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Results 501 - 550 of 691
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Ackland J F - - 1986
Corticotrophin releasing factor-like immunoreactivity (CRF-LI) and bioactivity, and arginine vasopressin-like immunoreactivity (AVP-LI) have been measured in extracts of human fetal and adult hypothalamic tissue and their development with the gestational age of the fetuses (12-27 weeks) studied. CRF-LI was measured by a radioimmunoassay developed for ovine corticotrophin-releasing factor (oCRF-41). Corticotrophin-releasing ...
Corenblum B - - 1986
Once other causes of hyperprolactinaemia have been excluded it is reasonable to assume that the cause lies within the hypothalamus or the pituitary. The pituitary may be the site of lactotroph hypertrophy and hyperplasia, a micro-adenoma or a macro-adenoma. Sixty-nine pregnancies in 53 patients, who required treatment of hyperprolactinaemia prior ...
Taylor G M - - 1986
In a study of 38 fetuses total kidney renin was significantly correlated with gestational age (r = 0.63). Although whole fetal kidney renin specific activity was found to decrease with gestational age (r = -0.65), the mean value of the specific activity was about 20 times greater than in normal ...
Greco A M - - 1986
We have studied the effects of a purified diet enriched with animal protein (casein 40%, lactalbumin 20%) on different stages of rat pregnancy. We observed that hyperproteic diet, especially when administered from the first day of pregnancy, induces morphological alterations of liver, adrenal cortex, heart and kidney. Moreover, haematic dosages, ...
Weil C - - 1986
The dopamine agonist bromocriptine has been widely used to facilitate pregnancy in hyperprolactinaemic women, with a success rate of 80% in relevant cases. Neither the inappropriate hyperprolactinaemia consequent upon bromocriptine withdrawal after conception nor the relative hypoprolactinaemia caused by treatment throughout gestation appears to affect adversely the course and outcome ...
Campbell G T - - 1986
The development of corticotropes and lactotropes was investigated in the golden Syrian hamster using an anti-porcine ACTH antiserum and a homologous anti-hamster PRL antiserum. Oval corticotropes were first visible in the ventral region of the pars distalis at 13 days of gestation. By the end of gestation, corticotropes were found ...
Deacon C F - - 1986
The adrenal gland of the Swiss albino strain was investigated with particular reference to the X zone. The degeneration of the X zone in the male occurred concomitant with puberty. The unmated female possessed an X zone which gradually degenerated with age. First pregnancy gave a rapid disappearance of the ...
Pajor L - - 1986
Adrenal cortex of fetuses from abortion and newborns as well as 3 anencephalic monsters between 16 and 40 weeks gestational age was investigated. In order to follow the activity of adrenal cortex the volumes of nuclei and of cells were determined by means of morphometry in both the fetal and ...
Charnvises S - - 1985
We undertook a study designed to evaluate whether it is feasible to suppress fetal adrenal secretion of androgens at mid-pregnancy by giving dexamethasone (DX) to the mother. Levels of DX and adrenal steroids were measured in maternal and cord plasma of 13 DX-treated and 16 untreated mothers undergoing abortion at ...
Klepac R - - 1985
Glycogen deposition was determined in pregnant rats and their fetuses twenty four hrs after maternal treatment with dexamethasone in the final days of pregnancy. Dexamethasone increases glycogen accumulation in the fetal liver, heart, adrenal glands and thymus. Simultaneously, it increases the glycogen concentration in maternal liver. In this study, dexamethasone ...
Hata K - - 1985
Ultrasonographic studies on the fetal adrenal gland were performed in utero on 100 fetuses 22-42 weeks of gestation. The correlations of the area of fetal adrenal gland (FAGA) with gestational age (r = 0.95, P less than 0.001) were high. The circumference of the fetal adrenal gland (FAGC) correlated well ...
Hunter J C - - 1985
The regional distribution of kassinin-like immunoreactivity (KLI) was investigated by radioimmunoassay in central and peripheral tissues of the cat. In the cat brain KLI was found to have a widespread distribution with the highest concentrations present in the substantia nigra followed by the hypothalamus and caudate nucleus. Moderate levels were ...
Rasmussen C - - 1985
Fifty-eight hyperprolactinemic women were followed up for 13 to 108 months after at least one bromocriptine-induced pregnancy for investigation of whether the pregnancy had any adverse long-term effects on the hyperprolactinemic state. Fifteen women had two term pregnancies. The prolactin (PRL) level decreased greater than 50% in 20 women after ...
Challis J R - - 1985
We examined the hypothesis that cortisol (F) modulates the activation of adrenal function induced by treating fetal sheep in vivo with pulsatile ACTH (P-ACTH). Chronically catheterized sheep fetuses were infused in utero for 100 h between day 127 and day 131 of pregnancy with P-ACTH; P-ACTH plus metopirone; P-ACTH plus ...
Monkhouse W S - - 1985
Administration of hydrocortisone in vivo to pregnant mice between the eighth and sixteenth days of gestation leads to highly significant increases in both the volume and the labelling index of extra-adrenal chromaffin tissue (as represented by the para-aortic body) of 16 days fetal mice. The labelling index of intra-adrenal chromaffin ...
Dunlap C E CE - - 1985
Enkephalin immunoreactive material from adrenal glands was characterized both in maternal and fetal sheep at various gestational ages. Whole gland extracts from both maternal and fetal sheep contained three major peaks of Enk immunoreactivity corresponding to apparent molecular weights of 10,000, 2800, and less than 1200 daltons. The majority of ...
Bresson J L - - 1985
In human fetus, newborn, infant and adult hypothalami, antibodies to ovine corticoliberin-41 stain a paraventriculo-infundibular neuroglandular pathway. The perikarya are located in the paraventricular nucleus, they mainly project to the ventral and lateral areas of the median eminence. Eminential corticoliberin-positive fibres appear during the 16th week of fetal life, and ...
Sobrinho-Simões M - - 1985
We describe the autopsy findings in a 24-year-old woman with a clinical picture of pituitary and adrenal insufficiency which had its onset shortly after a normal pregnancy and delivery of a normal infant, two years before the mother's death. There were heavy lymphocytic infiltrations of the adenohypophysis, thyroid, and adrenals ...
Durand P - - 1985
The responsiveness to several stimuli of the adenylate cyclase of crude adrenal membranes from fetal and neonate lambs has been measured under different conditions. The response to Gpp(NH)p, ACTH1-24 + Gpp(NH)p and NaF was significantly lower in membranes from fetuses than from neonate lambs, whereas the response to forskolin was ...
Fraser I S - - 1985
Sixty-eight women with pituitary tumours exhibiting gynaecological symptoms have been reviewed. Fifty-two tumours were prolactinomas while 6 were growth hormone secreting, 6 ACTH secreting, 1 was a large 'inert' adenoma and 3 were late-presenting craniopharyngiomas. Several of the prolactinomas exhibited unusual features including excessively high prolactin secretion, a wide spectrum ...
Branchaud C L - - 1985
Studies of human fetal adrenal function and its control have revolved mainly around the remarkable capacity of the unique fetal zone of this gland to elaborate dehydroepiandrosterone sulfate. Another important function of the fetal adrenal, however, is its production of cortisol. Because the human fetal adrenal is deficient in 3 ...
Herken R - - 1985
Whole-body autoradiography was used to investigate the distribution of acetyl-103-ruthenium-(103Ru)-ruthenocene in female mice 2 and 24 h after intravenous application. Two hours after the application of acetyl-(103Ru)-ruthenocene, the nasal mucosa, colon, lung, liver, spleen and especially the adrenal glands were labelled. After 24 h, apart from the absence of labelling ...
Lagopoulos M - - 1985
A stereological analysis has been made of the daily changes occurring in the ultrastructure of the melanotrophs of the pars intermedia of the pituitary gland of the Djungarian or Siberian hamster, Phodopus sungorus, maintained in long day photoperiods. The rough endoplasmic reticulum, Golgi apparatus and lysosomes all declined in fractional ...
Chatelain A - - 1985
When acid extracts (0.1 N HCl) of the anterior or neurointermediate lobes of fetal and newborn rat pituitary were subjected to gel filtration on Sephadex G-50 fine columns, polymorphism of ACTH was revealed by radioimmunoassay. At every stage of pregnancy and after birth three main ACTH forms were observed. The ...
Baron S A - - 1984
During pregnancy, rats show a progressive increase in jump threshold which is followed by a precipitous decrease after delivery. Overall, this pattern of change in pain threshold was not affected by adrenalectomy, with or without corticosterone replacement. It appears, therefore, that the adrenal glands are not necessary for the manifestation ...
David M - - 1984
In an attempt to prevent in utero virilization of female fetuses with 21-hydroxylase deficiency, six mothers at risk were treated with either hydrocortisone (n = 1) or dexamethasone (n = 5) in early pregnancy. Treatment was continued to term in the two pregnancies in which the diagnosis of an affected ...
Chamberlain P F - - 1984
Circadian rhythms have been identified in a variety of maternal and fetal biophysical and endocrinologic parameters. The authors have undertaken a 24-hour study to identify the normal variation in fetal bladder volumes in the healthy, term human fetus. A significant decrease in fetal bladder volumes occurred between 2400 hours and ...
Abou Samra A B - - 1984
The pars intermedia of the pituitary gland is well developed in most animal species but rudimentary in adult human subjects. Unlike the anterior pituitary, the intermediate lobe metabolizes proopiomelanocorticotrophin (POMC) mainly to beta-endorphin and to alpha-melanotrophin (alpha-MSH). This activity of the pars intermedia is under an inhibitory dopaminergic control. Biochemical ...
Klepac R - - 1984
Administration of pregnant rats with excess amounts of vitamin A from the 8th to the 10th day of pregnancy induced destruction in fetal brain. On the last day of pregnancy, fetuses of treated mothers have smaller weight of adrenal glands as compared with intact fetuses. Maternal treatment with high amounts ...
Goodman L A - - 1984
In patients with a large prolactin-secreting pituitary adenoma, a marked reduction in tumor size may be achieved with bromocriptine therapy. However, before consideration of pregnancy, surgical removal of the lesion usually is advised. A 36-year-old woman with a large extrasellar pituitary macroadenoma was treated with bromocriptine, 10 mg/day, which resulted ...
Miller W L - - 1984
In adult animal pituitaries or in cultured pituitary tumor cells, glucocorticoids are regulators of GH, PRL, and proopiomelancortin (POMC) synthesis. However, ovine fetal plasma cortisol concentrations are low until shortly before parturition, suggesting that cortisol may not normally regulate hormone synthesis in the fetal pituitary. To investigate whether cortisol could ...
Delprado W J - - 1984
A study of 103 fetal adrenals obtained from stillborn fetuses and those dying in the neonatal period was performed to assess the significance of definitive cortex cystic change, compact cell change and lipid patterns, and their relationship to other pathological processes. The findings confirm that these changes are more common ...
Murakoshi M - - 1984
In order to confirm the functional status of adrenal gland in human anencephalic fetuses, an enzyme histochemical and ultrastructural approach was used to study the adrenocortical cells of normal and anencephalic human fetuses. In the adrenal gland of the anencephalic fetuses (32nd, 34th and 36th week of gestation), enzyme histochemical ...
Hamana K - - 1984
Polyamines in various organs of larval, pupal, and moth stages of Bombyx mori, were assayed by high-performance ion-exchange chromatography and paper and thin-layer chromatography. Putrescine and spermidine were especially abundant in the silk gland, gonads, mucous gland, and sucking stomach; spermine was also present in them, but at much lower ...
Ruiz-Velasco V - - 1984
Pregnancy achieved in women who receive treatment to correct the secretory dysfunction of nontumoral HPRL or microprolactinomas requires close prenatal care, but generally its course does not vary from normal. When a macroprolactinoma is present, consequences of pregnancy are insignificant, provided the tumor has been previously treated or bromocriptine is ...
Pepperell R J - - 1984
Ninety-eight women with mild hyperprolactinaemia (less than 4N) were followed for a mean duration of 5.5 years. Where pregnancy was desired treatment with bromocriptine (+/- clomiphene) was effective in 87%. Following cessation of bromocriptine therapy almost one-third had a 'spontaneous' resolution of hyperprolactinaemia and resumed cyclical menstrual activity and fertility. ...
Bergh T - - 1984
A 21-year-old amenorrheic woman with hyperprolactinemia had rapid pituitary tumor enlargment during a bromocriptine-induced pregnancy. Before treatment the sella turcica was normal. In the 31st week of pregnancy she developed bitemporal hemianopsia and markedly decreased visual acuity. Computerized tomography showed a pituitary adenoma with suprasellar extension. Reinstitution of bromocriptine therapy ...
Gossain V V - - 1984
A 23-year-old woman presented with primary hypothyroidism and inability to lactate following uneventful childbirth. Endocrine evaluation revealed that she had autoimmune hypothyroidism and deficiencies of ACTH and prolactin. Despite partial hypopituitarism, she again conceived spontaneously, had an uneventful pregnancy and delivery but failed to lactate. Radiologic evaluation of the hypophysis, ...
Allen R G - - 1984
We have investigated the molecular weight forms of pro-opiomelanocortin (POMC)-derived peptides present in rat pituitaries during fetal and early postnatal development (embryonic Day 14 to 3 day neonate). At all early ages examined, the major immunoreactive form of corticotropin (ACTH) was POMC. Only during late fetal and early postnatal stages ...
Nillius S J - - 1984
Hyperprolactinemia is a frequent finding in infertile women with amenorrhea. Bromocriptine is the drug of choice for treatment of hyperprolactinemic amenorrhea. This dopamine agonist is very effective in normalizing raised prolactin levels. Ovulatory menstrual cycles and fertility are then rapidly restored. Bromocriptine therapy represents a major advance in the treatment ...
Daya S - - 1984
A complete reassessment of ovulation, pituitary reserve and function, and sella turcica anatomy was carried out in nine multiparous patients with intrasellar prolactinomas to determine whether long-term bromocriptine therapy was required and to document the natural history of the disease after two or more pregnancies. After the last pregnancy, bromocriptine ...
Turner M - - 1984
Three cases of trisomy 18 are described, each with evidence of diminished fetoplacental function, specifically reduced 24-hour maternal urinary estrogen. All three infants died within three months and showed gross and microscopic evidence of hypoplasia of the fetal adrenal cortical zone. This abnormality is consistent with and helps explain the ...
Kuhnle U - - 1984
The characteristic excess production of androgens in the cortisol 21-hydroxylase defect is generally considered to be secondary to ACTH stimulation of alternate pathways. Whenever a morphological examination of the adrenals has been possible in this disorder, adrenocortical hyperplasia was a constant finding. The availability of methods for the prenatal diagnosis ...
Khan-Dawood F S - - 1984
Seventeen human fetal and neonatal pituitary glands were removed at necropsy, and analyzed for oxytocin content by a specific and sensitive radioimmunoassay, after homogenization in 0.4M acetic acid. Serial dilution of the pituitary extract showed parallelism with the oxytocin standard curve on the radioimmunoassay. Column chromatography of the pituitary gland ...
Delprado W J - - 1984
The adrenal glands of 134 fetuses, either stillborn or dying within 24 h, were studied to ascertain the lipid droplet pattern in the fetal cortex. The findings were correlated with the associated placental pathology and clinical features. Three patterns were identified (types I, II and III), representing increasing amounts of ...
Keye W R WR - - 1984
The impact of environmental agents and occupational factors on hypothalamic and pituitary function and menstruation are poorly understood. To date, most research related to environment, occupation, and reproduction has focused on pregnancy outcome, not menstrual function. It is imperative, however, that menstrual function be considered as an outcome variable in ...
Pepperell R J - - 1983
One hundred and nineteen women with sustained hyperprolactinaemia were followed for a mean duration of 5.5 years. Where pregnancy was desired, treatment with bromocriptine (+/- clomiphene) was effective in 86% of subjects. Following cessation of bromocriptine therapy one third of subjects whose initial serum prolactin (PRL) level was less than ...
Longo L D - - 1983
During the course of gestation the increase of maternal total blood volume and cardiac output may result from two mechanisms acting in concert: 1) the production of several hormones by the fetus and the placenta, and 2) the uteroplacental circulation acting as an arteriovenous shunt. Plasma volume appears to increase ...
Milewicz A - - 1983
The site of androgen synthesis was determined in 21 women with polycystic ovary syndrome on the basis of radiographic studies, catheterization of ovarian and adrenal veins, and/or inferior vena cava samplings. Gradients of testosterone, androstenedione, and dehydroepiandrosterone sulfate were determined by comparing the levels in adrenal and ovarian veins with ...
Divers W A WA - - 1983
Fifty-four patients with evidence of a prolactin-producing pituitary microadenoma were followed through pregnancy. Obstetric complications included four spontaneous abortions, one stillbirth, and one premature delivery. Four patients developed visual defects (two with abnormal visual fields). Four patients noted headaches. The progressive rise in maternal prolactin levels seen in a control ...
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