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Allenby C F - - 1981
Clobetasone butyrate 0.05% (Eumovate), a halogenated topical steroid, was compared with hydrocortison butyrate 0.1% (Locoid) which does not contain any halogen atoms. In the treatment of eczema there was not difference between the preparations, but in that of psoriasis the halogen-containing steriod was significantly more effective. Under normal circumstances neither ...
Murphy B E - - 1981
A study of a new group of compounds and their possible relevance to human parturition is presented. These compounds behave chemically and chromatographically like steroids and have been tentatively identified as analogues of 11-hydroxypregnenolone. Determined by radioenzymatic assay, highest levels were found in the fetal zone of the fetal adrenal ...
Marchesoni D - - 1981
A case of a woman affected by a nephrotic postnephritic syndrome and treated during pregnancy with cortisone and prednisolone, is reported. The patient delivered at the 40th week of gestation a neonate with no malformations or clinical signs of adrenal deficiency. No interference between corticosteroid therapy and estrogen metabolism was ...
Campagnoli C - - 1981
Clinical and/or biological improvement has been observed in 7 out of 17 patients with hyperprolactinemic amenorrhea followed for 6-15 months after the successful outcome of bromocriptine (Parlodel, Sandoz)- induced pregnancy. The ovulatory cycle was resumed in 2 out of these 7 patients (with subsequent spontaneous conception in 1); in 3 ...
Parker F - - 1981
The many factors involved in the normal pigmentation of human skin are highly complex involving anatomic, biochemical, and genetic aspects of melanocytes in the skin and the influence of UV light and various hormones on the melanocytes. It is probably more than just coincidence that the melanocytes, which are of ...
Klepac R - - 1981
Progesterone, injected into pregnant rats on the last days of pregnancy, prolonged pregnancy and prevented parturition. The fetuses from mothers whose pregnancies were prolonged have greater body and adrenal weights on days 23 and 24 of gestation as compared with 1- and 2-day-old rats. The adrenal glands of fetuses and ...
Danchin E - - 1981
The pituitaries of adult and fetal crab-eating macaques (Macaca fascicularis) have been studied by immunofluorescence using 15 antibodies against most of the known hormones in the adenohypophysis. The antibodies used were first checked on adult pituitaries for their cross-specificity with macaque pituitary hormones. We found five types of endocrine cells ...
Buttle H L - - 1981
In the goat, maternal hypophysectomy on Day 60 of gestation or treatment with 5 mg bromocriptine/day between Days 60 and 120 of gestation did not affect fetal body weights or the weights of the fetal adrenals, thyroid, pituitary gland or gonads when examined at 120 days gestation. The maternal adrenal ...
Challis J R - - 1981
The response profiles of fetal sheep adrenals to tropic stimulation have been examined ih vivo and in vitro. Isolated adrenal cells from sheep fetuses in early pregnancy (Day 50) reduced cortisol in response to ACTH, dibutyryl cyclic AMP and GTP. The response was minimal on Day 100, but reappeared near ...
Batrinos M L - - 1981
Prolactin (PRL) and the placental hormones, estradiol (E2), estriol (E3), progesterone (PG), chorionic gonadotropin (HCG), and placental lactogen (HPL) were serially measured throughout pregnancy and early postpartum in three patients with prolactinomas in whom pregnancy was achieved by one of the three modalities of treatment: bromocriptine administration (patient I), irradiation ...
Vestfrid M A - - 1980
A small nodule of tissue, found deep within the liver parenchyma of a 3-day-old neonate, proved to be composed of adrenal cortical tissue of both fetal and adult types. Whilst ectopic adrenal tissue is widely recognized in many sites in the body, an intrahepatic localization does not previously appear to ...
del Pozo E - - 1980
To investigate the possible role of PRL in the control of fetal adrenal function, blood samples were collected from maternal peripheral and cord blood from six women at delivery, who had received treatment with bromocriptine (3.75--35 mg daily) for the entire gestation. A group of eight untreated parturients served as ...
Fencl M D - - 1980
Glucocorticoids accelerate fetal lung maturation in all mammals studied, and in some species, such as goat and sheep, concentrations of fetal cortisol increase sharply before term, bringing about a train of events leading to parturition. Studies of cortisol in the umbilical cord blood have revealed no such increase at the ...
Devaskar U - - 1980
Although there is a considerable body of evidence suggesting increased activity of the fetal and neonatal adrenal in the rabbit, the mechanism responsible for this increased activity has not yet been determined. This report provides data on the function of dispersed fetal, neonatal, and adult rabbit adrenocortical cells in vitro. ...
Buster J E - - 1980
The fetal adrenal cortex is the central steroid modulator in the fetal placental complex. Its anatomic structure and physiology clearly identify it as a uniquely fetal organ that undergoes atrophy to a fraction of its intrauterine size after birth and assumes markedly different steroidogenic functions on the assumption of extrauterine ...
Artal R - - 1980
The development of the fetal adrenal medulla can be considered an integral part of the complex process of maturation and preparation of the fetus for extrauterine life. Our understanding of the fetal sympathoadrenal function is facilitated by the relative separation that exists between the maternal and fetal catecholamine secretion and ...
Rappaport R - - 1980
Female pseudo-hermaphroditism is due, most frequently, to the presence of androgens during early fetal life as observed in congenital adrenal hyperplasia, or hormone administration to pregnant patients. In this report 121 cases are reviewed. The importance of a genitographic assessment of the internal genitalia, principally the urogenital sinus is documented. ...
Glickman J A - - 1980
Adrenal cells were prepared from non-pregnant (anoestrous) sheep, from ewes at days 50, 100 and 130 of pregnancy and at term, and from animals at 1-5 days post partum. The ability of the cells to respond to adrenocorticotrophin (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), or combinations of these peptides has been examined ...
Gray E S - - 1980
The adrenal glands of 12 anencephalic fetuses and 17 normal fetuses of 11 to 21 weeks' gestation were examined histometrically. The volume of the adrenal gland occupied by the fetal zone in the anencephalic fetuses was 57.5% compared with 76.5% in normal fetuses. The fetal zone in anencephaly showed involution ...
Marshall J R - - 1980
Although pregnancy increases the likelihood that prolactin-producing pituitary tumors will grow, become symptomatic, and need therapy, in selected patients this likeihood is small enough that the presence of the tumor, per se, does not constitute a contraindication to pregnancy. A symptom-free pregnancy is suggested by the presence of a small ...
Warsof S L - - 1980
In patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, the concentrations of the cortisol precursor 17-alpha hydroxyprogesterone (17-OHP) and its metabolite delta 4-androstenedione (delta 4 A) are increased. CAH was diagnosed in twins by measurement of 17-OHP and delta 4 A concentrations in amniotic fluid obtained by amniocentesis ...
Vaughn T C - - 1980
Although the traditional alternatives for treatment of pituitary tumors have been radiotherapy or surgery or both, further investigation and better understanding of the pathophysiology of this disturbance might make it possible to select a few small pituitary tumors to treat with bromoergocryptine with only a slight risk if pregnancy occurs. ...
Thliveris J A - - 1980
Human fetuses, 11.5 to 16.8 weeks' gestational age, were perfused with silicone rubber compound to study the hypothalamo-hypophyseal portal system. Impregnated vessels were observed throughout the median eminence, infundibular stalk, pars tuberalis and both lobes of the pituitary gland in all specimens. The data suggest that an intact portal system ...
Jewelewicz R - - 1980
Twenty-five patients, aged 23-39, with amenorrhea of 18 to 168 months' duration, galactorrhea, hyperprolactinemia (prolactin levels of 45 to 370 ng/ml), and radiologic evidence of a pituitary microadenoma, were treated with bromocriptine or lergotrile, 7.5 mg daily for 2 to 16 weeks until conception occurred. All conceived and were delivered ...
Dalle M - - 1980
Cortisol levels were very high in maternal and foetal plasma during the last days of pregnancy. The percentage of free cortisol was maximal in plasmas of the mother and the foetus on the last day before parturition; the increase in free cortisol levels resulted from the saturation of transcortin binding ...
Oxlund H - - 1980
Pregnancy influences the functional properties of both genital and extragenital connective tissues. The sex hormones induce a major part of these changes but also corticosteroids may play a role, as their concentration is elevated during pregnancy and early post-partum. The biomechanical properties of the pubic symphysis, muscle tendon and skin ...
Mrsević D - - 1980
The juxtaglomerular apparatus and zona glomerulosa were studied histologically in rabbits during the whole pregnancy period. The granularity of the kidney juxtaglomerular cells diminishes up to 25 days at which time it reaches control values. After delivery, the juxtaglomerular index increases significantly and rises above control values. The width of ...
Attia M A - - 1980
The pathogenesis of embryonic death following maternal treatment with ethinyloestradiol was investigated. Pregnant rabbits received daily oral doses of 0.4 mg/kg body weight of ethinyloestradiol starting on day 6 of pregnancy. Dams were autopsied after 3, 6, or 9 days of treatment. Uterine swellings, ovaries, and the pituitary gland were ...
Durand P - - 1980
The mechanism by which adrenal growth is achieved and steroidogenesis is stimulated in the fetal lamb during late pregnancy has been studied. Fetal plasma ACTH levels remained roughly constant between 14 and 3 days pre partum (298 +/- 38 pg/ml), then increased to a mean of 634 +/- 89 pg/ml. ...
Gross D S - - 1979
The objective of the present study was to determine, by means of immunocytochemistry, the age in fetal development at which GH is first detectable in the pituitary gland and somatostatin in the median eminence, and to correlate temporally the development of these two hormones throughout the remainder of pregnancy. Mice ...
Phillipou G - - 1979
A gas chromatographic procedure for the quantitation of neutral steroid sulphates in maternal urine and its application to a suspected case of placental sulphatase deficiency is described. Low levels of oestriol coincident with elevated 16-hydroxylated metabolites of dehydroepiandrosterone in the maternal urine are shown to occur in this particular condition, ...
Zárate A - - 1979
Management of the amenorrhoea-galactorrhoea syndrome due to pituitary tumour is still controversial. However, in cases of pituitary prolactin-producing adenomas, ovulation and pregnancy are readily induced medically with bromocriptine. In our series of 14 patients conception occurred in all cases within 6 months of treatment. All of the 14 women had ...
Rösler A - - 1979
To predict 11beta-hydroxylase deficiency congenital adrenal hyperplasia antenatally, studies were performed in urines and amniotic fluids from 2 pregnant women who had previously given birth to affected infants and whose present pregnancies also resulted in infants with the disease. Urinary tetrahydro-11-deoxycortisol [pregnane-3alpha, 17alpha, 21-triol-20-one (THS)] was abnormally elevated in the ...
Thorner M O - - 1979
Ninety-two pregnancies occurred in 76 hyperprolactinaemic patients treated with bromocriptine. Half conceived within three months of attempted conception. There was no evidence of an increased rate of spontaneous abortion, fetal abnormality, or multiple pregnancy; the three twin pregnancies occurred in women who were additionally treated with clomiphene and human chorionic ...
Kelly W F - - 1979
Observations are reported on 41 pregnancies in 27 patients who initially had infertility and raised serum prolactin concentrations. Associated symptoms were secondary amenorrhoea (81 per cent) and galactorrhoea (81 per cent). All patients were at risk of pituitary expansion during pregnancy, especially these 19 (70 per cent) with radiological evidence ...
Shackleton C H - - 1979
Congenital adrenal hypoplasia is reported in two siblings. The first died at 16 months of purulent bronchopneumonia after a history of adrenal insufficiency. No gross adrenal tissue was found at autopsy and urinary steroids were not excreted in detectable amounts before death. In a subsequent uncomplicated pregnancy, extremely low estrogens ...
Ikekawa N - - 1979
A new C26 sterol, 22-trans-27-norcholesta-5,22-dien-3 beta-ol, was found in the urine of a 6-year-old girl, with a clinical diagnosis of congenital adrenal hyperplasia of the salt losing type, accompanied by symptoms of mixed sex anatomy and skin pigmentation. The structure of the sterol was determined by comparison with the synthetic ...
March C M - - 1979
One hundred sixty-seven women with secondary amenorrhea were observed from six months to four years. In 66 patients, the amenorrhea followed the discontinuation of oral contraceptives (postpill) while in the remaining 101 the amenorrhea was not temporally pill related (non-postpill). Galactorrhea was present in 43 (65%) of those with postpill ...
Richardson B A - - 1979
This contribution is a review of investigations on the role(s) of the anterior pituitary in chiropteran reproduction. Information on this subject has come mainly from histological studies of cytological changes during the annual cycle and mostly from hibernating temperate-zone species. Although direct evidence is unavailable, it appears that variations in ...
Allingham J D - - 1979
Accidental pregnancies with intrauterine devices may in part be attributed to inappropriate patient selection, lack of insertion expertise by physicians, and downward migration of IUDs from initial placement position. Available research on these factors is reviewed and a clinical protocol using ultrasound is proposed to detect and correct malpositioned devices.
Griffith R W - - 1979
1 Out of 805 previously infertile women in whom pregnancy was achieved on bromocriptine treatment, 137 were diagnosed as having pituitary tumours. 2 In nine of these, tumour-related complications occurred during pregnancy, chiefly visual field impairment. Surgical intervention was considered necessary in two patients. In a third patient reinstitution of ...
Dorfman S G - - 1979
Antepartum pituitary infarction occurs only in insulin-dependent diabetic patients. It is manifested by severe headache, followed by decreasing insulin requirements. Delivery is frequently premature, with high fetal wastage and increased maternal mortality. During the puerperium, the first manifestation of pituitary deficiency, other than a lower insulin requirement than would be ...
Van Hale H M - - 1979
At autopsy, an incidental congenital neuroblastoma was found in the adrenal gland of an 8-day-old full-term anencephalic baby. This previously unreported coincidence of neuroblastoma and anencephaly prompted a retrospective study of adrenal morphologic features in 20 anencephalic patients and 20 matched controls. Anencephalic adrenal glands were smaller and the fasciculoreticular ...
Parvez S - - 1979
Influence of pregnancy, parturition and postparturition upon natural evolution of adrenaline, dopamine and enzyme of adrenaline synthesis, phenylethanolamine-N-methyltransferase in the adrenal gland was studied. Adrenaline content of the adrenal gland showed a progressive decrease from the 14th to the 18th day postcoitum. The mean values for adrenaline remained lower than ...
Yamauchi S - - 1979
The horse fetal adrenal gland was shown to begin to increase in weight from about the end of the 4th month of pregnancy when the fetus has a crown-rump length of about 20 cm. Growth then proceeds steadily to term but, in contrast to the adult horse, the medulla remains ...
Klepac R - - 1979
Two groups of female rats were treated with dexamethasone phosphate (DEX) for 24 h. One group received DEX in drinking water (10 micrograms/ml) on the 15th day of pregnancy (DEX15--16), and the second group on the 17th day of pregnancy (DEX 17--18). The mothers and fetuses were sacrificed on the ...
Kraeling R R - - 1978
Fetuses of nine gilts were decapitated (D) in utero and fetuses of eight gilts were sham operated (C) at 43 to 47 days of pregnancy. At 110 days, one fetus from each gilt was studied. Heart, liver, kidney, thyroid and body weights were recorded. Thyroids were evaluated for the degree ...
Miskin M - - 1978
Ultrasound has important uses in each trimester of pregnancy. This article outlines what information can be gained from ultrasound in each trimester, and which conditions can be detected by it.
Nolten W E - - 1978
Plasma concentrations of desoxycorticosterone (DOC) and aldosterone are markedly elevated in pregnancy. Although DOC secretion in nongravid women has been assumed to be dependent mainly on adrenocorticotropic hormone (ACTH), in a previous study of women in the third trimester of pregnancy it was found to be unresponsive to ACTH, dexamethasone, ...
Serón-Ferré M - - 1978
This study was performed to assess the relative contributions of the fetal and definitive zones of the human fetal adrenal gland to "corticoid" (cortisol and perhaps other corticosteroids) and dehydroepiandrosterone sulfate (DHAS) production, and the possible regulatory role of ACTH and the fetal pituitary in the secretion of of these ...
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