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Higashida Yuka Y Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, - - 2014
Our objective was to evaluate the level of pregnant women's exposure to tobacco smoke by urinary cotinine testing at prenatal examinations, and to examine the effects of disclosing the results of urinary cotinine tests to pregnant women and their families on their smoking activities. A prospective cohort study was conducted, ...
France Kathryn E - - 2014
Public awareness-raising campaigns targeting alcohol use during pregnancy are an important part of preventing prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. Despite this, there is little evidence on what specific elements contribute to campaign message effectiveness. This research evaluated three different advertising concepts addressing alcohol and pregnancy: a threat ...
Savitz David A - - 2014
Levels of exposure biomarkers vary among individuals because of differences in both environmental exposure and metabolism. However, the ultimate interest is in providing information about the impact of modifying environmental exposures through regulation or behavior change. Using these levels in studies of pregnancy outcomes, as nicely illustrated by the study ...
Larrimer Margaret B MB Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR. Electronic address: - - 2014
The study goal was to examine the impact of commonly prescribed antiemetic medications in pregnancy on neurobehavioral and obstetrical outcomes. 533 women accounting for 550 live births (17 multiple gestations) enrolled prior to 16 weeks gestation participating in an observational longitudinal study of stress and pharmacological exposure in pregnancy at ...
Tran Thach D - - 2014
Antenatal anaemia, iron deficiency and common mental disorders (CMD) are prevalent in low- and middle-income countries. The aim of this study was to examine the direct and indirect effects of antenatal exposures to these risks and infant motor development. A cohort of women who were pregnant with a single foetus ...
Gentile Salvatore S Mental Health Center Cava de' Tirreni - Vietri sul Mare, Department of Mental Health, ASL Salerno , Cava de' Tirreni, Piazza Galdi, 841013 Cava de' Tirreni (Salerno) , Italy +39 089 4455439 ; +39 089 4455440 ; - - 2014
Introduction: Several concerns have been raised regarding the reproductive safety of the antidepressants most frequently used in clinical practice, such as selective serotonin reuptake inhibitors (SSRIs). Areas covered: This article aims to assess the risk/benefit ratio of the use of alternative pharmacological options, specifically tricyclic antidepressants (TCAs) in pregnancy and ...
Bowman Christopher J CJ Pfizer Worldwide Research and Development, Groton, - - 2014
Understanding species differences in placental transfer of Fc-containing biopharmaceuticals (particularly monoclonal antibodies) will improve human risk extrapolation from nonclinical embryo-fetal development toxicity data. Maternal and fetal concentration data from 10, 15, 8, and 34 Fc-containing biopharmaceuticals in the rabbit, rat, mouse, and cynomolgus monkey, respectively, from an industry survey were ...
Vafeiadi Marina M Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Hospital del Mar Research Institute (IMIM), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. Electronic address: - - 2014
Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and pesticides bioaccumulate through the food chain and cross the placenta. POPs are developmental toxicants in animals but the epidemiological evidence on pregnancy outcomes is inconsistent. Maternal gestational weight gain has been recently suggested as a key factor explaining the association between ...
Hernández-Díaz Sonia S Department of Epidemiology, Harvard School of Public Health, and North American Antiepileptic Drug Pregnancy Registry, Massachusetts General Hospital for Children, Boston, Massachusetts; Loyola University Health System, Chicago, Illinois; the College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, New York; and Oregon Health and Science University, Portland, - - 2014
To assess the possible effects of topiramate and zonisamide use during pregnancy on fetal growth. The study population was the singleton liveborns born to women who enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2012. Data were collected through telephone interviews at enrollment, 7 months of ...
Brown Susan B - - 2014
Adequate folate status in early pregnancy is critical to prevent congenital malformations, yet little is known about whether exposure to folate, specifically folic acid supplementation beyond the recommended dose, influences chronic health outcomes. The link between maternal folate levels and risk of childhood asthma and allergic disease has been investigated ...
Grigoriadis Sophie S Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N - - 2014
To examine the risk for persistent pulmonary hypertension of the newborn associated with antenatal exposure to antidepressants. Systematic review and meta-analysis. Embase, Medline, PsycINFO, and CINAHL from inception to 30 December 2012. English language studies reporting persistent pulmonary hypertension of the newborn associated with exposure to antidepressants. Two independent reviewers ...
Dorce Ana Leticia C - - 2014
Scorpion envenoming is a public health problem in Brazil, where Tityus serrulatus and T. bahiensis are considered the most dangerous scorpions. They are well adapted to urbanized environments, and there is an increasing probability of human exposure to these venoms, including during pregnancy. Not much is known about the effects ...
Zhang Ying Y Department of Epidemiology, Public Health School, Shenyang Medical College, Shenyang, - - 2014
A large amount of organophosphate pesticides (OPs) are used in agriculture in China every year, contributing to exposure of OPs through dietary consumption among the general population. However, the level of exposure to OPs in China is still uncertain. To investigate the effect of the exposure to OPs on the ...
Chapalamadugu Kalyan C KC Department of Animal and Veterinary Science, University of Idaho, Moscow, Idaho, United States of - - 2014
Conditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis. Fetal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in rodents and monkeys. However, effects of BPA exposure on cardiac development have not been assessed. With ...
Varner Michael W MW *For a list of other members of the Stillbirth Collaborative Research Network, see the Appendix online at http://links.lww.com/AOG/A455. University of Utah School of Medicine, Salt Lake City, Utah; Rollins School of Public Health, Emory University, and Emory University School of Medicine, Atlanta, Georgia; the Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; RTI International, Research Triangle Park, North Carolina; Columbia University, New York, New York; the University of Texas Medical Branch at Galveston, Galveston, and the University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Brown University School of Medicine, Providence, Rhode - - 2014
To compare illicit drug and smoking use in pregnancies with and without stillbirth. The Stillbirth Collaborative Research Network conducted a case-control study from March 2006 to September 2008, covering more than 90% of deliveries to residents of five a priori-defined geographically diverse regions. The study attempted to include all stillbirths ...
Kaplan Yusuf Cem YC Department of Pharmacology, Teratology Information Service, Faculty of Medicine, Izmir Katip Celebi University, 35280 Izmir, - - 2014
To the best of our knowledge this is the first case report describing exposure to varenicline, an α 4 β 2 nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintentionally yet regularly 4 weeks ...
Remy Sylvie S Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Mol, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, - - 2014
There is increasing epidemiologic evidence that arsenic exposure in utero is associated with adverse pregnancy outcomes and may contribute to long-term health effects. These effects may occur at low environmental exposures but the underlying molecular mechanism is not clear. We collected cord blood samples of 183 newborns to identify associations ...
Dung Dung Aldrin Anthony AA Institute of Human Behaviour and Allied Sciences, New Delhi, - - 2014
On the basis of evidence from clinical trials, contraindications to the use of interferon (INF) are pregnancy, epilepsy and depression. Management of multiple sclerosis during pregnancy is a difficult issue because of pregnancy-related complications and fear of congenital anomalies due to exposure to disease-modifying therapy. In different series, INF therapy ...
Boynukalin F K - - 2014
Naphthalene is one of the abused inhalants. It has been associated with acute and chronic health problems. To the authors' knowledge, prenatal exposure to naphthalene has never been discussed in humans. The authors discuss a case of naphthalene-addicted pregnant women with multiple fetal anomalies. At 15 weeks gestation, ultrasound screening ...
Ferguson Kelly K KK Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann - - 2014
Preterm birth is a leading cause of neonatal mortality, with a variety of contributing causes and risk factors. Environmental exposures represent a group of understudied, but potentially important, factors. Phthalate diesters are used extensively in a variety of consumer products worldwide. Consequently, exposure in pregnant women is highly prevalent. To ...
Askaa Bjarke B 0000-0003-2546-2888 Department of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, - - 2014
Background. There is little knowledge regarding the characteristics of women treated with hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy. In this large Danish cohort study, we characterize women exposed to HBRA during pregnancy. We determined changes in prevalence of HBRA use from 1997 to 2010 and exposure to HBRAs in ...
Håkonsen Linn Berger LB Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus C, - - 2014
Epidemiological studies have raised concerns about the reproductive consequences of in utero exposure to alcohol. Maternal lifestyle factors have been associated with altered pubertal development, but the impact of prenatal alcohol exposure on male puberty is unknown. Thus, the objective was to explore whether prenatal alcohol exposure alters pubertal development ...
Mayhoub Flora F Laboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Faculty of Medicine, Tishreen University, Latakia, - - 2014
The MecoExpo study was performed in the Picardy region of northern France, in order to investigate the putative relationship between parental exposures to pesticides (as reported by the mother) on one hand and neonatal parameters on the other. The cohort comprised 993 mother-newborn pairs. Each mother completed a questionnaire that ...
Mund Mathias M Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt am Main, Theodor-Stern-Kai 7, Frankfurt 60590, Germany. - - 2014
The exposure to tobacco smoke during pregnancy is considered to be amongst the most harmful avoidable risk factors. In this scientometric and gender study scientific data on smoking and pregnancy was analyzed using a variety of objective scientometric methods like the number of scientific contributions, the number of citations and ...
Shirangi Adeleh A School of Population Health, The University of Western Australia, Crawley, WA 6009, Australia. - - 2014
We examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female veterinarians. This study is a follow up survey of 321 female participants (633 pregnancies) who participated in the Health Risks of Australian Veterinarian project. Data on pregnancies ...
Pembrey Marcus M School of Social and Community Medicine, University of Bristol, Bristol, UK Centre for Child and Adolescent Health, University of Bristol, Bristol, UK Institute of Child Health, University College London, London, - - 2014
Transgenerational effects of different environmental exposures are of major interest, with rodent experiments focusing on epigenetic mechanisms. Previously, we have shown that if the study mother is a non-smoker, there is increased mean birth weight, length and body mass index (BMI) in her sons if she herself had been exposed ...
Morton Russell A RA Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center; - - 2014
Exposure to alcohol during development can result in a constellation of morphological and behavioral abnormalities that are collectively known as Fetal Alcohol Spectrum Disorders (FASDs). At the most severe end of the spectrum is Fetal Alcohol Syndrome (FAS), characterized by growth retardation, craniofacial dysmorphology, and neurobehavioral deficits. Studies with animal ...
Shin In-Sik IS Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon 305-811, Republic of - - 2013
Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer and is widely dispersed in the environment. In this study, we investigated the effects of maternal exposure to DEHP during pregnancy on neonatal asthma susceptibility using a murine model of asthma induced by ovalbumin (OVA). Pregnant BALB/c mice received DEHP from gestation ...
Ma Noelle N Departments of Physiology & Pharmacology and Obstetrics & Gynecology, The University of Western Ontario; The Lawson Health Research Institute, The University of Western - - 2013
While nicotine replacement therapy is assumed to be a safer alternative to smoking during pregnancy, the long-term consequences for the offspring remain elusive. Animal studies now suggest that maternal nicotine exposure during perinatal life leads to a wide range of adverse outcomes for the offspring including increased adiposity. The focus ...
Castelino Jovita M JM Division of Epidemiology, School of Medicine, University of Leeds, Leeds, - - 2014
Aflatoxin is known to cross the placental barrier and exposures in utero could influence genomic programming, foetal growth and development, resulting in long-term health effects. We aimed to determine aflatoxin exposure in Gambian women at two stages of pregnancy and during the rainy and dry seasons. We examined aflatoxin exposure ...
Slama Rémy - - 2013
Adverse pregnancy outcomes entail a large health burden for the mother and offspring; a part of it might be avoided by better understanding the role of environmental factors in their etiology. Our aims were to review the assessment tools to characterize fecundity troubles and pregnancy-related outcomes in human populations and ...
Zhang Yuanyuan Y 1Institute of Animal Nutrition, Northeast Agricultural University, Harbin, People's Republic of - - 2013
The objectives of this study were to determine the effects of high-dose and early gestational exposure to zearalenone (ZEN) in female Sprague-Dawley (SD) rats, to correlate the maternal uterus with the fetus, and to explore the development and malformation of fetuses. Pregnant female SD rats were fed diets containing 0.3, ...
de Steenwinkel Florentien D O FD Department of Rheumatology, Erasmus MC, Rotterdam, The - - 2013
Pregnant women suffering from autoimmune disease use glucocorticoids. Glucocorticoids can partly diffuse to the fetus, and may influence the development of the fetal hypothalamic-pituitary-adrenal axis, especially in early stage of pregnancy. The objective was to investigate whether prednisone-exposure in utero influences the cortisol levels of the prepubertal children. Mothers participated ...
Hyrich Kimme L KL Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester, - - 2013
Biologic therapies have revolutionized treatment outcomes for patients with inflammatory arthritis. However, there remains a concern regarding their safety during conception, pregnancy and breastfeeding. Data on the safety of these treatments are largely limited to uncontrolled case reports. Collective evidence from many hundreds of pregnancies in inflammatory arthritis and IBD ...
Illi Sabina S University Children's Hospital, Munich, Germany. Electronic address: - - 2014
In most children with asthma and atopy, onset of disease occurs early in life, indicating a crucial role of in utero and early childhood environment. However, only a small part of this burden of disease established early in life has been explained. To examine the effects of early environmental exposures ...
Buck Louis Germaine M - - 2013
Speculation has arisen that human fecundity may be declining, possibly a function of exposure to persistent environmental chemicals that resist degradation resulting in various pathways for human exposure. In contrast to considerable animal evidence suggesting adverse effects of such chemicals on reproduction, limited human research has been undertaken. To date, ...
Hoffman Kate - - 2013
Organophosphate flame retardants (OPFRs) are commonly added to consumer products to reduce their flammability. Based on levels of OPFRs in indoor environments, human exposure is likely chronic and ubiquitous. Animal studies suggest that exposure to some OPFRs may result in adverse health impacts, particularly for Tris (1,3-dichloropropyl) phosphate (TDCPP); however, ...
Yonkers Kimberly A - - 2013
Women in their reproductive years are at risk of experiencing depressive and anxiety disorders. As such, it is likely that pregnant women will undergo treatment with antidepressants. We review the risk of adverse birth outcomes and neonatal complications subsequent to antidepressant use in pregnancy. An inconsistent literature shows that antidepressant ...
Maccani Jennifer Zj - - 2013
Aims: The developmental origins of health and disease hypothesis states that later-life disease may be influenced by the quality of the in utero environment. Environmental toxicants can have detrimental effects on fetal development, potentially through effects on placental development and function. Maternal smoking during pregnancy is associated with low birth ...
Wesselink Amelia - - 2013
Animal evidence suggests an association between exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and adverse pregnancy outcomes. Epidemiologic studies report inconsistent results, but are limited by narrow range of exposure, small sample size, and lack of a biologic measure of highest lifetime exposure. On July 10, 1976, a chemical explosion in Seveso, Italy ...
Vázquez-Salas Ruth Argelia - - 2014
Objective To evaluate the association between prenatal exposure to molybdenum (Mo) and infant neurodevelopment during the first 30 months of life. Methods We selected a random sample of 147 children who participated in a prospective cohort study in four municipalities in the State of Morelos, Mexico. The children were the ...
Diav-Citrin Orna - - 2013
To evaluate pregnancy safety of anti-TNF-α medications. Prospective, comparative, observational study done at the Israeli Teratology Information Service between 2002 and 2011. 83 anti-TNF-α-exposed-pregnancies (97.6% in the first trimester, T1) were followed-up and compared with 86 disease-matched (DM) and 341 non-teratogenic-exposed (NTE) pregnancies. The anti-TNF-α group consisted of 35 infliximab-, ...
Novakovic Boris - - 2013
The intrauterine environment has the potential to 'program' the developing fetus in a way that can be potentially deleterious to later health. While in utero environmental/stochastic factors are known to influence DNA methylation profile at birth, it has been difficult to assign specific examples of epigenetic variation to specific environmental ...
Brown Mary Jean - - 2013
Cultural and environmental factors can cause lead poisoning in the pregnant patient. The data regarding the reproductive risks associated with chelation during human pregnancy are sparse. Assessment of the exposure setting, including anticipatory counseling for each pregnant woman, would help assure the ideal outcome of no added lead intake.
Paixão Ana D - - 2013
Environmental conditions during perinatal development such as maternal undernutrition, maternal glucocorticoids, placental insufficiency and maternal sodium overload can program changes in renal Na(+) excretion leading to hypertension. Experimental studies indicate that fetal exposure to an adverse maternal environment may reduce glomerular filtration rate by decreasing the surface area of the ...
Velez Edwards Digna R DR Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, TN; Institute of Medicine and Public Health, Vanderbilt University, Nashville, TN; Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN; Center for Human Genetics Research, Vanderbilt University, Nashville, TN. Electronic address: - - 2013
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most common medications reported in pregnancy. NSAIDs directly impact prostaglandin pathways and have been proposed as potential risk factors for spontaneous abortions (SABs, gestation <20 weeks). SAB risk and drug response across several medications differ by race; therefore, we evaluated whether associations ...
Savitz David A - - 2013
Building on a unique exposure assessment project in New York, New York, we examined the relationship of particulate matter with aerodynamic diameter less than 2.5 μm and nitrogen dioxide with birth weight, restricting the population to term births to nonsmokers, along with other restrictions, to isolate the potential impact of ...
Zhao Shufang - - 2013
Abstract Background: Although maternal smoking during pregnancy disrupts offspring development, it is not clear whether smoking before pregnancy has any effect on the next generation. Given that nicotine, the major psychoactive component in cigarettes, is toxic to many organs, we hypothesized that maternal smoking even before a pregnancy affects offspring ...
Forns Joan - - 2013
There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the ...
Pearlstein Teri - - 2013
Women with active psychiatric disorders who become pregnant face treatment dilemmas. Although results from studies are inconsistent, small but significant, risks on birth outcomes occur with exposure to untreated disorders, as well as to psychotropic medications. Prenatal antidepressant medication exposure may increase the risk for spontaneous miscarriage, preterm birth, cardiac ...
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