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Results 551 - 600 of 701
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Daya S - - 1984
A complete reassessment of ovulation, pituitary reserve and function, and sella turcica anatomy was carried out in nine multiparous patients with intrasellar prolactinomas to determine whether long-term bromocriptine therapy was required and to document the natural history of the disease after two or more pregnancies. After the last pregnancy, bromocriptine ...
Turner M - - 1984
Three cases of trisomy 18 are described, each with evidence of diminished fetoplacental function, specifically reduced 24-hour maternal urinary estrogen. All three infants died within three months and showed gross and microscopic evidence of hypoplasia of the fetal adrenal cortical zone. This abnormality is consistent with and helps explain the ...
Kuhnle U - - 1984
The characteristic excess production of androgens in the cortisol 21-hydroxylase defect is generally considered to be secondary to ACTH stimulation of alternate pathways. Whenever a morphological examination of the adrenals has been possible in this disorder, adrenocortical hyperplasia was a constant finding. The availability of methods for the prenatal diagnosis ...
Khan-Dawood F S - - 1984
Seventeen human fetal and neonatal pituitary glands were removed at necropsy, and analyzed for oxytocin content by a specific and sensitive radioimmunoassay, after homogenization in 0.4M acetic acid. Serial dilution of the pituitary extract showed parallelism with the oxytocin standard curve on the radioimmunoassay. Column chromatography of the pituitary gland ...
Delprado W J - - 1984
The adrenal glands of 134 fetuses, either stillborn or dying within 24 h, were studied to ascertain the lipid droplet pattern in the fetal cortex. The findings were correlated with the associated placental pathology and clinical features. Three patterns were identified (types I, II and III), representing increasing amounts of ...
Keye W R WR - - 1984
The impact of environmental agents and occupational factors on hypothalamic and pituitary function and menstruation are poorly understood. To date, most research related to environment, occupation, and reproduction has focused on pregnancy outcome, not menstrual function. It is imperative, however, that menstrual function be considered as an outcome variable in ...
Pepperell R J - - 1983
One hundred and nineteen women with sustained hyperprolactinaemia were followed for a mean duration of 5.5 years. Where pregnancy was desired, treatment with bromocriptine (+/- clomiphene) was effective in 86% of subjects. Following cessation of bromocriptine therapy one third of subjects whose initial serum prolactin (PRL) level was less than ...
Longo L D - - 1983
During the course of gestation the increase of maternal total blood volume and cardiac output may result from two mechanisms acting in concert: 1) the production of several hormones by the fetus and the placenta, and 2) the uteroplacental circulation acting as an arteriovenous shunt. Plasma volume appears to increase ...
Milewicz A - - 1983
The site of androgen synthesis was determined in 21 women with polycystic ovary syndrome on the basis of radiographic studies, catheterization of ovarian and adrenal veins, and/or inferior vena cava samplings. Gradients of testosterone, androstenedione, and dehydroepiandrosterone sulfate were determined by comparing the levels in adrenal and ovarian veins with ...
Divers W A WA - - 1983
Fifty-four patients with evidence of a prolactin-producing pituitary microadenoma were followed through pregnancy. Obstetric complications included four spontaneous abortions, one stillbirth, and one premature delivery. Four patients developed visual defects (two with abnormal visual fields). Four patients noted headaches. The progressive rise in maternal prolactin levels seen in a control ...
Casey M L - - 1983
We determined the specific activity of 21-hydroxysteroid sulfotransferase in a number of human fetal tissues and in tissues of a prepubertal boy (5 years of age). In fetal tissues, the highest specific activities of this enzyme were found in adrenal gland, liver, kidney, intestine, aorta, and testis. In the tissues ...
McShane P M - - 1983
Midterm fetal adrenal and kidney tissue homogenates were incubated with 3H-progesterone (1 microM) and its conversion to te 3H-corticosteroids metabolites studied. Cortisol (36.3%) and corticosterone (4.7%) were isolated from the adrenal, and 11-deoxycortisol (32.5%) and deoxycorticosterone (21.1%) from the kidney. The results of these incubations confirmed the presence of 17- ...
Kan K W - - 1983
The metabolism of [3H]progesterone by the fetal calf adrenal was examined in homogenates and microsomal fractions of adrenals obtained from mid- or late gestational fetal calves. Throughout the course of gestation, there was no detectable difference in the formation of corticosterone from progesterone by adrenal homogenates. In contrast, cortisol production ...
Konopka P - - 1983
Continuous bromocriptine treatment was given throughout pregnancy to 10 pregnant women with prolactinomas. The dosage of bromocriptine was modified to reduce the serum prolactin level to below 20 ng/ml. Eight patients had continuous bromocriptine treatment started early in their pregnancies, and no tumor-related neurological complications were observed. Continuous bromocriptine treatment ...
Falsetti L - - 1983
59 patients affected by amenorrhea or anovulation, 37 of whom also with galactorrhea, and with hyperprolactinemia of unknown origin (idiopathic hyperprolactinemia, 24 patients) or due to a pituitary microadenoma (tumoral hyperprolactinemia, 35 patients) were treated with metergoline (4-12 mg/day) or with bromocriptine (2.5 to 10 mg/day) for 90 days. The ...
Klepac R - - 1983
Pregnant rats were treated with dexamethasone in drinking water (10 micrograms/ml) from the 15th to the 22nd day of pregnancy. Dexamethasone significantly depressed cell numbers in fetal rat adrenal glands, liver, lung, testes and pituitary from the 17th to the 22nd day of pregnancy. These data indicated that dexamethasone retarded ...
Laws E R ER - - 1983
This report describes 200 women in the childbearing age group with prolactin-secreting pituitary adenomas treated by transsphenoidal microsurgery. There were 136 patients with microadenomas (10 mm or less in diameter), 30 with macroadenomas, 11 with invasive adenomas, and one with hyperplasia. The overall rate for postoperative normalization of serum prolactin ...
Novy M J - - 1983
To determine the effects of suppressing fetal and maternal adrenal activity on parturition, we treated pregnant rhesus macaques with dexamethasone (0.25 to 4.0 mg, twice a day) from gestation day 130 until delivery (term = 167 days). Long-term dexamethasone treatment increased gestation length: 71% of fetuses were born postmaturely (after ...
Sánchez de la Peña S - - 1983
An old controversy is resolved as a novel effect: In a rhythmic fashion, aqueous pineal homogenate (APH) enhances, attenuates or leaves unaffected the production of corticosterone by mouse adrenals incubated with pituitary media. All glands stem from the same circadian stage in these (isophasic) studies on 72 female CD2F1 mice, ...
Yogev L - - 1983
At mid-pregnancy in the rat, episodic secretion of pituitary prolactin ceases when the placenta is sufficiently developed. At this time, sufficient placental lactogen is secreted by the placenta to inhibit prolactin secretion. The present study tested whether the fully developed placenta at mid-pregnancy can inhibit prolactin secreted by a donor ...
Gunasegaram R - - 1983
With a view to establish the hitherto undescribed role of cholesterol in foetal-membranous steroidogenesis, homogenates of term chorion pars reflexa and amnion pars reflexa and pars placentaris collected from 6 women after spontaneous labour at term (38 to 41 weeks gestation) were incubated with [26-14C]cholesterol. Using reverse-isotope dilution analysis, [14C]isocaproic ...
Margulies P L - - 1983
We present the first report of pregnancy with Cushing's syndrome due to an adrenal cortical adenoma, in which the hypercortisolemia disappeared during the third trimester of pregnancy, but recurred following the delivery of a normal male infant at 38 weeks by Cesarean section. The case is also unique because plasma ...
Yamamoto M - - 1983
Maternal adrenalectomy on days 14 and 15 of gestation did not alter the fetal adrenal weight 2 days later. The same operation on day 16 caused a significant increase in the adrenal weight with a hypertrophy of the cortical cells. Nevertheless, the operation on days 17 and 18 induced no ...
Challis J R - - 1983
To understand the factors responsible for the increased pre-partum output of cortisol from the adrenal glands of the goat foetus, we measured changes in responsiveness to ACTH in vitro of dispersed adrenal cells from foetal goats of various gestational ages and we determined the output of cortisol (F) and corticosterone ...
Maeda T - - 1983
A 32-year-old woman with 5 years of oligomenorrhea and 2 years of amenorrhea became pregnant after ovulation induced by clomiphene citrate, human menopausal gonadotropin, and human chorionic gonadotropin. Although there were no neurologic or ophthalmologic symptoms before pregnancy, ptosis and diplopia developed progressively from 14 weeks' gestation. Physical, radiologic, and ...
Dietemann J L - - 1983
In the last few years complete or partial regression of prolactinomas has been demonstrated in nonpregnant women treated by bromocriptine. Thus bromocriptine therapy appears as an attractive alternative to surgery for management of infertility related to hyperprolactinemia. However, numerous reports emphasized the possibility of an excessive growth of the pituitary ...
Bergh T - - 1982
Fourteen women with large prolactinomas experienced a total of nineteen bromocriptine-induced term pregnancies. None of the women had received prior pituitary tumour therapy. Post-partum sellar X-ray examinations showed signs of tumour enlargement in two women. Only one of them had clinical symptoms of tumour expansion with visual field defects during ...
Rosenberg E R - - 1982
Seventy-five consecutive pregnant patients at 15--40 weeks of gestation underwent sonography, with special attention to identification of the fetal adrenal gland. The gland was found in 12% of fetuses of less than 26 weeks gestation and 90% of fetuses of more than 26 weeks. The gland characteristically has two long ...
Cone R I - - 1982
Dynorphin-32 was recently isolated from porcine pituitary and shown to consist of dynorphin A (the originally isolated dynorphin heptadecapeptide) at the amino terminus, followed by Lys-Arg (a putative signal for proteolytic cleavage) and then a tridecapeptide, dynorphin B, at the carboxyl terminus. Dynorphin B, like dynorphin A, contains leucine enkephalin. ...
Sholl S A - - 1982
There is indirect evidence that cortisol synthesis in the fetal rhesus monkey adrenal gland is limited at Day 135 of gestation but increases thereafter. This study was conducted to ascertain whether a reduced synthetic capacity is caused by a deficiency in 17-, 21- or 11-hydroxylase activity. For the sake of ...
Korte K - - 1982
The sulfurylation of pregnenolone (delta 5P), dehydroepiandrosterone (D) and cholesterol in subcellular fractions of the separated zones of normal human fetal adrenals as well as the mitochondrial sterol desmolase activities are investigated. The values obtained are compared to those found in adrenal tissues of anencephalics and adults. The 3 beta-hydroxysteroid ...
Lewis E - - 1982
Using real-time ultrasonography, the normal fetal adrenal glands can be consistently imaged after 30 weeks of gestational life. It was found that the normal fetal adrenals had specific size, shape, and echogenicity and could be consistently separated from the adjacent kidneys. The long axis of the adrenal gland had a ...
Manchester L - - 1982
To examine the factors responsible for the changing responsiveness of ovine fetal adrenals during pregnancy, we incubated dispersed adrenal cells obtained from fetal sheep on days 50, 100, and 130 of pregnancy and at term with ACTH (1--24), a GTP analog [guanosine 5(1)-(beta, gamma-imido)triphosphate], dibutyryl cAMP, and potential substrates for ...
Khir A S - - 1982
A patient with active Cushing's disease who became pregnant following treatment with cyproheptadine is described. Despite stopping the cyproheptadine treatment at 3 mth gestation, the previous amelioration of the clinical and biochemical features of the adrenal hyperfunction was maintained and the pregnancy progressed satisfactorily. Moreover, serial evaluation of maternal glucose ...
Rjosk H K - - 1982
Hyperprolactinaemic patients desiring pregnancy with a normal sella turcica or radiological evidence for a microprolactinoma without suprasellar extension were treated with bromocriptine. Females desiring pregnancy with large adenomas or suprasellar extension were treated by transsphenoidal surgery and in most instances post-operatively with bromocriptine. This differentiated management allowed the outcome of ...
Gomez E C - - 1982
Isotretinoin administered subcutaneously to male hamsters results in marked involution of the sebaceous glands of the flank organ without discernible effort on the other androgen-dependent structures, pigmented hair follicles, and dermal melanocytes. Treatment of androgen-stimulated female hamsters with isotretinoin prevented the androgen-induced growth of the sebaceous glands but not the ...
Fitzgerald B P - - 1982
Metoclopramide and bromocriptine, drugs which are respectively antagonistic and agonistic to dopamine receptor activity, were used to investigate the control of prolactin secretion in the ewe during pregnancy. Normal concentrations of prolactin were found during pregnancy, i.e. values were low and stable during the first 100 days but thereafter increased ...
Rundle J S - - 1982
This study examined an association between cerebral palsy and cryptorchism. Twenty-one (53.8%) in a group of 39 severely disabled males exhibited cryptorchism to a varying degree. A striking feature was the high proportion with an impalpable testis on one (15.4%) or both (7.7%) sides. Early damage to the fetal hypothalamo-pituitary ...
Demey-Ponsart E - - 1982
Parameters of cortisol metabolism were studied in pregnancy and early post partum and in non pregnant women. Total serum cortisol was measured by a specific radioimmunoassay and its unbound- and CBG-bound fractions by equilibrium dialysis at 37 degrees C. CBG was measured directly, by an immunodiffusion method (true CBG) and ...
Stadnicka A - - 1982
The ultrastructure and cytochemistry of fetal porcine adrenal medullae have been studied at 60, 80, and 100 days of gestation. Adrenal medullae from fetuses at 60 days of pregnancy consisted of norepinephrine cells only. Some cells containing chromaffin granules were seen in the process of mitosis. A few epinephrine cells ...
Ulick S - - 1982
The most abundant substance in the urinary free steroid fraction of patients with primary aldosteronism has been identified as 18-hydroxycortisol. 18-hydroxycortisol is very likely an adrenocortical secretory product rather than a peripheral metabolite, since it is abundantly synthesized by aldosteronoma tissue slices. The biogenesis of 18-hydroxycortisol takes place from cortisol ...
Baskin D S - - 1982
Diffuse lymphocytic infiltration of the adenohypophysis occurring in temporal relation to pregnancy was found in two patients, each of whom had an intrasellar mass with suprasellar extension that caused compression of the optic chiasm. The pathology and etiology of this lesion is discussed. This entity should be considered when evaluating ...
Randall S - - 1982
Fifty pregnancies occurred in 37 women with hyperprolactinaemia. Thirty women (81%) initially attended with infertility and 24 (65%) had secondary amenorrhoea. Twelve women (31%) had pituitary macroadenomas, of whom seven (19%) were treated with neurosurgery and/or external radiotherapy before conception. Forty-one conceptions (82%) followed treatment with bromocriptine. There were no ...
Johnson J W - - 1981
In previous studies, we noted that treatment of pregnant rhesus monkeys with betamethasone resulted in a marked increase in fetal lung distensibility. The purpose of the present study was to determine whether these changes persisted during subsequent in utero development. Pregnant rhesus monkeys were treated with 2 mg of betamethasone ...
Crosignani P G - - 1981
Sixty-nine pregnancies were observed in 57 hyperprolactinemic women (5 with pituitary macroadenoma, 20 with microadenoma, and 32 with normal tomography of the sella turcica). Ten of these pregnancies took place spontaneously in women with mild to moderate hyperprolactinemia (up to 70 ng/ml); 2 were induced by exogenous gonadotropins, 2 by ...
Gardner D F - - 1981
A 42-year-old man presented with clinical and biochemical evidence of hypothyroidism, hypoadrenalism, and hypogonadism. Initial diagnostic studies suggested intrinsic pituitary disease and were supported by the finding of a roentgenographically abnormal sella turcica. Detailed endocrine evaluation subsequently showed normal pituitary function and primary target organ deficiencies. Adrenal and thyroid hormone ...
Bergh T - - 1981
Twenty-eight women with hyperprolactinaemia and amenorrhoea received bromocriptine treatment which resulted in 31 term pregnancies. Bromocriptine treatment was stopped as soon as pregnancy was established. Nineteen of the women had radiological signs of a pituitary tumour. The pregnancies were clinically uneventful in all cases except one who developed headache. Post-partum ...
van Roon E - - 1981
A patient is described with hyperprolactinemia, post-pill amenorrhea, galactorrhea, and a normal pituitary fossa. Pregnancy occurred after induction of ovulation with bromocriptine. During pregnancy rapidly increasing visual field defects due to suprasellar extension of a pituitary tumor were observed. Operation was advised but refused. The patient was treated with bromocriptine ...
Ikeda Y - - 1981
In normal fetal development nodular collections of neuroblast cells were found in the adrenal glands from 7 wk gestation; there nodules increased in size and number, and in all specimens from fetuses of 14-18 wk gestation, aggregates of nodules closely resembling neuroblastoma in situ could be found. From about 12 ...
Batrinos M - - 1981
Females with pituitary dwarfism of the multiple pituitary hormone deficiency form have ovarian failure due to hypogonadotropism which would be expected to respond favorably to human gonadotropin treatment. This is a description of a pituitary dwarf in whom pregnancy was achieved with gonadotropin therapy; its progress was followed regularly by ...
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