This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between ...

(Uncorrected OCR) Abstract of the thesis entitled Fetoplacental Circulation And The Role Of Placental IGF-1 In Placental Remodeling By Apoptosis And Proliferation In Diabetic Pregnancies Submitted by Ghazala Sikandar Basir For the Degree of Doctor of Philosophy at the University of Hong Kong in October 2004 Maternal diabetes mellitus poses ...

AIMS: Gestational diabetes mellitus (GDM) is a predictor for overt diabetes later in life. Thus, during pregnancy GDM patients are instructed to change lifestyle after pregnancy. The purpose of the present study was to assess the lifestyle changes made by these women. METHODS: The study was a mailed survey with ...

The judged likelihood of a focal outcome should generally decrease as the list of alternative possibilities increases. For example, the likelihood that a runner will win a race goes down when 2 new entries are added to the field. However, 6 experiments demonstrate that the presence of implausible alternatives (duds) ...

BACKGROUND: During pregnancy, serum cholesterol (TC) and triglyceride (TG) concentrations are known to increase significantly, but whether remnant lipoprotein particles (RLP) increase has not been shown. METHODS: We compared lipid profiles in 22 healthy pregnant women to 31 healthy nonpregnant women and 24 patients with diabetes mellitus (DM), by measuring ...

The aim of this study was to investigate whether prenatal and social factors are associated with the development of type 1 diabetes. A case-control study was conducted in Belgrade during the period 1994-97. A total of 105 children </= 16 years old with recently onset of diabetes and 210 control ...

Obese hyperinsulinemic women with polycystic ovary syndrome (PCOS) present a markedly increased risk of developing glycaemic alterations during pregnancy, commonly recognized as a "diabetogenic" condition. This risk seems to be safely reduced by the administration of metformin during gestation. We analyzed the metabolic changes in two hyperinsulinemic PCOS women, who ...

Diabetes during pregnancy is accompanied by increasing needs for maternal insulin and ongoing biological changes that cause maternal insulin requirements to reach higher and lower extremes throughout the day than in non-pregnant patients. As maternal hyperglycemia increases the risk of fetal and maternal morbidity, it is essential for the mother ...

AIM: To evaluate whether computerized CTG (cCTG) is a reliable method of predicting neonatal outcome in pregnancies complicated by pregestational diabetes at term. PATIENTS AND METHODS: We considered 27 pregnant women affected by pregestational diabetes and 46 normal pregnancies as controls that fulfilled the following criteria: singleton, Caucasian, euglycemic pregnancies ...

One hundred and thirteen pregnancies in 73 women who received a renal transplant were studied. The duration between the transplant operation and the conception averaged 19.9 months with a range of I month to 72 months. The mean age was 28 years. The majority (50 recipients had one pregnancy each, ...

OBJECTIVES: To evaluate the measurement of the fetal abdominal fat layer (FFL), cardiac interventricular septum (IVS) and abdominal circumference (AC) percentile in the early third trimester as predictors of macrosomia at birth in the fetuses of women with gestational diabetes. METHODS: Ninety patients attending the hospital's special diabetic clinic were ...

OBJECTIVE: To determine reference values of fetal subcutaneous tissue thickness (SCTT) throughout gestation in a healthy population and to compare them with those from a population of pregnant women with gestational diabetes under standard therapy. METHODS: Three hundred and three women recruited from a high-risk pregnancy clinic were classified as ...

PURPOSE OF REVIEW: This review describes how the physiological demands of pregnancy act as a maternal stress test that can predict a woman's health in later life. Pregnancy transiently catapults a woman into a metabolic syndrome that predisposes to vascular endothelial dysfunction. Women who are already predisposed to this phenotype ...

STUDY OBJECTIVE: To examine the relationship between nocturnal bruxism and gastroesophageal reflux. DESIGN: Controlled descriptive study and double-blind, placebo-controlled, clinical study. SETTING: Portable pH monitoring, electromyography, and audio-video recordings were conducted during the night in the subjects' home. PARTICIPANTS: Ten patients with bruxism and 10 normal subjects were matched for ...

Fetal development is dependent on maternal supply of fuels and building blocks. Disturbed maternal metabolism or inappropriate maternal nutrition confronts the fetus with an unfavourable intra-uterine milieu. Structural and functional adaptations occur during development and maturation of organs. Consequences of these fetal alterations persist postnatally and may result in metabolic ...

OBJECTIVES: Studies in the early 1990s showed that the normal levels of the biochemical markers used to screen for Down syndrome in the second trimester of pregnancy differ between healthy women and women with insulin-dependent diabetes mellitus (IDDM). Thereafter, most laboratories adopted correcting factors to adjust for these differences. However, ...

INTRODUCTION: Hydroperoxides are well-recognized reactive oxygen species which are associated with oxidative stress, a phenomenon of current clinical interest as oxidative stress is associated with a number of disease condition. Ferrous ion oxidation xylenol orange (FOX) methods of hydroperoxide estimation has outdated other methods available for hydroperoxide estimation. Two versions ...

We monitored blood pressure (BP) for a 24-h period in type 1 diabetic women at each trimester of pregnancy (10-13, 20-22, and 30-33 weeks of gestation) to identify early alterations of BP profile in pregnancies complicated by hypertension. PATIENTS AND METHODS: We prospectively studied 71 type 1 diabetic pregnant women ...

OBJECTIVE: Glycodelin is a glycoprotein released by secretory/decidualized endometrial glands. Its synthesis increases during pregnancy. Hormonal factors whose levels have been shown to change in diabetes (vascular endothelial growth factor, relaxin) may mediate the actions or regulate the synthesis of glycodelin. Cord serum glycodelin levels have not been studied in ...

Diabetes is a common complication of pregnancy. Third trimester hyperglycemia has been associated in both gestational and pregestational diabetes with deviant fetal growth. Recent studies demonstrated that peak postprandial glucose levels in normal pregnancy are lower than previously thought. This finding could explain the lack of effectiveness reported by some ...

The occurrence of diabetic ketoacidosis in pregnancy compromises both the fetus and the mother. It usually occurs in the later stages of pregnancy and is also seen in newly presenting type 1 diabetes patients. Despite improvement in its incidence rates and outcomes over the years, it still remains a major ...

We use an empirical statistical model to demonstrate significant skill in making extended-range forecasts of the monthly-mean Arctic Oscillation (AO). Forecast skill derives from persistent circulation anomalies in the lowermost stratosphere and is greatest during boreal winter. A comparison to the Southern Hemisphere provides evidence that both the time scale ...

BACKGROUND: Changes in maternal bone during pregnancy may affect fetal bone mineralization. ISSUES: The biphasic changes in maternal bone histology (temporary loss of cancellous bone in early pregnancy restored by term gestation) are consistent with corresponding blood biochemistry changes; increased bone resorption markers in the first trimester, while bone formation ...

We examined a phenomenon related to hindsight bias, specifically, retrospective judgements about the foreseeability of an outcome. We predicted that negative, self-relevant outcomes would be judged as less foreseeable by the recipient of the outcome than by others, unlike either positive outcomes or outcomes that are not self-relevant. In the ...

BACKGROUND: The aim of this study was to compare the pregnancy outcome, especially the prevalence of gestational diabetes mellitus (GDM), in a group of patients with polycystic ovary syndrome (PCOS), with a group of healthy weight-matched women. METHODS: Retrospectively, we evaluated the pregnancies of 66 women with PCOS, who had ...

OBJECTIVE: To emphasize preconception care of women with type 1 diabetes and the role of primary care physicians in evaluating and counseling them. QUALITY OF EVIDENCE: Substantial level II evidence indicates that tight glycemic control before conception and early in pregnancy reduces the rate of congenital malformations. Most evidence concerning ...

Use of metformin in polycystic ovary syndrome (PCOS) is becoming increasingly accepted and widespread, but clinical practice is ahead of the evidence. Although a wide range of benefits in metabolic, reproductive, and clinical measures have been reported from non-randomised trials with metformin, close inspection of results from the adequately controlled ...

OBJECTIVES: To determine the impact of polycystic ovary syndrome (PCOS) on glucose tolerance during pregnancy and perinatal outcome. METHODS: Pregnancy records of 38 PCOS patients were compared retrospectively with 136 non-PCOS patients randomly. Patients with glucose challenge tests values of >130 mg/dl were referred for the 3-h, 100-g oral glucose ...

Stillbirth and perinatal mortality rates are 5 times greater for an insulin-dependant diabetic mother than in the general population. Neonatal and infant mortality rates are 15 and 3 times greater, respectively. In addition, macrosomia is a major problem resulting in both fetal and maternal injury. Fetal monitoring is considered mandatory ...

OBJECTIVE: To evaluate glycemic control and maternal and fetal outcomes of patients with type 1 diabetes treated with insulin lispro before and during pregnancy. METHODS: We undertook a retrospective review of medical records of 62 women with type 1 diabetes who were treated with insulin lispro before and during pregnancy ...

Despite the importance molecular structure has acquired in 20th century chemistry, more traditional macroscopic notions in terms of a continuous concept of matter continue to play a role in chemical theorizing. In the light of the extensive and determined criticism of reductionism in recent philosophy of chemistry, it is of ...

Bordetella bronchiseptica lipopolysaccharide (LPS) expression varies depending on growth conditions, regulated by the Bvg system. A B. bronchiseptica pagP homologue was identified that is required for Bvg-mediated modification of the lipid A core region of LPS that occurs on switching from the Bvg- to the Bvg+ phase. Structural analysis demonstrated ...

OBJECTIVE: Type-I diabetic pregnancies are associated with congenital cardiac malformations, fetal cardiomyopathy, venous thrombosis and altered placental vascularization, even with tight maternal glucose control. The aim of this study was to investigate if, with good glucose control achieved with continuous subcutaneous insulin infusion, normal blood flow within the fetal heart ...

PURPOSE: The purpose of the present study was to investigate the influence of degradation using repeated impacts on the ability of different shock-absorbing insoles to reduce peak impact loading during running in military boots. METHODS: Four insole types were degraded mechanically to simulate typical running loads that occur during approximately ...

Visual changes in pregnancy are common, and many are specifically associated with the pregnancy itself. Serous retinal detachments and blindness occur more frequently during preeclampsia and often subside postpartum. Pregnant women are at increased risk for the progression of preexisting proliferative diabetic retinopathy, and diabetic women should see an ophthalmologist ...

OBJECTIVES: Serum alpha-1-antitrypsin (AAT) concentration may not be representative of the functional capacity of this inhibitor. The aim of this study was to determine the antigenic and functional serum levels of AAT during normal and diabetic pregnancy. METHODS: Serum AAT concentration was measured on NOR-Partigen plates (Dade Behring). Trypsin inhibitory ...

OBJECTIVES: To identify websites providing information about early pregnancy loss and compare this information with published guidelines from the Royal College of Obstetricians and Gynaecologists (RCOG). The value of 'Silberg' and 'Health on the net (HON)' website scoring systems in predicting the information provided via websites identified was assessed. STUDY ...

Pregnancy outcomes among patients who underwent total hip arthroplasty (THA) during their reproductive years were retrospectively evaluated. Twenty-one patients reported pregnancies after THA and 20 had live births. No prosthesis-related problems were reported. This is the first study that provides a patient-based assessment of pregnancy outcomes and delivery in women ...

AIMS: Chorioangiomas are rare hamartomatous lesions. Possible correlations between their occurrence and the progression of a pregnancy have been objects of discussions for quite some time. METHODS: In a retrospective study 22439 unselected placentas were examined for incidences of chorioangiomas, morphological features and accompanying clinical characteristics. RESULTS: Chorioangiomas occur in ...

This study was designed to evaluate the effects of Cd exposure on morphological aspects of beta-cell and weights of fetus and placenta in streptozotocin (STZ)-induced diabetic pregnant rats. Ninety-nine virgin female Wistar rats (200-220 g) were mated with 33 males for at least 12 h. From the onset of pregnancy, ...

A 43-year-old diabetic woman was admitted in the 15th week of her first pregnancy. When HbA1c levels were 8.2%, we began diet therapy and continuous subcutaneous insulin infusion (CSII) therapy. The HbA1c levels subsequently ranged from 6.2 to 6.7%. She was delivered without complications of a healthy male infant (3120g) ...

AIMS: The use of insulin lispro in pregnancy has not been systematically investigated despite its increasing use. Pooled data from seven centres with experience in the use of insulin lispro were accumulated to evaluate pregnancy outcome in women with Type 1 diabetes. METHODS: Seven units with specialist obstetric diabetes services ...

Spontaneous fetal movement in the last third of human gestation is dominated by irregular oscillations on a scale of minutes (cyclic motility, CM). The core properties of these oscillations are stable during the third trimester of gestation in normal fetuses, but disrupted by poorly controlled maternal diabetes. Here we investigated ...

OBJECTIVE: To determine maternal parameters with the strongest influence on fetal growth in different periods of pregnancies complicated by an abnormal glucose tolerance test (GTT). RESEARCH DESIGN AND METHODS: Retrospective study of 368 women with gestational diabetes mellitus (GDM; > or = 2 abnormal GTT values, n = 280) and ...

This study was designed to investigate the effects of Cd exposure on the glycogen localization in the placenta and in fetal and maternal livers in streptozotocin (STZ)-induced-diabetic pregnant rats. Ninety-nine virgin female Wistar rats (200-220 g) were mated with 33 males for at least 12 h. From the onset of ...

OBJECTIVE: To assess the significance of recurrent pregnancies for the progression of Type 1 diabetes as well as the glycemic level and the occurrence of pre-eclampsia in consecutive pregnancies of the same Type 1 diabetic women. METHODS: A retrospective population-based birth cohort from the years 1986-95, comprising data of all ...

This article provides a literature review and opinion concerning the need for fetal surveillance in diabetic pregnancy. Low rates of intervention for suspected fetal jeopardy accompany well-controlled diabetic pregnancies in the absence of vascular disease or hypertension. The clinical utility of routine tests of fetal surveillance in uncomplicated type 1 ...

The contribution of the tumor necrosis factor (TNF) system and leptin was studied in insulin resistance and neonatal development during the course of normal pregnancy and gestational diabetes mellitus (GDM). Thirty patients with GDM and their neonates (n = 30), 35 healthy pregnant women (15 in the first, nine in ...

OBJECTIVE: To identify changing trends, if any, of fetal loss in diabetic patients undergoing antepartum fetal evaluation in a case-control study. METHODS: Fetal assessment (non-stress test and/or biophysical profile) logbooks from January 1981 to June 1998 were reviewed and the patients with diabetes were identified. The study group comprised patients ...

A case of successful pregnancy in a patient with complete Wolfram's syndrome is described. The diagnosis of diabetes insipidus (DI) was made during the pregnancy. The patient was the product of a consanguineous marriage. Our case is the fifth report of successful pregnancy; we underlined the importance of DI for ...