Search Results
Results 401 - 450 of 1376
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Maintz Laura - - 2008
BACKGROUND: Histamine has been assumed to contribute to embryo-uterine interactions due to its vasoactive, differentiation and growth-promoting properties. However, its exact functions in pregnancy are unclear. The histamine-degrading enzyme diamine oxidase (DAO) is produced in high amounts by the placenta and has been supposed to act as a metabolic barrier ...
Teo S B L - - 2008
Placenta percreta is a rare but potentially life-threatening condition associated with high maternal mortality and morbidity rates, usually arising from severe obstetric haemorrhage. Due to rising caesarean section rates, an increase in the incidence of morbidly adherent placentas (accreta, increta and percreta) has been observed. Various treatment strategies have been ...
Sebastian M M - - 2008
Placentitis, funisitis and fetal bronchopneumonia were diagnosed in an aborted full-term Thoroughbred fetus and its placenta by histopathological examination. Dermatophilus congolensis organisms were isolated from placenta, lung and stomach content. The genotypic identification of aerobic culture was confirmed by sequential analysis of the entire 16S rDNA gene. This is the ...
Ashfaq Muhammad - - 2008
BACKGROUND: Wet snuff is commonly used by both males and females in different parts of Pakistan. Apart from other ingredients, tobacco is the major component of snuff. Adverse effects of smoking on morphology of human placenta have been shown by some previous studies. But snuff is not considered as dangerous ...
Marin Jose J G - - 2008
Potentially toxic endogenous compounds, such as bile acids (BAs) and biliary pigments, as well as many xenobiotics, such as drugs and food components, are biotransformed and eliminated by the hepatobiliary system with the collaboration of the kidney. However, the situation is very different during pregnancy because the fetal liver produces ...
Tamura Hiroshi - - 2008
We investigated how maternal melatonin is regulated in pregnant rats. To examine the involvement of the conceptus (fetus and placenta) in serum melatonin concentrations, the number of conceptuses was experimentally reduced to one on day 7 of pregnancy (1-conceptus group). Maternal circulating nighttime melatonin levels increased toward day 21 of ...
Mattace Raso G - - 2008
Hypertension in pregnancy is often associated to placental deficiency. Therefore several physiopathological modifications occur to sustain fetal well-being through protective mechanisms. Here, we used spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto (WKY) counterpart to evaluate in late gestation (d 20) modification of placental proteins involved in adaptation to hypertension. Placenta ...
Cygalova Lenka - - 2008
Breast cancer resistance protein (BCRP/ABCG2) is an ABC family drug efflux transporter expressed in a number of physiological tissues including placenta. Here we investigated the expression and function of Bcrp in the rat placenta and fetus during pregnancy. We show that the expression of Bcrp mRNA in placenta peaks on ...
Carluccio A - - 2008
This study was designed to establish the morphological features of the placenta of the Martina Franca jenny. Ten placentas were harvested at the time of foal delivery and examined both for gross and histological characteristics. The following factors were determined: the total weight and volume of the placenta and its ...
Onderdonk Andrew B - - 2008
The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation. Biopsy specimens of chorion parenchyma from 1083 placentas delivered before the beginning of the 28th week of gestation were cultured, and the placentas ...
Barbato O - - 2008
The present study describes the isolation and characterization of new pregnancy-associated glycoprotein molecules (PAG) from midpregnancy and late-pregnancy placentas in the water buffalo (Bubalus bubalis). After extraction, the homogenates are subjected to acid and ammonium sulfate precipitations followed by DEAE chromatography. Subsequently, the water buffalo PAG (wbPAG) from these solutions ...
Wilson Bettye - - 2008
One of the earliest medical uses of ultrasound was in the obstetrics specialty. The primary objective of obstetric sonography is to determine the well-being of the fetus and, to some extent, the mother. The placenta and umbilical cord play an essential part in that determination. This Directed Reading examines the ...
Biswas Sharmistha - - 2008
The present study aimed to throw light to any gross morphological changes of placenta that might contribute to the development of idiopathic IUGR. Gross examination of placentas from full-term uncomplicated pregnancies delivering singleton live IUGR babies, and live normal-weight babies (controls) were performed; then the results were compared. Fifty full-term ...
Arnold D R - - 2008
This workshop focused on describing clinical problems identified in the placentae of cloned animals and some of the potential biological mechanisms by which these anomalies arise. It was shown that placental anomalies related to somatic cell nuclear transfer (SCNT) in cattle often can be detected by ultrasonography early in gestation, ...
Furuya Mitsuko - - 2008
Preeclampsia is a serious disorder that may result in severe morbidity and mortality for mother and fetus, and it is thought that the placental dysfunction is important in the pathogenesis of preeclampsia. As the model of preeclampsia, we previously generated a transgenic mouse model that developed pregnancy-associated hypertension (PAH) by ...
Abramowicz J S - - 2008
Diagnostic ultrasound has been in use in clinical obstetrics for close to half-a-century. However, in the literature, examination of the placenta appears to be treated with less attention than the fetus or the pregnant uterus. This is somewhat unexpected, given the obvious major functions this organ performs during the entire ...
Fowden A L AL Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. - - 2008
Intrauterine programming is the process by which the structure and function of tissues are altered permanently by insults acting during early development. In mammals, the placenta controls intrauterine development by supplying oxygen and nutrients, and by regulating the bioavailability of specific hormones involved in foetal growth and development. Consequently, the ...
Cho Jeong Yeon - - 2008
PURPOSE: To correlate the incidence and rate of placental migration with the mode of delivery, pregnancy outcome, and maternal complication according to the location (anterior versus posterior) and type of placenta previa (PP). METHODS: We prospectively evaluated the placentas of 98 pregnant women with PP or low-lying placenta (LLP) at ...
Gordijn S J - - 2008
The placenta is often not submitted for histopathological examination and obstetricians may be sceptical of the value of the examination. This article looks at the reasons for histopathological assessment of the placenta, examines what clinical information should be provided to pathologists and reviews what information can be gained from this ...
Aziken, M E; ;
Morbidly adherent placenta often presents as a case of retained placenta or occasionally encountered at caesarian section especially repeat caesarian section. O.T. had placenta percreta and presented as a case of acute abdomen with haemoperitoneum in pregnancy. The haemoperitoneum resulted from complete placenta penetration of the uterine wall. She was ...
Buhimschi I A - - 2008
Proteomics is the study of expressed proteins and has emerged as a complement to genomic research. The major advantage of proteomics over DNA-RNA based technologies is that it more closely relates to phenotypes and not the source code. Proteomics thus holds the promise of providing a direct insight into the ...
Sekita Yoichi - - 2008
Eutherian placenta, an organ that emerged in the course of mammalian evolution, provides essential architecture, the so-called feto-maternal interface, for fetal development by exchanging nutrition, gas and waste between fetal and maternal blood. Functional defects of the placenta cause several developmental disorders, such as intrauterine growth retardation in humans and ...
Mayhew Terry M - - 2009
Stereology applied to randomly-generated thin sections allows minimally-biased and economical quantitation of the 3D structure of the placenta from molecular to whole-organ levels. With these sampling and estimation tools, it is possible to derive global quantities (tissue volumes, interface surface areas, tubule lengths and particle numbers), average values (e.g. mean ...
Carter A M - - 2008
Evidence from several sources supports a close phylogenetic relationship between elephants and sirenians. To explore whether this was reflected in similar placentation, we examined eight delivered placentae from the Amazonian manatee using light microscopy and immunohistochemistry. In addition, the fetal placental circulation was described by scanning electron microscopy of vessel ...
Hecht Jonathan L - - 2008
Prolonged exposure to infection appears to influence fetal/neonatal development. We characterize the relationship between histologic patterns of inflammation and microorganism recovery from the placentas of live born infants delivered before the 28th postmenstrual week. The subamniotic parenchyma of 835 placentas delivered by cesarean section were cultured and evaluated for specific ...
Ekerhovd Erling - - 2008
BACKGROUND: A common approach in the management of retained placenta is administration of oxytocin followed by controlled cord traction. Previously it has also been demonstrated that intravenously administered nitroglycerin facilitates manual extraction of retained placenta. The purpose of the present trial was to examine the success rate and safety of ...
Papadakis J C - - 2008
Placenta percreta complicating pregnancy in the first trimester is extremely rare, and only a few cases have been reported in the literature. A patient with risk factors for placenta percreta that presented as first trimester fetal demise, unresponsive to medical management with prostaglandin, is presented. The patient required an emergency ...
Malassiné André - - 2008
Human trophoblast expresses two fusogenic retroviral envelope proteins, the widely studied syncytin 1, encoded by HERV-W and the recently characterized syncytin 2 encoded by HERV-FRD. Here we studied syncytin 2 in normal and Trisomy 21-affected placenta associated with abnormal trophoblast differentiation. Syncytin 2 immunolocalization was restricted throughout normal pregnancy to ...
Nanovskaya Tatiana N - - 2008
OBJECTIVE: The objective of the study was to determine the effect of gestational age and P-glycoprotein expression on transplacental transfer of methadone. STUDY DESIGN: Dual perfusion of placental lobule was utilized. Methadone (200 ng/mL) and its [3H]-isotope were cotransfused from the maternal-to-fetal circuit with the marker compound antipyrine (20 microg/mL) ...
Marini M - - 2008
The aim of the present study was to determine the expression of vascular endothelial growth factor (VEGF) receptors VEGFR-1, VEGFR-2 and VEGFR-3 in placentas from pregnancies complicated by altered glycaemia. Placentas from women with physiological pregnancies (Group 1), pregnancies complicated by minor degree of glucose intolerance (MDGI, Group 2) and ...
Menghrajani Pareesa - - 2008
Hemorrhagic endovasculitis (HEV) is an alteration of fetal chorionic blood vessels within the placenta. This disruption of the integrity of the parietal blood vessels has been reported in association with poor pregnancy outcomes and perinatal complications. In stillbirths, its presence has been implicated as part of the mechanism of the ...
Kralova Alena - - 2008
The placenta is an important site for iron metabolism in humans. It transfers iron from the mother to the fetus. One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake. Its localization and expression may be one of the markers to ...
Kudaka W - - 2008
We previously investigated tissue specificity and temporal changes in expression of five human endogenous retroviruses (HERVs), including syncytin/ERVWE1 and syncytin 2. In the current study, we examined the cellular localization and quantified the transcripts of five HERVs, syncytin, syncytin 2, HERV-H7/F(XA34), HERV-Fb1, and HERV-HML6-c14, in order to elucidate their physiological ...
Choi Suk-Joo - - 2008
The objective of this study was to identify antepartum risk factors for peripartum hysterectomy in women with placenta previa. The medical records of women with placenta previa who underwent cesarean section (C/S) were reviewed retrospectively. Data regarding the reproductive history and peripartum outcomes were analyzed. Multivariable analysis was used to ...
Sudhakaran Sreeja - - 2008
We have shown previously using the dually perfused isolated human placenta model that the maternal to foetal transfer of the antiviral protease inhibitor drug indinavir is substantially lower than the transfer in the opposite direction. This finding is not consistent with passive diffusion and indicates that a carrier-mediated mechanism is ...
Gellhaus Alexandra - - 2007
It is thought that preeclampsia results from a shallow invasion of the extravillous trophoblast into the decidua and maternal vessels, which in turn leads to hypoxia and uteroplacental insufficiency. Here, the authors focus on the expression of the proangiogenic secreted molecules CYR61 (CCN1) and NOV (CCN3) in human placentae during ...
Quintero Rubén A - - 2007
Vasa previa, defined as fetal vessels coursing within the membranes between the presenting part and the cervix, occurs in approximately 1:2500-5000 pregnancies. Type II vasa previa consists of fetal vessels crossing over the internal os connecting a bilobed placenta or a succenturiate lobe with the main placental mass. These vessels ...
Barigye Robert - - 2007
Following a routine necropsy of a bovine fetus aborted at 5 months of gestation, placenta, fetal tissue samples, and stomach contents were subjected to a number of laboratory tests. Staphylococcus warneri was isolated in pure culture from the lung, liver, and stomach contents, whereas the placenta yielded S. warneri and ...
Karpf Eva F - - 2007
A 28-year-old patient presented with a 5 cm endometrial stromal tumor situated at the uteroplacental interface, which was diagnosed ultrasonographically at the 28th week of pregnancy. The tumor was asymptomatic and closely attached to the decidua; after a normal term delivery, it was revealed to be embedded within the placenta. ...
Suzuki Shunji - - 2008
OBJECTIVES: This study examined the clinical significance of patients complicated by succenturiate lobes of placenta in comparison with patients with normal placenta. METHODS: Data were collected from 47 patients complicated by succenturiate lobes of placenta and from 7,666 unaffected controls. RESULTS: The frequency of maternal age > or =35 years ...
Tranquilli Andrea L - - 2007
OBJECTIVE: We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN: Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human Inflammatory Cytokines ...
Ju W - - 2007
Placenta increta during the first trimester of pregnancy is extremely rare. Only a few cases of placenta accreta during the latter half of pregnancy manifesting as a uterine mass have been published. This report describes a case of placenta increta that caused prolonged bleeding after a first-trimester abortion, and was ...
Son Gahyun - - 2007
Placenta increta is an uncommon and life-threatening complication of pregnancy characterized by complete or partial absence of the decidua basalis. Placenta increta usually presents with vaginal bleeding during difficult placental removal in the third-trimester. Although placenta increta may complicate first and early second-trimester pregnancy loss, the diagnosis can be very ...
Liguori A - - 2007
OBJECTIVE: Maternal hypercholesterolaemia during pregnancy increases lipid peroxidation in mothers and fetuses and programs increased susceptibility to atherosclerosis later in life. The objective of this study was to elucidate the role of the placenta in mediating oxidative stress from mother to offspring. DESIGN: Comparison between normo- and hypercholesterolaemic mothers (n ...
Colleen Anne Wright; University ...
Introduction The placenta is rarely sent for histopathological examination, despite its availability after delivery and the valuable contribution it may make to understanding adverse pregnancy outcome.This may be due to reluctance on the part of surgical pathologists to examine the placenta, due to a number of reasons that are applicable ...
Gonzalez Juan M - - 2007
OBJECTIVE: These studies were performed to elucidate the expression of Toll-like receptors (TLRs) in the uterus, cervix, and placenta in pregnancy and across gestation. STUDY DESIGN: Message expressions of TLR-2, -3, -4, and -9 were investigated in nonpregnant mice and across gestation in CD-1 mice. Uterine, cervical, and placental tissues ...
Hong Eui-Ju - - 2007
Calbindin-D(9k) (CaBP-9k) gene is expressed in the uterus of pregnant rats, which is regulated by steroid hormones during estrous cycle or gestation. We hypothesized that there is a positive correlation between altered CaBP-9k expression and change in one or more of the hormones to provide a clue to the mechanism ...
Al-Saleh Eyad - - 2007
OBJECTIVE: Platinum-containing drugs are widely used in the treatment of various malignancies in humans. There is a paucity of data on maternal-fetal transport characteristics of one such widely used drug, carboplatin, and this prompted us to study its permeation characteristics in the human placenta in vitro. METHODS: Placentae from uncomplicated, ...
Cobellis Luigi - - 2007
Apoptosis is intimately involved in placental homeostasis, growth and remodelling, and apoptotic rates increase progressively during normal pregnancy as part of normal placental development. Moreover, apoptosis increases in pregnancies complicated by some pathologies such as preeclampsia, fetal growth restriction and diabetes. In the present study, we describe differences in the ...
Perez Maria J - - 2007
Maternal cholestasis is usually a benign condition for the mother but induces profound placental damage and may be lethal for the fetus. The aim of this study was to investigate the protective effects in rat maternal and fetal livers as also the placenta of melatonin or silymarin against the oxidative ...
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