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Results 401 - 450 of 829
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Yoshimura S - - 1997
OBJECTIVE: Our goal was to examine the effects of oligohydramnios and cervical cord transection on fetal lung development, pulmonary surfactant, and lung mechanics in rabbits. STUDY DESIGN: The amniotic fluid was shunted into the maternal abdominal cavity in a group of 12 fetal rabbits. In another group (n = 12) ...
Galan H L - - 1997
OBJECTIVE: Whether fetal breathing movements or gasping result in the movement of amniotic fluid substances into the distal airways remains controversial. We evaluated the effect of paralysis of the preterm rabbit fetus on the pulmonary distribution of iron dextran. STUDY DESIGN: Laparotomy was performed on 10 New Zealand White rabbits ...
Hallman M - - 1997
To investigate the metabolism of intra-amniotic surfactant, surfactant containing double-labeled dipalmitoylphosphatidylcholine (DPPC) was injected in amniotic fluid on days 23-27 of gestation. Within 44 h, DPPC was distributed to the gastrointestinal tract (45.9%), fetal membranes and placenta (8.2%), fetal lung (6.6%), and liver (1.9%). DPPC uptake was higher in the ...
Bry K - - 1997
Intraamniotic infection is associated with increased IL-1 activity in amniotic fluid, increased incidence of preterm labor, and with decreased incidence of respiratory distress syndrome in infants born prematurely. We hypothesized that an elevated IL-1 in amniotic fluid promotes fetal lung maturation. On day 23 or 25 of gestation (term 31 ...
Harding R - - 1997
The lung develops before birth as a collapsible, liquid-filled, organ. Throughout the later stages of gestation the fetal lungs are maintained at a level of expansion that is considerably greater than the level achieved as a result of passive equilibration between lung recoil and the chest wall. Fetal breathing movements ...
Lammens M - - 1997
Nine patients with the characteristic signs of fetal akinesia sequence (polyhydramnion, multiple joint contractures and lung hypoplasia) are described. In 8 of the 9 patients nemaline myopathy could be demonstrated with histology. The ninth patient presented the same phenotype as his 4 affected siblings in whom the nemaline myopathy could ...
Lines A - - 1997
Previous studies have suggested that the volume and production rate of fetal lung liquid decrease late in gestation, before the onset of labor, in preparation for the clearance of lung liquid at birth. In contrast, our earlier studies have not shown a decrease in lung liquid volume near term, although ...
Graf J L - - 1997
In utero tracheal occlusion accelerates fetal lung growth in experimental animals. Following tracheal occlusion, animals with an intact diaphragm can develop hydrops; presumably the enlarged lungs increase intrathoracic pressure, compress the fetal heart, and occlude venous return. In contrast, in animals with a diaphragmatic hernia, even excessive lung expansion has ...
Hedrick H L - - 1997
PURPOSE: Prenatal glucocorticoids reverse pulmonary immaturity in rodents with pharmacologically induced congenital diaphragmatic hernia (CDH). The authors applied quantitative stereologic morphometric techniques to test whether these effects could be reproduced in large animals (sheep) with surgically created CDH. METHODS: Diaphragmatic hernias were created surgically in fetal lambs at gestational day ...
Joe P - - 1997
Previous fetal studies indicated that endocrine factors control surfactant maturation, whereas mechanical forces affect lung growth, but not surfactant. We altered mechanical forces in fetal sheep lungs at 100-108 days gestation by tracheal ligation (TL, n = 15, 7 successful studies) to accelerate lung growth, transection of cervical spinal cord ...
Dalecki D - - 1997
Hemorrhage to fetal tissues occurred when late-term pregnant mice were exposed to lithotripter fields of relatively low amplitude. These hemorrhages were always observed in tissues near developing bone or cartilaginous structures such as the head, limbs and ribs, while soft tissues distant from bone were relatively free of hemorrhage. Thresholds ...
Kurashima K - - 1997
Chronic eosinophilic pneumonia (CEP) is a rare, idiopathic lung disorder characterized pathologically by massive eosinophil infiltration into lung. In the bronchoalveolar lavage fluid (BALF) of patients with CEP, eosinophil numbers were markedly increased but returned to normal-levels upon the resolution of clinical symptoms, which suggests the crucial role of eosinophils ...
Gélinas Y - - 1997
Inductively coupled plasma-mass spectrometry (ICP-MS) was used to study the distribution of 26 major and trace elements in six tissues from 21 human fetuses aged 16-22 wk. Brain, lung, spleen, kidney, heart, and liver were analyzed following a microwave oven digestion step carried out according to clean techniques designed for ...
Kitterman J A - - 1996
Abnormalities of fetal lung growth, especially pulmonary hypoplasia, are important causes of neonatal morbidity and mortality. For most clinical conditions associated with abnormal lung growth, studies in experimental animals indicate that these conditions affect the mechanical forces acting on the fetal lung. The major stimulus to growth in the fetal ...
Parry D - - 1996
Successful pregnancy in a single lung transplant recipient has not been reported previously. The long term effect of pregnancy on graft function and management of deteriorating pulmonary function is not defined. This case describes the management, outcome, and problems encountered when a single lung transplant recipient developed a progressive deterioration ...
Flake A W - - 1996
Fetal surgery for congenital diaphragmatic hernia (CDH) is controversial. The rationale for fetal intervention remains as compelling today as it was a decade ago. There continue to be newborns delivered with CDH who have severe enough pulmonary hypoplasia to result in significant morbidity or mortality. During the past decade ECMO, ...
D'Arcy T J - - 1996
OBJECTIVE: To measure fetal lung volume using a computer based, enhanced, 3-dimensional ultrasound imaging system. DESIGN: An observational study. SETTING: The Fetal Medicine Unit at Guys Hospital, London. PARTICIPANTS: Twenty healthy women with a singleton pregnancy between 24 and 36 weeks of gestation were scanned on one occasion during pregnancy ...
Skarsgard E D - - 1996
Despite recent advances in surgical technique, posthysterotomy preterm labor remains a major determinant of postoperative fetal morbidity and mortality after in utero repair of congenital diaphragmatic hernia (CDH). Temporary fetal tracheal occlusion, or "PLUG" (Plug the Lung Until it Grows), reverses the pulmonary hypoplasia seen in experimental models of CDH ...
Harrison M R - - 1996
Most fetuses with congenital diaphragmatic hernia (CDH) diagnosed before 24 weeks' gestation die despite optimal postnatal care. In fetuses with liver herniation into the chest, prenatal repair has not been successful. In the course of exploring the pathophysiology of CDH and its repair in fetal lambs, the authors found that ...
Mills P C - - 1996
OBJECTIVE: To investigate the effects of ozone and airway inflammation on indices of oxidant injury in horses. ANIMALS: 5 clinically normal horses and 25 horses referred for poor performance. PROCEDURE: Blood, tracheal wash, and bronchoalveolar lavage fluid samples were collected before and after ozone exposure (n = 5) or from ...
Podobnik M - - 1996
OBJECTIVE: To determine a relationship between gestational age and the quantitative assessment of ultrasonic signs of placental tissue, fetal lung and liver tissue for determining fetal lung maturity in normal pregnancies and pregnancies with preeclampsia. METHODS: Placental, fetal lung and fetal liver tissue was examined by ultrasound in 240 normal ...
Lee A - - 1996
OBJECTIVE: Pulmonary hypoplasia is common in compromised pregnancies. However, prenatal diagnosis by volume measurement has not become routine until now. The performance of three-dimensional ultrasonography in fetal lung volume determination was evaluated in this study. STUDY DESIGN: In a total of 78 singleton pregnancies 108 measurements were performed. Lung volume ...
Yoshimura S - - 1996
OBJECTIVE: The aim of this study was to determine the usefulness of eight different ultrasonographic fetal parameters for predicting fetal pulmonary hypoplasia. STUDY DESIGN: Nomograms of eight different ultrasonographic fetal parameters were evaluated by studying uncomplicated single fetus pregnancies with well-established dates between 18 and 40 weeks of gestation. The ...
Garden A S - - 1996
OBJECTIVE: Our purpose was to estimate, with the Cavalieri method of stereology and a point-counting technique, the volume of the fetus, fetal brain, fetal liver, and fetal lungs. STUDY DESIGN: Four pregnancies were studied on three to five occasions at gestations from 27 weeks until term. RESULTS: In the four ...
Reber A - - 1996
We have investigated the effect of pre-oxygenation and hyperoxygenation (an increase in inspired oxygen fraction from 0.4 to 1.0 after induction of general anaesthesia) on aeration and atelectasis formation in the lungs during total intravenous anaesthesia. Twenty-seven consecutive patients were randomly allocated to group 1 (with pre-oxygenation), group 2 (without ...
Mavrelos K - - 1996
During the last 5 years 82 women underwent laparoscopic treatment of ectopic pregnancy, three ovarian and one interstitial. The mean preoperative beta-human chorionic gonadotropin (beta-hCG) value was 1550 mg/ml (range 375-200 mg/ml). The salpinx was ruptured in 12 women. At laparoscopy 35 salpingotomies and 47 salpingectomies were performed. Intraoperative laparotomies ...
VanderWall K J - - 1996
Fetal surgery can correct several life-threatening malformations before birth. Despite recent advances in fetal surgery, preterm labor remains a major problem directly related to the large uterine incision required for fetal exposure. Fetal endoscopic surgery ("Fetendo") obviates the need for a large uterine incision and may reduce the overall risks ...
Gibson K J - - 1996
1. In nine chronically catheterized fetuses in which all lung liquid was drained continuously from the time of surgery, the effects of continuous drainage of fetal urine for 1 week on fetal renal function, lung liquid production and salt and water balance were studied. Fetal wellbeing, as judged by fetal ...
Roth P - - 1996
Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF-1 plays a role in the perinatal development of these cells, CSF-1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF-1 concentrations ...
Guibaud L - - 1996
OBJECTIVE: This study evaluated the diagnostic accuracy of prenatal sonography in congenital diaphragmatic hernia (CDH) and assessed sonographic predictors of postnatal outcome. MATERIALS AND METHODS: Sonograms and medical records of 43 fetuses with CDH were retrospectively reviewed. Sonographic features were correlated to clinical evolution and surgical and pathologic findings. RESULTS: ...
Keramidaris E - - 1996
The growth response of the fetal lung to increased expansion was compared at two gestational ages. In fetal sheep, lung expansion was increased by occluding the trachea for 48 h at either 112-114 days (younger fetuses) or 125-127 days (older fetuses) of gestation (term is approximately 145 days). After 24 ...
Tanaka A - - 1996
Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with ...
Rotschild A - - 1996
We studied the left lung using multi-focus microphotography in 378 rat fetuses, assessing airway branching from day 13 to day 19 of gestation, and lung growth variables from day 13 to day 21. Longitudinal growth, and monopodial and dichotomous branching brought about a consistent airway pattern with variations within each ...
Fanti S - - 1996
Pertechnegas is a new ventilation agent produced by modifying the atmosphere of combustion of Technegas. Due to its rapid disappearance from the lungs, Pertechnegas has been suggested as useful in measuring pulmonary epithelial permeability. This study aimed to assess the reliability of ventilation scans with Pertechnegas to evaluate alveolar-capillary permeability. ...
Clementi M E - - 1996
The functional properties of fetal bovine hemoglobin have been studied as a function of temperature, chloride and 2,3-diphosphoglycerate (DPG) concentration. The fetal bovine erythrocyte has six times the concentration of the allosteric modulator DPG compared with the adult cell, and yet the oxygen affinity of the fetal hemoglobin still exceeds ...
Wallace M J - - 1996
Our aim was to determine the role of the fetal adrenal glands in the gestational age-related increase in the ability of epinephrine to induce the reabsorption of lung liquid. Fetal lung liquid volumes and secretion rates were measured in five chronically catheterized control and six bilaterally adrenalectomized (ADX) fetal sheep ...
Baker D G - - 1996
In June 1993 an unusual coccidian parasite was identified in lung tissue from a northern cardinal (Cardinalis cardinalis), collected near Tucson, Arizona (USA), which died in respiratory distress. Histologically, there was evidence of severe, generalized interstitial pneumonia, associated with the parasite. Both asexual and sexual stages were seen. Schizonts, gamonts, ...
Lu Y - - 1996
The in vitro dielectric properties of human fetal organ tissues were measured in the frequency range from 100 kHz to 500 MHz at 24 degrees C. The dielectric measurements were performed by using a network analyzer (HP4195A) and a coaxial line capacitive sensor. The tested samples, including skin, muscle, heart, ...
Beierle E A - - 1996
The observation that tracheal ligation produces pulmonary hyperplasia even in animals with surgically induced diaphragmatic hernia (DH) has led to rapid application of the technique to human fetuses with DH. The aim of this study was to determine how rapidly fetal lung volume increases after creation of a high-grade tracheal ...
BielaƄska-Osuchowska Z - - 1996
Ultrastructure of hepatocytes was investigated during pig fetal development from 18 to 113 day post coitum (dpc). Stereological measurements were taken on the electronograms determining the area and perimeter of the cross-sections of cells, the nucleo-cytoplasmic ratio, and the volume density of hyaloplasm, mitochondria, endoplasmic reticulum, lisosomes, dictyosomes, lipids and ...
Seelbach-Göbel B - - 1996
At the Women's University Hospital Würzburg, pulse oximetry as well as Near Infrared Spectroscopy (NIR) measurements are performed on the fetus during labor in order to compare both methods. Changes of oxygen saturation seem to be positively correlated to concentration changes of oxidized hemoglobin measured by NIR, partially correlated to ...
Devaskar U P - - 1996
Maternal administration of thyrotropin-releasing hormone, alone or in combination with corticosteroid, accelerates functional, morphologic and biochemical fetal lung maturation. However, the dose-response relationship of maternal thyrotropin-releasing hormone treatment and acceleration of fetal lung ultrastructural maturation or disaturated phosphatidylcholine content has not been investigated. We administered (i.p.) saline or thyrotropin-releasing hormone ...
Luks F I - - 1996
Tracheal obstruction to promote lung growth may be a less aggressive alternative to open fetal surgery in the antenatal treatment of congenital diaphragmatic hernia. Herein, we explore the feasibility of placing an occluding device through fetal tracheoscopy. A self-expanding umbrella allowed adequate sealing of the tracheal lumen even as the ...
Rodríguez J L - - 1995
Described in this study are 2 cases of caprine abortion associated with the LC type of Mycoplasma mycoides , subsp. mycoides . This mycoplasma and Mycoplasma mycoides , subsp. capri had been previously reported in adult goats in this herd. The abortion took place in the latter part of gestation. ...
Ikegami M - - 1995
We previously found that a single dose of betamethasone in combination with thyroxine given by intramuscular injection to fetal sheep 48 h before preterm delivery at 128 d gestation improved postnatal lung function. We have now asked how the combination of 0.5 mg/kg betamethasone and 15 micrograms/kg T4 given by ...
Millar B J - - 1995
This study compared the effect of a clinical surfactant and one of three laboratory surfactants used before pouring dies from elastomeric impression materials. A total of 154 impressions were recorded. Hydrosystem surfactant was used before the recording of 78 of these impressions. A total of 154 dies were poured with ...
Barret J - - 1995
The prenatal diagnosis of an echogenic fetal lung (EFL) is now often made in the early second trimester using high-resolution ultrasound. This ultrasound appearance is usually caused by a congenital cystic adenomatoid lung malformation (CCAM), an intrapulmonary lung sequestration or obstruction of a major airway. In order to provide prognostic ...
Peri A - - 1995
Uteroglobin (UG) gene encodes a cytokine-like, multifunctional, antiinflammatory protein, with potent phospholipase A2-inhibitory activity. It has been suggested that during implantation this protein protects the embryos from maternal immunological assault, facilitates the maintenance of quiescence in the uterus throughout pregnancy, prevents the onset of premature labor, and helps maintain an ...
Cummings J J - - 1995
The normal switch from placental to pulmonary gas exchange at birth requires rapid removal of liquid from the lungs. Previous reports contend that vasopressin may be important in regulating this process, but this notion derives from studies in which fetal sheep received very large doses of vasopressin that yielded plasma ...
Tsao F H - - 1995
The level of annexin I, a 36 kDa calcium-dependent phospholipid-binding protein (36 kDa PLBP) in the reproductive organs of young, mature, and pregnant rabbits was determined immunologically with antibodies raised against purified rabbit lung annexin I. In the cytosolic fractions of the ovary, fallopian tube, uterus, and placenta, annexin I ...
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