Search Results
Results 101 - 150 of 1498
1 2 3 4 5 6 7 8 9 10 >
Margerison-Zilko Claire C Department of Epidemiology and Biostatistics, Michigan State University, East Lansing. Electronic address: - - 2014
The purpose of this study was to examine associations between maternal exposure to unexpected economic contraction and health behaviors during pregnancy using methods to account for impacts of economic contraction on selection into pregnancy. Data on health behaviors among 7074 pregnancies in the National Longitudinal Survey of Youth 1979 were ...
Dunstan Hj H United Kingdom Teratology Information Service, Wolfson Unit, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, - - 2014
To conduct enhanced surveillance for signals of teratogenesis following use of the neuraminidase inhibitors zanamivir and oseltamivir in the treatment or post-exposure prophylaxis of 2009 A/H1N1 influenza during pregnancy. Prospective cohort study, using national surveillance data collected by the UK Teratology Information Service (UKTIS) during the 2009 A/H1N1 pandemic. United ...
Balaraman Sridevi S Department of Neuroscience and Experimental Therapeutics, and Women's Health in Neuroscience Program, Texas A&M Health Science Center, College of Medicine, Bryan, - - 2014
Plasma or circulating miRNAs (cir miRNAs) have potential diagnostic value as biomarkers for a range of diseases. Based on observations that ethanol (EtOH) altered intracellular miRNAs during development, we tested the hypothesis that plasma miRNAs were biomarkers for maternal alcohol exposure, and for past in utero exposure, in the neonate. ...
Auger Nathalie N From the aInstitut national de santé publique du Québec, Montreal, Quebec, Canada; bResearch Centre of the University of Montreal Hospital Centre, Montreal, Quebec, Canada; cDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; dDepartment of Environmental and Occupational Health, University of Montreal, Quebec, Canada; and eBritish Columbia Centre for Disease Control, Vancouver, British Columbia, - - 2014
The relationship between ambient temperature and risk of delivery is poorly understood. We examined the association between heat and risk of delivery among preterm and term pregnancies with the use of a time-to-event design to minimize bias from seasonal variation in conception rates. We used data on 206,929 term and ...
Simons Elinor E Clinical Epidemiology and Health Services Research, University of Toronto, Ontario, Canada; Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, - - 2014
Childhood asthma development has been associated with active maternal smoking during pregnancy, but its association with maternal second-hand smoke exposure in pregnancy needs to be evaluated. We investigated longitudinal associations between maternal smoke exposure in pregnancy and childhood asthma development. In a population-based cohort of 5619 seven-year-old Toronto children, parents ...
Akcakaya Adem - - 2014
Cholangitis and pancreatitis are the most gruesome complications that can be potentially fatal for the mother and fetus. The management of bile stone disease complicated with duct stones during pregnancy is challenging. Conservative treatment instead of surgery has always been advocated due to the increased risk for fetal compromise. Minimally ...
Kancherla Vijaya V Department of Epidemiology, The University of Iowa, Iowa City, - - 2014
Choanal atresia causes serious posterior nasal obstruction. This defect is the leading cause of nasal surgery in newborns, although its etiology is largely unknown. Data from the National Birth Defects Prevention Study, a population-based case-control study, were used to examine associations between maternal self-reports of exposures and occurrence of choanal ...
Canisso I F IF Reproduction Laboratory, The Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, - - 2014
Nocardioform placentitis (NPL) in horses is poorly understood, and development of an experimental model would help understand the pathogenesis of the disease. To investigate (1) whether intrauterine inoculation of Crossiela equi (C. equi) during the periovulatory period or (2) intravenous, oral or intranasopharyngeal inoculation of C. equi during mid-gestation would ...
Tain You-Lin - - 2014
Abstract Glucocorticoids are administered to premature infants to accelerate pulmonary maturation. In experimental model, prenatal dexamethasone (DEX) results in reduced nephron number and adulthood hypertension. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), can cause oxidative stress and is involved in the development of hypertension. L-citrulline can ...
Yucra S S Universidad Peruana Cayetano Heredia, Lima, - - 2014
Exposure to pollution from biomass fuel has been associated with low birthweight in some studies. Few studies have included exposure-response analyses. We conducted a case-control study of biomass fuel use and reproductive outcome at high altitude in Peru. Cases (n=101) were full term births who were SGA (birth weight <10th ...
Vom Saal Frederick S FS Division of Biological Sciences, University of Missouri, Columbia, MO, United States. Electronic address: - - 2014
We measured serum dBPA in non-pregnant and pregnant female rhesus monkeys, fetuses and amniotic fluid. dBPA was administered by a daily oral bolus or sc implantation of Silastic capsules; both resulted in daily average serum unconjugated dBPA concentrations of <1ng/ml. We observed lower serum concentrations of unconjugated dBPA in pregnant ...
Buck Louis Germaine M GM Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland. Electronic address: - - 2014
To assess the relationship between environmental chemicals and couple fecundity or time to pregnancy (TTP). Prospective cohort. Communities of targeted populations with reported exposure. 501 couples recruited upon discontinuing contraception to become pregnant, 2005-2009. None. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) estimated for each partner's chemical concentrations ...
Bateman Brian T BT From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (B.T.B.); Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (S.H.-D.); Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (J.P.R.); and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (J.D.S., M.D., M.A.F., - - 2014
There are few data regarding the utilization of opioids during pregnancy. The objective of this study was to define the prevalence and patterns of opioid use in a large cohort of pregnant women who were commercial insurance beneficiaries. Data for the study were derived from a deidentified research database of ...
Beau A-B AB Service de Pharmacologie Médicale, CHU Toulouse, Université de Toulouse, INSERM 1027, Toulouse, - - 2014
To compare pregnancy outcome between women exposed and unexposed to oseltamivir during pregnancy. A comparative observational cohort study of women exposed to oseltamivir during pregnancy. A French prescription database (EFEMERIS) that includes data for pregnant women was used. EFEMERIS records prescribed and dispensed reimbursed drugs during pregnancy and pregnancy outcomes ...
Fleisch Abby F AF Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, - - 2014
Exposure to fine particulate matter (PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied. We studied Boston-area pregnant women without known diabetes. We identified impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM) during pregnancy from clinical glucose tolerance ...
Lieberman Jay J Department of Pediatrics, The University of Tennessee Health Science Center, LeBonheur Children's Hospital, 51 North Dunlap, #400, Memphis, TN 38105, - - 2014
Primary prevention of allergy is a laudable goal, but one that has unfortunately proven difficult to achieve. Many different strategies have been reported to date, but unequivocal supporting data for any single strategy does not exist. Any successful strategy must lead to immunomodulation and must be encountered very early on ...
Harden Cynthia L - - 2014
This review encompasses issues regarding the management of women with epilepsy and pregnancy, including preconception planning, antiepileptic drug (AED) effects on the exposed offspring, and consequences of seizures during pregnancy, with an emphasis on counseling points and risk management. In utero valproate exposure continues to show the highest risk of ...
Cooper William O WO Vanderbilt University, Nashville, - - 2014
To assess the risk of adverse fetal outcomes following exposure to individual immunosuppressive drugs in pregnant women with chronic immune-mediated diseases. Health plan data were obtained from the Tennessee Medicaid and Kaiser Permanente Northern California and Southern California claims databases, with linkage to both vital records and medical records. Women ...
Karlsson Goeril G From Novartis Pharma AG (G. Karlsson, P.H., W.C.), Basel, Switzerland; Novartis Pharmaceuticals Corporation (G.F., X.Z.), East Hanover, NJ; Motherisk Program (G. Koren), Hospital for Sick Children, Toronto, Canada; Neurological Institute (J.A.C.), Cleveland Clinic, OH; and Neurology and Department of Biomedicine (L.K.), University Hospital, Basel, - - 2014
To report outcomes of pregnancies that occurred during the fingolimod clinical development program. Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolimod treatment at the time of conception or in ...
Magnus Maria C MC Department of Chronic Diseases, Division of Epidemiology , Norwegian Institute of Public Health, Oslo, Norway; Epidemiology Branch, Division of Intramural Research , National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North - - 2014
Many women drink during pregnancy and lactation despite recommendations to abstain. In animals, alcohol exposure during pregnancy and lactation influences lung and immune development, plausibly increasing risk of asthma and lower respiratory tract infections (LRTIs). Studies in humans are few. In the Norwegian Mother and Child Cohort Study, we examined ...
Gorini Francesca F Institute of Clinical Physiology, National Council of Research (CNR), via Moruzzi, 1, 56124, Pisa, Italy, - - 2014
There is compelling evidence that prenatal exposures to environmental xenobiotics adversely affect human development and childhood. Among all birth defects, congenital heart disease (CHD) is the most prevalent of all congenital malformations and remains the leading cause of death. It has been estimated that in most cases the causes of ...
Milne Elizabeth E Telethon Institute for Child Health Research, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia, - - 2014
Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but parental, fetal, and early life exposures are likely to be important given the early age at diagnosis of many cases. We aimed ...
Räikkönen Katri K Institute of Behavioral Sciences, University of Helsinki, 00014, - - 2014
Low socioeconomic status (SES) is associated with increased disease risk in the involved and the next generation. The effects of low maternal SES on the offspring may be initiated prenatally. We hypothesized that feto-placental glucocorticoid exposure might mediate the links. We examined associations between maternal level of education and occupational ...
Källén Bengt B Tornblad Institute, University of Lund , Lund , - - 2014
Abstract Objective. Most previous studies have failed to demonstrate any effect of maternal use of 5-aminosalicylates (5-ASA) on malformation risk, but the number of infants studied have, in most cases, been low. The objective of the study was to get data from a large study with prospectively ascertained exposure information. ...
Campbell E E Neurology Department, Belfast Health and Social Care Trust, Royal Victoria Hospital, , Belfast, Co Antrim, - - 2014
Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine. Fifteen-year prospective ...
Moya Jacqueline J US Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Mailcode 8623P, 1200 Pennsylvania Avenue Northwest, Washington, DC 20460, - - 2014
Exposures to environmental contaminants can pose risks to pregnant women's health, their developing fetuses, children, and adults later in their lives. Assessing risks to this potentially susceptible population requires a sound understanding of the physiological and behavioral changes that occur during pregnancy and lactation. Many physiological and anatomical changes occur ...
Higashida Yuka Y Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, - - 2014
Our objective was to evaluate the level of pregnant women's exposure to tobacco smoke by urinary cotinine testing at prenatal examinations, and to examine the effects of disclosing the results of urinary cotinine tests to pregnant women and their families on their smoking activities. A prospective cohort study was conducted, ...
France Kathryn E - - 2014
Public awareness-raising campaigns targeting alcohol use during pregnancy are an important part of preventing prenatal alcohol exposure and Fetal Alcohol Spectrum Disorder. Despite this, there is little evidence on what specific elements contribute to campaign message effectiveness. This research evaluated three different advertising concepts addressing alcohol and pregnancy: a threat ...
Savitz David A - - 2014
Levels of exposure biomarkers vary among individuals because of differences in both environmental exposure and metabolism. However, the ultimate interest is in providing information about the impact of modifying environmental exposures through regulation or behavior change. Using these levels in studies of pregnancy outcomes, as nicely illustrated by the study ...
Larrimer Margaret B MB Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR. Electronic address: - - 2014
The study goal was to examine the impact of commonly prescribed antiemetic medications in pregnancy on neurobehavioral and obstetrical outcomes. 533 women accounting for 550 live births (17 multiple gestations) enrolled prior to 16 weeks gestation participating in an observational longitudinal study of stress and pharmacological exposure in pregnancy at ...
Tran Thach D - - 2014
Antenatal anaemia, iron deficiency and common mental disorders (CMD) are prevalent in low- and middle-income countries. The aim of this study was to examine the direct and indirect effects of antenatal exposures to these risks and infant motor development. A cohort of women who were pregnant with a single foetus ...
Gentile Salvatore S Mental Health Center Cava de' Tirreni - Vietri sul Mare, Department of Mental Health, ASL Salerno , Cava de' Tirreni, Piazza Galdi, 841013 Cava de' Tirreni (Salerno) , Italy +39 089 4455439 ; +39 089 4455440 ; - - 2014
Introduction: Several concerns have been raised regarding the reproductive safety of the antidepressants most frequently used in clinical practice, such as selective serotonin reuptake inhibitors (SSRIs). Areas covered: This article aims to assess the risk/benefit ratio of the use of alternative pharmacological options, specifically tricyclic antidepressants (TCAs) in pregnancy and ...
Bowman Christopher J CJ Pfizer Worldwide Research and Development, Groton, - - 2014
Understanding species differences in placental transfer of Fc-containing biopharmaceuticals (particularly monoclonal antibodies) will improve human risk extrapolation from nonclinical embryo-fetal development toxicity data. Maternal and fetal concentration data from 10, 15, 8, and 34 Fc-containing biopharmaceuticals in the rabbit, rat, mouse, and cynomolgus monkey, respectively, from an industry survey were ...
Vafeiadi Marina M Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Hospital del Mar Research Institute (IMIM), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. Electronic address: - - 2014
Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and pesticides bioaccumulate through the food chain and cross the placenta. POPs are developmental toxicants in animals but the epidemiological evidence on pregnancy outcomes is inconsistent. Maternal gestational weight gain has been recently suggested as a key factor explaining the association between ...
Hernández-Díaz Sonia S Department of Epidemiology, Harvard School of Public Health, and North American Antiepileptic Drug Pregnancy Registry, Massachusetts General Hospital for Children, Boston, Massachusetts; Loyola University Health System, Chicago, Illinois; the College of Physicians and Surgeons and Mailman School of Public Health, Columbia University, New York, New York; and Oregon Health and Science University, Portland, - - 2014
To assess the possible effects of topiramate and zonisamide use during pregnancy on fetal growth. The study population was the singleton liveborns born to women who enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2012. Data were collected through telephone interviews at enrollment, 7 months of ...
Brown Susan B - - 2014
Adequate folate status in early pregnancy is critical to prevent congenital malformations, yet little is known about whether exposure to folate, specifically folic acid supplementation beyond the recommended dose, influences chronic health outcomes. The link between maternal folate levels and risk of childhood asthma and allergic disease has been investigated ...
Grigoriadis Sophie S Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N - - 2014
To examine the risk for persistent pulmonary hypertension of the newborn associated with antenatal exposure to antidepressants. Systematic review and meta-analysis. Embase, Medline, PsycINFO, and CINAHL from inception to 30 December 2012. English language studies reporting persistent pulmonary hypertension of the newborn associated with exposure to antidepressants. Two independent reviewers ...
Dorce Ana Leticia C - - 2014
Scorpion envenoming is a public health problem in Brazil, where Tityus serrulatus and T. bahiensis are considered the most dangerous scorpions. They are well adapted to urbanized environments, and there is an increasing probability of human exposure to these venoms, including during pregnancy. Not much is known about the effects ...
Zhang Ying Y Department of Epidemiology, Public Health School, Shenyang Medical College, Shenyang, - - 2014
A large amount of organophosphate pesticides (OPs) are used in agriculture in China every year, contributing to exposure of OPs through dietary consumption among the general population. However, the level of exposure to OPs in China is still uncertain. To investigate the effect of the exposure to OPs on the ...
Chapalamadugu Kalyan C KC Department of Animal and Veterinary Science, University of Idaho, Moscow, Idaho, United States of - - 2014
Conditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis. Fetal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in rodents and monkeys. However, effects of BPA exposure on cardiac development have not been assessed. With ...
Varner Michael W MW *For a list of other members of the Stillbirth Collaborative Research Network, see the Appendix online at http://links.lww.com/AOG/A455. University of Utah School of Medicine, Salt Lake City, Utah; Rollins School of Public Health, Emory University, and Emory University School of Medicine, Atlanta, Georgia; the Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; RTI International, Research Triangle Park, North Carolina; Columbia University, New York, New York; the University of Texas Medical Branch at Galveston, Galveston, and the University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Brown University School of Medicine, Providence, Rhode - - 2014
To compare illicit drug and smoking use in pregnancies with and without stillbirth. The Stillbirth Collaborative Research Network conducted a case-control study from March 2006 to September 2008, covering more than 90% of deliveries to residents of five a priori-defined geographically diverse regions. The study attempted to include all stillbirths ...
Kaplan Yusuf Cem YC Department of Pharmacology, Teratology Information Service, Faculty of Medicine, Izmir Katip Celebi University, 35280 Izmir, - - 2014
To the best of our knowledge this is the first case report describing exposure to varenicline, an α 4 β 2 nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintentionally yet regularly 4 weeks ...
Remy Sylvie S Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Mol, Belgium; Department of Biomedical Sciences, University of Antwerp, Antwerp, - - 2014
There is increasing epidemiologic evidence that arsenic exposure in utero is associated with adverse pregnancy outcomes and may contribute to long-term health effects. These effects may occur at low environmental exposures but the underlying molecular mechanism is not clear. We collected cord blood samples of 183 newborns to identify associations ...
Dung Dung Aldrin Anthony AA Institute of Human Behaviour and Allied Sciences, New Delhi, - - 2014
On the basis of evidence from clinical trials, contraindications to the use of interferon (INF) are pregnancy, epilepsy and depression. Management of multiple sclerosis during pregnancy is a difficult issue because of pregnancy-related complications and fear of congenital anomalies due to exposure to disease-modifying therapy. In different series, INF therapy ...
Boynukalin F K - - 2014
Naphthalene is one of the abused inhalants. It has been associated with acute and chronic health problems. To the authors' knowledge, prenatal exposure to naphthalene has never been discussed in humans. The authors discuss a case of naphthalene-addicted pregnant women with multiple fetal anomalies. At 15 weeks gestation, ultrasound screening ...
Askaa Bjarke B 0000-0003-2546-2888 Department of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, - - 2014
Background. There is little knowledge regarding the characteristics of women treated with hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy. In this large Danish cohort study, we characterize women exposed to HBRA during pregnancy. We determined changes in prevalence of HBRA use from 1997 to 2010 and exposure to HBRAs in ...
Håkonsen Linn Berger LB Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus C, - - 2014
Epidemiological studies have raised concerns about the reproductive consequences of in utero exposure to alcohol. Maternal lifestyle factors have been associated with altered pubertal development, but the impact of prenatal alcohol exposure on male puberty is unknown. Thus, the objective was to explore whether prenatal alcohol exposure alters pubertal development ...
Mayhoub Flora F Laboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Faculty of Medicine, Tishreen University, Latakia, - - 2014
The MecoExpo study was performed in the Picardy region of northern France, in order to investigate the putative relationship between parental exposures to pesticides (as reported by the mother) on one hand and neonatal parameters on the other. The cohort comprised 993 mother-newborn pairs. Each mother completed a questionnaire that ...
Mund Mathias M Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt am Main, Theodor-Stern-Kai 7, Frankfurt 60590, Germany. - - 2014
The exposure to tobacco smoke during pregnancy is considered to be amongst the most harmful avoidable risk factors. In this scientometric and gender study scientific data on smoking and pregnancy was analyzed using a variety of objective scientometric methods like the number of scientific contributions, the number of citations and ...
Shirangi Adeleh A School of Population Health, The University of Western Australia, Crawley, WA 6009, Australia. - - 2014
We examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female veterinarians. This study is a follow up survey of 321 female participants (633 pregnancies) who participated in the Health Risks of Australian Veterinarian project. Data on pregnancies ...
1 2 3 4 5 6 7 8 9 10 >