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- - 1991
OBJECTIVE: To compare two regimens of mifepristone plus gemeprost for early pregnancy termination. DESIGN: A prospective, randomized, multicenter trial. SETTING: Ten gynecological services, mostly in academic hospitals. PARTICIPANTS: Three hundred eighty-five healthy women up to 35 years of age with amenorrhea less than or equal to 49 days requesting pregnancy ...
Spear G S - - 1991
An 18-week fetus was born following termination of pregnancy by prostaglandin induction. Pregnancy was terminated because of elevated maternal serum alpha-fetoprotein and ultrasonographic evidence of severe oligohydramnios, intrauterine growth retardation, non-visualization of the bladder, dolichocephaly and possible mild hydrocephalus. Pathologic examination disclosed diffuse mesangial sclerosis and histologic evidence of the ...
Macfie A G - - 1991
The rate of gastric emptying in pregnancy was measured indirectly using the rate of paracetamol absorption in four groups of 15 patients: non-pregnant controls, first trimester patients presenting for termination of pregnancy, second trimester patients presenting for prostaglandin termination of pregnancy, and patients presenting for elective Caesarean section. All patients ...
Norman J E - - 1991
Mifepristone stimulates uterine activity in pregnant women in the first trimester. In-vitro studies have shown that the addition of mifepristone to culture medium increases the ability of decidual cells to generate prostaglandins. In this study, pregnant women of less than 56 days gestation were treated with mifepristone (600 mg) 24, ...
Romagnoli S E - - 1991
Natural PGF administered at a dose of at least 250 micrograms/kg twice daily subcutaneously for at least 4 days starting no earlier than day 5 of cytologic diestrus induces luteolysis and pregnancy termination in the mated bitch. The resulting shortening of the luteal phase is associated with a shortening of ...
Evans M I - - 1991
The ethical attitudes of health care providers toward abortion, sex selection, and selective termination of normal and anomalous fetuses in singleton or multiple pregnancies were evaluated by questionnaires distributed to members of the American Society of Human Genetics, the International Fetal Medicine and Surgery Society, the Society of Perinatal Obstetricians, ...
Zhou H J - - 1991
DL 111-IT is a new non-hormonal early pregnancy-terminating agent. The subsequent embryotoxic and teratogenic effects of DL111-IT were studied in the rats whose first pregnancy had been terminated by the agent. The secondary pregnancy of the treated rats were allowed to initiate at 30-, 45-, and 90-day intervals, respectively, after ...
Gaertner A - - 1991
Insertin, a protein purified from chicken gizzard smooth muscle, has been shown to retard but not to inhibit actin polymerization at the barbed ends of actin filaments. This effect has been explained by a model in which insertin remains bound to the barbed ends of actin filaments and new actin ...
Herabutya Y - - 1991
Nineteen cases of mid-trimester pregnancy were terminated using prostaglandin E2 gel applied intracervically. In this prospective study, 42% were primipara with gestational age at the time of abortion between 16 and 28 weeks. The induction to abortion time was 19.65 +/- 10.37 h with a success rate of 89%. The ...
Elder S H - - 1991
The reactions of women who had had a termination of pregnancy for fetal abnormality in the second trimester have been studied retrospectively using a semi-structured questionnaire. The severity of the grief reaction was measured and the outcome at 6 months was compared with the findings from a previous study in ...
De Paepe A - - 1991
A 29-year-old woman consulted together with her husband for a problem of congenital joint contractures. Clinical findings in the woman were characteristic of "amyoplasia congenita". In view of the severe distal limb involvement, the possibility of a distal arthrogryposis was also considered. Unexpectedly, the husband presented terminal transverse defects, mainly ...
Gottlieb C - - 1991
Pretreatment with laminaria tent is often used in prostaglandin-induced second-trimester abortion to increase efficacy and shorten induction-to-abortion time. In the present study, two alternatives to soften the cervix and dilate the cervical canal, the antiprogestin RU 486 and intra-cervical application of PGE2, were studied. The study included 71 women requesting ...
Gita R - - 1990
Wurm's technique for correction of an incompetent os during pregnancy is a simple, but not well recognized procedure. In this study, an attempt has been made to evaluate this procedure for elective and emergency cases. Pregnancy outcome of 142 patients who underwent Wurm's operation at the Nehru Hospital, Postgraduate Institute ...
Chard T - - 1990
The occurrence of fetomaternal haemorrhage was investigated in 30 women by measuring maternal serum alphafetoprotein (AFP) levels before and after the administration of mifepristone (RU 486) for termination of first trimester pregnancy. A significant rise in AFP levels was seen in 21 women (70%), the increase ranging from 6 to ...
Haeger M - - 1990
Complement activation was studied in ten consecutive pregnant women developing hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) and ten other women with normal pregnancies. Blood samples for anaphylatoxin (C3a/C3a desArg and C5a/C5a desArg) and terminal C5b-9 complement complex determinations were drawn at delivery and 24 hours and ...
Brandt L P - - 1990
In a case-base study among 214,108 commercial and clerical employees in Denmark the potential effect of the use of video display terminals on the risk of congenital malformations in pregnancy was investigated. The study base was identified by means of register linkage of the Medical Birth Register and the National ...
Maria B - - 1990
Termination of early pregnancy (less than 49 days of amenorrhea) was induced in 75 patients with the combination of the antigestagen mifepristone and a prostaglandin analogue, meteneprost. After 48 h a single oral dose of 600 mg of mifepristone was followed by a 10 mg meteneprost vaginal pessary. Pregnancy was ...
Turkelson C M - - 1990
The immunoreactivity of intact and trypsinized canine cholecystokinin-58 was examined using five C-terminally directed cholecystokinin antisera. Cholecystokinin-58 was nearly as immunoreactive as sulfated, amidated cholecystokinin-8 with one cholecystokinin-specific antiserum and an antiserum with moderate (18%) gastrin cross-reactivity, but two to four times less immunoreactive than the octapeptide with two other ...
Ong C N - - 1990
It has been suggested that pregnant women working with computer terminals and visual display unit (VDUs) could be at an increased risk of having a spontaneous abortion or giving birth to children with congenital defects. This has led to apprehensions and worry among computer operators. This review attempts to evaluate ...
Dresner N - - 1990
A 17-year-old single, Hispanic woman with congenital class III heart disease was found to be 15 weeks pregnant at a clinic visit where she presented in mild failure. She discussed her wish to continue with the pregnancy, knowing it might very well kill her, and plans for her infertile sister ...
Sung R Y - - 1990
The closure time of the ductus arteriosus was investigated in 29 full term babies born vaginally after induction with prostaglandin E2 and in 22 controls. Serial Doppler echocardiography studies showed a significantly prolonged closure time in babies induced by prostaglandin E2. Whether the difference is related to changes in fetal ...
Hill N C - - 1990
Termination of pregnancy at 4-8 weeks gestation in 1085 patients using either local prostaglandin instillation (n = 820) or uterine aspiration under local anesthetic (n = 265) have been analyzed. Morbidity for both methods was similar although the incidence of side-effects (0.4%) and the transfusion rate (0%) were lower after ...
Koren G - - 1990
As part of a new approach to counselling pregnant women concerned about antenatal exposure to drugs, chemicals, or radiation, we measured their tendency to terminate their pregnancy by using a visual analogue scale (VAS). Analysis of 78 cases where women had less than 50% tendency to continue pregnancy before they ...
Shulman L P - - 1990
Dilation and evacuation (D&E) is the most common procedure for second-trimester pregnancy termination currently used by United States obstetrician-gynecologists. Although this method carries morbidity and mortality rates significantly lower than methods requiring labor induction, the procedure most commonly used for second-trimester genetic terminations seems to be labor induction (eg, vaginal ...
Toppozada M - - 1990
Medical methods have been used for many years to terminate mid-trimester pregnancy, ranging from irritant chemicals and traditional plants to ecbolic agents and solutions instilled locally into the uterus. These methods had serious limitations, with relatively high rates of maternal mortality and morbidity. Surgical evacuation requires special skills not available ...
Christodoulou C N - - 1990
An original route for prostaglandin F2 alpha administration for midtrimester pregnancy termination is presented. The diagnosis of nuchal cystic hygroma in a hydropic fetus with severe oligohydramnios was made by real-time ultrasonography. Forty milliliters of fluid was aspirated for laboratory studies and prostaglandin F2 alpha was injected into the nuchal ...
McElhatton P R - - 1990
A study was carried out to investigate the outcome of pregnancy in 115 women who had been exposed to paracetamol overdose. Follow up was obtained in 48 cases. Exposure occurred in all trimesters, and the most striking feature of this series is that the majority of the pregnancy outcomes were ...
Otake M - - 1990
Of all the data sets pertinent to the estimation of the genetic risks to humans following exposure to ionizing radiation, potentially the most informative is that composed of the cohort of children born to atomic bomb survivors. We present here an analysis of the relationship between parental exposure history and ...
Iwamoto I - - 1990
The tachykinins substance P (SP) and neurokinin A are believed to be major mediators of neurogenic inflammation. To determine whether the skin reactivity to tachykinins is increased in asthmatics, we examined the erythemas and wheals induced by intradermal injections of SP, the C-terminal peptide SP6-11, the N-terminal peptide SP1-9 and ...
Hill N C - - 1990
The effect of a single dose of RU 486 (600mg) on prostaglandin metabolite levels has been studied over a 48 h period in 20 women undergoing medical termination of early pregnancy. The results were compared with controls of similar gestation who were treated surgically. The mean (SD) PGEM levels at ...
Iles S - - 1989
It is often assumed that early loss of pregnancy is not followed by emotional distress. When such distress does occur, it often goes undetected. Early loss of pregnancy is frequently followed by typical grief such as that occurring after any bereavement. Most recent studies have shown that although social termination ...
Heath P J - - 1989
The incidence and severity of pain and nausea experienced by 40 primigravid day patients who presented for vaginal termination of pregnancy were examined. Controlled-release dihydrocodeine had no effect upon the incidence or severity of these minor sequelae. The requirements for escape analgesia and antiemetic therapy were less than anticipated and ...
Ylikorkala O - - 1989
To study the usefulness of mifepristone for outpatient abortion induction, we administered 600 mg of mifepristone in a single dose to 50 women exhibiting delay of menses of between 4-15 days. All but two started to bleed within 1-3 days after mifepristone. This treatment resulted in complete abortion (uterine cavity ...
Maymon R - - 1989
We conducted a detailed literature search for the rare combination of scleroderma and pregnancy. Ninety-four patients were reported, 14 of whom died during the course of the pregnancy, mainly due to secondary renal and cardiopulmonary involvement. Out of the 95 fetuses, 19 were lost. Thus, when complications arise, the option ...
Howell R J - - 1989
Ten patients underwent successful termination of first trimester pregnancies with RU38486 (Mifepristone, Roussel Laboratories Ltd., Broadwater Park, Uxbridge, Middlesex, United Kingdom) followed 2 days later by a prostaglandin (Gemeprost, May and Baker Ltd., Dagenham, Essex, United Kingdom) pessary. Four hours after administration of RU38486, the levels of progesterone (P) started ...
Papp Z - - 1989
The practice of prenatal diagnosis has brought with it the utilization of pregnancy termination as a preventive approach. In this paper the genetic/teratologic, fetal and maternal indications for termination of pregnancy used in Hungary are described, as well as the legal requirements and the proposed mode of termination at the ...
Bygdeman M - - 1989
Although vacuum aspiration could be regarded as a simple procedure, complications do occur and attempts have been made to develop non-surgical procedures for termination of pregnancy during the first 3-4 weeks following the first missed menstrual period. A variety of prostaglandin (PG) analogs have been developed which are equally effective ...
Rogo K O - - 1989
This study describes 58 cases of legal termination of pregnancy done in the acute gynaecology ward, Kenyatta National Hospital (KNH), Nairobi, over a 4 year period. The ward handles 20-40 new cases of incomplete abortion daily. Patients in the midtrimester received extra-amniotic or inter-amniotic prostaglandins (PGF2 alpha). Most of the ...
Julian C - - 1989
The acceptability of prenatal diagnosis for Down's syndrome has been extensively studied over the last 15 years but that of other pathologies remains largely unexplored. The main goals of this study were to approach physicians' opinions on six reasons for termination of pregnancy showing different deficiencies, i.e., Down's, Turner and ...
Kirz D S - - 1989
In the management of second-trimester medical terminations of pregnancy, it is a commonly accepted practice to allow 2 hours for the third stage of labor. This practice is based on data from terminations with saline solution as the abortifacient. Herein we report our experience with the use of prostaglandin E2 ...
Urquhart D R - - 1989
Forty-nine patients undergoing mid-trimester extra-amniotic prostaglandin termination of pregnancy were studied. Twenty patients acted as controls and received the standard hospital regime. Twenty-nine patients received the same regime, but in addition were given a single 200-mg oral dose of the antiprogesterone, mifepristone (RU 486), 24 h prior to prostaglandin infusion. ...
Bygdeman M - - 1989
There is considerable interest in the development of a non-surgical method to terminate early pregnancy. During the three weeks immediately following the first missed menstrual period, several prostaglandin (PG) analogs such as sulprostone, gemeprost and 9-methylene PGE2 have been used to terminate the pregnancy. Prostaglandins, however, at the doses required ...
Van Look P F - - 1989
Termination of early pregnancy by vacuum aspiration is a well-established technique. The procedure is highly effective and has a low complication rate, particularly when performed during the first few weeks after missed menses. However, this parasurgical method requires skilled health care personnel, and attempts have therefore been made to find ...
Ulmann A - - 1989
This paper reviews much of the clinical data obtained with the antiprogestin RU 486 (mifepristone) in the fields of obstetrics and gynecology. To interrupt early pregnancy (less than 50 days of amenorrhea) RU 486 as a single dose of 600 mg followed 36-48 hours later by a prostaglandin derivative, constitutes ...
Zheng S R - - 1989
Four multicentre clinical trials on interruption of early pregnancy (less than or equal to 49 days of amenorrhea) using RU 486 have been conducted in China, including 2321 subjects. The data from trials 1, 2 and 4 are presented here. RU 486 (600 mg as a single dose) was given ...
Maria B - - 1989
Mifepristone, (RU 486), is an antiprogesterone which, when administered alone will terminate early pregnancy in 80% of cases. Prostaglandins at high doses have also been used to terminate pregnancy but there are often unacceptable side effects. The combined treatment of mifepristone with low doses of prostaglandin analogs appears to be ...
Nurminen T - - 1988
In an examination of the possible harmful effects of work in an office environment and the use of a video display terminal (VDT) on the course of pregnancy, the experience of 1,475 reference mothers from a Finnish case-referent study of birth defects was analyzed. The study was based on the ...
Golbus M S - - 1988
Twenty-two selective terminations in multiple gestations were performed by a number of different methods. In 17 dichorionic pregnancies there was a successful delivery in surviving singletons or twins. In five monochorionic pregnancies undergoing selective termination there was a successful delivery in only one and a pregnancy loss in the other ...
Rådestad A - - 1988
Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg ...
Ford R M - - 1988
The results of the first 40 patients, whose pregnancies were terminated using Gemeprost vaginal suppositories are presented. The indication for termination of pregnancy was either fetal abnormality, or fetal death in utero. The mean gestational age was 20.9 +/- 4.4 weeks. 82.5% of patients were delivered within 24 hours, following ...
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