Search Results
Results 51 - 100 of 1496
1 2 3 4 5 6 7 8 9 10 >
Mosha Dominic - - 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women inadvertently exposed to artemether-lumefantrine (AL) ...
Rudnai Tamás T National Institute of Environmental Health, Budapest, Hungary. Electronic address: - - 2014
Inorganic arsenic can get easily through the placenta however there are very few human data on congenital anomalies related to arsenic exposure. Objective of our study was to explore the associations between arsenic content of drinking water and prevalence of some congenital anomalies. Four anomalies reported to the Hungarian Congenital ...
Rydell Mina M Department of Public Health Sciences, Karolinska Institutet, 17177, Stockholm, Sweden, - - 2014
Previous studies have linked maternal smoking during pregnancy with regular tobacco use in offspring, but findings are not consistent and confounding from genetic and environmental factors have not fully been taken into account. A comparison between siblings discordant for prenatal smoking exposure adjusts for confounding by shared familial (i.e., genetic ...
Fowler Paul A PA Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK - - 2014
How does maternal cigarette smoking disturb development of the human fetal ovary? Maternal smoking increases fetal estrogen titres and dysregulates several developmental processes in the fetal ovary. Exposure to maternal cigarette smoking during gestation reduces human fetal ovarian cell numbers, germ cell proliferation and subsequent adult fecundity. The effects of ...
Padberg Stephanie S Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie (Institute for Clinical Teratology and Drug Risk Assessment in Pregnancy), Charité Universitätsmedizin Berlin, Berlin, Germany - - 2014
Fluoroquinolones are avoided during pregnancy due to developmental toxicity in animals. The aim of this study was to assess the fetal risk after intrauterine fluoroquinolone exposure. We performed an observational study of a prospectively ascertained cohort of pregnant women exposed to a fluoroquinolone during the first trimester. Pregnancy outcomes were ...
Spector Logan G LG Departments of - - 2014
Tobacco smoking by pregnant women is a major public health hazard with both short- and long-term effects on offspring. This study describes the presence and level of the nicotine metabolite cotinine in newborn dried blood spots (DBS) and compares it with the reported maternal smoking recorded on state birth registries. ...
Martel Michelle M MM Psychology Department, University of Kentucky. Electronic address: - - 2014
Disruptive Behavior Disorders (DBD) exhibit a sex-biased prevalence rate favoring boys, and prenatal testosterone exposure appears to be part of the complex etiology of these disorders. The current study examines whether high prenatal testosterone exposure may heighten risk for DBD symptoms in males by increasing susceptibility to negative environmental conditions ...
Zahran Sammy S Department of Economics, Colorado State University, , Fort Collins, Colorado, - - 2014
The majority of research documenting the public health impacts of natural disasters focuses on the well-being of adults and their living children. Negative effects may also occur in the unborn, exposed to disaster stressors when critical organ systems are developing and when the consequences of exposure are large. We exploit ...
Gidaya Nicole B NB Drexel University, School of Public Health, Nesbitt Hall, 3215 Market Street, Philadelphia, PA, 19104, USA, - - 2014
We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark's health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases ...
Ephross Sara A SA Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, - - 2014
To monitor for a signal of major teratogenicity by determining the risk of all birth major defects following in utero exposure to sumatriptan, naratriptan, and the sumatriptan/naproxen sodium combination product (tablets marketed in the United States as Treximet [GlaxoSmithKline, Research Triangle Park, NC, USA]), and to monitor for unusual patterns ...
Ratsch Angela A Queensland Health and School of Nursing and Midwifery, The University of Queensland, Brisbane, Australia, - - 2014
To systematically critique and summarise the available evidence on the outcomes of smokeless tobacco use in pregnancy to inform the public health response. In March 2013, a search was conducted of observational studies where the exposure to smokeless tobacco during pregnancy and maternal, placental and/or neonatal outcomes was assessed. Two ...
Calvigioni Daniela D Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, - - 2014
Cannabis remains one of the world's most widely used substance of abuse amongst pregnant women. Trends of the last 50 years show an increase in popularity in child-bearing women together with a constant increase in cannabis potency. In addition, potent herbal "legal" highs containing synthetic cannabinoids that mimic the effects of ...
Vizcaino Esther E Department of Preventive Medicine and Public Health, University of Oviedo, Asturias; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Barcelona, Catalonia; and Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, - - 2014
Exposure to persistent organic pollutants (POPs) during fetal development can increase the risk of adverse health effects during childhood. Maternal characteristics and physiological changes during gestation such as gestational weight gain (GWG) may have an influence in the overall burden of POPs in neonates. However, the associations between GWG and ...
Williams Marvin M aSection of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine bArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, - - 2014
Tumour necrosis factor inhibitors (TNFi) and other biologic response modifiers are being increasingly used for the treatment of rheumatoid arthritis (RA) among women of childbearing age, raising concerns regarding the potential safety of inadvertent or intentional exposure of these agents to the developing fetus. TNFi and other biologics whose constructs ...
Bermas Bonnie L BL Associate Physician, Division of Rheumatology, Brigham and Women's Hospital, Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts, - - 2014
To review the recent literature on the safety of nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids and traditional disease-modifying antirheumatic drugs before and during pregnancy. Recent data suggest that the risk of cleft palate formation after in-utero glucocorticoid exposure is lower than previously reported. Two studies of inadvertent leflunomide exposure during early ...
Wright Tricia E TE University of Hawaii John A. Burns School of Medicine, Honolulu, - - 2014
Methamphetamines are one of the most commonly abused illicit drugs in pregnancy, yet little is known about birth outcomes of exposed neonates. Previous studies were limited because of confounding factors: other drugs of abuse, including tobacco; poverty; poor diet; and lack of prenatal care. This study presents data on birth ...
Foster Teri-Lee TL Meharry Medical College, Nashville, - - 2014
Preterm birth is significantly higher in African Americans. They also have higher lifelong exposure to environmental toxins like benzo(a)pyrene, which has been reported to affect fetal growth. Initial studies from our laboratory showed that rats treated with benzo(a)pyrene deliver preterm. In addition, superarray suggested that benzo(a)pyrene regulates histone deacetylases in ...
Schroeder Christina C Kaiser San Francisco, San Francisco, - - 2014
The objective of this study was to examine the effect of maternal antidepressant exposure on first- and second-trimester maternal serum markers for aneuploidy. We conducted a 10-year retrospective cohort study within a large health care organization. Pregnant women diagnosed with depression who underwent serum screening for aneuploidy were identified. Antidepressant ...
Fraser Abigail A MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK, - - 2014
In this review, we critically assess recent evidence from human studies regarding the potential implications of exposure to maternal diabetes in-utero for long-term adiposity, cardiometabolic outcomes, and cognitive ability of the offspring. Evidence supports a direct causal role for exposure to maternal diabetes in utero in determining offspring long-term greater ...
Aldridge Tiara D TD Vanderbilt Epidemiology Center, Nashville, TN, USA; Vanderbilt University, Institute of Medicine and Public Health, Nashville, TN, USA; Vanderbilt University, Department of Obstetrics and Gynecology, Nashville, TN, - - 2014
We tested whether antihistamine exposure during early pregnancy is associated with spontaneous abortion (SAB) or preterm birth (PTB). Women were enrolled in Right from the Start (2004-2010), a prospective pregnancy cohort. Data about first-trimester antihistamine use were obtained from screening and first-trimester interviews. Self-reported outcomes included SAB and PTB and ...
Ostuzzi G G Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, - - 2014
A possible link between prenatal exposure to the selective serotonin reuptake inhibitors (SSRIs) and development of autism spectrum disorders (ASDs), previously suggested by two case-control studies, was not confirmed by a recent cohort study that followed for 5-10 years more than 600,000 births. However, this study failed to demonstrate that ...
Mandelia Chetan C Intern, Kasturba Medical College , Manipal University, Mangalore, India - - 2014
Though there is ample evidence on adverse effects of tobacco exposure caused by smoking during pregnancy on foetal outcomes, there is lack of studies done on the effects of exposure caused by transdermal absorption, as is seen among beedi rolling women. Therefore, this study was planned, to assess the effect ...
Murnane Pamela M PM aDepartment of Epidemiology bDepartment of Global Health, University of Washington, Seattle, Washington, USA cUniversity of Manitoba, Department of Internal Medicine, Winnipeg, Canada dCenter for Microbiology Research, Kenya Medical Research Institute eDepartment of Obstetrics & Gynaecology, University of Nairobi fDepartment of Obstetrics & Gynaecology, Kenyatta National Hospital, Nairobi gDepartment of Reproductive Health, Moi University, Eldoret, Kenya hDepartment of Medicine, University of Washington iStatistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, - - 2014
For women at risk of HIV-1, effective contraception and effective HIV-1 prevention are global priorities. In a clinical trial of pre-exposure prophylaxis (PrEP) for HIV-1 prevention in HIV-1-serodiscordant couples, we estimated the effectiveness of hormonal contraceptives (oral contraceptive pills, injectable depot medroxyprogesterone acetate, and hormonal implants) for pregnancy prevention relative ...
Diav-Citrin Orna - - 2014
OBJECTIVE The authors conducted a prospective, comparative observational study to evaluate the risk of major anomalies following exposure to lithium during pregnancy. METHOD A total of 183 lithium-exposed pregnancies of women who contacted the Israeli Teratology Information Service were followed up (90.2% in the first trimester) and compared with 72 ...
Jensen Elizabeth T ET Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, North - - 2014
To assess the association between in utero exposure to either diethylstilbestrol (DES) or an oral contraceptive in pregnancy and offspring obesity. Using data from the Collaborative Perinatal Project (1959-1974), a multicenter prospective study of pregnant women and their offspring, we examined overweight or obesity among 34,419 children with height and ...
Orione Maria Angélica M MA Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, Faculdade de Medicina da Universidade de São Paulo, Brazil; Pediatric Rheumatology Unit, Children's Institute, Faculdade de Medicina da Universidade de São Paulo, Brazil; Pediatric Department, Faculdade de Medicina da Universidade Federal de Mato Grosso, - - 2014
Objective: To evaluate the influence of exposures to inhaled environmental factors during pregnancy on juvenile dermatomyositis (JDM) diagnosis. Methods: A case-control study comprising 20 JDM and 56 healthy controls matched by age and gender residents in the metropolitan region of a large city. A questionnaire assessed demographic data and environmental ...
Alberg Anthony J - - 2014
Parental smoking is known to have prenatal health effects on developing fetuses, and postnatal exposure to secondhand smoke causes adverse health effects during childhood and beyond. Further, there is solid evidence that parental smoking during childhood is a potent risk factor for smoking in offspring. In this issue of the ...
Jusko Todd A TA Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Boulevard, Rochester, New York, - - 2014
The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the ...
Joubert Bonnie R BR Epidemiology, National Institute of Environmental Health - - 2014
Background: Maternal smoking in pregnancy is associated with adverse health outcomes in children, including cancers; underlying mechanisms may include epigenetic modifications. Using Illumina's 450K array, we previously identified differential DNA methylation related to maternal smoking during pregnancy at 26 CpG sites (CpGs) in 10 genes in newborn cord bloods from ...
Kile Molly L - - 2014
Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few studies have examined its effect on maternal health. A prospective cohort was recruited in Bangladesh from 2008-2011 (N = 1,458). At enrollment (<16 weeks gestational age [WGA]), arsenic was measured in personal drinking water using inductively-coupled plasma ...
Savitz David A DA Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, 47 George Street, Room 302, Providence, RI 02912, USA. Electronic address: - - 2014
Although there is indirect evidence to suggest that persistent organochlorines might increase risk of hypertensive disorders of pregnancy, there are no epidemiologic studies directly addressing this question. In this cohort study, sampled from the Collaborative Perinatal Project, 1933 women had complete data on organochlorine measurements, covariates, and pregnancy outcomes. Exposures ...
Mårild Karl - - 2014
The infant microbiota may play a pathogenic role in coeliac disease (CD). Antibiotic treatment in pregnancy is common and could significantly impact the infant microbiota. In this study, we aimed to investigate the association between antibiotic exposure during pregnancy and CD in offspring. Prospective questionnaire data on antibiotic exposure in ...
Leclerc François F Department of Obstetrics and Gynecology - - 2014
Objectives: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. Methods: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. Results: BPA was detected in maternal blood, fetal blood ...
Fort Marta M Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, Jordi Girona, 18., 08034, Barcelona, Catalonia, - - 2014
Prenatal exposure to trace metals, whether they are essential, non-essential, or toxic, must be assessed for their potential health effects in the offspring. Herein is reported an approach to this end which involved collection of urine samples during the first and third trimesters of pregnancy from 489 mothers from Sabadell ...
Togher Katie L KL Irish Centre for Fetal and Neonatal Translational Research (INFANT); Cork University Maternity Hospital; Cork, Ireland; Department of Obstetrics and Gynaecology; Cork University Maternity Hospital; Cork, Ireland; Department of Anatomy and Neuroscience; Biosciences Institute; University College Cork; Cork, - - 2014
"Fetal programming" is a term used to describe how early-life experience influences fetal development and later disease risk. In humans, prenatal stress-induced fetal programming is associated with increased risk of preterm birth, and heightened risk of metabolic and neurological diseases later in life. A critical determinant of this is the ...
de Vries Loes L Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the - - 2014
During influenza pandemics, pregnant women have an increased risk of severe complications. Vaccination can diminish these complications. In the Netherlands, the adjuvanted vaccines Focetria® and Pandemrix® were used during the A/H1N1 (2009) influenza pandemic. The national vaccination scheme included pregnant women, but knowledge concerning the safety of adjuvants during pregnancy ...
Solan Tom Daniel - - 2014
Abstract Mercury exposure in pregnancy has been associated with both pregnancy complications and developmental problems in infants. Apart from industrial accidents and contaminated food, mercury exposure is likely to arise from predatory fish consumption, environmental contamination and dental amalgam restorations placed before or during pregnancy. It would be prudent to ...
Jian'an Liu L Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, - - 2014
Our pilot studies showed that there was a significant relationship between blood lead levels of women at the first trimester and scores of neonatal behavioral neurological assessment (NBNA). This study went further 1) to determine particular neurotoxicity during a specific trimester, 2) to analyze "safe" levels of Pb in neonates, ...
Bryanton Janet J School of Nursing, University of Prince Edward Island, Charlottetown, - - 2014
Fetal alcohol spectrum disorder (FASD) is a leading preventable cause of neurodevelopmental disability in North America. The stigma associated with alcohol use and abuse during pregnancy makes it difficult to obtain information on prenatal alcohol use through self-reporting. We assessed the incidence of prenatal alcohol exposure in Prince Edward Island ...
Galbally Megan M Perinatal Mental Health, Mercy Hospital for Women, 16 Studley Road, Heidelberg, VIC 3084, - - 2014
Understanding the risks of antipsychotic medication use in pregnancy is becoming an important clinical concern given the evidence of their increasing rate of prescription in the general population for a range of disorders. Despite antipsychotics being amongst the earliest of psychotropic medications to be introduced, the evidence for their effects ...
Liew Zeyan Z Department of Epidemiology, Fielding School of Public Health, University of California, Los - - 2014
Acetaminophen (paracetamol) is the most commonly used medication for pain and fever during pregnancy in many countries. Research data suggest that acetaminophen is a hormone disruptor, and abnormal hormonal exposures in pregnancy may influence fetal brain development. To evaluate whether prenatal exposure to acetaminophen increases the risk for developing attention-deficit/hyperactivity ...
Dadvand Payam P Centre for Research in Environmental Epidemiology (CREAL), , Barcelona, - - 2014
To investigate the association between preeclampsia and maternal exposure to ambient particulate matter (PM) with aerodynamic diameter less than 10 μm (PM10) and 2.5 μm (PM2.5) mass and sources. Our analysis was based on a hospital cohort of pregnant women (N=3182) residing in Barcelona, Spain, during 2003-2005. Positive matrix factorisation ...
Koutroulakis D D Department of Obstetrics & Gynecology, University Hospital of Heraklion, Crete, - - 2014
The aim of this study was to evaluate fetal exposure to organophosphate pesticides (OPs) by measuring their non-specific dialkyl-phosphate metabolites (DAPs) in amniotic fluid (AF), and to examine the potential association between prenatal exposure and fetal growth. AF samples were collected from 415 women during the second gestational trimester. The ...
Akar Melek M Department of Neonatology, Diyarbakir Children Hospital , Diyarbakir , - - 2014
Abstract Haloperidol is commonly used in the treatment of psychiatric disorders. Data from animal experiments indicate haloperidol is not teratogenic, but is embryotoxic in high doses. For the first time, we report a neonate with transient nephrogenic diabetes insipidus (DI) caused by fetal exposure to haloperidol. The magnitude of risk ...
Laurberg Peter P P Laurberg, Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, DK-9000, - - 2014
ANTITHYROID DRUGS (ATDS) MAY HAVE TERATOGENIC EFFECTS WHEN USED IN EARLY PREGNANCY.OBJECTIVE: To review the association between the time period of ATD exposure in early pregnancy and the development of birth defects. We identified publications on birth defects after early pregnancy exposure to the ATDs Methimazole (MMI) (and its prodrug ...
Bailey Helen D HD International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, Lyon Cedex 08, - - 2014
Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). ...
Hickey Martha M Dept. of Obstetrics and Gynaecology, University of Melbourne and Royal Women's - - 2014
Background:Prenatal estrogen exposure is thought to contribute to later life diseases such as breast cancer. However, few studies have directly measured prenatal estrogens and most have relied on proposed "markers" of estrogen exposure. We used a large population-based birth cohort to directly measure the relationship between prenatal estrogens and perinatal ...
Tertti Kristiina K Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, Turku, Finland, - - 2014
The purpose of the study was to examine in vivo placental transfer of metformin, its association with neonatal outcome in metformin-treated gestational diabetes (GDM) patients, and influence of metformin exposure on maternal glycemic control and weight gain. Two hundred and seventeen GDM patients were randomized to metformin or insulin in ...
Rosenbaum Janet E JE Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Medical Center, Brooklyn, New York, - - 2014
Adolescents may use condoms inconsistently or incorrectly, or may over-report condom use. This study used a semen exposure biomarker to evaluate the accuracy of female adolescents' reports of condom use and predict subsequent pregnancy. The sample comprised 715 sexually active African-American female adolescents, ages 15-21 years. At baseline, 6 months ...
Margerison-Zilko Claire C Department of Epidemiology and Biostatistics, Michigan State University, East Lansing. Electronic address: - - 2014
The purpose of this study was to examine associations between maternal exposure to unexpected economic contraction and health behaviors during pregnancy using methods to account for impacts of economic contraction on selection into pregnancy. Data on health behaviors among 7074 pregnancies in the National Longitudinal Survey of Youth 1979 were ...
1 2 3 4 5 6 7 8 9 10 >