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Vajda F J E FJ Department of Medicine and Neurosciences, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address: - - 2014
To determine the outcomes in regards to seizure control and foetal malformation in pregnant women with epilepsy not treated with antiepileptic drugs (AEDs). Analysis of data from the Australian Register of AEDs in Pregnancy on 148 women with epilepsy who were not receiving AEDs before and during at least the ...
Fuchs Florent F Department of Obstetrics and Gynecology, CHU Sainte Justine - Université de Montréal, Montréal, Qué., - - 2014
An increased prevalence of syphilis has been observed in many developed countries over the last decade. During pregnancy, syphilis can affect the fetus through development of nonspecific symptoms such as microcephaly, ascites, hepatosplenomegaly, dilated and echogenic bowel, placentomegaly, and, uncommonly, fetal hydrops. Congenital syphilis also leads to hematologic abnormalities such ...
Thompson Kimberly M KM Kid Risk, Inc, 10524 Moss Park Road, Ste. 204-364, Orlando, FL 32832, USA; University of Central Florida, College of Medicine, Orlando, FL, - - 2014
Although most infections with the rubella virus result in relatively minor sequelae, rubella infection in early pregnancy may lead to severe adverse outcomes for the fetus. First recognized in 1941, congenital rubella syndrome (CRS) can manifest with a diverse range of symptoms, including congenital cataracts, glaucoma, and cardiac defects, as ...
- - 2014
: Listeriosis is predominantly a foodborne illness, with sporadic and outbreak-related cases tied to consumption of food contaminated with listeria (Listeria monocytogenes). The incidence of listeriosis associated with pregnancy is approximately 13 times higher than in the general population. Maternal infection may present as a nonspecific, flu-like illness with fever, ...
Bonde Ulla U Department of Gynaecology and Obstetrics, Odense University Hospital, Sdr. Boulevard 29, Odense C 5000, - - 2014
There is now incontrovertible evidence that HPV is the cause of almost all cases of genital warts, cervical dysplasia and cervical cancer. Moreover the current review of the recent literature on HPV in relation to pregnancy found strong indications that HPV plays an important role in adverse outcomes of pregnancy. ...
Mészáros Beáta B University of Debrecen Department of Medical Microbiology Debrecen - - 2014
The aim of the present study was to assess the frequency of human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) infection during pregnancy. 100-100 blood samples were collected from pregnant and non-pregnant women, then nucleic acid was isolated from both plasma and leukocytes fraction. Nested and real-time PCR were ...
Bouthry Elise E Paris-Sud University, AP-HP, Hôpital Paul Brousse, Virologie, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, Villejuif, - - 2014
Rubella is a mild viral disease that typically occurs in childhood. Rubella infection during pregnancy causes congenital rubella syndrome, including the classic triad of cataracts, cardiac abnormalities and sensorineural deafness. Highly effective vaccines have been developed since 1969, and vaccination campaigns have been established in many countries. Although there has ...
Cantón Germán J GJ Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 0PZ Penicuik, United Kingdom; Instituto Nacional de Tecnología Agropecuaria (INTA), EEA Balcarce, CC276, 7620, - - 2014
Neospora caninum is recognized as a major cause of reproductive losses worldwide but its pathogenesis is not completely understood. Immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to the adverse effects of exacerbated Th1 type response at the maternal-foetal interface. Different clinical outcomes ...
Papp Eszter E Toronto General Research Institute, University Health Network, Toronto, Ontario, - - 2014
 Protease inhibitor (PI)-based combination antiretroviral therapy (cART) is administered during pregnancy to prevent perinatal HIV-transmission. However PI use has been associated with adverse birth outcomes, including preterm delivery and small for gestational age (SGA) births. The mechanisms underlying these are unknown. We hypothesized that PIs contribute to these adverse events ...
Hemelaar Steffannie J A L SJ Department of Obstetrics and Gynaecology, Division of Obstetrics & Prenatal Medicine , Erasmus MC, Rotterdam , The Netherlands - - 2014
Abstract Objective: To monitor the incidence of neonatal herpes in The Netherlands between 2006 and 2011, as well as the adherence to the rather conservative Dutch prevention policy. Methods: Questionnaires were sent to all virology laboratories (n = 44), gynaecology and paediatrics departments of all hospitals in The Netherlands (n = 89). Questionnaires for ...
Morocco Sarah S Departments of Obstetrics and Gynecology and Gastroenterology, Mount Sinai Beth Israel, New York, New - - 2014
Influenza A has been described in association with hepatitis. We present a case of complicated influenza A hepatitis in a pregnant woman, adding to the broad differential of liver disease in pregnancy. A 32-year-old woman, gravida 3 para 2002, at 31 4/7 weeks of gestation had influenza A diagnosed and ...
Luckett Rebecca R Brigham and Women's Hospital, Boston, - - 2014
Babesiosis is an emerging infectious disease caused by a tick-borne parasite that infects red blood cells. Pregnancy is a relatively immunocompromised state that can underlie severe manifestations of parasitic disease. A healthy primiparous patient in the second trimester developed nonspecific symptoms after a tick bite. Evaluation by obstetrics, primary care, ...
Racicot Karen K Division of Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, - - 2014
Progress in our understanding of the role of the maternal immune system during healthy pregnancy will help us better understand the role of the immune system in adverse pregnancy outcomes. In this review, we discuss our present understanding of the 'immunity of pregnancy' in the context of the response to ...
Kebed Kalie Y KY Department of Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address: - - 2014
The objective of this review was to describe the clinical characteristics, risk factors, and outcomes of infective endocarditis (IE) in pregnancy and the postpartum period. We conducted a systematic review of Ovid MEDLINE, Ovid Embase, Web of Science, and Scopus from January 1, 1988, through October 31, 2012. Included studies ...
Chêne Arnaud A Inserm UMR_1134, Paris, FranceUniversité Paris Diderot, Sorbonne Paris Cité, UMR_S1134 Paris, France Institut National de la Transfusion Sanguine, Paris, France Laboratory of excellence GR-Ex, Paris, - - 2014
Pregnancy-associated malaria (PAM) can lead to severe complications for both mother and baby. Certain placental cytokine/chemokine profiles have been shown to reflect poor pregnancy outcomes, including maternal anemia and low birth weight. In intervillous plasma samples from 400 Beninese women living in a Plasmodium falciparum-endemic area we quantified 16 cytokines/chemokines. ...
Daud Ibrahim I II Center for Global Health Research, Kenya Medical Research Institute, Kisumu, - - 2014
The role of Plasmodium falciparum malaria in Epstein-Barr virus (EBV) transmission among infants early in life remain elusive. We hypothesized that infection with malaria during pregnancy could cause EBV reactivation leading to high EBV load in circulation, which could subsequently enhance early age of EBV infection. Pregnant women in Kisumu, ...
- - 2014
Unintended pregnancy and sexually transmitted infections (STIs) are the major negative consequences of unsafe sex. Both are common and have long-term social and health consequences. Barrier methods of contraception can prevent both, but unfortunately they are much less effective than the more modern methods at pregnancy prevention. Modern effective contraceptives, ...
Marchesini Paola P Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, - - 2014
In Brazil, malaria remains a disease of major epidemiological importance because of the high number of cases in the Amazonian Region. Plasmodium spp infections during pregnancy are a significant public health problem with substantial risks for the pregnant woman, the foetus and the newborn child. In Brazil, the control of ...
Raj Renju S RS Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, - - 2014
Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt ...
Plotkin Marya M Jhpiego Tanzania, Dar es Salaam, Tanzania; Zanzibar Malaria Control Program, Zanzibar Ministry of Health, Tanzania; Jhpiego Baltimore, Baltimore, Maryland; Department of International Health, John Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Department of Medicine, University of California, San Francisco, California; US President's Malaria Initiative and Centers for Disease Control and Prevention Tanzania, Dar es Salaam, Tanzania; Centers for Disease Control and Prevention, Atlanta, Georgia - - 2014
Zanzibar has transitioned from malaria control to the pre-elimination phase, and the continued need for intermittent preventive treatment during pregnancy (IPTp) has been questioned. We conducted a prospective observational study to estimate placental malaria positivity rate among women who did not receive IPTp with sulfadoxine-pyrimethamine. A convenience sample of pregnant ...
Khalesi Nasrin N Department of Pediatrics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, - - 2014
To assess the relationship between maternal UTI during pregnancy and neonatal UTI. This cross-sectional study included eighty neonates referred to Ali-e-Asghar Hospital, Tehran, Iran, in 2011. The participants were divided into the study (with diagnosis of UTI; n = 40) and the control (without this type of infection; n = ...
Park James S JS Division of Gastroenterology, Department of Medicine, NYU Langone Medical Center, NYU School of Medicine, New York, 10016, - - 2014
Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data ...
Ford Nathan N 1HIV/AIDS Dept, World Health Organization, Geneva, Switzerland. 2Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, United Kingdom. 3Department of Medicine, Divisions of Infectious Diseases and General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA. 4ICAP, Mailman School of Public Health, and College of Physicians & Surgeons, Columbia University, New York, USA. 5Dept of Paediatrics and Child Health, Tygerberg Hospital, University of Stellenbosch, South Africa. 6Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, - - 2014
Cotrimoxazole is widely prescribed to treat a range of infections and for HIV-infected individuals it is administered as prophylaxis to protect against opportunistic infections. Some reports suggest that fetuses exposed to cotrimoxazole during early pregnancy may have an increased risk of congenital anomalies. We carried out this systematic review in ...
Calitri Carmelina - - 2014
In the Highly Active Antiretroviral Therapy (HAART) era, the prognosis of children perinatally infected with HIV-1 has significantly improved, so the number of perinatally-infected females entering child-bearing age and experiencing motherhood is increasing. A description of the medical history and pregnancy outcomes of women with perinatal acquired HIV-1 infection enrolled ...
Ostensen Monika M National Service for Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, Trondheim, - - 2014
The safety of biologic agents during pregnancy is still being investigated. Tumor necrosis factor α (TNF-α) inhibitors are the only well-studied biological drugs in pregnancy; they do not appear to be teratogenic but increase the risk of infection after birth when given in late pregnancy. The long-term effects in exposed ...
Govender N N Optics and Imaging Centre, University of KwaZulu-Natal, South - - 2014
Hypertensive disorders of pregnancy are the commonest direct cause of maternal deaths in South Africa, 83% being attributed to pre-eclampsia. Elevated placental sFlt-1 levels are linked with angiogenic disruption and subsequent pre-eclampsia development. The impact of HIV infection on pre-eclampsia is controversial. Its effect on angiogenic imbalance in both normotensive ...
Greenup Astrid-Jane AJ Gastroenterology, Liverpool Hospital, - - 2014
Perinatal transmission of Hepatitis B Virus still occurs despite immunoprophylaxis in approximately 9% of children from highly viraemic mothers. Antiviral therapy in this setting has been suggested, however with limited evidence to direct agent choice. We conducted a multi-centre, prospective, opt-in observational study of antiviral safety and efficacy in pregnant ...
Han Y W YW Department of Periodontics, School of Dental Medicine and Departments of Pathology and Reproductive Biology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, - - 2014
Interrelationships between periodontal infection and systemic conditions such as cardiovascular disease, adverse pregnancy outcomes, and head-and-neck cancer have become increasingly appreciated in recent years. Periodontitis is associated with cardiovascular disease (CVD) and, experimentally, with measures of atherosclerosis and endothelial dysfunction. Periodontal therapy may reduce atherosclerotic changes and improve endothelial function. ...
Vigliani Marguerite B MB Warren Alpert School of Medicine, East Providence, - - 2014
A recent case of typhoid fever in the first trimester of pregnancy stimulated our curiosity about organisms that can cross the placenta. Despite early diagnosis and prompt treatment with appropriate antibiotic therapy, fetal loss occurred at 16 weeks of gestation as a result of abruption, and Salmonella enterica serovar typhi ...
Nwali Matthew Igwe MI Department of Obstetrics and Gynecology, Federal Teaching Hospital,Abakaliki, Ebonyi, - - 2014
Malaria infestation during pregnancy is mostly asymptomatic and untreated especially in unbooked pregnancies. It presents with almost all the fetal complications of overt malaria in pregnancy. The aim of this study was to determine the effect of asymptomatic malaria parasitaemia on the neonates of unbooked parturients delivered at term at ...
da Costa Cássia Mariana Bronzon CM Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo. Electronic address: - - 2014
Chagas disease induces a strong immune response and L-arginine is an essential amino acid which plays an important role in homeostasis of the immune system. The aims of this study were to evaluate parasitemia, corticosterone levels, production of nitric oxide (NO), fetal morphological measurements, and histothology of heart and placenta. ...
Binello Nicolò - - 2014
In the Western world, the diagnosis and management of Plasmodium vivax malaria in pregnant women can be challenging, and the pathogenesis of adverse outcomes for both the mother and the foetus is still poorly known. The authors describe the case of a 29-year-old Pakistani woman at the 29th week of ...
Di Gangi Stefania S Department of Woman and Child Health - University of Padua - Padua - - 2014
Abstract Prion diseases are fatal neurological disorders that are thought to be caused by the accumulation of an altered variant of a benign, widely expressed protein (PrPC) into a distinct pathological conformation(s) (PrPSc). The prion diseases are a so rare but lethal pathologies that need an early diagnosis to support ...
Stewart Robert D RD Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: - - 2014
To determine if inter-pregnancy HIV viral load suppression affects outcomes in subsequent pregnancies. This is a retrospective review of all women who delivered two consecutive pregnancies while diagnosed with HIV from January 1, 1984 until January 1, 2012. Medical records were reviewed for maternal, infant, and delivery data. Pregnancies were ...
Ibitokou Samad A SA Centre d'étude et de recherche sur le paludisme associé à la grossesse et à l'enfance (CERPAGE), Faculté des Sciences de la Santé, Université d'Abomey-Calavi, - - 2014
Background:The immunological consequences of pregnancy-associated malaria (PAM) due to Plasmodium falciparum have been extensively investigated in cross-sectional studies conducted at delivery, but there have been very few longitudinal studies of changes due to PAM during pregnancy.Methods:We conducted a prospective study in Benin to investigate the changes associated with PAM in ...
McClure Elizabeth M EM Social, Statistical and Environmental Sciences, Research Triangle Institute, Durham, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA. Electronic address: - - 2014
To use ultrasound to explore the impact of malaria in pregnancy on fetal growth and newborn outcomes among a cohort of women enrolled in an intermittent presumptive treatment in pregnancy (IPTp) with sulfadoxine/pyrimethamine (SP) program in coastal Kenya. Enrolled women were tested for malaria at first prenatal care visit, and ...
Serafim Anie Savi AS Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, - - 2014
Introduction The aim of this study was to establish the incidence rates of congenital syphilis in the South Region of Brazil from 2001 to 2009. Methods Temporal ecological and descriptive study based on the cases recorded by the System of Information of Notifiable Diseases. Results The incidence of congenital syphilis ...
Nigro Giovanni G Pediatric Unit and School, University of L'Aquila, San Salvatore Hospital, L'Aquila, - - 2014
Abstract Background. CMV hyperimmune globulin (HIG) may be helpful after a primary maternal CMV infection during pregnancy as a therapy for infected fetuses or to prevent maternal-to-fetus transmission of CMV. Although immunoglobulins administered during pregnancy appear safe, previous studies have not monitored HIG for a possible effect on duration of ...
Adam O O Department of Medical Biotechnology, Commission for Biotechnology and Genetic Engineering, the National Centre for Research, Khartoum, - - 2014
SUMMARY Parvovirus B19 (B19V) infection during pregnancy may have serious consequences like fetal anaemia, hydrops fetalis, and fetal loss. Since epidemiological data on B19V infection are generally lacking in Sudan, the current study aimed to determine the seroprevalence of B19V in Sudanese pregnant women. Five hundred women, attending antenatal clinics ...
Marder Wendy W aDivision of Rheumatology, Department of Internal Medicine bDivision of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan cDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, - - 2014
To review the association of pregnancy with the risk of subsequent development of rheumatic autoimmune diseases in women, including rheumatoid arthritis (RA), systemic lupus erythematosus, and scleroderma. There is a small but growing literature related to the risk of autoimmune rheumatic disease in association with pregnancy history. However, results conflict ...
Hegazi Aseel A Department of Genitourinary Medicine, St George's University Hospital, London, - - 2014
Young people attending genitourinary medicine services are at high risk of unplanned pregnancy. We performed a retrospective cohort study to identify characteristics of pregnant teenagers accessing an inner London genitourinary medicine service. There were 481 pregnancies in 458 teenagers with 54 previous pregnancies and 46 previous terminations of pregnancy. The ...
Jaroensuk Juthamas J Shoklo Malaria Research Unit (SMRU), Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United - - 2014
Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly ...
Conti Fabiana Mendes FM Hospital Israelita Albert Einstein, São Paulo, SP, - - 2014
Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the ...
Pedrassani Daniela D Laboratório de Parasitologia Veterinária, Curso de Medicina Veterinária, Universidade do Contestado ? UnC, Canoinhas, SC, - - 2014
This study reports a case of parasitism by Dioctophyme renale in a supernumerary kidney and abdominal cavity of a female cat in Brazil. The three-year-old cat of indeterminate breed presented abdominal distension and was taken to the University of Contestado Veterinary Hospital in Canoinhas, state of Santa Catarina, since the ...
Barral Maria F M - - 2014
In the absence of intervention, the rate of vertical transmission of HIV can range from 15-45%. With the inclusion of antiretroviral drugs during pregnancy and the choice of delivery route this amounts to less than 2%. However ARV use during pregnancy has generated several questions regarding the adverse effects of ...
González Raquel - - 2014
Control of malaria in pregnant women is still a major challenge as it constitutes an important cause of maternal and neonatal mortality. Mefloquine (MQ) has been used for malaria chemoprophylaxis in non-immune travellers for several decades and it constitutes a potential candidate for intermittent preventive treatment in pregnant women (IPTp). ...
Xie Fang F Pacific Northwest Research Institute, Seattle, WA, - - 2014
Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early-onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and low platelets syndrome (HELLPs) are unexplored. A case-control study was performed to examine maternal CMV antibodies, neutrophil Toll-like receptor (TLR)-2 and -4 ...
Phiri Kelesitse K 1 Department of Epidemiology, Harvard School of Public Health , Boston, - - 2014
Abstract Optimal use of antiretroviral drugs by pregnant women living with human immunodeficiency virus (HIV) is crucial to treat maternal HIV infection and prevent perinatal transmission of the virus effectively. Our goal was to describe national trends of antiretroviral (ARV) use during pregnancy among HIV-infected women living in the U.S. ...
Fontenot Holly B - - 2014
Sexually transmitted infections (STI) occur during pregnancy and can have serious consequences for women and infants. National guidelines include recommendations for STI screening in all pregnant women; however women continue to be underscreened, and risks related to infection during pregnancy persist. Nurses caring for women of childbearing age should be ...
Mpairwe Harriet H MRC/UVRI Uganda Research Unit on AIDS, P.O. Box 49, Entebbe, - - 2014
It has been proposed that helminth infection may be particularly detrimental during pregnancy, through adverse effects on maternal anaemia and on birth outcomes, and that anthelminthic treatment during pregnancy will therefore be particularly beneficial. However, the few treatment trials that have been conducted have given but little support to this ...
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