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Results 201 - 250 of 1482
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Eskenazi B - - 2013
Impaired fetal growth and preterm birth are the leading causes of neonatal and infant mortality worldwide and there is a growing scientific literature suggesting that environmental exposures during pregnancy may play a causal role in these outcomes. Our purpose was to assess the environmental exposure of the Fetal Growth Longitudinal ...
Kim Chang-Hee - - 2013
Prenatal environmental conditions affect the development of the fetus. In the present study, we investigated the effects of exposure to music and noise during pregnancy on neurogenesis and thickness in the motor and somatosensory cortex of rat pups. The pregnant rats in the music-applied group were exposed to 65 dB ...
Mølgaard-Nielsen Ditte D Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. - - 2013
Case reports suggest that long-term, high-dose fluconazole treatment for severe fungal infections during pregnancy causes a pattern of birth defects. It is unclear whether commonly used lower doses increase the risk of specific birth defects. In a registry-based cohort of liveborn infants in Denmark, we evaluated first-trimester oral fluconazole exposure ...
Jin Yuanxiang - - 2013
The commercial bifenthrin (BF) contains two cis isomers. In the present study, a dose of 15mg/kg of 1R-cis-BF or 1S-cis-BF was orally administered for 3 weeks to female mice before or during pregnancy. Then, the expression of steroidogenesis related genes which were considered as effective biomarkers of endocrine disruption were ...
McFadden J P - - 2013
One explanation for the large increase in the prevalence of atopic disease during the last 50 years in developed countries is the 'hygiene hypothesis'. This proposes that a reduced exposure to pathogenic microorganisms at a key period(s) during development result in the maintenance or acquisition of an atopic phenotype. Alternatively, ...
Braun Thorsten - - 2013
An adverse early life environment is associated with long-term disease consequences. Adversity early in life is hypothesized to elicit developmental adaptations that serve to improve fetal and postnatal survival and prepare the organism for a particular range of postnatal environments. These processes, while adaptive in their nature, may later prove ...
Gennings Chris - - 2013
Polychlorinated biphenyls (PCBs) remain ubiquitous environmental contaminants. Developmental exposures are suspected to impact reproduction. Analysis of mixtures of PCBs may be problematic as components have a complex correlation structure, and along with limited sample sizes, standard regression strategies are problematic. We compared the results of a novel, empirical method to ...
Di Leo Milena - - 2013
The effect of fetal radiation during endoscopic retrograde cholangiopancreatography (ERCP) on pregnant women is a very interesting topic. Smith et al recently estimated the fetal radiation exposure in pregnant women undergoing ERCPs using thermoluminescent dosimeters (TLDs). The authors concluded that TLDs are unnecessary during ERCP with modified techniques. We believe ...
Philippat Claire - - 2013
Maternal urinary biomarkers are often used to assess fetal exposure to phenols and their precursors. Their effectiveness as a measure of exposure in epidemiological studies depends on their variability during pregnancy and their ability to accurately predict fetal exposure. We assessed the relationship between urinary and amniotic fluid concentrations of ...
Chelchowska Magdalena - - 2013
To assess the effect of lead exposure from cigarette smoke on fetal growth, blood lead concentrations were measured using inductively coupled plasma mass spectrometry in 150 healthy pregnant women. Mean lead concentrations in plasma and whole blood were significantly higher in the smoking group compared with the nonsmoking group in ...
Valent Francesca - - 2013
Background: Mercury is a neurotoxin, and limited prenatal exposure to it can affect long-term child neurodevelopment. However, results of epidemiologic studies of such exposure have been inconsistent. We examined the association of prenatal mercury exposure from maternal fish consumption with child neurodevelopment in northern Italy.Methods: A population-based cohort of 606 ...
Harrison-Woolrych Mira - - 2013
The purpose of this study was to investigate the extent of exposure to varenicline during pregnancy in 'real-life' post-marketing use and follow-up all pregnancy exposures to identify maternal and fetal outcomes. This was a prospective observational cohort study conducted in New Zealand using intensive prescription event monitoring methods. A nationwide ...
Abdelouahab Nadia - - 2013
Thyroid hormones play a critical role in the growth of many organs, especially the brain. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) interact with the thyroid pathway and may disturb neurodevelopment. This prospective study was designed to examine associations between maternal blood PBDEs and PCBs in early pregnancy and ...
Meador Kimford J - - 2013
Fetal valproate exposure has been associated with the highest risk of congenital malformations among antiepileptic drugs.(1) Valproate's effect is dose-dependent(1) and has been associated with multiple specific malformations.(2,3) Vadja et al.(4) examined data from the Australian Pregnancy Registry (1999-2012 data), which included 1,705 pregnancies with 436 valproate exposures.(4) They found ...
Haukland Lars Utne - - 2013
Functional and behavioural deficits in neonates following the use of selective serotonin and norepinephrine reuptake inhibitors (SNRI) in the third trimester of pregnancy is well documented.(1,2,3) Venlafaxine and its active metabolite, O-desmethylvenlafaxine are recognized as potent SNRIs. Up to 63% of neonates exposed to venlafaxine may develop symptoms, which are ...
Caserta D - - 2013
Heavy metals (HMs) are environmental contaminants with toxic properties for wildlife and humans. The placenta is a privileged organ that, along with the fetal membranes and amniotic fluid, enables growth and development of the fetus during the physiological pregnancy. It also acts as a filter reducing the passage of harmful ...
Liu Kang-Sheng - - 2013
Prenatal lead and cadmium exposure will not only influence the mother' organ systems, but also will provide an environment that may influence the fetus and neonate in a harmful way.In the present study, we detected the blood lead levels (BLLS) and cadmium levels for the duration of pregnancy and 6-12 ...
Senczuk-Przybylowska M M Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Poznan, Poland. - - 2013
Pregnant women are exposed to benzodiazepines for therapeutic purposes during gestation. The goal of this study was to evaluate prenatal exposure to benzodiazepines. Time of exposure during course of pregnancy is a significant aspect of fetal exposure to drugs. Benzodiazepine concentration assay in hair of mothers and newborns exposed prenatally ...
Kongtip Pornpimol - - 2013
Objective: Prenatal exposure to organophosphate pesticides can lead to developmental neurotoxicity. A longitudinal birth cohort was established to investigate pesticide exposures from different agricultural activities. Maternal urinary organophosphate metabolites were measured at 28 weeks of pregnancy (n=86), delivery (n=67) and 2-months postpartum (n=51). Method: Subjects were interviewed with questionnaires about ...
Bjelland E K - - 2013
Is pre-pregnancy hormonal contraception use associated with the development of pelvic girdle pain during pregnancy? In contrast to combined oral contraceptive pills, long lifetime exposure to progestin-only contraceptive pills or the use of a progestin intrauterine device during the final year before pregnancy were associated with pelvic girdle pain. Pelvic ...
Nilsen Roy M - - 2013
This study examined potential self-selection bias in a large pregnancy cohort by comparing exposure-outcome associations from the cohort to similar associations obtained from nationwide registry data. The outcome under study was specialist-confirmed diagnosis of autism spectrum disorders (ASDs). The cohort sample (n = 89 836) was derived from the population-based prospective Norwegian Mother ...
Goldberg Ori - - 2013
Antibacterial drugs are among the most common medications used by pregnant women. While medical literature generally defines nitrofurantoin as an antibiotic that is safe for use during the first trimester of pregnancy, new concerns about a possible association between congenital malformations following exposure to nitrofurantoin during the first trimester of ...
Bellantuono Cesario - - 2013
Maternal psychiatric disorders can have negative consequences on the fetus and newborn. Thus, the risks of untreated mental disorders in pregnancy should be balanced against the potential risks of a psychopharmacological treatment. The aim of the present report is to provide information on the infant safety of duloxetine exposure, an ...
Garlantézec Ronan - - 2013
Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function. To study the relation between women's exposure to glycol ethers and time to pregnancy. Urine from randomly selected women in the PELAGIE mother-child cohort who ...
Bortlik Martin - - 2013
Abstract Objective. Substantial number of women with inflammatory bowel disease (IBD) conceives while on anti-TNF-α therapy. The aim was to assess the safety and efficacy of anti-TNF-α treatment during pregnancy and to analyze relationship of neonatal and maternal anti-TNF-α levels at delivery with gestational age at the last exposure. Material ...
Llop Sabrina - - 2013
There is little evidence about exposure to currently used insecticides during early life periods and adverse effects on child neuropsychological development. The aim of this study is to examine the association between residential insecticide use during pregnancy and infancy, and the development of children. Study subjects were participants in the ...
Parboosing Raveen R Department of Virology, National Health Laboratory Service and University of KwaZulu-Natal, Albert Luthuli Central Hospital, Durban, South - - 2013
Gestational influenza has been associated previously with schizophrenia in offspring, but the relationship between this exposure and bipolar disorder (BD) is unclear. The identification of gestational influenza as a risk factor for BD may have potential for preventive approaches. To test the hypothesis that maternal influenza during pregnancy is related ...
Babu Rameswarapu Suman RS Associate Professor, Department of Anatomy, Mediciti Institute of Medical Sciences , Ghanpur, Ranga Reddy District-501401, Andhra Pradesh, India - - 2013
The present study was undertaken to explore the incidence of congenital foetal anomalies and the advantages of ultrasonography in detecting the foetal anomalies during the antenatal period. We focused our study on 1000 consecutive pregnancies that came for check up in the second and third trimesters, with major or minor ...
Weinberger Barry - - 2013
Abstract Objective: Phthalates and bisphenol A (BPA) are ubiquitous environmental toxicants, present in high concentrations in numerous consumer products. We hypothesized that maternal exposure to phthalates and BPA in pregnancy is associated with shortened gestation. Methods: Urinary phthalate and BPA metabolites from 72 pregnant women were measured at the last ...
Stowell Sean R SR Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Children’s Healthcare of Atlanta, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, GA 30322, - - 2013
Exposure to nonself red blood cell (RBC) antigens, either from transfusion or pregnancy, may result in alloimmunization and incompatible RBC clearance. First described as a pregnancy complication 80 years ago, hemolytic disease of the fetus and newborn (HDFN) is caused by alloimmunization to paternally derived RBC antigens. Despite the morbidity/mortality ...
Skurtveit Svetlana - - 2013
To assess the impact of exposure misclassification on risk associations when using prescription databases as the source for drug exposure in pregnancy by applying results from a validation analysis of exposure classification. Linkage of data on 27,656 participants in the Norwegian Mother and Child Cohort Study (MoBa) with the Norwegian ...
Bellingham Michelle M Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, - - 2013
Exposure of female fetuses to environmental chemicals (ECs) during pregnancy results in a disturbed ovarian adult phenotype. We investigated the influence of pre- and/or post-conception exposure to low-level mixtures of ECs on the structure and function of the fetal ovine ovary. We examined ovarian morphology, expression of oocyte and granulosa ...
Zhang Tao - - 2013
Although levels of poly- and perfluoroalkyl substances (PFASs) in human maternal and neonatal blood have been widely reported in the literature, maternal-fetal transmission of PFASs with carbon chain length is presently not well understood. In this study, 11 PFASs were analyzed in matched samples, including not only maternal blood (MB, ...
Gisbert Javier P - - 2013
OBJECTIVES:Anti-tumor necrosis factor (TNF) drugs are an effective therapeutic option in patients with inflammatory bowel disease (IBD). However, data regarding their safety during pregnancy and breastfeeding are scarce. The aim of this study was to critically review available data on the safety of anti-TNF therapy during pregnancy and breastfeeding in ...
Couto Arnaldo C - - 2013
OBJECTIVE: To investigate the association between maternal exposure to hair dyes and hair straightening cosmetics (HDSC) during pregnancy and leukemia at an early age (< 2 yr., EAL). METHODS: A multicenter hospital-based case-control study was carried out in 13 states in Brazil between 1999 and 2007. Mothers of 176 ALL ...
Morini Luca - - 2013
BACKGROUND:: The deleterious effects exerted by prenatal ethanol exposure include physical, mental, behavioral, and/or learning disabilities that are included in the term fetal alcohol spectrum disorder. The measurement of ethylglucuronide (EtG) in alternative biological matrices, including neonatal and maternal hair, neonatal meconium, and maternal nails, is receiving increasing interest for ...
Memo Luigi - - 2013
Ethanol consumption during pregnancy is a widespread problem which is increasing in the generation of young women. Gestational alcohol consumption causes fetal exposure to this teratogen and is associated with the onset of fetal alcohol spectrum disorders (FASD) including fetal alcohol syndrome (FAS). FASD and FAS can lead to several ...
Panait Nicoleta - - 2013
Newborns prenatally exposed to methimazole (active metabolite of carbamizole) for maternal hyperthyroidism may present some disorders in common, but the phenotype is not well defined. Choanal atresia is the most frequent, and other anomalies such as esophageal atresia and aplasia cutis were described with this embryopathy. Additionally, patent omphalomesenteric duct ...
Intapad Suttira - - 2013
Pregnancy complications such as preeclampsia and diabetes affect approximately 5 to 10 % of all pregnancies and compromise maternal and fetal health during gestation. Complications during pregnancy may also contribute to the development of hypertension and future cardiovascular risk in the mother. Moreover, fetal exposure to hypertension and diabetes during ...
Cooper Duncan L - - 2013
BACKGROUND: Various human and animal studies suggest that peak alcohol exposure during a binge episode, rather than total alcohol exposure, may determine fetal development. Research about the impact of binge drinking on birth outcomes is sparse and inconclusive. Data from the Born in Bradford cohort study were used to explore ...
Hougaard Karin S - - 2013
[0] We studied the effects of preconceptional exposure to multiwalled carbon nanotubes (MWCNTs): mature, female C57BL/6J mice were intratracheally instilled with 67μg NM-400 MWCNT, and the following day co-housed with mature males, in breeding pairs. Time to delivery of the first litter, litter parameters, maternal inflammation and histopathology of lung ...
Corbel Tanguy - - 2013
The widespread human exposure to bisphenol A (BPA), a xenoestrogen interfering with developmental processes, raises the question of the mechanisms determining fetal exposure to BPA. A physiological model was developed in ewes to determine whether the pregnancy-associated physiological changes and the metabolic specificities of the feto-placental unit can influence BPA ...
Huang Changxiao - - 2013
BACKGROUND: Cases of ectopic pregnancy (EP) following levonorgestrel (LNG) emergency contraception (EC) failure were reported, however, the effects of LNG on tubal microenvironment or chorionic villi in EP have not yet been documented. METHODS: Fifty-five women with tubal pregnancy were divided into two groups according to whether LNG-EC was administrated ...
Dickenson Carrie A - - 2013
Mercury exposure during pregnancy can have serious health effects for a developing fetus including impacting the child's neurological and cognitive development. Through biomonitoring in a low-income Latina population, we identified a patient with high levels of mercury and traced the source to face creams purchased in a pharmacy in Mexico.
Marchioni Renée M RM Division of Gastroenterology and Hepatology, University of Connecticut Health Center, Farmington, CT 06032, - - 2013
Tumor necrosis factor-α inhibitors (anti-TNFs) are effective in the treatment of inflammatory bowel disease (IBD) recalcitrant to conventional medical therapy. As the peak incidence of IBD overlaps with the prime reproductive years, it is crucial to establish pharmacologic regimens for women of childbearing age that achieve effective disease control without ...
Bahat Dinur Anat A Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, - - 2013
Macrolide antibiotics are largely used in pregnancy for different bacterial infections. Their fetal safety has been studied by several groups, yielding opposing results. In particular, there have been studies claiming an association between macrolides and cardiovascular malformations. Exposure in early infancy has been associated with pyloric stenosis and intussusception. This ...
Waterman Emily H - - 2013
Fetal alcohol exposure is the leading preventable cause of birth and developmental defects in the United States. Despite a growing body of knowledge about the spectrum of disorders resulting from fetal alcohol exposure, 1 in 9 pregnant women continues to drink alcohol during pregnancy, and a small percentage of pregnant ...
Kallen Amanda N - - 2013
This is an unusual case of embryonic exposure to clomiphene citrate (CC) in the setting of an undiagnosed early pregnancy with successful follicular response to CC and progression of pregnancy despite markedly attenuated serum progesterone and estradiol levels and a thin endometrium. A review of literature on the potential of ...
Liu Xiao-Li XL Department of Histology and Embryology, Anhui Medical University, Anhui, Hefei - - 2013
Bisphenol A (BPA), a xenoestrogen and endocrine-disrupting chemical, is a cause for concern due to its being a potential human carcinogen. The aim of this study was to investigate the effects of continued maternal exposure to BPA on the testicular structures and expression of caspase-3 protein in male ICR offspring ...
- - 2013
The National Toxicology Program (NTP) Office of Health Assessment and Translation (OHAT) conducted an evaluation of the developmental effects and pregnancy outcomes associated with cancer chemotherapy use during pregnancy in humans. The final NTP monograph was completed in May 2013 (available at http:// ntp.niehs.nih.gov/go/36495). The incidence of cancer during pregnancy ...
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