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Morton Russell A RA Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center; - - 2014
Exposure to alcohol during development can result in a constellation of morphological and behavioral abnormalities that are collectively known as Fetal Alcohol Spectrum Disorders (FASDs). At the most severe end of the spectrum is Fetal Alcohol Syndrome (FAS), characterized by growth retardation, craniofacial dysmorphology, and neurobehavioral deficits. Studies with animal ...
Piasek Martina M a Institute for Medical Research and Occupational Health , Zagreb , - - 2014
Rats were exposed to cadmium (Cd) during pregnancy orally (50 ppm Cd in drinking water from gestation day [GD] 1-20) or parenterally (5 mg/kg sc during GD 1-19 or on GD 16). Cadmium levels were measured in blood, placenta, and fetus at the end of exposure. Human studies comprised of ...
Pembrey Marcus M School of Social and Community Medicine, University of Bristol, Bristol, UK Centre for Child and Adolescent Health, University of Bristol, Bristol, UK Institute of Child Health, University College London, London, - - 2014
Transgenerational effects of different environmental exposures are of major interest, with rodent experiments focusing on epigenetic mechanisms. Previously, we have shown that if the study mother is a non-smoker, there is increased mean birth weight, length and body mass index (BMI) in her sons if she herself had been exposed ...
Ferguson Kelly K KK Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann - - 2014
Preterm birth is a leading cause of neonatal mortality, with a variety of contributing causes and risk factors. Environmental exposures represent a group of understudied, but potentially important, factors. Phthalate diesters are used extensively in a variety of consumer products worldwide. Consequently, exposure in pregnant women is highly prevalent. To ...
Gietka-Czernel MaƂgorzata M Dept. of Endocrinlogy Medical Center of Postgraduate Education Warsaw. - - 2014
To evaluate the usefulness of measuring maternal anti-TSH receptor antibodies (TRAbs) and foetal ultrasound (US) monitoring in cases of current or past maternal hyperthyroidism. 77 pregnant women suffering from hyperthyroidism or with a history of Graves' hyperthyroidism were observed prospectively. Maternal serum TSH, fT4, fT3, TRAbs, and foetal US were ...
Polak Michel M Pediatric Endocrinology, Gynecology and Diabetology, Necker Enfants-Malades University Hospital, Assistance Publique-Hôpitaux de Paris, INSERM U1016, IMAGINE Institute, Université Paris Descartes, Sorbonne Paris Cité, Paris, - - 2014
The early steps of thyroid development that lead to its function in the human fetus and subsequently the further maturation that allows the human fetus to secrete thyroxine (T4) in a significant amount are reviewed here. We underline the importance of the transfer of T4 from the pregnant woman to ...
Raoofi Zahra Z 1. Assistant Professor, Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran. - - 2014
To investigate thyroid function in preeclamptic patients in comparison with normal pregnant women. In this analytical cross-sectional study free Thyroxine (T4), and Thyroid Stimulating Hormone (TSH) levels were measured in 100 preeclamptic patients and were compared with Free T4 and TSH levels in 101 normal pregnant women in their third ...
Negro Roberto R Division of Endocrinology, Department of Internal Medicine, "V Fazzi" Hospital, Lecce, 73100, Italy - - 2014
In prospective studies, the prevalence of undiagnosed subclinical hypothyroidism in pregnant women ranges from 3% to 15%. Subclinical hypothyroidism is associated with multiple adverse outcomes in the mother and fetus, including spontaneous abortion, pre-eclampsia, gestational hypertension, gestational diabetes, preterm delivery, and decreased IQ in the offspring. Only two prospective studies ...
Shin In-Sik IS Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon 305-811, Republic of - - 2013
Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer and is widely dispersed in the environment. In this study, we investigated the effects of maternal exposure to DEHP during pregnancy on neonatal asthma susceptibility using a murine model of asthma induced by ovalbumin (OVA). Pregnant BALB/c mice received DEHP from gestation ...
Ma Noelle N Departments of Physiology & Pharmacology and Obstetrics & Gynecology, The University of Western Ontario; The Lawson Health Research Institute, The University of Western - - 2013
While nicotine replacement therapy is assumed to be a safer alternative to smoking during pregnancy, the long-term consequences for the offspring remain elusive. Animal studies now suggest that maternal nicotine exposure during perinatal life leads to a wide range of adverse outcomes for the offspring including increased adiposity. The focus ...
Castelino Jovita M JM Division of Epidemiology, School of Medicine, University of Leeds, Leeds, - - 2014
Aflatoxin is known to cross the placental barrier and exposures in utero could influence genomic programming, foetal growth and development, resulting in long-term health effects. We aimed to determine aflatoxin exposure in Gambian women at two stages of pregnancy and during the rainy and dry seasons. We examined aflatoxin exposure ...
Slama Rémy - - 2013
Adverse pregnancy outcomes entail a large health burden for the mother and offspring; a part of it might be avoided by better understanding the role of environmental factors in their etiology. Our aims were to review the assessment tools to characterize fecundity troubles and pregnancy-related outcomes in human populations and ...
Zhang Yuanyuan Y 1Institute of Animal Nutrition, Northeast Agricultural University, Harbin, People's Republic of - - 2013
The objectives of this study were to determine the effects of high-dose and early gestational exposure to zearalenone (ZEN) in female Sprague-Dawley (SD) rats, to correlate the maternal uterus with the fetus, and to explore the development and malformation of fetuses. Pregnant female SD rats were fed diets containing 0.3, ...
de Steenwinkel Florentien D O FD Department of Rheumatology, Erasmus MC, Rotterdam, The - - 2013
Pregnant women suffering from autoimmune disease use glucocorticoids. Glucocorticoids can partly diffuse to the fetus, and may influence the development of the fetal hypothalamic-pituitary-adrenal axis, especially in early stage of pregnancy. The objective was to investigate whether prednisone-exposure in utero influences the cortisol levels of the prepubertal children. Mothers participated ...
Hyrich Kimme L KL Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester, - - 2013
Biologic therapies have revolutionized treatment outcomes for patients with inflammatory arthritis. However, there remains a concern regarding their safety during conception, pregnancy and breastfeeding. Data on the safety of these treatments are largely limited to uncontrolled case reports. Collective evidence from many hundreds of pregnancies in inflammatory arthritis and IBD ...
Illi Sabina S University Children's Hospital, Munich, Germany. Electronic address: - - 2014
In most children with asthma and atopy, onset of disease occurs early in life, indicating a crucial role of in utero and early childhood environment. However, only a small part of this burden of disease established early in life has been explained. To examine the effects of early environmental exposures ...
Buck Louis Germaine M - - 2013
Speculation has arisen that human fecundity may be declining, possibly a function of exposure to persistent environmental chemicals that resist degradation resulting in various pathways for human exposure. In contrast to considerable animal evidence suggesting adverse effects of such chemicals on reproduction, limited human research has been undertaken. To date, ...
Hoffman Kate - - 2013
Organophosphate flame retardants (OPFRs) are commonly added to consumer products to reduce their flammability. Based on levels of OPFRs in indoor environments, human exposure is likely chronic and ubiquitous. Animal studies suggest that exposure to some OPFRs may result in adverse health impacts, particularly for Tris (1,3-dichloropropyl) phosphate (TDCPP); however, ...
Yonkers Kimberly A - - 2013
Women in their reproductive years are at risk of experiencing depressive and anxiety disorders. As such, it is likely that pregnant women will undergo treatment with antidepressants. We review the risk of adverse birth outcomes and neonatal complications subsequent to antidepressant use in pregnancy. An inconsistent literature shows that antidepressant ...
Maccani Jennifer Zj - - 2013
Aims: The developmental origins of health and disease hypothesis states that later-life disease may be influenced by the quality of the in utero environment. Environmental toxicants can have detrimental effects on fetal development, potentially through effects on placental development and function. Maternal smoking during pregnancy is associated with low birth ...
Bisgaard H H Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte & Naestved, Denmark; Health Sciences, University of Copenhagen, Copenhagen, - - 2013
We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the genetic predisposition to cause an abnormal immune modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others. The aim of this study is to explore these ...
Wesselink Amelia - - 2013
Animal evidence suggests an association between exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and adverse pregnancy outcomes. Epidemiologic studies report inconsistent results, but are limited by narrow range of exposure, small sample size, and lack of a biologic measure of highest lifetime exposure. On July 10, 1976, a chemical explosion in Seveso, Italy ...
Vázquez-Salas Ruth Argelia - - 2014
Objective To evaluate the association between prenatal exposure to molybdenum (Mo) and infant neurodevelopment during the first 30 months of life. Methods We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the ...
Diav-Citrin Orna - - 2013
To evaluate pregnancy safety of anti-TNF-α medications. Prospective, comparative, observational study done at the Israeli Teratology Information Service between 2002 and 2011. 83 anti-TNF-α-exposed-pregnancies (97.6% in the first trimester, T1) were followed-up and compared with 86 disease-matched (DM) and 341 non-teratogenic-exposed (NTE) pregnancies. The anti-TNF-α group consisted of 35 infliximab-, ...
Novakovic Boris - - 2013
The intrauterine environment has the potential to 'program' the developing fetus in a way that can be potentially deleterious to later health. While in utero environmental/stochastic factors are known to influence DNA methylation profile at birth, it has been difficult to assign specific examples of epigenetic variation to specific environmental ...
Brown Mary Jean - - 2013
Cultural and environmental factors can cause lead poisoning in the pregnant patient. The data regarding the reproductive risks associated with chelation during human pregnancy are sparse. Assessment of the exposure setting, including anticipatory counseling for each pregnant woman, would help assure the ideal outcome of no added lead intake.
Paixão Ana D - - 2013
Environmental conditions during perinatal development such as maternal undernutrition, maternal glucocorticoids, placental insufficiency and maternal sodium overload can program changes in renal Na(+) excretion leading to hypertension. Experimental studies indicate that fetal exposure to an adverse maternal environment may reduce glomerular filtration rate by decreasing the surface area of the ...
Velez Edwards Digna R DR Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, TN; Institute of Medicine and Public Health, Vanderbilt University, Nashville, TN; Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN; Center for Human Genetics Research, Vanderbilt University, Nashville, TN. Electronic address: - - 2013
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most common medications reported in pregnancy. NSAIDs directly impact prostaglandin pathways and have been proposed as potential risk factors for spontaneous abortions (SABs, gestation <20 weeks). SAB risk and drug response across several medications differ by race; therefore, we evaluated whether associations ...
Savitz David A - - 2014
Building on a unique exposure assessment project in New York, New York, we examined the relationship of particulate matter with aerodynamic diameter less than 2.5 μm and nitrogen dioxide with birth weight, restricting the population to term births to nonsmokers, along with other restrictions, to isolate the potential impact of ...
Zhao Shufang - - 2013
Abstract Background: Although maternal smoking during pregnancy disrupts offspring development, it is not clear whether smoking before pregnancy has any effect on the next generation. Given that nicotine, the major psychoactive component in cigarettes, is toxic to many organs, we hypothesized that maternal smoking even before a pregnancy affects offspring ...
Forns Joan - - 2013
There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the ...
Pearlstein Teri - - 2013
Women with active psychiatric disorders who become pregnant face treatment dilemmas. Although results from studies are inconsistent, small but significant, risks on birth outcomes occur with exposure to untreated disorders, as well as to psychotropic medications. Prenatal antidepressant medication exposure may increase the risk for spontaneous miscarriage, preterm birth, cardiac ...
Starling Anne P - - 2013
Perfluoroalkyl substances (PFASs) are widespread and persistent environmental pollutants. Previous studies, primarily among non-pregnant individuals, suggest positive associations between PFAS levels and certain blood lipids. If there is a causal link between PFAS concentrations and elevated lipids during pregnancy, this may suggest a mechanism by which PFAS exposure leads to ...
Tan Michael - - 2013
Question My patient received 62 units of botulinum toxin type A (BTX-A) for facial lines. Two weeks later, she found out that she was pregnant. Will this cause any harm to her fetus? Answer Botulinum toxin is not expected to be present in systemic circulation following proper intramuscular or intradermal ...
Goel Himanshu - - 2013
The teratogenic effects of antenatal exposure of antithyroid drugs, carbimazole and methimazole have been well reported in the literature. These comprise of typical facial features and a wide variety of malformations such as choanal atresia, tracheo-esophageal anomalies, congenital heart disease and ectodermal defects. However, the longitudinal studies have failed to ...
Huang Boxian B Department of Life Science and Technology, China Pharmaceutical University, Nanjing 210038, China; State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, - - 2013
So far, the pathogenesis of Parkinson's disease (PD) remains unclear. Current studies implicate environmental toxins may be potential causes of fetal origin of PD. BPA is a member of the family of estrogenic chemicals existing widely in environment. Significant evidences from animal experimentation have demonstrated that BPA interfere with fetal ...
Kwegyir-Afful Emma - - 2013
Prematurity (<37 weeks gestation) is among the major determinants of infant morbidity and mortality (1). Within developing countries, where the condition is of major public health importance, incidence is around 19% versus 5-7% in developed nations (2). The global estimation of preterm delivery in 2005 was 9.6% of all births, ...
Colbers Angela - - 2013
Treatment with combination antiretroviral therapy during pregnancy reduces the chance of mother to child transmission of HIV. Physiological changes during pregnancy can lead to lower exposure to antiretrovirals, possibly resulting in virological failure. For most antiretrovirals, data on exposure during pregnancy and transplacental passage are limited. This review summarizes the ...
Bagcioglu Erman - - 2013
Our aim is to evaluate the prevalence of domestic violence (DV) among pregnant women and find out whether several factors were associated with DV or not. A total of 317 pregnant women applied at Sanliurfa Obstetrics Hospital and Harran University obstetrics and gynecology department outpatient clinic were interviewed using the ...
Lupattelli Angela - - 2013
This study aimed to examine obstetric bleeding outcomes after exposure during pregnancy to selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic (TCAs), and other antidepressants (OADs).The Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway constituted the data source for the present study. We ...
Dadvand Payam - - 2013
Preterm premature rupture of membranes (PROM) is the leading identifiable predisposing factor for preterm birth. Although maternal exposure to air pollution can potentially have an impact on preterm PROM, there is no available evidence on such an impact. In this study, based on 5,555 singleton births occurring in Barcelona, Spain ...
Morton Suzanna - - 2013
The use of statins in women of reproductive age to prevent adverse cardiovascular events is on the rise. This is attributed to an increase in metabolic risk factors such as obesity, raised lipids, diabetes and high blood pressure. Statins are contraindicated in pregnancy because of the perceived increased risk of ...
Laurent Olivier - - 2013
Little is known about the impacts of green spaces on pregnancy outcomes. The relationship between green space exposure and preeclampsia has never been studied. We used a hospital-based perinatal database including more than 80,000 births to study the relationships between greenness exposure and three pregnancy outcomes: birth weight in term ...
Wu Jun - - 2013
Maternal exposures to traffic-related air pollution have been associated with adverse pregnancy outcomes. Exposures to traffic-related air pollutants are strongly influenced by time spent near traffic. However, little is known about women's travel activities during pregnancy and whether questionnaire-based data can provide reliable information on travel patterns during pregnancy.ObjectivesExamine women's ...
Malir Frantisek - - 2013
Abstract The mycotoxin ochratoxin A (OTA) can elicit a wide range of toxic properties including embryotoxicity and teratogenicity. OTA crosses the placenta at early gestation rather than in late gestation, maternal OTA exposure may represent a risk for the developing fetus. The study focuses on the assessment of OTA intake ...
Mira-Escolano María-Pilar MP Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia School of Medicine, Espinardo (Murcia) 30100, - - 2013
Animal models suggest that anogenital distance (AGD) at birth reflects androgen concentrations during in-utero development and predicts adult AGD. Several human observational studies show an association between menstrual cycle irregularities and a hyperandrogenic environment and that may result in a potential alteration of the female reproductive tract during in-utero development. ...
Zahedi Yasmin - - 2013
To evaluate possible risks of strong static magnetic fields for embryo implantation, gestation, organogenesis, and embryonic development. Pregnant mice were exposed for 75 minutes daily during the entire course of pregnancy at the bore entrance, representing the position of medical staff, and at the isocenter, representing the position of patients, ...
Zaun Gregor - - 2013
To investigate the effect of daily exposure in utero to static magnetic fields during prenatal development on germ cell development and fertility of exposed offspring in adulthood. Mice were exposed daily in utero to different static magnetic field strengths at the bore entrance or in the isocenter of 1.5 T ...
Perera Frederica P FP DrPH, Mailman School of Public Health, Columbia University, 722 W 168th St, 12th floor, New York, NY 10032. - - 2013
Airborne polycyclic aromatic hydrocarbons (PAHs) are pollutants generated by combustion of fossil fuel and other organic material. Both prenatal PAH exposure and maternal psychological distress during pregnancy have each been associated with neurodevelopmental problems in children. The goal was to evaluate potential interactions between prenatal exposure to airborne PAHs and ...
Bapat Priya - - 2013
Varicella infection during pregnancy is associated with serious maternal and fetal complications such as congenital varicella syndrome, maternal pneumonia and neonatal varicella. Pregnant women are ineligible to receive the varicella vaccination, thus women who lack evidence of immunity to varicella are at an increased risk for developing a varicella infection ...
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