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Fraser Abigail A MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK, - - 2014
In this review, we critically assess recent evidence from human studies regarding the potential implications of exposure to maternal diabetes in-utero for long-term adiposity, cardiometabolic outcomes, and cognitive ability of the offspring. Evidence supports a direct causal role for exposure to maternal diabetes in utero in determining offspring long-term greater ...
Williams Marvin M aSection of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine bArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, - - 2014
Tumour necrosis factor inhibitors (TNFi) and other biologic response modifiers are being increasingly used for the treatment of rheumatoid arthritis (RA) among women of childbearing age, raising concerns regarding the potential safety of inadvertent or intentional exposure of these agents to the developing fetus. TNFi and other biologics whose constructs ...
Bermas Bonnie L BL Associate Physician, Division of Rheumatology, Brigham and Women's Hospital, Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts, - - 2014
To review the recent literature on the safety of nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and traditional disease-modifying antirheumatic drugs before and during pregnancy. Recent data suggest that the risk of cleft palate formation after in-utero glucocorticoid exposure is lower than previously reported. Two studies of inadvertent leflunomide exposure during early ...
Jusko Todd A TA Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Boulevard, Rochester, New York, - - 2014
The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the ...
Kile Molly L - - 2014
Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few studies have examined its effect on maternal health. A prospective cohort was recruited in Bangladesh from 2008-2011 (N = 1,458). At enrollment (<16 weeks gestational age [WGA]), arsenic was measured in personal drinking water using inductively-coupled plasma ...
Joubert Bonnie R BR Epidemiology, National Institute of Environmental Health - - 2014
Background: Maternal smoking in pregnancy is associated with adverse health outcomes in children, including cancers; underlying mechanisms may include epigenetic modifications. Using Illumina's 450K array, we previously identified differential DNA methylation related to maternal smoking during pregnancy at 26 CpG sites (CpGs) in 10 genes in newborn cord bloods from ...
Mårild Karl - - 2014
The infant microbiota may play a pathogenic role in coeliac disease (CD). Antibiotic treatment in pregnancy is common and could significantly impact the infant microbiota. In this study, we aimed to investigate the association between antibiotic exposure during pregnancy and CD in offspring. Prospective questionnaire data on antibiotic exposure in ...
Leclerc François F Department of Obstetrics and Gynecology - - 2014
Objectives: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. Methods: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. Results: BPA was detected in maternal blood, fetal blood ...
Fort Marta M Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, Jordi Girona, 18., 08034, Barcelona, Catalonia, - - 2014
Prenatal exposure to trace metals, whether they are essential, non-essential, or toxic, must be assessed for their potential health effects in the offspring. Herein is reported an approach to this end which involved collection of urine samples during the first and third trimesters of pregnancy from 489 mothers from Sabadell ...
Togher Katie L KL Irish Centre for Fetal and Neonatal Translational Research (INFANT); Cork University Maternity Hospital; Cork, Ireland; Department of Obstetrics and Gynaecology; Cork University Maternity Hospital; Cork, Ireland; Department of Anatomy and Neuroscience; Biosciences Institute; University College Cork; Cork, - - 2014
"Fetal programming" is a term used to describe how early-life experience influences fetal development and later disease risk. In humans, prenatal stress-induced fetal programming is associated with increased risk of preterm birth, and heightened risk of metabolic and neurological diseases later in life. A critical determinant of this is the ...
de Vries Loes L Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the - - 2014
During influenza pandemics, pregnant women have an increased risk of severe complications. Vaccination can diminish these complications. In the Netherlands, the adjuvanted vaccines Focetria® and Pandemrix® were used during the A/H1N1 (2009) influenza pandemic. The national vaccination scheme included pregnant women, but knowledge concerning the safety of adjuvants during pregnancy ...
Solan Tom Daniel - - 2014
Abstract Mercury exposure in pregnancy has been associated with both pregnancy complications and developmental problems in infants. Apart from industrial accidents and contaminated food, mercury exposure is likely to arise from predatory fish consumption, environmental contamination and dental amalgam restorations placed before or during pregnancy. It would be prudent to ...
Jian'an Liu L Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, - - 2014
Our pilot studies showed that there was a significant relationship between blood lead levels of women at the first trimester and scores of neonatal behavioral neurological assessment (NBNA). This study went further 1) to determine particular neurotoxicity during a specific trimester, 2) to analyze "safe" levels of Pb in neonates, ...
Dadvand Payam P Centre for Research in Environmental Epidemiology (CREAL), , Barcelona, - - 2014
To investigate the association between preeclampsia and maternal exposure to ambient particulate matter (PM) with aerodynamic diameter less than 10 μm (PM10) and 2.5 μm (PM2.5) mass and sources. Our analysis was based on a hospital cohort of pregnant women (N=3182) residing in Barcelona, Spain, during 2003-2005. Positive matrix factorisation ...
Koutroulakis D D Department of Obstetrics & Gynecology, University Hospital of Heraklion, Crete, - - 2014
The aim of this study was to evaluate fetal exposure to organophosphate pesticides (OPs) by measuring their non-specific dialkyl-phosphate metabolites (DAPs) in amniotic fluid (AF), and to examine the potential association between prenatal exposure and fetal growth. AF samples were collected from 415 women during the second gestational trimester. The ...
Akar Melek M Department of Neonatology, Diyarbakir Children Hospital , Diyarbakir , - - 2014
Abstract Haloperidol is commonly used in the treatment of psychiatric disorders. Data from animal experiments indicate haloperidol is not teratogenic, but is embryotoxic in high doses. For the first time, we report a neonate with transient nephrogenic diabetes insipidus (DI) caused by fetal exposure to haloperidol. The magnitude of risk ...
Laurberg Peter P P Laurberg, Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, DK-9000, - - 2014
ANTITHYROID DRUGS (ATDS) MAY HAVE TERATOGENIC EFFECTS WHEN USED IN EARLY PREGNANCY.OBJECTIVE: To review the association between the time period of ATD exposure in early pregnancy and the development of birth defects. We identified publications on birth defects after early pregnancy exposure to the ATDs Methimazole (MMI) (and its prodrug ...
Bailey Helen D HD International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, - - 2014
Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). ...
Hickey Martha M Dept. of Obstetrics and Gynaecology, University of Melbourne and Royal Women's - - 2014
Background:Prenatal estrogen exposure is thought to contribute to later life diseases such as breast cancer. However, few studies have directly measured prenatal estrogens and most have relied on proposed "markers" of estrogen exposure. We used a large population-based birth cohort to directly measure the relationship between prenatal estrogens and perinatal ...
Tertti Kristiina K Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, Turku, Finland, - - 2014
The purpose of the study was to examine in vivo placental transfer of metformin, its association with neonatal outcome in metformin-treated gestational diabetes (GDM) patients, and influence of metformin exposure on maternal glycemic control and weight gain. Two hundred and seventeen GDM patients were randomized to metformin or insulin in ...
Rosenbaum Janet E JE Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Medical Center, Brooklyn, New York, - - 2014
Adolescents may use condoms inconsistently or incorrectly, or may over-report condom use. This study used a semen exposure biomarker to evaluate the accuracy of female adolescents' reports of condom use and predict subsequent pregnancy. The sample comprised 715 sexually active African-American female adolescents, ages 15-21 years. At baseline, 6 months ...
Margerison-Zilko Claire C Department of Epidemiology and Biostatistics, Michigan State University, East Lansing. Electronic address: - - 2014
The purpose of this study was to examine associations between maternal exposure to unexpected economic contraction and health behaviors during pregnancy using methods to account for impacts of economic contraction on selection into pregnancy. Data on health behaviors among 7074 pregnancies in the National Longitudinal Survey of Youth 1979 were ...
Dunstan Hj H United Kingdom Teratology Information Service, Wolfson Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, - - 2014
To conduct enhanced surveillance for signals of teratogenesis following use of the neuraminidase inhibitors zanamivir and oseltamivir in the treatment or post-exposure prophylaxis of 2009 A/H1N1 influenza during pregnancy. Prospective cohort study, using national surveillance data collected by the UK Teratology Information Service (UKTIS) during the 2009 A/H1N1 pandemic. United ...
Balaraman Sridevi S Department of Neuroscience and Experimental Therapeutics, and Women's Health in Neuroscience Program, Texas A&M Health Science Center, College of Medicine, Bryan, - - 2014
Plasma or circulating miRNAs (cir miRNAs) have potential diagnostic value as biomarkers for a range of diseases. Based on observations that ethanol (EtOH) altered intracellular miRNAs during development, we tested the hypothesis that plasma miRNAs were biomarkers for maternal alcohol exposure, and for past in utero exposure, in the neonate. ...
Auger Nathalie N From the aInstitut national de santé publique du Québec, Montreal, Quebec, Canada; bResearch Centre of the University of Montreal Hospital Centre, Montreal, Quebec, Canada; cDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; dDepartment of Environmental and Occupational Health, University of Montreal, Quebec, Canada; and eBritish Columbia Centre for Disease Control, Vancouver, British Columbia, - - 2014
The relationship between ambient temperature and risk of delivery is poorly understood. We examined the association between heat and risk of delivery among preterm and term pregnancies with the use of a time-to-event design to minimize bias from seasonal variation in conception rates. We used data on 206,929 term and ...
Simons Elinor E Clinical Epidemiology and Health Services Research, University of Toronto, Ontario, Canada; Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, - - 2014
Childhood asthma development has been associated with active maternal smoking during pregnancy, but its association with maternal second-hand smoke exposure in pregnancy needs to be evaluated. We investigated longitudinal associations between maternal smoke exposure in pregnancy and childhood asthma development. In a population-based cohort of 5619 seven-year-old Toronto children, parents ...
Liew Zeyan Z Department of Epidemiology, Fielding School of Public Health, University of California, Los - - 2014
IMPORTANCE Acetaminophen (paracetamol) is the most commonly used medication for pain and fever during pregnancy in many countries. Research data suggest that acetaminophen is a hormone disruptor, and abnormal hormonal exposures in pregnancy may influence fetal brain development. OBJECTIVE To evaluate whether prenatal exposure to acetaminophen increases the risk for ...
Kancherla Vijaya V Department of Epidemiology, The University of Iowa, Iowa City, - - 2014
Choanal atresia causes serious posterior nasal obstruction. This defect is the leading cause of nasal surgery in newborns, although its etiology is largely unknown. Data from the National Birth Defects Prevention Study, a population-based case-control study, were used to examine associations between maternal self-reports of exposures and occurrence of choanal ...
Canisso I F IF Reproduction Laboratory, The Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, - - 2014
Nocardioform placentitis (NPL) in horses is poorly understood, and development of an experimental model would help understand the pathogenesis of the disease. To investigate (1) whether intrauterine inoculation of Crossiela equi (C. equi) during the periovulatory period or (2) intravenous, oral or intranasopharyngeal inoculation of C. equi during mid-gestation would ...
Tain You-Lin - - 2014
Abstract Glucocorticoids are administered to premature infants to accelerate pulmonary maturation. In experimental model, prenatal dexamethasone (DEX) results in reduced nephron number and adulthood hypertension. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), can cause oxidative stress and is involved in the development of hypertension. L-citrulline can ...
Yucra S S Universidad Peruana Cayetano Heredia, Lima, - - 2014
Exposure to pollution from biomass fuel has been associated with low birthweight in some studies. Few studies have included exposure-response analyses. We conducted a case-control study of biomass fuel use and reproductive outcome at high altitude in Peru. Cases (n=101) were full term births who were SGA (birth weight <10th ...
Vom Saal Frederick S FS Division of Biological Sciences, University of Missouri, Columbia, MO, United States. Electronic address: - - 2014
We measured serum dBPA in non-pregnant and pregnant female rhesus monkeys, fetuses and amniotic fluid. dBPA was administered by a daily oral bolus or sc implantation of Silastic capsules; both resulted in daily average serum unconjugated dBPA concentrations of <1ng/ml. We observed lower serum concentrations of unconjugated dBPA in pregnant ...
Buck Louis Germaine M GM Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. Electronic address: - - 2014
To assess the relationship between environmental chemicals and couple fecundity or time to pregnancy (TTP). Prospective cohort. Communities of targeted populations with reported exposure. 501 couples recruited upon discontinuing contraception to become pregnant, 2005-2009. None. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) estimated for each partner's chemical concentrations ...
Bateman Brian T BT From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (B.T.B.); Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (S.H.-D.); Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (J.P.R.); and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.D.S., M.D., M.A.F., - - 2014
There are few data regarding the utilization of opioids during pregnancy. The objective of this study was to define the prevalence and patterns of opioid use in a large cohort of pregnant women who were commercial insurance beneficiaries. Data for the study were derived from a deidentified research database of ...
Beau A-B AB Service de Pharmacologie Médicale, CHU Toulouse, Université de Toulouse, INSERM 1027, Toulouse, - - 2014
To compare pregnancy outcome between women exposed and unexposed to oseltamivir during pregnancy. A comparative observational cohort study of women exposed to oseltamivir during pregnancy. A French prescription database (EFEMERIS) that includes data for pregnant women was used. EFEMERIS records prescribed and dispensed reimbursed drugs during pregnancy and pregnancy outcomes ...
Fleisch Abby F AF Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, - - 2014
Exposure to fine particulate matter (PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied. We studied Boston-area pregnant women without known diabetes. We identified impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM) during pregnancy from clinical glucose tolerance ...
Lieberman Jay J Department of Pediatrics, The University of Tennessee Health Science Center, LeBonheur Children's Hospital, 51 North Dunlap, #400, Memphis, TN 38105, - - 2014
Primary prevention of allergy is a laudable goal, but one that has unfortunately proven difficult to achieve. Many different strategies have been reported to date, but unequivocal supporting data for any single strategy does not exist. Any successful strategy must lead to immunomodulation and must be encountered very early on ...
Harden Cynthia L - - 2014
This review encompasses issues regarding the management of women with epilepsy and pregnancy, including preconception planning, antiepileptic drug (AED) effects on the exposed offspring, and consequences of seizures during pregnancy, with an emphasis on counseling points and risk management. In utero valproate exposure continues to show the highest risk of ...
Cooper William O WO Vanderbilt University, Nashville, - - 2014
To assess the risk of adverse fetal outcomes following exposure to individual immunosuppressive drugs in pregnant women with chronic immune-mediated diseases. Health plan data were obtained from the Tennessee Medicaid and Kaiser Permanente Northern California and Southern California claims databases, with linkage to both vital records and medical records. Women ...
Karlsson Goeril G From Novartis Pharma AG (G. Karlsson, P.H., W.C.), Basel, Switzerland; Novartis Pharmaceuticals Corporation (G.F., X.Z.), East Hanover, NJ; Motherisk Program (G. Koren), Hospital for Sick Children, Toronto, Canada; Neurological Institute (J.A.C.), Cleveland Clinic, OH; and Neurology and Department of Biomedicine (L.K.), University Hospital, Basel, - - 2014
To report outcomes of pregnancies that occurred during the fingolimod clinical development program. Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolimod treatment at the time of conception or in ...
Magnus Maria C MC Department of Chronic Diseases, Division of Epidemiology , Norwegian Institute of Public Health, Oslo, Norway; Epidemiology Branch, Division of Intramural Research , National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North - - 2014
Many women drink during pregnancy and lactation despite recommendations to abstain. In animals, alcohol exposure during pregnancy and lactation influences lung and immune development, plausibly increasing risk of asthma and lower respiratory tract infections (LRTIs). Studies in humans are few. In the Norwegian Mother and Child Cohort Study, we examined ...
Gorini Francesca F Institute of Clinical Physiology, National Council of Research (CNR), via Moruzzi, 1, 56124, Pisa, Italy, - - 2014
There is compelling evidence that prenatal exposures to environmental xenobiotics adversely affect human development and childhood. Among all birth defects, congenital heart disease (CHD) is the most prevalent of all congenital malformations and remains the leading cause of death. It has been estimated that in most cases the causes of ...
Milne Elizabeth E Telethon Institute for Child Health Research, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia, - - 2014
Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but parental, fetal, and early life exposures are likely to be important given the early age at diagnosis of many cases. We aimed ...
Räikkönen Katri K Institute of Behavioral Sciences, University of Helsinki, 00014, - - 2014
Low socioeconomic status (SES) is associated with increased disease risk in the involved and the next generation. The effects of low maternal SES on the offspring may be initiated prenatally. We hypothesized that feto-placental glucocorticoid exposure might mediate the links. We examined associations between maternal level of education and occupational ...
Källén Bengt B Tornblad Institute, University of Lund , Lund , - - 2014
Abstract Objective. Most previous studies have failed to demonstrate any effect of maternal use of 5-aminosalicylates (5-ASA) on malformation risk, but the number of infants studied have, in most cases, been low. The objective of the study was to get data from a large study with prospectively ascertained exposure information. ...
Campbell E E Neurology Department, Belfast Health and Social Care Trust, Royal Victoria Hospital, , Belfast, Co Antrim, - - 2014
Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine. Fifteen-year prospective ...
Moya Jacqueline J US Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Mailcode 8623P, 1200 Pennsylvania Avenue Northwest, Washington, DC 20460, - - 2014
Exposures to environmental contaminants can pose risks to pregnant women's health, their developing fetuses, children, and adults later in their lives. Assessing risks to this potentially susceptible population requires a sound understanding of the physiological and behavioral changes that occur during pregnancy and lactation. Many physiological and anatomical changes occur ...
Higashida Yuka Y Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, - - 2014
Our objective was to evaluate the level of pregnant women's exposure to tobacco smoke by urinary cotinine testing at prenatal examinations, and to examine the effects of disclosing the results of urinary cotinine tests to pregnant women and their families on their smoking activities. A prospective cohort study was conducted, ...
France Kathryn E - - 2014
Public awareness-raising campaigns targeting alcohol use during pregnancy are an important part of preventing prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. Despite this, there is little evidence on what specific elements contribute to campaign message effectiveness. This research evaluated three different advertising concepts addressing alcohol and pregnancy: a threat ...
Savitz David A - - 2014
Levels of exposure biomarkers vary among individuals because of differences in both environmental exposure and metabolism. However, the ultimate interest is in providing information about the impact of modifying environmental exposures through regulation or behavior change. Using these levels in studies of pregnancy outcomes, as nicely illustrated by the study ...
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