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Maslova Ekaterina E From the Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark (EM, SFO, and TIH); the Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark (DR and BHB); the Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark (TBH); the Faculty of Science, University of Copenhagen, Frederiksberg, Denmark (MAR); the Department of Nutrition, Harvard School of Public Health, Boston, MA (SFO); the Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, Reykjavik, Iceland (TIH); and the Unit for Nutrition Research, Landspitali University Hospital, Reykjavik, Iceland - - 2014
Animal studies have shown that protein intake in pregnancy may influence offspring fat metabolism and adiposity. The macronutrient ratio in human pregnancy appears to be important for offspring glucose tolerance; however, less is known about the influence on offspring adiposity. We examined the relation between maternal dietary protein intake during ...
Fantus I George IG Medicine, Mount Sinai Hospital, - - 2014
Metformin is one of the most commonly used drugs to treat type 2 diabetes and is safe and effective. Its main mechanism of action is thought to be the activation of AMP-activated protein kinase (AMPK) via inhibition of mitochondrial ATP generation. Recent use of metformin as an "insulin sensitizer" in ...
Miura Yuichiro Y School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, - - 2014
Intrauterine infection with Ureaplasma spp. is strongly associated with preterm birth and adverse neonatal outcomes. We assessed whether combined intra-amniotic (IA) and maternal intravenous (IV) treatment with one of two candidate antibiotics, azithromycin (AZ) or solithromycin (SOLI), would eradicate intrauterine Ureaplasma parvum (UP) infection in a sheep model of pregnancy. ...
Mazer-Amirshahi Maryann M Division of Clinical Pharmacology, Children's National Medical Center, Washington, DC; Department of Emergency Medicine, MedStar Washington Hospital Center, Washington, DC; Department of Environmental and Occupational Health, The George Washington University, Washington, DC. Electronic address: - - 2014
Over the past decades, there have been significant efforts in the U.S. to improve pharmaceutical labeling pertaining to pregnancy. The goal of this study is to describe trends in pregnancy labeling at the time of drug approval and over time. The labeling data of 213 new pharmaceutical approvals between January ...
Trasorras V V Cátedra de Teriogenología Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Argentina. Electronic address: - - 2014
The aim of this study was to evaluate the developmental competence and pregnancy rate of llama hatched blastocysts produced in vitro using gametes from live animals and two different culture conditions. Fifteen adult females were superstimulated with 1500IU of eCG, eleven (73%) responded to the treatment and were used as ...
Zobel Robert R Department of Agriculture, Sisacko-Moslavacka County, A. i B. Radića 24, 44000 Sisak, - - 2014
The objectives of the current study were to investigate the influence of denaverine hydrochloride and carbetocin on softening and dilatation of the birth canal, the need for assistance during parturition, calf mortality, retention of fetal membranes, endometritis, and subsequent fertility. Altogether 200 animals (100 cows and 100 heifers) of the ...
Jiang Xinyin X Department of Health and Nutrition Sciences, Brooklyn College, Brooklyn, NY 11210, - - 2014
The modulatory role of choline on the fetal epigenome and the impact of in utero choline supply on fetal programming and health are of great interest. Studies in animals and/or humans suggest that maternal choline supplementation during pregnancy benefits important physiologic systems such as offspring cognitive function, response to stress, ...
Spiegler Sonja S Physiology Weihenstephan, ZIEL, Technische Universitaet Muenchen, Weihenstephaner Berg 3, 85350 Freising-Weihenstephan, - - 2014
This study aimed to evaluate the effect of different phases of feed restriction on the metabolism and placental indices of growing heifers inseminated with sexed semen of one bull and on the birth weights of their calves. Red-Holstein heifers were randomly divided into three groups. C-group animals (N=17) daily received ...
Krebs Thomas T Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, - - 2014
The pathogenesis of intestinal dysmotility in gastroschisis is not completely understood. Peel formation and disorganization of interstitial Cajal cells (ICC) have been proposed in humans. The aim of this study was to evaluate the impact of prenatal coverage of gastroschisis on gut inflammation and expression of ICC in a fetal ...
Mari Giancarlo G Division of Maternal and Fetal Medicine, University of Tennessee Health Science Center, Memphis, Tenn., - - 2014
Introduction: Percutaneous fetoscopic endoluminal reversible tracheal occlusion (FETO) was developed to prevent the pulmonary complications of fetal congenital diaphragmatic herniation. There is an urgent need to establish the closest to human translational model of FETO in order to improve fetal outcomes and to determine new clinical approaches and applications. Material ...
Salim Sarwat S Glaucoma Service, 925 N. 87th St., Milwaukee, WI, - - 2014
Glaucoma management during pregnancy generates numerous therapeutic challenges and potential risks for both the patient and the fetus. Data are limited on this topic given the lack of large, prospective, and randomized clinical trials because of ethical and legal constraints in this patient population. Therefore, many ophthalmologists remain unsure about ...
Parrott Andrew C AC Swansea University, Swansea, UK; Centre for Human Psychopharmacology, Swinburne University, Melbourne, - - 2014
The illicit recreational drug 3,4-methylenedioxymethamphetamine (MDMA) or Ecstasy has strong neurohormonal effects. When taken by recreational users at dance clubs and raves, it can generate an 800% increase in the stress hormone cortisol, whereas drug-free users show chronically raised levels of cortisol. The aim here is to critically debate this ...
Ma Li L Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA 1401 Rockville Pike, Rockville, MD 20852, - - 2014
Despite the success of postexposure prophylaxis (PEP) of the newborn in preventing mother-to-child transmission of hepatitis B virus), in non-US clinical trials, administering hepatitis B immune globulin (HBIG) to mothers at the end of pregnancy (in addition to passive-active PEP of the newborn) only partially improved outcomes. That is, a ...
Hussain Syed Ashaq SA Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab 141004, - - 2014
This prospective study was conducted on 15 animals (eight buffaloes and seven cows), diagnosed with late pregnancy indigestion. Ten buffaloes and 10 cows served as the control group. The animals were in advanced pregnancy and had partial or complete anorexia, reduced water intake, loss of defecation or scanty faecal output, ...
Giussani Dino A DA Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, UK, - - 2014
The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how fetal chronic hypoxia programmes cardiac and endothelial dysfunction in the offspring in adult life and discusses ...
Lu Ellen E Division of Neurology, Brain Research Centre and Department of Medicine, Faculty of Medicine, University of British Columbia, Room S178, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, - - 2013
The recent approval of several oral disease-modifying drugs (DMDs) for multiple sclerosis (MS) brings promise of improved clinical effectiveness as well as greater drug compliance compared to the existing non-oral DMDs, and substantially increases patient choice and therapeutic options in the effective management of MS. However, for men and women ...
Domínguez Rubio Ana Paula - - 2013
Preterm delivery is the leading cause of neonatal mortality and contributes to delayed physical and cognitive development in children. At present, there is no efficient therapy to prevent preterm labor. A large body of evidence suggests that intra-amniotic infections may be a significant and potentially preventable cause of preterm birth. ...
Kiryanova Veronika - - 2013
During and following pregnancy, women are at high risk of experiencing depression, for which fluoxetine (FLX; brand names Prozac, Sarafem, Rapiflux) is the most commonly prescribed treatment. An estimated 1.4-2.1% of pregnant women use this medication, which inhibits the reuptake of serotonin and thereby increases serotonergic activity at the synapse. ...
Pereira Gabriel Ribas - - 2013
Neosporosis has been considered the main cause of abortion between the first and the second trimester of pregnancy in cattle. Therefore, the objective of this study was to identify the presence of Neospora caninum DNA obtained from experimental models based on the evaluation of different areas of the fetal nervous ...
Adzick N Scott - - 2013
Until about forty years ago, the womb shielded the fetus from observation and therapy. The rapid changes in the diagnosis and treatment of human fetal anatomical abnormalities are due to improved fetal imaging studies as well as fetal sampling techniques (e.g. amniocentesis, chorionic villus sampling), and a better understanding of ...
Pasek Raymond C RC Tennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, - - 2013
The maintenance of glucose homeostasis during pregnancy is critical to the health and well-being of both the mother and the developing fetus. Strikingly, approximately 7% of human pregnancies are characterized by insufficient insulin production or signaling, resulting in gestational diabetes mellitus (GDM). In addition to the acute health concerns of ...
Nathanielsz Peter W PW Center for Pregnancy and Newborn Research, Department of Obstetrics, University of Texas Health Sciences Center San Antonio, San Antonio, Texas, - - 2013
Maternal obesity is a global epidemic affecting both developed and developing countries. Human and animal studies indicate that maternal obesity adversely programs the development of offspring, predisposing them to chronic diseases later in life. Several mechanisms act together to produce these adverse health effects. There is a consequent need for ...
Emmett Susan D SD Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA; Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, W2041, Baltimore, MD 21205, USA. Electronic address: - - 2014
Hearing loss is a substantial public health problem with profound social and economic consequences in the developing world. The World Health Organization (WHO) estimates that there are 360 million people living with disabling hearing loss globally, and 80% of these individuals are from low- and middle-income countries. The epidemiology of ...
Vasconcelos Bruno Gomes - - 2013
Although the guinea pig is an important animal model for human placentation, aspects of fetal nutrition are not fully understood, especially in regard to the yolk sac that is regarded to be essential for early development of the embryo. We investigated differentiation by means of histology, histochemistry, immunohistochemistry, and transmission ...
Blatter Joshua J Department of Pediatrics, Children's Hospital of Pittsburgh, PA, - - 2013
Findings from experimental studies and animal models led to the hypothesis that folic acid supplementation during pregnancy confers an increased risk of asthma. This review provides a critical examination of current experimental and epidemiologic evidence of a causal association between folate status and asthma. In industrialized nations, the prevalence of ...
Aguiar Ts - - 2013
The main objective of this study was to determine if administration of meloxicam, a cyclooxygenase (COX) two inhibitor, to heifers in which embryo transfer (ET) is more difficult and requires a greater manipulation of the tract, would be beneficial. Nulliparous recipient heifers were divided in two groups: CON (n = 102), in ...
Ebersole J L - - 2013
BACKGROUND/OBJECTIVES: Chronic periodontal infections have been suggested to contribute to the risk of adverse pregnancy outcomes. MATERIAL AND METHODS: This study describes the relationship of patterns of systemic inflammatory mediators and IgG antibody to 20 oral bacteria in pregnant female baboons (Papio anubis) coupled with clinical features of ligature-induced periodontitis, ...
Nourinezhad Jamal - - 2013
This study aims at clarifying the detailed morphological and topographical changes of the thoracic part of the sympathetic trunk of sheep during fetal development. Bilateral micro-dissection of the thoracic sympathetic trunk was performed on 40 sheep fetuses aged 6-20weeks (18 males and 22 females) under a stereomicroscope. The cervicothoracic ganglion ...
Auharek Sarah Alves - - 2013
ETHNOPHARMACOLOGICAL RELEVANCE: There is no evidence in the literature that substantiates the safety of Campomanesia. xanthocarpa (Berg.) use during pregnancy. MATERIALS AND METHODS: Thirty three female rats were randomly assigned to three groups. One group of animals received the C. xanthocarpa extract via gavage at a dose of 26.3mg/kg/day from ...
Ngamprasertwong Pornswan P Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. - - 2013
Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal-fetal hemodynamic instability and fetal myocardial depression. The authors' preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane supplemented with propofol and remifentanil IV anesthesia (SIVA). In this animal study, the ...
Vilés K - - 2013
Artificial insemination (AI) involving the placing of frozen-thawed semen directly into the jenny uterine body is associated with very low pregnancy rates. This might be because of an exacerbation of the acute response of the endometrium to sperm, as seen in mares with persistent induced mating endometritis. Pregnancy rates can ...
Bonney Elizabeth A EA Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA. - - 2013
This represents an overview of the use of animal models to study the adverse pregnancy outcomes seen in humans. The purpose is to entice clinicians to utilize some of this information to seek out the literature and have more meaningful and profitable discussions with their academic colleagues and enhance transdisciplinary ...
Pařízek Antonín - - 2013
The initiation of human parturition is not fully understood to date. The data from animal experiments demonstrate that the primary impulse for the initiation of physiological labor arises from the fetal hypothalamo-pituitary-adrenal axis (HPA). HPA is responsible for the stimulation of steroid synthesis and prostaglandin production and, in turn, the ...
Langley-Evans Simon C - - 2013
The developmental origins of health and disease hypothesis postulates that exposure to a less than optimal maternal environment during fetal development programmes physiological function, and determines risk of disease in adult life. Much evidence of such programming comes from retrospective epidemiological cohorts, which demonstrate associations between birth anthropometry and non-communicable ...
Rodríguez-Burgos Antonio - - 2013
After defining the term 'foreign embryonic isoantigens', the author describes the experimental sequence which has allowed this new fetoprotein class to be identified. Experiments have followed three different directions, namely (i) passive immunization, by which conceptus antibodies raised in another animal species are transferred to the female animal, the effects ...
van der Wijk Anne-Eva AE Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT 05405, - - 2013
Pregnancy increases the risk of several complications associated with the cerebral veins, including thrombosis and hemorrhage. In contrast to the cerebral arteries and arterioles, few studies have focused on the effect of pregnancy on the cerebral venous side. Here, we investigated for the first time the effect of pregnancy on ...
Balhara Ashok K AK Central Institute for Research on Buffaloes, Hisar 125001, - - 2013
An early and accurate diagnosis of reproductive dysfunctions or aberrations is crucial to better reproductive management in livestock. High reproductive efficiency is a prerequisite for high life-time production in dairy animals. Early pregnancy diagnosis is key to shorten the calving interval through early identification of open animals and their timely ...
Herse Florian F Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, Berlin, - - 2013
Autoantibodies can cause complications in pregnancy. Preeclampsia is the leading cause of maternal and fetal morbidity and mortality during pregnancy. Overall, 5-10% of all pregnancies worldwide develop preeclampsia. Women who developed preeclampsia and their children have an increased risk to suffer from cardiovascular diseases later in life. In preeclampsia, agonistic ...
Kawamura Yoshinori - - 2012
We retrospectively analyzed the reproductive variables and the spontaneous malformations in the historical control data from the embryo-fetal development studies conducted in our laboratories with Kbl:JW rabbits over two decades (1990-2010) and fetal malformations induced by thalidomide in 1988, 1995 and 2007. These analyses in the control animals revealed that ...
Umapathy Govindhaswamy - - 2012
Development of non-invasive steroid hormone assays using fecal samples is crucial for detection of pregnancy and monitoring of fertility status in big cats and thus facilitates conservation and management of wild animals. Due to changes in metabolism and excretory pattern, animals excrete different steroid metabolites in feces and urine. The ...
da Costa Cássia Mariana Bronzon - - 2012
BACKGROUND & AIMS: The occurrence of infectious disease processes during pregnancy has significant effects on maternal health and can lead to adverse pregnancy outcomes. The aim of the present study was to examine the potential role of zinc treatment during Trypanosoma cruzi infection in pregnant animals. METHODS: Female Wistar rats ...
Skidmore J A - - 2012
Artificial insemination (AI) is an important technique in all domestic species to ensure rapid genetic progress. The use of AI has been reported in camelids although insemination trials are rare. This could be because of the difficulties involved in collecting as well as handling the semen due to the gelatinous ...
Albarzanchi Ahmed M Taiyeb - - 2012
BACKGROUND: Administration of a phosphodiesterase three enzyme inhibitor (PDE3-I) in rodents and primates results in ovulation of immature oocytes. Concerns regarding inhibition of PDE3 enzymes that are expressed in heart and blood vessels discouraged further development of PDE3-Is as nonsteroidal contraceptives. Cilostazol (CLZ) is a PDE3A-I that is approved for ...
Andrulonis Ryan - - 2012
We present the case of a female, aged 22 years, with a long history of recalcitrant pustular psoriasis and psoriatic arthritis, treated with ustekinumab during pregnancy. The result of treatment was an uncomplicated pregnancy with delivery, at term, of a healthy boy. To our knowledge, this is the first reported ...
Drehmer Michele - - 2012
OBJECTIVE: To evaluate the effect of fibre intake on the evolution of maternal BMI from pregnancy to postpartum and to identify dietary patterns associated with fibre intake. DESIGN: Cohort study. Food intake was obtained using an FFQ. Focused principal component analysis was used focusing on the variables: postpartum weight retention ...
Rudick B - - 2012
BACKGROUNDVitamin D plays a role in reproductive capacity. Recently, several investigators have demonstrated higher IVF pregnancy rates in vitamin D replete women. The objective of this study was to validate these findings and to further elucidate the role of vitamin D in reproduction among a diverse group of women.METHODSThis was ...
Barbieri Patrícia - - 2012
OBJECTIVE: To evaluate the ability of an FFQ, designed for use in Brazilian pregnant women, to estimate nutrient intakes during pregnancy. DESIGN: A prospective study was conducted among 103 pregnant women attended by the Brazilian national health-care service. Food intake during pregnancy was evaluated by three 24 h dietary recalls ...
Patrelli Tito Silvio - - 2012
Abstract Background: Since the early '80s, epidemiological evidence has suggested a connection between low calcium intake and preeclampsia The purpose of this meta-analysis is to summarize current evidence regarding calcium supplementation during pregnancy in predicting preeclampsia and associated maternal-fetal complications. Methods: Literature revision of all RCT (random allocation of calcium ...
Kayiran Sinan Mahir - - 2012
Abstract Objective: Black tea is associated with antioxidant properties. The objective of this study was to investigate the effect of the amount of black tea consumption during pregnancy on the oxidant/antioxidant status of breastmilk. Subjects and Methods: Breastmilk was obtained from 30 mothers and analyzed for lipid peroxidation based on ...
Moran L J - - 2012
Background:Ensuring adequate dietary intake during pregnancy has important implications for optimising maternal and fetal health. It is not known whether diet quality is altered over pregnancy and the post-partum period.Objective:The aim of this study was to perform a comprehensive assessment of diet quality in overweight and obese women during pregnancy ...
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