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Tuovinen S S Institute of Behavioural Sciences, University of Helsinki, Helsinki, - - 2014
To study whether pre-eclampsia and hypertension without proteinuria during pregnancy are associated with adaptive functioning, and psychiatric and psychological problems, of older offspring. Retrospective longitudinal cohort study. Participants in the Helsinki Birth Cohort 1934-44 Study. A cohort of 778 participants born after normotensive, pre-eclamptic, or hypertensive pregnancies, defined based on ...
Vachkova Eva - - 2013
Pregnancy is a specific condition that is neither a disease nor a normal state of health. The attention has been devoted to the relation between the normal, physiological process of pregnancy and the quality of life of women in this period is paid much less attention. Our study focuses on ...
Hall Jennifer - - 2013
The London Measure of Unplanned Pregnancy (LMUP) is a new and psychometrically valid measure of pregnancy intention that was developed in the United Kingdom. An improved understanding of pregnancy intention in low-income countries, where unintended pregnancies are common and maternal and neonatal deaths are high, is necessary to inform policies ...
Tsai Shao-Yu - - 2013
Fatigue is among the most prevalent and distressing symptoms in pregnant and postpartum women. Estimating fatigue severity with a psychometrically sound instrument provides the most fundamental information for understanding women's fatigue experience and assessing the need for intervention to improve maternal and infant health outcomes. To evaluate the psychometric properties ...
Stoll Kathrin - - 2013
to examine attitudes towards birth that may be common among young adults who have been socialised into a medicalised birth culture. Specifically, we were interested in examining factors that might be associated with fear of birth and preferences for elective obstetric interventions among the next generation of maternity care consumers. ...
Hostiuc Sorin - - 2013
PURPOSE: The main purpose of this article is to analyze the way in which young physicians analyze and address the issue of therapeutic abortion. METHODS: A multi-institutional survey was conducted using an online questionnaire containing 10 items. RESULTS: Most respondents agreed with therapeutic abortion (1) if the fetus is not ...
Mellingen Sonja - - 2013
ABSTRACT: BACKGROUND: Numerous studies have documented a profound reduction in alcohol use among pregnant women, whereas research on expectant fathers has been scarce. The aim of this study was to measure changes in alcohol consumption from before pregnancy to 17 weeks in gestation for mothers and fathers, differentiating between parents ...
Bellantuono Cesario - - 2013
The aim of this paper is to report maternal and neonatal outcomes in pregnant women treated with escitalopram during pregnancy and breastfeeding. Women enrolled in the DEGRA Database at the Clinic of Affective Disorders in Pregnancy and Postpartum in Italy, treated during pregnancy with escitalopram and followed up throughout pregnancy, ...
Vatten Lars J - - 2012
Objective. To study associations of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in maternal circulation with the risk of preeclampsia with and without fetal growth restriction. Design. Nested case-control study. Setting. A cohort of 29 948 pregnant women in Norway. Sample. Cases were identified through linkage ...
Espinoza Jimmy - - 2012
There is clinical and ultrasonographic evidence that "abnormal fetal-maternal interactions" or "fetal-maternal conflicts" may be central to the mechanisms of injury in pregnancy complications such as fetal growth restriction, preeclampsia, fetal death, gestational diabetes, and a subset of patients with preterm parturition. This conceptual framework integrates abnormalities in the placental ...
Mäkikallio Kaarin - - 2012
BACKGROUND: Cytokines and growth factors synthesized by placental trophoblasts are suggested to induce endothelial and vascular smooth muscle cell apoptosis and affect angiogenesis. OBJECTIVE: To investigate cord blood and placental immunoproteins in order to find new clues on pathogenetic factors of preterm preeclampsia. METHODS: Cord blood samples were collected on ...
Capellini I - - 2012
The placenta is fundamental to mammalian reproduction and is surprisingly diverse in gross morphology among species. Whether and how this diversity affects maternal investment and fetal growth is still poorly understood. Contrary to suggestions that highly invasive hemochorial placentation is beneficial to fetal development, recent comparative studies have revealed that ...
Kent Etaoin M - - 2012
OBJECTIVE: We sought to evaluate the association between placental histological abnormalities and birthweight discordance and growth restriction in twin pregnancies. STUDY DESIGN: We performed a multicenter, prospective study of twin pregnancies. Placentas were examined for evidence of infarction, retroplacental hemorrhage, chorangioma, subchorial fibrin, or abnormal villus maturation. Association of placental ...
Hodges Ryan J - - 2012
Clinical and experimental studies suggest that the growth-restricted fetus at increased risk of impaired cardiovascular function that likely contributes to both increased mortality rate and in survivors, to cardiovascular dysfunction apparent in childhood and later life. Fetal growth restriction is also associated with a high risk of preterm birth. Accordingly, ...
Melchiorre Karen - - 2012
Fetal growth restriction and preeclampsia are both conditions of placental etiology and associated to increased risk for the long-term development of cardiovascular disease in the mother. At presentation, preeclampsia is associated with maternal global diastolic dysfunction, which is determined, at least in part, by increased afterload and myocardial stiffness. The ...
Gonzalez-Bulnes Antonio - - 2012
The effects of undernutrition during pregnancy on prenatal and postnatal development of the offspring were evaluated in sows with obesity/leptin resistance. Females were fed, from Day 35 of pregnancy onwards, a diet fulfilling either 100% (group control, n = 10) or 50% of the nutritional requirements (group underfed, n = ...
Qiu Qing - - 2012
Background:Fetal growth restriction (FGR) is a leading cause of perinatal mortality and morbidity. Animal studies suggest dysregulation of IGF-binding protein (IGFBP)-4 is significant in the development of FGR, although human data are lacking. We postulated that IGFBP-4 is expressed at the maternal fetal interface and plays a role in regulating ...
Jansson T - - 2012
Nutrient-sensing signaling pathways regulate cell metabolism and growth in response to altered nutrient levels and growth factor signaling. Because trophoblast cell metabolism and associated signaling influence fetal nutrient availability, trophoblast nutrient sensors may have a unique role in regulating fetal growth. We review data in support of a role for ...
Ferraro Z M - - 2012
Does maternal obesity affect insulin-like growth factor (IGF) axis protein expression patterns in maternal and cord blood? Maternal obesity attenuates cord blood expression of IGF-binding protein (IGFBP)-4. The IGF axis plays a critical role in fetal growth and development. Maternal obesity compromises IGF axis protein expression in fetal circulation, which ...
Itonaga Keisuke - - 2012
Placentotrophy is the nourishment of embryos by resources provided via the placenta during gestation. The magnitude and timing of placental nutrient support during pregnancy are important for embryonic growth, especially in highly placentotrophic animals such as mammals. However, no study has yet investigated how placental organic nutrient support may change ...
Miller Suzanne L - - 2012
Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced ...
Breathnach Fionnuala M - - 2012
Twin growth is frequently mismatched. This review serves to explore the pathophysiologic mechanisms that underlie growth aberrations in twin gestations, the prenatal recognition of abnormal twin growth, and the critical importance of stratifying management of abnormal twin growth by chorionicity. Although poor in utero growth of both twins may reflect ...
Mayer Chantal - - 2012
The perinatal literature includes several potentially confusing and controversial terms and concepts related to fetal size and growth. This article discusses fetal growth from an obstetric perspective and addresses various issues including the physiologic mechanisms that determine fetal growth trajectories, known risk factors for abnormal fetal growth, diagnostic and prognostic ...
Carr David J - - 2012
The purpose of this study was to evaluate ultrasonographically fetal growth trajectories, placental biometry, and umbilical artery (UA) Doppler indices in growth-restricted pregnancies of overnourished adolescent ewes and normally developing pregnancies of control-fed ewes. Singleton pregnancies were established using embryo transfer in 42 adolescent ewes that were overnourished (n = ...
Gourvas Victor - - 2012
The placenta is the organ that is responsible for providing the developing fetus with all the nutrients necessary for its growth and is also responsible for removing fetal waste. Placentation is a crucial process that includes angiogenesis. Angiogenesis involves not only the fetal circulation, but also placental and endometrial vascular ...
Wadsack Christian - - 2012
This review aims to provide a comprehensive summary of the aspects of endothelial and vascular dysfunction in the feto-placental vasculature occurring in pregnancy pathologies. This endothelium is continuous with the fetal circulation. Its function and potential dysfunction in pathologies will have a profound impact on fetal development. Gestational diabetes mellitus ...
Proos Lemm - - 2012
Undernutrition during fetal and postnatal life is still a major problem in many low- and middle-income countries. Even in high-income countries malnutrition may exist in cases of intrauterine growth retardation, as well as in chronic conditions such as anorexia nervosa and inflammatory bowel disease. Children adopted from developing countries are ...
Padilha R T - - 2012
The objective was to evaluate the effects of insulin-like growth factor-I (IGF-I) on the quality and fertility of frozen/thawed ovine semen. Five rams (five ejaculates/ram) were used for evaluation of semen parameters. Before cryopreservation, ejaculates were divided into four aliquots and extended with Tris alone or supplemented with human IGF-I ...
Almasry Shaima M - - 2012
The aim of this study is to compare the gross morphology of the placentae and the morphometry of terminal villi and terminal villous capillaries in pregnancies complicated by idiopathic intrauterine growth restriction (IUGR) with those of normal pregnancies. 75 placentae were collected between April 2010 and March 2011. 50 placentae ...
Nardozza Luciano Marcondes Machado - - 2012
BACKGROUND: Fetal growth restriction (FGR) is a condition that affects 5-10 % of gestations, and it is the second primary cause of perinatal mortality. In this review the most recent knowledge about FGR is presented focusing on its concept, etiology, classification, diagnosis, management, and prognosis. METHODS: Searches were conducted in Pubmed, ...
Greer Laura G - - 2012
Objective We sought to determine whether chronic villitis, an immunologic disease of the placenta, was related to fetal growth restriction.Methods Beginning in October 1999, a protocol was instituted that required placentas of high-risk births be submitted for standardized histological examination. Chronic villitis was diagnosed when a lymphohistiocytic infiltrate involving placental ...
Schäfer-Somi S - - 2012
The aim of this study was to investigate the course of expression of platelet-activating factor (PAF), PAF-receptor (PAF-R), epidermal growth factor (EGF), EGF-R, vascular endothelial growth factor (VEGF), VEGF-R1 and VEGF-R2 in uterine tissue during canine pregnancy. For this purpose, 20 bitches were ovariohysterectomized at days 10-12 (n = 10), 18-25 (n = 5) ...
Conover Cheryl A CA Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. - - 2012
Twenty-five years after it was identified as a circulating protein of unknown function derived from the placenta, pregnancy-associated plasma protein-A (PAPP-A) was discovered to be a novel zinc metalloproteinase expressed by a variety of cell types. Great progress has been made in understanding the biology of PAPP-A and its regulation ...
Rao K Rajender - - 2012
Fetal growth is a complex process which depends both on the genetic makeup and intrauterine environment. Maternal nutrition during pregnancy is an important determinant of fetal growth. Adequate nutrient supply is required during pregnancy and lactation for the support of fetal/infant growth and development. Macro- and micronutrients are both important ...
Luo Zhong-Cheng - - 2012
Context:It remains uncertain whether maternal IGF-I is associated with fetal growth. Little is known about the role of maternal IGF-II in fetal growth and whether IGF-I or IGF-II is implicated in fetal hypertrophy in gestational diabetes.Objective:The objective of the study was to assess maternal and fetal IGF-I and IGF-II levels ...
Thaete Larry G - - 2012
AIMS: Endothelin receptor A (ET(A)) antagonism normalizes fetal growth in several models of rodent fetal growth restriction (FGR). Our aims were to determine the levels of ET(A) antagonist in maternal and fetal plasma following chronic maternal administration, and to determine its impact on pregnancy outcome, survival and growth of rat ...
Chalana Harsh - - 2012
Pregnancy plays a unique role in the transformation of women towards completeness. For those women who have had a previous unsuccessful outcome, pregnancy may bring a lot of inevitable negative emotions. We studied psychiatric morbidity during second trimester of pregnancy subsequent to abortion in the previous pregnancy. The study was ...
March Melissa I - - 2012
Fetal biometry is the measurement of the fetus and various segments of the fetal anatomy. Every part of the fetal anatomy may be imaged, but fetal head, abdomen, and femur measurements are the most commonly used, as well as the crown-rump length in early gestation. These biometric measurements can be ...
Li Lei - - 2012
Concentrations of adrenomedullin (ADM) in circulation, the uterus, and corpora lutea (CL) increase during pregnancy. We previously reported a temporal-spatial pattern of ADM level and gene expression of Adm and its receptor components, from early pregnancy through midpregnancy to late pregnancy in rats. Two earlier reports using an in vivo ...
Lindell Gun - - 2012
Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, ...
Wilsher S - - 2012
The development of the equine placenta involves a series of stage-specific events which ensure that the fetus is nourished throughout its 11 months of gestation. Initially, placental exchange to the developing embryo is histotrophic, via the yolk sac but, as the allantochorion develops and microcotyledons form, haemotrophic nutrition plays the ...
Wilsher S - - 2012
The development of the equine placenta involves a series of stage-specific events which ensure that the fetus is nourished throughout its 11 months of gestation. Initially, placental exchange to the developing embryo is histotrophic, via the yolk sac but, as the allantochorion develops and microcotyledons form, haemotrophic nutrition plays the ...
Moh Wendy - - 2012
The causes of intrauterine growth restriction (IUGR) are multifactorial with both intrinsic and extrinsic influences. While many studies focus on the intrinsic pathological causes, the possible long-term consequences resulting from extrinsic intrauterine physiological constraints merit additional consideration and further investigation. Infants with IUGR can exhibit early symmetric or late asymmetric ...
Jank Alexander - - 2012
BACKGROUND; Although intrauterine presence of the placenta is essential in the etiology of preeclampsia (PE), case reports showed that the viability of the fetus influences the clinical course of PE and the intensity of the clinical symptoms. We examined the course of angiogenic factors soluble fms-like tyrosine kinase-1 receptors (sFlt-1) ...
Higgins Mary F - - 2012
[This corrects the article on p. e29164 in vol. 7.].
Xu Mengyan - - 2012
Abstract Background: Impaired cardiac function leads to impaired renal function. We assessed renal function in pregnant patients with heart failure. Methods: This was a retrospective study. From 1999 to 2010, 42 pregnant patients with heart failure were classified into the single-pregnancy group and the twin or multifetation group. Clinical manifestations ...
Higgins Mary F - - 2012
Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) ...
Ayoola Omolola O - - 2012
Malaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth size has not been ...
Fuller-Tyszkiewicz Matthew - - 2012
Available data suggest that body dissatisfaction is common during pregnancy and may even be a precursor to post-natal depression. However, in order to accurately identify at-risk women, it is essential to first establish that body image measures function appropriately in pregnant populations. Our study examines the suitability of the Body ...
Vonnahme Kimberly A - - 2011
As placental growth and vascularity precedes exponential fetal growth, not only is proper establishment of the placenta important, but also a continual plasticity of placental function throughout gestation. Inadequate maternal environment, such as nutritional plane, has been documented to alter fetal organogenesis and growth, thus leading to improper postnatal growth ...
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