicated pregnancies is ...
Phillips Brandon N - - 2013
Nodular fasciitis (NF) is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the periorbital region. We report what we believe to be the first case of periorbital NF associated with pregnancy. A case of intravascular fasciitis, a NF variant, has been reported during pregnancy, but it was ...
Badir Sabrina - - 2013
OBJECTIVE: To quantitatively describe the evolution of ecto-cervical stiffness in normal pregnancy. METHODS: The stiffness of ecto-cervical tissue was measured using the aspiration method. This non-invasive technique allows to safely and objectively determining the pressure required to displace cervical tissue to a predefined deformation level (pcl ). In this prospective ...
Haslinda Abd-Rahim - - 2013
Myositis is a rare unknown inflammatory disorder of the skeletal muscle tissue. Generalized inflammatory myopathies, polymyositis, and dermatomyositis have been reported during pregnancy. Isolated orbital myositis in pregnancy has not been previously described in the literature. The authors report a case of left isolated orbital myositis in a primigravida at ...
Griffith O W - - 2013
Placentation is a common feature of live-bearing reptiles and mammals. Placentae are variable between species and can be classified by the extent that embryonic tissue breaches (invades) the uterus. Non-invasive placentation in eutherians is maternally imposed as extra-uterine embryos of species with epitheliochorial placentation will readily invade non-uterine tissues. This ...
Smith Cynthia R - - 2013
A routine pregnancy ultrasound examination of a 30-yr-old, multiparous, common bottlenose dolphin, Tursiops truncatus, detected an approximately 16-wk (gestational age) fetus with an omphalocele, an abdominal wall defect at the base of the umbilical cord. Throughout the pregnancy, ultrasound allowed for identification of the omphalocele contents, which included a portion ...
Hsu Andrew R - - 2013
Hallux varus deformity typically results from soft-tissue overcorrection at the metatarsophalangeal joint during surgery for hallux valgus. There are several soft-tissue procedures available for flexible hallux varus deformity including transfer of the extensor hallucis longus or abductor hallucis. To our knowledge, there have not been any previous reports in the ...
Kim Yohan - - 2013
Non-invasive histotripsy therapy has previously been used to achieve precise fetal tissue ablation in a sheep model. To further assess the clinical viability of the technique, this study investigated potential effects of histotripsy therapy during the remaining gestation and its local impact on fetal development. Five ewes (six lambs) at ...
Polonsky Marlo - - 2013
The following guidelines reflect a collation of the evaluable medical literature about surgical abortion prior to 7 weeks of gestation. Early surgical abortion carries lower risks of morbidity and mortality than procedures performed later in gestation. Surgical abortion is safe, practicable and successful as early as 3 weeks from the ...
Coder P Sawhney - - 2013
Antibody-like biopharmaceuticals cross the placenta by utilizing transport pathways available for transfer of maternal antibodies to the conceptus. To characterize the timing and magnitude of this transfer in the rat, embryo/fetal biodistribution of maternally administered radiolabeled humanized IgG2 was quantified over the course of gestation using gamma counting and whole ...
Kaitu'u-Lino Tu'uhevaha J - - 2013
STUDY QUESTION: What is the nature of cellular Corin expression in human gestational tissues? SUMMARY ANSWER: CORIN is expressed in non-pregnant late secretory phase endometrium, first trimester human implantation sites and is up-regulated with decidualization ex vivo. WHAT IS KNOWN ALREADY: Adequate trophoblast invasion and spiral artery remodeling/transformation is critical ...
Schlabritz-Loutsevitch N N Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN 38103-2896, USA. - - 2013
Abruptio placentae, defined as premature separation of a normally implanted placenta, is a life threatening pregnancy complication with unknown pathophysiology. A history of abruptio placentae is the major risk factor for this pregnancy complication in humans. We describe the first case of recurrent abruptio placentae in a Macaca fascicularis. A ...
Kaczmarek Monika M - - 2013
Introduction of semen into the female reproductive tract may induce molecular and cellular changes facilitating conception and pregnancy. Since prostaglandins (PGs) and appropriate vascularization of the endometrium are crucial for pregnancy success, the effect of seminal plasma (SP) on PGs synthesis and angiogenesis was investigated. Gilts received at estrus 100 ...
Astiz S - - 2013
Previous studies indicate that reproductive prolificacy of obese swine breeds is markedly influenced by embryo losses in early pregnancy. In such period, adequate secretion of progesterone (P4) by the ovary is essential for pregnancy success. This study analyses the luteal functionality during the oestrous cycle and early pregnancy of Iberian ...
Fernandez Michael - - 2013
The mechanical integrity of the uterine cervix is critical for a pregnancy to successfully reach full term. It must be strong to retain the fetus throughout gestation and then undergo a remodeling and softening process before labor for delivery of the fetus. It is believed that cervical insufficiency (CI), a ...
Matlow J N - - 2013
INTRODUCTION: Alcohol consumption during pregnancy can lead to Fetal Alcohol Spectrum Disorder (FASD), and because maternal self-reports are often unreliable, biomarkers of alcohol use are sometimes necessary to accurately determine fetal risk. Ethyl glucuronide (EtG), a direct metabolite of ethanol, has been detected in the meconium of infants born to ...
Rosefort Audrey - - 2013
Abstract Chorioangioma is the most common benign vascular placental tumor. It is often small and has no clinical significance. Large chorioangiomata are rarer and can lead to fetal or maternal complications. Chorangiomatosis or chorioangomatosis is even rarer and is defined as a focal or multifocal proliferation of placental capillaries permeating ...
van Poppel Mireille Nm - - 2013
OBJECTIVE: Chemerin is a novel adipokine implicated in inflammation and obesity. We hypothesized that fetal chemerin would be elevated in gestational diabetes mellitus (GDM) and correlate with fetal and maternal adiposity. DESIGN: Observational, longitudinal study SUBJECTS AND MEASUREMENTS: Fetal chemerin was measured separately in arterial and venous cord blood of ...
Bebbere Daniela - - 2013
The insulin-like growth factor 2 receptor (IGF2R) is essential for prenatal growth regulation and shows gene dosage effects on fetal weight that can be affected by in-vitro embryo culture. Imprinted maternal expression of murine Igf2r is well documented for all fetal tissues excluding brain, but polymorphic imprinting and biallelic expression ...
Justice Tiffany - - 2013
There are multiple clinical situations where cryopreservation of sperm is required including sperm banking prior to chemotherapy or radiation treatment for cancer, donor sperm for couples without a male partner, and various etiologies of male factor infertility. Bunge and Sherman presented the first pregnancy resulting from the thawing of cryopreserved ...
Critchell Karon - - 2013
This chapter describes the method used for serial sectioning and soft tissue examination of the Bouin's fixed fetus (mainly whole rat and or mouse fetuses or rabbit fetal heads) for the assessment of developmental and structural abnormalities. Fetuses are examined externally, together with the internal structures of the head as ...
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