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Tan Michael - - 2013
Question My patient received 62 units of botulinum toxin type A (BTX-A) for facial lines. Two weeks later, she found out that she was pregnant. Will this cause any harm to her fetus? Answer Botulinum toxin is not expected to be present in systemic circulation following proper intramuscular or intradermal ...
Goel Himanshu - - 2013
The teratogenic effects of antenatal exposure of antithyroid drugs, carbimazole and methimazole have been well reported in the literature. These comprise of typical facial features and a wide variety of malformations such as choanal atresia, tracheo-esophageal anomalies, congenital heart disease and ectodermal defects. However, the longitudinal studies have failed to ...
Huang Boxian B Department of Life Science and Technology, China Pharmaceutical University, Nanjing 210038, China; State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, - - 2013
So far, the pathogenesis of Parkinson's disease (PD) remains unclear. Current studies implicate environmental toxins may be potential causes of fetal origin of PD. BPA is a member of the family of estrogenic chemicals existing widely in environment. Significant evidences from animal experimentation have demonstrated that BPA interfere with fetal ...
Kwegyir-Afful Emma - - 2013
Prematurity (<37 weeks gestation) is among the major determinants of infant morbidity and mortality (1). Within developing countries, where the condition is of major public health importance, incidence is around 19% versus 5-7% in developed nations (2). The global estimation of preterm delivery in 2005 was 9.6% of all births, ...
Colbers Angela - - 2013
Treatment with combination antiretroviral therapy during pregnancy reduces the chance of mother to child transmission of HIV. Physiological changes during pregnancy can lead to lower exposure to antiretrovirals, possibly resulting in virological failure. For most antiretrovirals, data on exposure during pregnancy and transplacental passage are limited. This review summarizes the ...
Bagcioglu Erman - - 2013
Our aim is to evaluate the prevalence of domestic violence (DV) among pregnant women and find out whether several factors were associated with DV or not. A total of 317 pregnant women applied at Sanliurfa Obstetrics Hospital and Harran University obstetrics and gynecology department outpatient clinic were interviewed using the ...
Lupattelli Angela - - 2013
This study aimed to examine obstetric bleeding outcomes after exposure during pregnancy to selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic (TCAs), and other antidepressants (OADs).The Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway constituted the data source for the present study. We ...
Dadvand Payam - - 2013
Preterm premature rupture of membranes (PROM) is the leading identifiable predisposing factor for preterm birth. Although maternal exposure to air pollution can potentially have an impact on preterm PROM, there is no available evidence on such an impact. In this study, based on 5,555 singleton births occurring in Barcelona, Spain ...
Morton Suzanna - - 2013
The use of statins in women of reproductive age to prevent adverse cardiovascular events is on the rise. This is attributed to an increase in metabolic risk factors such as obesity, raised lipids, diabetes and high blood pressure. Statins are contraindicated in pregnancy because of the perceived increased risk of ...
Laurent Olivier - - 2013
Little is known about the impacts of green spaces on pregnancy outcomes. The relationship between green space exposure and preeclampsia has never been studied. We used a hospital-based perinatal database including more than 80,000 births to study the relationships between greenness exposure and three pregnancy outcomes: birth weight in term ...
Wu Jun - - 2013
Maternal exposures to traffic-related air pollution have been associated with adverse pregnancy outcomes. Exposures to traffic-related air pollutants are strongly influenced by time spent near traffic. However, little is known about women's travel activities during pregnancy and whether questionnaire-based data can provide reliable information on travel patterns during pregnancy.ObjectivesExamine women's ...
Malir Frantisek - - 2013
Abstract The mycotoxin ochratoxin A (OTA) can elicit a wide range of toxic properties including embryotoxicity and teratogenicity. OTA crosses the placenta at early gestation rather than in late gestation, maternal OTA exposure may represent a risk for the developing fetus. The study focuses on the assessment of OTA intake ...
Mira-Escolano María-Pilar MP Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia School of Medicine, Espinardo (Murcia) 30100, - - 2013
Animal models suggest that anogenital distance (AGD) at birth reflects androgen concentrations during in-utero development and predicts adult AGD. Several human observational studies show an association between menstrual cycle irregularities and a hyperandrogenic environment and that may result in a potential alteration of the female reproductive tract during in-utero development. ...
Bisgaard Hans - - 2013
We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interacts with a genetic predisposition to cause an abnormal immune-modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others. To explore these interactions by conducting a longitudinal study in ...
Zahedi Yasmin - - 2013
To evaluate possible risks of strong static magnetic fields for embryo implantation, gestation, organogenesis, and embryonic development. Pregnant mice were exposed for 75 minutes daily during the entire course of pregnancy at the bore entrance, representing the position of medical staff, and at the isocenter, representing the position of patients, ...
Zaun Gregor - - 2013
To investigate the effect of daily exposure in utero to static magnetic fields during prenatal development on germ cell development and fertility of exposed offspring in adulthood. Mice were exposed daily in utero to different static magnetic field strengths at the bore entrance or in the isocenter of 1.5 T ...
Perera Frederica P FP DrPH, Mailman School of Public Health, Columbia University, 722 W 168th St, 12th floor, New York, NY 10032. - - 2013
Airborne polycyclic aromatic hydrocarbons (PAHs) are pollutants generated by combustion of fossil fuel and other organic material. Both prenatal PAH exposure and maternal psychological distress during pregnancy have each been associated with neurodevelopmental problems in children. The goal was to evaluate potential interactions between prenatal exposure to airborne PAHs and ...
Bapat Priya - - 2013
Varicella infection during pregnancy is associated with serious maternal and fetal complications such as congenital varicella syndrome, maternal pneumonia and neonatal varicella. Pregnant women are ineligible to receive the varicella vaccination, thus women who lack evidence of immunity to varicella are at an increased risk for developing a varicella infection ...
Huang Hsiang - - 2013
To examine the relationship between antidepressant use in pregnancy and low birth weight (LBW) and preterm birth (PTB). We searched English and non-English language articles via PubMed, CINAHL and PsychINFO (from their start dates through December 1st, 2012). We used the following keywords and their combinations: antidepressant, selective serotonin reuptake ...
Pereira Gavin - - 2013
Several studies have examined associations between particulate matter with aerodynamic diameter of 2.5 µm or less (PM2.5) and preterm birth, but it is uncertain whether results were affected by individual predispositions (e.g., genetic factors, social conditions) that might vary considerably between women. We tested the hypothesis that a woman is ...
Gunier Robert B - - 2013
Manganese (Mn) is an essential nutrient, but overexposure can be neurotoxic. Over 800 000 kg of Mn-containing fungicides are applied each year in California. Manganese levels in teeth are a promising biomarker of perinatal exposure. Participants in our analysis included 207 children enrolled in the Center for the Health Assessment of ...
Duarte-Salles Talita - - 2013
Maternal exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy has been associated with reduced fetal growth. However, the role of diet, the main source of PAH exposure among non-smokers, remains uncertain. To assess associations between maternal exposure to dietary intake of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy and birth ...
Nielsen S Y - - 2013
SUMMARY Maternal infection in pregnancy is a known risk factor for adverse pregnancy outcome, and a number of zoonotic pathogens may constitute a risk to pregnant women and their fetuses. With animal contact as a proxy for the risk of zoonotic infection, this study aimed to evaluate pregnancy outcome in ...
Ruixue Wang - - 2013
This study aimed to investigate the effect of male semen quality, occupational exposure, and lifestyle on recurrent pregnancy loss (RPL). Information on couples' occupational exposure and lifestyle was collected using a detailed questionnaire from 68 RPL couples and 63 randomly selected healthy controls. Semen parameters were estimated by computer-assisted sperm ...
Wang Liming - - 2013
Tenofovir disoproxil fumarate (TDF) safety during pregnancy has important public health implications. This review summarizes TDF safety during pregnancy, focusing on pregnancy outcomes, congenital anomaly risk, and other potential toxicities on neonates. Although information is limited, TDF appears to be safe during pregnancy. In six studies of HIV-1 (and/or HBV) ...
Liu Haitao - - 2013
The aim of this study was to investigate the effects of diagnostic ultrasound on chorionic villi during early pregnancy in rats through the examination of heat shock protein 70 (HSP70) expression and apoptosis in chorionic villi. Using TUNEL, RT-PCR, western blot analysis and immunohistochemistry, the extent of apoptosis and the gene/protein ...
Mazaud-Guittot Séverine S Institut de Recherche en Santé, Environnement et Travail-Institut National de la Santé et de la Recherche Médicale U1085, Campus de Beaulieu, F-35042 Rennes, France. - - 2013
Masculinization depends on the fetal testis. Exposure of the human fetus during pregnancy to paracetamol and/or to other mild analgesics is associated with an increased risk of cryptorchidism. We aimed to determine whether mild analgesics disrupted the morphology and endocrine function of the human testis. We used an in vitro ...
Hak Eelko - - 2013
Recent studies have reported an association between maternal use of gastric acid-suppressive drugs during pregnancy and asthma in the offspring, but the association could have been confounded by unmeasured risk factors. We assessed the association between the use of acid-suppressive drugs during pregnancy and the risk of developing childhood asthma ...
Dadvand Payam - - 2013
Available evidence concerning the association between air pollution and preeclampsia is limited, and specific associations with early- and late-onset preeclampsia have not been assessed. To investigate the association, if any, between preeclampsia (all, early-, and late-onset) and exposure to NO2, NOx, PM10, PM2.5, PM<sub>2.5-10</sub>, and PM2.5 light absorption (a proxy ...
Chambers Christina D - - 2013
There is a need for additional information on the fetal risks and relative safety of the pandemic H1N1 monovalent or trivalent influenza (pH1N1)-containing vaccines in women exposed during pregnancy. To assess risks and relative safety of the pH1N1-containing vaccines, we conducted a prospective cohort study of pH1N1-vaccine-exposed and unexposed comparison ...
Fraser Abigail - - 2013
Given that the primordial ovarian follicular pool is established in utero, it may be influenced by parental characteristics and the intrauterine environment. Anti-Müllerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian reserve in females in adulthood and adolescence. We examined and compared associations of maternal and paternal ...
Chi Ching-Chi - - 2013
IMPORTANCE Topical corticosteroids are indicated for pregnant women with skin conditions, but their safety in pregnancy is not fully understood. OBJECTIVE To investigate whether maternal exposure to topical corticosteroids results in adverse pregnancy outcomes. DESIGN Retrospective cohort study. SETTING United Kingdom National Health Service. PARTICIPANTS A total of 2658 pregnant ...
Eskenazi B - - 2013
Impaired fetal growth and preterm birth are the leading causes of neonatal and infant mortality worldwide and there is a growing scientific literature suggesting that environmental exposures during pregnancy may play a causal role in these outcomes. Our purpose was to assess the environmental exposure of the Fetal Growth Longitudinal ...
Kim Chang-Hee - - 2013
Prenatal environmental conditions affect the development of the fetus. In the present study, we investigated the effects of exposure to music and noise during pregnancy on neurogenesis and thickness in the motor and somatosensory cortex of rat pups. The pregnant rats in the music-applied group were exposed to 65 dB ...
Mølgaard-Nielsen Ditte D Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. - - 2013
Case reports suggest that long-term, high-dose fluconazole treatment for severe fungal infections during pregnancy causes a pattern of birth defects. It is unclear whether commonly used lower doses increase the risk of specific birth defects. In a registry-based cohort of liveborn infants in Denmark, we evaluated first-trimester oral fluconazole exposure ...
Jin Yuanxiang - - 2013
The commercial bifenthrin (BF) contains two cis isomers. In the present study, a dose of 15mg/kg of 1R-cis-BF or 1S-cis-BF was orally administered for 3 weeks to female mice before or during pregnancy. Then, the expression of steroidogenesis related genes which were considered as effective biomarkers of endocrine disruption were ...
McFadden J P - - 2013
One explanation for the large increase in the prevalence of atopic disease during the last 50 years in developed countries is the 'hygiene hypothesis'. This proposes that a reduced exposure to pathogenic microorganisms at a key period(s) during development result in the maintenance or acquisition of an atopic phenotype. Alternatively, ...
Braun Thorsten - - 2013
An adverse early life environment is associated with long-term disease consequences. Adversity early in life is hypothesized to elicit developmental adaptations that serve to improve fetal and postnatal survival and prepare the organism for a particular range of postnatal environments. These processes, while adaptive in their nature, may later prove ...
Gennings Chris - - 2013
Polychlorinated biphenyls (PCBs) remain ubiquitous environmental contaminants. Developmental exposures are suspected to impact reproduction. Analysis of mixtures of PCBs may be problematic as components have a complex correlation structure, and along with limited sample sizes, standard regression strategies are problematic. We compared the results of a novel, empirical method to ...
Di Leo Milena - - 2013
The effect of fetal radiation during endoscopic retrograde cholangiopancreatography (ERCP) on pregnant women is a very interesting topic. Smith et al recently estimated the fetal radiation exposure in pregnant women undergoing ERCPs using thermoluminescent dosimeters (TLDs). The authors concluded that TLDs are unnecessary during ERCP with modified techniques. We believe ...
Philippat Claire - - 2013
Maternal urinary biomarkers are often used to assess fetal exposure to phenols and their precursors. Their effectiveness as a measure of exposure in epidemiological studies depends on their variability during pregnancy and their ability to accurately predict fetal exposure. We assessed the relationship between urinary and amniotic fluid concentrations of ...
Chelchowska Magdalena - - 2013
To assess the effect of lead exposure from cigarette smoke on fetal growth, blood lead concentrations were measured using inductively coupled plasma mass spectrometry in 150 healthy pregnant women. Mean lead concentrations in plasma and whole blood were significantly higher in the smoking group compared with the nonsmoking group in ...
Valent Francesca - - 2013
Background: Mercury is a neurotoxin, and limited prenatal exposure to it can affect long-term child neurodevelopment. However, results of epidemiologic studies of such exposure have been inconsistent. We examined the association of prenatal mercury exposure from maternal fish consumption with child neurodevelopment in northern Italy.Methods: A population-based cohort of 606 ...
Harrison-Woolrych Mira - - 2013
The purpose of this study was to investigate the extent of exposure to varenicline during pregnancy in 'real-life' post-marketing use and follow-up all pregnancy exposures to identify maternal and fetal outcomes. This was a prospective observational cohort study conducted in New Zealand using intensive prescription event monitoring methods. A nationwide ...
Abdelouahab Nadia - - 2013
Thyroid hormones play a critical role in the growth of many organs, especially the brain. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) interact with the thyroid pathway and may disturb neurodevelopment. This prospective study was designed to examine associations between maternal blood PBDEs and PCBs in early pregnancy and ...
Meador Kimford J - - 2013
Fetal valproate exposure has been associated with the highest risk of congenital malformations among antiepileptic drugs.(1) Valproate's effect is dose-dependent(1) and has been associated with multiple specific malformations.(2,3) Vadja et al.(4) examined data from the Australian Pregnancy Registry (1999-2012 data), which included 1,705 pregnancies with 436 valproate exposures.(4) They found ...
Haukland Lars Utne - - 2013
Functional and behavioural deficits in neonates following the use of selective serotonin and norepinephrine reuptake inhibitors (SNRI) in the third trimester of pregnancy is well documented.(1,2,3) Venlafaxine and its active metabolite, O-desmethylvenlafaxine are recognized as potent SNRIs. Up to 63% of neonates exposed to venlafaxine may develop symptoms, which are ...
Caserta D - - 2013
Heavy metals (HMs) are environmental contaminants with toxic properties for wildlife and humans. The placenta is a privileged organ that, along with the fetal membranes and amniotic fluid, enables growth and development of the fetus during the physiological pregnancy. It also acts as a filter reducing the passage of harmful ...
Liu Kang-Sheng - - 2013
Prenatal lead and cadmium exposure will not only influence the mother' organ systems, but also will provide an environment that may influence the fetus and neonate in a harmful way.In the present study, we detected the blood lead levels (BLLS) and cadmium levels for the duration of pregnancy and 6-12 ...
Senczuk-Przybylowska M - - 2013
Pregnant women are exposed to benzodiazepines for therapeutic purposes during gestation. The goal of this study was to evaluate prenatal exposure to benzodiazepines. Time of exposure during course of pregnancy is a significant aspect of fetal exposure to drugs. Benzodiazepine concentration assay in hair of mothers and newborns exposed prenatally ...
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