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Results 251 - 300 of 470
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Neumeyer P - - 1987
From 70 infants born after gestation periods of 28-41 weeks HbF and HbA2 were determined in the cord blood; HbA was calculated from the two values. HbF decreased with maturity, HbA and HbA2 increased. The percentage of HbA2 calculated from the sum of HbA + HbA2 (non-fetal Hb) increased from ...
Masturzo P - - 1987
The results are presented of fluorescence polarization as a method for measurement of surfactant production in 159 specimens of amniotic fluid collected from pregnant women with diabetes, hypertension, Rh immunization, premature rupture of membranes (for more than 48 h prior to delivery) and intrauterine growth retardation (IUGR). The predictability of ...
Tsai M Y - - 1987
We determined concentrations of disaturated phosphatidylcholine (DSPC) in nearly 2000 amniotic fluid samples obtained either transabdominally or as vaginal pools. Here we report our comparison of these DSPC values with the lecithin/sphingomyelin (L/S) ratios for amniotic fluid samples obtained from diabetic and nondiabetic pregnancies and also between transabdominally or vaginally ...
Coustan D R - - 1987
The background, history, and physiologic basis for the use of corticosteroids to enhance fetal pulmonic maturation are presented. Clinical data relevant to this topic are discussed, and recommendations for the use of these agents are proposed. Finally, other pharmacologic agents that may become clinically useful for this indication are described.
Slocum W A - - 1987
The major fetal risk associated with elective delivery is unexpected fetal lung immaturity and the development of hyaline membrane disease soon after birth. Prior to elective vaginal or abdominal delivery it has become standard obstetric practice to predict fetal lung maturity by the analysis of amniotic fluid obtained by amniocentesis ...
Simon N V - - 1987
Amniotic fluid fluorescence polarization was determined in 105 pregnant diabetic women who delivered between 31 and 41 weeks gestation within 48 hours of an amniocentesis. Seventy-seven of these 105 women had lecithin/sphingomyelin (L/S) ratio and phosphatidylglycerol (PG) determinations. Seven (6.6%) of the 105 neonates suffered from hyaline membrane disease (HMD). ...
Singh U - - 1987
In this study, identification of cholinergic nerves in the murine thymic rudiments during ontogenetic development, by immunonocytochemical localization of the enzyme cholin acetyltransferase (ChAT) was carried out. Fetal thymic rudiments from day 13 of gestation to the time of birth, and upto 8th post natal week were examined. Contrary to ...
Lavigne-Rebillard M - - 1987
Thirteen cochleas from human fetuses ranging in age from week 9 to week 22 were observed by scanning electron microscopy. The classical 'base-to-apex' and 'internal-to-external' gradients of maturation were confirmed by surface observations of the developing organ of Corti. The tectorial membrane begins to be secreted around week 9, i.e. ...
Ivie W M - - 1987
We used a modified lamellar body phospholipid (LB-PL) assay to evaluate the effect of sample processing and to evaluate the clinical efficacy of LB-PL determinations. Within-run and between-run CVs for the modified LB-PL assay respectively ranged from 2.9 to 6.7% and from 3.4 to 14.3%. Freezing and storage at -20 ...
Mori N - - 1987
The summating potential (SP) recorded concurrently with transtympanic (TT) and extratympanic (ET) electrocochleography in Menière ears was compared with respect to polarity and amplitude. There was a difference in SP polarity and amplitude between the two methods. The incidence of the increase in the ratio of -SP amplitude to the ...
Carter J A - - 1986
The Datex Relaxograph is a recently introduced electromyographic monitor of neuromuscular transmission. It has been assessed in patients requiring neuromuscular blockade and the results compared with those obtained simultaneously with a force transducer. There was a good correlation between the two methods of measurement for both twitch height and train-of-four ...
Davidson B J - - 1986
There is no simple and rapid test available to predict the outcome of an early pregnancy complicated by vaginal bleeding. In this prospective study, 15 women with normal pregnancies collected a weekly urine sample between 6 and 13 weeks' gestation. A single random urine sample was obtained from 15 women ...
Nugent C E - - 1986
Although use of the lecithin-sphingomyelin (L/S) ratio has contributed to a reduction in the frequency of respiratory distress syndrome (RDS), its accuracy in pregnancies complicated by fetomaternal disease has been questioned. Disaturated phosphatidylcholine is the major active component of surfactant and has been advocated as being a more specific indicator ...
Dohnal J C - - 1986
Data are presented which show that the functional phospholipid/sphingomyelin (FPL/S) ratio is a sensitive and specific prenatal indicator of fetal respiratory status. Phospholipids included in the ratio are acetone precipitable lecithin(L), phosphatidylglycerol(PG), phosphatidylethanolamine(PE), and sphingomyelin(S). These lipids have been shown to contribute to either the lowering of surface tension or ...
Berkowitz G S - - 1986
A retrospective study was undertaken to evaluate the obstetric events preceding delivery of infants who developed respiratory distress syndrome (RDS) at one New York City hospital between January 1970 and July 1973, and January 1980 and July 1983. Elective delivery without adequate documentation of fetal maturity occurred in 7 (11.1%) ...
Prechtl H F - - 1986
A new hypothesis is presented concerning the maturation of the human nervous system and the duration of pregnancy. It has been found that many neural functions characteristic of the fetus continue after birth until a major transformation takes place at the end of the second postnatal month. From a comparative ...
Hobson D W - - 1986
Amniotic fluid lecithin-to-sphingomyelin ratios are widely used to predict fetal lung maturity. The inclusion of acetone precipitation in the determination of the lecithin/sphingomyelin ratio has been widely accepted as a necessary step for enhancing predictivity. The lecithin/sphingomyelin ratio of 181 amniotic fluid samples was analyzed with and without acetone precipitation. ...
Trahair J - - 1986
Intestinal development was noted from 27 days gestation. By 50 days gestation the ovine small intestine shows the beginning of villus formation. The lumen becomes patent by 70 days. Proximal regions mature earlier than distal regions. Vacuolation of enterocytes occurs in all regions of the small intestine at some stage ...
Capute A J - - 1986
While motor milestones--the neurodevelopmental functional end point of the transitioning of the immature and mature primitive reflexes into volitional activity--have been highlighted in predicting future motor function, the primitive reflexes represent the earliest neurodevelopmental markers available for study. By pediatricians becoming familiar with their quantitative and qualitative aspects coupled with ...
Kogon D P - - 1986
The contents of phosphatidylglycerol and phosphatidylcholine phosphorus in amniotic fluid (10,000 X g pellets) were studied as predictors of fetal lung maturity. The presence of phosphatidylglycerol predicted the absence of neonatal respiratory distress syndrome with 99% probability. When phosphatidylglycerol was absent, phosphatidylcholine phosphorus was a reliable predictor if measured 3 ...
Pandolfo L - - 1986
The effects of bendazac-L-lysine salt (bendazac-lysine) on some biochemical parameters (soluble and insoluble proteins, reduced glutathione, sulphydryl and disulphide groups, water content) in rabbit lens at different times after X-rays (2000 rads) were studied. The mature cataract (swelling and total lens opacity) developed 11-12 weeks after irradiation. In the mature ...
Ashwood E R - - 1986
We clinically evaluated, retrospectively, our improved fluorescence polarization assay for fetal lung maturity. The procedure requires 0.5 mL of amniotic fluid and a standard clinical laboratory fluorescence polarimeter (TDx Analyzer, Abbott Laboratories). We measured the L/S ratios for 93 freshly collected amniotic fluids, uncontaminated with blood or meconium, collected within ...
Pachi A - - 1986
In 142 diabetic pregnancies fetal biparietal diameter (BPD), transverse abdominal diameter (TAD) and abdominal circumference (AC) were estimated by means of serial ultrasound examinations. An accurate evaluation of fetal growth was obtained in 85% of the cases. AC was found to have the highest degree of reliability in predicting macrosomia ...
Shah Y G - - 1986
Real-time sonographic placental grading was performed on 215 patients who had amniocentesis for determination of fetal pulmonary maturity between 26 and 42 weeks of gestation. The results of this placental grading were correlated with clinical gestational age and fetal pulmonary maturity, assessed by lecithin-sphingomyelin ratio, phosphatidylglycerol, and the subsequent presence ...
Roessmann U - - 1986
Patterns of appearance and maturation of astrocytes, as demonstrated by the immunohistochemical detection of glial fibrillary acidic protein (GFAP), were studied in fetal and mature neonatal brains. Mature astrocytes were present throughout much of the normal central nervous system at 15 weeks of gestation, but they varied in density in ...
Maretzki D - - 1986
The [32P]phosphate labelling of ATP and polyphosphoinositides (PI) of intact rabbit reticulocytes and mature erythrocytes was compared. Despite the fact that reticulocytes have a 30-fold higher turnover of ATP than mature erythrocytes, the 32P-labelling of the cellular ATP pool was identical. The 32P-Pi entry into the cells is the rate-limiting ...
Koszalka M F MF - - 1986
This paper presents an evaluation of a modified absorbance method for estimating fetal lung maturity. Absorbance at 650 nm in combination with a two-step centrifugation procedure was used in an attempt to focus more directly on lamellar bodies and evaluate the contribution of residual absorbance due to non-lamellar body materials. ...
Rudd E G - - 1985
Premature rupture of the membranes remains a significant problem area in obstetrics. When the fetal lung maturity is inadequate and there is no evidence of intrauterine infection, a delay in delivery is recommended. When fetal lung maturity is expected or documented, lengthy delays in delivery should be avoided. Assays for ...
Teng S H - - 1985
The relation between the choline containing surfactant phospholipids lecithin and sphingomyelin in amniotic fluid and fetal lung maturity is well established. An enzymatic method that had been automated and optimised for use on a centrifugal analyser was used to measure the total choline containing phospholipids in amniotic fluid. The total ...
Mullin T J - - 1985
Ultrasound examination to measure the fetal biparietal diameter (BPD) and examine amniotic fluid for the presence or absence of free-floating particles was performed in 213 patients undergoing amniocenteses for maturity testing at term. A modified lecithin to sphingomyelin ratio (L/S) was performed on all samples. A BPD greater than or ...
Halvorsen P R - - 1985
The reported effects of alcohol on lung and brain phospholipid metabolism in adult animals have been numerous, but its effect on the fetal lung has not been examined. We investigated the effect of heavy maternal ethanol intake on fetal pulmonary maturation, as measured by the amniotic fluid phospholipids, lecithin and ...
Nielsen H C - - 1985
A sexual dimorphism in fetal pulmonary maturation has been described in which the female fetal lung produces surfactant earlier in gestation than the male fetal lung. This is felt to be related to the increased incidence in male newborns of the Respiratory Distress Syndrome. Dihydrotestosterone will delay surfactant production in ...
Gross T L - - 1985
Amniocentesis for the determination of fetal lung maturity is associated with some morbidity, and so the prediction of a mature fetus by noninvasive means could be useful in managing certain high-risk patients. In the first portion of this study, 467 amniotic fluid specimens were classified into one of five groups ...
Kazzi G M - - 1985
Accurate prediction of fetal pulmonary maturity by means of a less invasive procedure than amniocentesis would be desirable. Sonographic diagnosis of a Grade III placenta has been reported to be an excellent predictor of fetal lung maturity. The standard classification of placental grading assigns grade according to the most advanced ...
Hadlock F P - - 1985
Amniocentesis for determination of fetal lung maturity and ultrasonographic (US) evaluation of the biparietal diameter (BPD) and placental grade were performed simultaneously in 261 nondiabetic pregnant women. A BPD of at least 9.3 cm and a grade 3 placenta were evaluated as predictors of fetal lung maturity using amniotic fluid ...
Matile G - - 1985
Amniotic fluid OD 650 (optical density at 650 nm) greater than 0.15 has been associated with mature L/S ratios. This study compared OD 650 with the L/S ratio on 235 uncontaminated amniotic fluid specimens. Follow-up was obtained on 138 neonates delivered within 72 hours of amniocentesis. Of 124 amniotic fluid ...
Heynen M J - - 1985
Late erythroblasts and reticulocytes from bone marrow of male Wistar rats were studied by electron-microscopic stereology. Late erythroblasts with morphological signs of nuclear extrusion (EN + erythroblasts) and late erythroblasts without these signs (EN-erythroblasts) were analysed separately. The volumes of mitochondria, autophagosomes, autophagocytosed mitochondria, autophagocytosed cytoplasm and degraded material inside ...
Cavalieri R L - - 1984
Lamellar bodies were purified from human amniotic fluid obtained from pregnancies at 17, 31, and 40 weeks' gestation by means of Sephacryl S-300 column chromatography. Fractions were labeled with diphenylhexatriene and two peaks of phospholipid were identified at each gestational age. The size of peak I increased relative to that ...
Tydén O - - 1984
In 56 strictly controlled diabetic pregnancies, altogether 60 amniotic fluid samples were analysed for their content of lipid-carrying cells and the presence of phosphatidylglycerol. The outcome of the amniotic fluid tests was examined for its association to macrosomia and to minor neonatal complications such as hypoglycaemia, hypocalcaemia, respiratory disturbances and ...
Sbarra A J - - 1984
In this study we have attempted to correlate amniotic fluid optical density measurements and lecithin/sphingomyelin (L/S) ratios with the presence of phosphatidylglycerol. An 85% correlation (126 of 148) of all three parameters was noted. When the assumption was made that phosphatidylglycerol is indicative of fetal pulmonary maturity, 93 of 94 ...
Gebhardt D O - - 1984
We have attempted to determine why the lecithin/sphingomyelin (L/S) ratio of amniotic fluid is lower than 2 during an early stage of pregnancy. We found that, at 16 wk of gestation, long before the fetal lung secretes lecithin into the amniotic fluid, the L/S ratio was about 1. High-density lipoprotein ...
Creasy G W - - 1984
A review of the literature was made, and 762 titles relating to fetal lung maturity were screened. From these, 195 articles or abstracts on the L/S ratio were reviewed. Five articles met the following criteria: (1) L/S ratio by the method of Borer and Gluck including acetone precipitation; and silica-gel-H ...
Farrell P M - - 1984
To assess fetal lung maturation in normal and diabetic pregnancies, the authors studied two phospholipids that are more specific for pulmonary surfactant than total phosphatidylcholine (lecithin), namely saturated phosphatidylcholine and phosphatidylglycerol. Results indicated that saturated phosphatidylcholine concentrations normally increase from 10 to 20 nmol/mL before 34 weeks to as high ...
Gross T L - - 1984
For several years standard obstetric practice has been to perform an amniocentesis for evaluation of fetal maturity. In order to provide a more definitive answer as to which pregnancies need an amniocentesis, a group of 294 nondiabetic pregnant women in whom an amniocentesis for the evaluation of fetal maturity had ...
Golde S H - - 1984
We have shown that there is a relationship between a BPD of at least 9.2 cm and the presence of lung maturity in the fetus of a nondiabetic pregnancy. The presence of a grade III placenta in the late third trimester appears to be a reliable predictor of maturity, but ...
Hopper K D - - 1984
Pregnancies complicated by preeclampsia or intrauterine growth retardation have an earlier and faster placental maturation than normal. This is demonstrated in a study of 1,096 obstetrical examinations of 473 non-diabetic mothers. It is recommended that a pregnancy demonstrating grade I maturational changes prior to 27 weeks, grade II changes prior ...
Gentili P - - 1984
The main fetal ossification centers appear ultrasonically as egg-shaped echo-rich areas. The calcaneal and talar ossification centers are seen at the level of the tarsus osseus, and the distal femoral epiphyseal and proximal tibial epiphyseal ossification centers are found at the level of the knee. Examination of 312 normal pregnancies ...
Quinlan R W - - 1984
That the lecithin/sphingomyelin (L/S) ratio correlates very closely with fetal gestational age in the uncomplicated pregnancy is well accepted. The presence of fetal or maternal disease has been found to accelerate or retard the development of fetal lung maturity in certain pregnancies. Although only a very small number of isoimmunized ...
Felicetti L - - 1984
The relative amounts of HbF, HbA and HbA2 were determined in about 1000 newborns and their parents. In newborns the mean value of HbA2 was 0.27 +/- 0.02% and that of HbF 74.69 +/- 0.25%. The ratio HbA/HbA2 was estimated at different gestational ages and was found to range from ...
Wysocki S J - - 1984
Lipid profiles were analysed by gas chromatography of underivatised extracts from pellets and supernatant fractions of amniotic fluid (AFP and AFS). Peaks, identified as diglycerides resulting from on column decomposition of phosphoglycerides at high temperature, were obvious in gas chromatograms of AFS. The C32 diglyceride, mainly derived from dipalmityl lecithin, ...
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