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Taylor Peter N PN Thyroid Research Group, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, - - 2014
Objective: Thyroid dysfunction is associated with impaired cognitive development. Perchlorate decreases thyroidal iodine uptake, potentially reducing thyroid hormone production. It is unclear whether perchlorate exposure in early life affects neurodevelopment. Design: Historical cohort analysis. Patients: During 2002-2006, 21,846 women at gestational age <16 weeks recruited from antenatal clinics in Cardiff, ...
Zhao Fei F 501 DW Brooks Dr., Department of Physiology and Pharmacology, College of Veterinary Medicine; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: - - 2014
Exposure timing could play an important role in the effects of estrogenic endocrine disrupting chemicals (EEDCs) on early pregnancy. This study examined the sensitivity of different exposure periods from weaning to gestation day 4.5 (D4.5) to 50 ppb diethylstilbestrol (DES, a test EEDC) diet on embryo implantation and potential recovery ...
Xie Chuanbo C Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, - - 2014
To compare predictive values of small-for-gestational-age (SGA) by different measures for secondhand smoke (SHS) exposure during pregnancy and to develop and validate a prediction model for SGA using SHS exposure along with sociodemographic and pregnancy factors. We compared the predictability of different measures of SHS exposure during pregnancy for SGA ...
Zheng Guanchao G State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, - - 2014
To better understand the relationship between prenatal exposure to heavy metals and trace elements and the risk of adverse pregnancy outcomes, we investigated the status of heavy metals and trace elements level in a Chinese population by collecting umbilical cord blood. Umbilical cord blood heavy metals and trace elements concentrations ...
Fauchet Floris F EA 3620 Université Paris Descartes, Sorbonne Paris Cité, France; Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, - - 2014
The main goal of the study was to describe the pharmacokinetics of maternal zidovudine (ZDV) administrations during pregnancy and labor and to evaluate its impact on fetal concentrations and exposures. A total of 195 HIV-infected pregnant and non-pregnant women aged 16-59 years were included, 273 maternal and 79 cord blood ...
Zhao Yan Y School of Public Health, Fudan University, Shanghai, - - 2014
BACKGROUND:No study has examined the association between prenatal phthalate exposure and Intrauterine Growth Retardation (IUGR). This study aimed to investigate whether prenatal exposure to phthalates was associated with increased risk of IUGR.METHODS:A total of 126 mother-newborn pairs, including 42 IUGR cases and 84 control newborns and their mothers, were enrolled ...
Wollenhaupt Martina M Pharmaceutical Development Safety and Risk Management, F. Hoffmann-La Roche Ltd, Basel, - - 2014
Influenza infection places pregnant women at greater risk of morbidity and hospitalization. The use of oseltamivir to treat influenza increased markedly in all population groups during the A/H1N1pdm09 pandemic, including pregnant women. Given this increase in exposure, a reassessment of the safety of oseltamivir in pregnancy was conducted. The Roche ...
Feng Jianghua J Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005, China. Electronic address: - - 2014
Prenatal nicotine exposure causes adverse birth outcome. However, the corresponding metabonomic alterations and underlying mechanisms of nicotine-induced developmental toxicity remain unclear. The aims of this study were to characterize the metabolic alterations in biofluids in nicotine-induced intrauterine growth retardation (IUGR) rat model. In the present study, pregnant Wistar rats were ...
Poon Shirley - - 2014
I have a patient recently confirmed to be 6 weeks pregnant. For the past 6 months she has been treated for an opioid addiction with buprenorphine-naloxone combination. Should I be concerned about her exposure to this drug combination up to this point of the pregnancy? Should I switch her medication ...
Mandelbrot Laurent L Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstetrique, Colombes, France Université Paris-Diderot, Paris, France - - 2014
Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1000 ng/ml) in the maternal-fetal direction. The mean fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0% ± 2.1% and clearance index (darunavir FTR/antipyrine FTR) ...
Pycke Benny - - 2014
Triclosan (TCS) and triclocarban (TCC) are antimicrobial agents formulated in a wide variety of consumer products (including soaps, toothpaste, medical devices, plastics, and fabrics) that are regulated by the U.S. Food and Drug Administration (FDA) and U.S. Environmental Protection Agency. In late 2014, the FDA will consider regulating the use ...
Sinclair Susan S University of North Carolina Wilmington, Wilmington, NC, USA; INC Research LLC, Wilmington, NC, - - 2014
The International Lamotrigine Pregnancy Registry monitored for a signal of a substantial increase in the frequency of major congenital malformations associated with lamotrigine exposures in pregnancy over an 18-year period. Key methodological lessons are discussed. The strengths and weaknesses of the Registry were assessed using quantifiable methodological and operational parameters ...
Subramanian Kaviarasan K Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, - - 2014
Alcohol exposure during pregnancy results in an array of structural and functional abnormalities called fetal alcohol spectrum disorders (FASD). Alcohol dysregulates the exquisite coordination and regulation of gestational adaptations at the level of the uterine vasculature. We herein hypothesized that chronic binge-like alcohol results in uterine vascular dysfunction and impairs ...
Zhao Fei F Department of Physiology and Pharmacology, College of Veterinary Medicine; Interdisciplinary Toxicology Program; University of Georgia, Athens, GA 30602, - - 2014
This study investigated potential cumulative effects of multiple pregnancy and multigenerational exposure to dietary ZEA (0, 0.8, 4, or 20ppm) on female puberty and reproduction in C57BL/6J mice. Multiple pregnancies did not significantly affect litter size or offspring puberty. Significant effects were observed in 20ppm ZEA-treated females: advanced puberty onset ...
Shelton Janie F JF Department of Public Health Sciences, University of California, Davis, Davis, California, - - 2014
Gestational exposure to several common agricultural pesticides can induce developmental neurotoxicity in humans, and has been associated with developmental delay and autism. To evaluate whether residential proximity to agricultural pesticides during pregnancy is associated with autism spectrum disorders (ASD) or developmental delay (DD) in the Childhood Autism Risks from Genetics ...
Dougan M M MM Department of Epidemiology, Harvard School of Public Health, Boston, - - 2014
Background/Objectives:In animal studies, exposure to multi-vitamins may be associated with obesity in the offspring; however, data in humans is sparse. We therefore examined the association between prenatal vitamin intake during pregnancy and offspring obesity.Subjects/Methods:We investigated the association between prenatal vitamin intake and obesity among 29 160 mother-daughter dyads in the ...
Corbel T T INRA, UMR 1331 Toxalim, Research Center in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France. Electronic address: - - 2014
The widespread human exposure to Bisphenol A (BPA), an endocrine disruptor interfering with developmental processes, raises the question of the risk for human health of BPA fetal exposure. In humans, highly variable BPA concentrations have been reported in the feto-placental compartment. However the human fetal exposure to BPA still remains ...
Ferguson Kelly K KK Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United - - 2014
Preterm birth is a significant public health problem, affecting over 1 in 10 live births and contributing largely to infant mortality and morbidity. Everyday exposure to environmental chemicals such as phthalates could contribute to prematurity, and may be modifiable. In the present study we examine variability in phthalate exposure across ...
Hewitt Amy J AJ Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada K7L - - 2014
Maternal-fetal signaling is critical for optimal fetal development and postnatal outcomes. Chronic ethanol exposure alters programming of the fetal hypothalamic-pituitary-adrenal (HPA) axis, resulting in a myriad of neurochemical and behavioral alterations in postnatal life. Based on a recent study which showed that human intra-partum fetal stress increased fetal secretion of ...
Zhang Tao T School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-Sen University, 135 Xingang West Street, Guangzhou 510275, China. - - 2014
In this study, we estimated the body burden (BB) of perfluoroalkyl substances (PFASs) in a fetus at the time of delivery, and elimination of PFASs in female adults during pregnancy; and explored the isomer branching pattern-related placental transfer of perfluorooctane sulfonate (PFOS). The mean BB of PFASs were 3980 ng ...
Mozurkewich Ellen L EL Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC 10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: - - 2014
Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use. As part of a comprehensive care plan, such therapy may result in improved access to ...
Holbrook Bradley D BD Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA. Electronic address: - - 2014
Substance use is prevalent in the United States, especially in the reproductive age population. Even though a reduction in substance use may occur during pregnancy, some women may not alter their drug use patterns until at least pregnancy is confirmed. For these reasons, a large number of fetuses are exposed ...
Meyer Marjorie M Fletcher Allen Health Care and the University of Vermont, 111 Colchester Avenue, Burlington, VT 05401, USA. Electronic address: - - 2014
Chronic opioid therapy during pregnancy is perilous, but not simply because of neonatal effects: it is perilous because women are at particular risk for misprescription, misuse, dependence, overdose, and death. Opioids may be teratogens and should be avoided in the periconception period. Accidental childhood poisoning and purposeful teen experimentation are ...
Gray Bobbe Ann - - 2014
Psychoactive bath salts (PABS) comprise a group of highly dangerous designer drugs showing a sharp escalation in reported U.S. exposures from 2010 through 2012, following rapid spread of the drug in Europe. Since a federal ban on the major ingredients in October 2011, numbers have declined. However, evidence from the ...
Lim H H University of Texas Houston Health Science Center, Houston, - - 2014
Results of previous studies of occupational exposure to ionising radiation (IR) and birth defects are inconsistent. Our objective was to assess the association between maternal and paternal occupational exposure to ionising radiation (IR) and birth defects using a larger sample than previous studies. We studied 27 809 case mothers and ...
Rappazzo Kristen M KM Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, - - 2014
Particulate matter < 2.5 micrometers in aerodynamic diameter (PM2.5) has been variably associated with preterm birth (PTB). We classified preterm births into four categories (20-27, 28-31, 32-34, and 35-36 weeks completed gestation) and estimated risk differences (RD) for each category in association with a 1-µg/m(3) increase in PM2.5 exposure during ...
Hutton Jill J Houston, Texas, USA; The Woman's Hospital of Texas. Electronic address: - - 2014
While it is commonly accepted that rubella is well-controlled, a recent reemergence of both pertussis and measles might also predict a reemergence of rubella. This study was designed to estimate the current incidence of rubella exposure in pregnancy. This was a prospective, descriptive study, conducted in Houston, Texas, at The ...
Moisiadis Vasilis G VG Department of Physiology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON M5S 1A8, - - 2014
The lifelong health of an individual is shaped during critical periods of development. The fetus is particularly susceptible to internal and external stimuli, many of which can alter developmental trajectories and subsequent susceptibility to disease. Glucocorticoids are critical in normal development of the fetus, as they are involved in the ...
Kahn Linda G LG Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, - - 2014
Although maternal hypothyroidism increases the risk of adverse neonatal and obstetric outcomes as well as lower IQ in children, the environmental determinants of maternal thyroid dysfunction have yet to be fully explored. We aimed to examine associations between mid-pregnancy blood lead (BPb) and concomitant measures of thyroid function among participants ...
Mosha Dominic - - 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women inadvertently exposed to artemether-lumefantrine (AL) ...
Rudnai Tamás T National Institute of Environmental Health, Budapest, Hungary. Electronic address: - - 2014
Inorganic arsenic can get easily through the placenta however there are very few human data on congenital anomalies related to arsenic exposure. Objective of our study was to explore the associations between arsenic content of drinking water and prevalence of some congenital anomalies. Four anomalies reported to the Hungarian Congenital ...
Rydell Mina M Department of Public Health Sciences, Karolinska Institutet, 17177, Stockholm, Sweden, - - 2014
Previous studies have linked maternal smoking during pregnancy with regular tobacco use in offspring, but findings are not consistent and confounding from genetic and environmental factors have not fully been taken into account. A comparison between siblings discordant for prenatal smoking exposure adjusts for confounding by shared familial (i.e., genetic ...
Fowler Paul A PA Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK - - 2014
How does maternal cigarette smoking disturb development of the human fetal ovary? Maternal smoking increases fetal estrogen titres and dysregulates several developmental processes in the fetal ovary. Exposure to maternal cigarette smoking during gestation reduces human fetal ovarian cell numbers, germ cell proliferation and subsequent adult fecundity. The effects of ...
Padberg Stephanie S Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie (Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy), Charité Universitätsmedizin Berlin, Berlin, Germany - - 2014
Fluoroquinolones are avoided during pregnancy due to developmental toxicity in animals. The aim of this study was to assess the fetal risk after intrauterine fluoroquinolone exposure. We performed an observational study of a prospectively ascertained cohort of pregnant women exposed to a fluoroquinolone during the first trimester. Pregnancy outcomes were ...
Spector Logan G LG Departments of - - 2014
Tobacco smoking by pregnant women is a major public health hazard with both short- and long-term effects on offspring. This study describes the presence and level of the nicotine metabolite cotinine in newborn dried blood spots (DBS) and compares it with the reported maternal smoking recorded on state birth registries. ...
Martel Michelle M MM Psychology Department, University of Kentucky. Electronic address: - - 2014
Disruptive Behavior Disorders (DBD) exhibit a sex-biased prevalence rate favoring boys, and prenatal testosterone exposure appears to be part of the complex etiology of these disorders. The current study examines whether high prenatal testosterone exposure may heighten risk for DBD symptoms in males by increasing susceptibility to negative environmental conditions ...
Zahran Sammy S Department of Economics, Colorado State University, , Fort Collins, Colorado, - - 2014
The majority of research documenting the public health impacts of natural disasters focuses on the well-being of adults and their living children. Negative effects may also occur in the unborn, exposed to disaster stressors when critical organ systems are developing and when the consequences of exposure are large. We exploit ...
Gidaya Nicole B NB Drexel University, School of Public Health, Nesbitt Hall, 3215 Market Street, Philadelphia, PA, 19104, USA, - - 2014
We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark's health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases ...
Ephross Sara A SA Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, - - 2014
To monitor for a signal of major teratogenicity by determining the risk of all birth major defects following in utero exposure to sumatriptan, naratriptan, and the sumatriptan/naproxen sodium combination product (tablets marketed in the United States as Treximet [GlaxoSmithKline, Research Triangle Park, NC, USA]), and to monitor for unusual patterns ...
Ratsch Angela A Queensland Health and School of Nursing and Midwifery, The University of Queensland, Brisbane, Australia, - - 2014
To systematically critique and summarise the available evidence on the outcomes of smokeless tobacco use in pregnancy to inform the public health response. In March 2013, a search was conducted of observational studies where the exposure to smokeless tobacco during pregnancy and maternal, placental and/or neonatal outcomes was assessed. Two ...
Calvigioni Daniela D Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, - - 2014
Cannabis remains one of the world's most widely used substance of abuse amongst pregnant women. Trends of the last 50 years show an increase in popularity in child-bearing women together with a constant increase in cannabis potency. In addition, potent herbal "legal" highs containing synthetic cannabinoids that mimic the effects of ...
Vizcaino Esther E Department of Preventive Medicine and Public Health, University of Oviedo, Asturias; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Barcelona, Catalonia; and Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, - - 2014
Exposure to persistent organic pollutants (POPs) during fetal development can increase the risk of adverse health effects during childhood. Maternal characteristics and physiological changes during gestation such as gestational weight gain (GWG) may have an influence in the overall burden of POPs in neonates. However, the associations between GWG and ...
Williams Marvin M aSection of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine bArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, - - 2014
Tumour necrosis factor inhibitors (TNFi) and other biologic response modifiers are being increasingly used for the treatment of rheumatoid arthritis (RA) among women of childbearing age, raising concerns regarding the potential safety of inadvertent or intentional exposure of these agents to the developing fetus. TNFi and other biologics whose constructs ...
Bermas Bonnie L BL Associate Physician, Division of Rheumatology, Brigham and Women's Hospital, Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts, - - 2014
To review the recent literature on the safety of nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and traditional disease-modifying antirheumatic drugs before and during pregnancy. Recent data suggest that the risk of cleft palate formation after in-utero glucocorticoid exposure is lower than previously reported. Two studies of inadvertent leflunomide exposure during early ...
Wright Tricia E TE University of Hawaii John A. Burns School of Medicine, Honolulu, - - 2014
Methamphetamines are one of the most commonly abused illicit drugs in pregnancy, yet little is known about birth outcomes of exposed neonates. Previous studies were limited because of confounding factors: other drugs of abuse, including tobacco; poverty; poor diet; and lack of prenatal care. This study presents data on birth ...
Foster Teri-Lee TL Meharry Medical College, Nashville, - - 2014
Preterm birth is significantly higher in African Americans. They also have higher lifelong exposure to environmental toxins like benzo(a)pyrene, which has been reported to affect fetal growth. Initial studies from our laboratory showed that rats treated with benzo(a)pyrene deliver preterm. In addition, superarray suggested that benzo(a)pyrene regulates histone deacetylases in ...
Schroeder Christina C Kaiser San Francisco, San Francisco, - - 2014
The objective of this study was to examine the effect of maternal antidepressant exposure on first- and second-trimester maternal serum markers for aneuploidy. We conducted a 10-year retrospective cohort study within a large health care organization. Pregnant women diagnosed with depression who underwent serum screening for aneuploidy were identified. Antidepressant ...
Fraser Abigail A MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK, - - 2014
In this review, we critically assess recent evidence from human studies regarding the potential implications of exposure to maternal diabetes in-utero for long-term adiposity, cardiometabolic outcomes, and cognitive ability of the offspring. Evidence supports a direct causal role for exposure to maternal diabetes in utero in determining offspring long-term greater ...
Aldridge Tiara D TD Vanderbilt Epidemiology Center, Nashville, TN, USA; Vanderbilt University, Institute of Medicine and Public Health, Nashville, TN, USA; Vanderbilt University, Department of Obstetrics and Gynecology, Nashville, TN, - - 2014
We tested whether antihistamine exposure during early pregnancy is associated with spontaneous abortion (SAB) or preterm birth (PTB). Women were enrolled in Right from the Start (2004-2010), a prospective pregnancy cohort. Data about first-trimester antihistamine use were obtained from screening and first-trimester interviews. Self-reported outcomes included SAB and PTB and ...
Ostuzzi G G Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, - - 2014
A possible link between prenatal exposure to the selective serotonin reuptake inhibitors (SSRIs) and development of autism spectrum disorders (ASDs), previously suggested by two case-control studies, was not confirmed by a recent cohort study that followed for 5-10 years more than 600,000 births. However, this study failed to demonstrate that ...
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