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Karalis K - - 1996
In most mammals, labor is heralded by progesterone withdrawal, which is believed to be related to the activation of multiple pathways leading to parturition. In humans, despite no decrease in placental progesterone production, activation of similar pathways preceding labor suggests the presence of an endogenous antiprogestin, which we reasoned might ...
Yallampalli C - - 1996
We recently established that the chronic inhibition of nitric oxide production with NG-nitro-L-arginine methyl ester (L-NAME) increases blood pressure and fetal mortality in pregnant rats. Using this animal model, we have investigated whether calcitonin gene-related peptide (CGRP) can reverse the pre-eclampsia-like conditions produced by L-NAME. CGRP and L-NAME were chronically ...
Check J H - - 1996
PROBLEM: The immunomodulatory effect of progesterone (P) in pregnancy manifested via a protein named the P-induced blocking factor (PIBF) was previously reported. The goal of this study was to measure and compare the PIBF expression on lymphocytes between pregnant and non-pregnant women especially in early pregnancy. METHODS: PIBF expression was ...
Walsh J W - - 1996
Women in pregnancy experience nausea, which correlates with gastric slow-wave rhythm disruption. Mediators of these dysrhythmias were explored. To quantitate slow-wave disruption, eight pregnant women with first-trimester nausea underwent electrogastrography after a 250-kcal meal. Results were compared with nonpregnant women with nausea during a prior pregnancy who received estradiol and/or ...
Szilagyi A - - 1996
We examined the course of delayed oral cecal transit time (OCTT) and the impact of different variables in late pregnancy. Thirty-three women in late trimester were evaluated and 29 were re-tested post partum. Results were compared with 17 controls. A breath hydrogen test was used to measure OCTT. The impact ...
Lo Y M - - 1996
It has been a long-sought goal of human genetics to develop safe and reliable prenatal diagnostic procedures that constitute no risk to the fetus. At present, the safety of available methods is limited by the need to obtam fetal tissues through invasive means, such as chorlomc villus sampling (CVS) and ...
Dawson-Basoa M E - - 1996
Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of 17-beta-estradiol (E2) and progesterone (P) produces an opioid antinociception which closely ...
Taddei G - - 1996
First-trimester chorion villosum plays the key role in the development of human placenta and secretes a large number of hormones and hormone-related substances. To test whether progesterone and estrogen could have regulatory effects on first-trimester chorion villosum functions, we investigated the presence of progesterone receptor (PR) and estrogen receptor (ER) ...
Spitz I M - - 1996
Antiprogestins are characterized by substitutions at the 11 beta and 17 alpha positions of the steroid ring system and bind strongly to both progesterone and glucocorticoid receptors. Although they function predominantly as antiprogestins and antiglucocorticoids, on occasion they display progestin agonistic and even antiestrogenic properties. The most common clinical use ...
Crombie D L - - 1995
Anti-progesterone treatment using specific anti-progesterone antibodies or a progesterone receptor (PR) antagonist during first pregnancy impairs postpartum maternal behaviour in mice. This effect is demonstrable only if the treatment is given during pregnancy but not immediately after parturition. The purpose of the present studies was to investigate if maternal behaviour ...
Wilkinson S M - - 1995
A patient with persistent urticaria related to the premenstrual phase of the menstrual cycle is presented. Although systemic administration of progesterone provoked the eruption, we were unable to confirm that there was an immunological reaction to endogenous progesterone or oestrogen. Mechanisms whereby progesterone can augment subclinical types I and IV ...
Htwe M - - 1995
BACKGROUND: Aggressive angiomyxoma is a rare neoplasm of undetermined etiology that occurs mainly in the female vulva and perineum. It tends to recur but does not metastasize. This case report describes findings suggestive of the possible hormone dependency of this neoplasm. CASE: A 41-year-old gravid woman developed an aggressive angiomyxoma ...
Hirata S - - 1995
Characterization of the estrous cycle and the ability to detect pregnancy are essential for the development of efficient captive breeding programs in wild mammalian species and for their conservation. We assess here the feasibility of using fecal progesterone analysis as a non-invasive method of monitoring the ovarian function of the ...
White P J - - 1995
We validated fecal metabolite analysis as a noninvasive means of diagnosing pregnancy in uncaptured, free-ranging Rocky Mountain elk (Cervus elaphus nelsoni). During November 1991, we collected blood samples from 21 radiocollared, 1- to 10-year-old female elk in Yellowstone National Park, Wyoming (USA), and determined their pregnancy status by radioimmunoassay of ...
Zhu L J - - 1995
The female sex steroid, progesterone, plays a central role in mammalian pregnancy by regulating crucial events in the uterus such as transformation of endometrium for implantation and maintenance of pregnancy. The hormone acts through its specific nuclear receptor and modulates the functions of target cells by controlling the synthesis of ...
Ben-Nun I - - 1995
Repeated attempts with oral oestrogens and injectable progesterone failed to induce secretory endometrium in a woman with 17-alpha-hydroxylase deficiency. The insertion of s.c. 17-beta-oestradiol implants dramatically improved the endometrial response and enabled the establishment of endometrial maturation. A viable pregnancy was achieved after the uterine transfer of in-vitro fertilized donated ...
Shion Y L - - 1995
Changes in the basal plasma membrane and lamina densa of uterine epithelial cells have been studied in the rat during early pregnancy and under the influence of progesterone and oestrogen. Both the basal plasma membrane and lamina densa become increasingly tortuous by day 6 of pregnancy and this condition is ...
Beatty C W - - 1995
For a long time, it has been speculated that pregnancy stimulates the growth of acoustic schwannomas. To test this hypothesis, immunohistochemical stains for estrogen receptor, progesterone receptor, and proliferating cell nuclear antigen (PCNA) were performed. Flow cytometric studies for DNA ploidy and S-phase fraction determinations were also performed. The study ...
Miyamoto H - - 1995
Female reproductive properties, early embryonic development, and serum estradiol and progesterone levels of the senescence-accelerated mouse (SAM)-prone (SAM-P) strain were compared with those of a SAM-resistant (SAM-R) strain. The reproductive life span of SAM-P (from 11.4 to 25.0 weeks old) was shorter than that of SAM-R (11.1 to 41.6 weeks ...
Zhou H H - - 1995
BACKGROUND: The minimum alveolar concentration (MAC) of volatile anesthetics is decreased during pregnancy, but MAC in the early postpartum period has not been reported. The aim of this study was to determine the MAC of isoflurane and to evaluate the relation between MAC and serum progesterone and beta-endorphin in patients ...
Wang M W - - 1995
The rapid onset of normal maternal behaviour after parturition in mice, consisting of cleaning, warming, feeding and protection of offspring, is primed by oestrogen, progesterone and oxytocin. Previous studies showed that passive transfer of monoclonal antibodies against progesterone significantly increases the incidence of maternal rejection of pups. To test the ...
Lee M Y - - 1995
Mammalian flavin-containing monooxygenase (FMO, EC 1.14.13.8) metabolizes a vast number of structurally diverse xenobiotics containing a soft-nucleophile, typically a nitrogen or sulfur. FMO is not inducible by the classical cytochrome P450 (CYP) inducers, such as phenobarbital, polycyclic aromatic hydrocarbons, ethanol or macrolide antibiotics. Evidence does exist from a number of ...
Pliskow S - - 1995
A patient with a headache and seizures in the second trimester of her fifth pregnancy was diagnosed as having an intracranial meningioma. She underwent pregnancy termination followed by craniotomy and removal of the tumor one week later. She recovered fully. The final pathology report confirmed the diagnosis of meningioma, progesterone ...
Gunasegaram R - - 1995
Activity of 3 beta-hydroxysteroid dehydrogenase-5, 4-en isomerase was investigated with [7n-3H] pregnenolone as substrate in the homogenates of amnion and chorion collected from women (n = 6, age 20-34 years) after spontaneous labour at term (37-40 weeks gestation) from uncomplicated pregnancies. Controls were heat-denatured homogenates instead of fresh homogenates. Reverse-isotope ...
Telleria C M - - 1994
Changes in progesterone production were analysed after intrabursal ovarian administration of the antiprogesterone RU486, mifepristone, in rats at pro-oestrus and during pregnancy. RU486 was administered at 09:00-10:00 h and serum progesterone was measured 8 h after treatment, except for those on days 3 and 12 of pregnancy when the steroid ...
Rodriguez G C - - 1994
OBJECTIVE: To evaluate the utility of the serum progesterone level for discriminating pregnancy from gestational trophoblastic neoplasia. METHODS: Serum progesterone levels were measured in 61 women with histories of trophoblastic disease who developed a re-elevation in hCG during surveillance and underwent a work-up to differentiate pregnancy from gestational trophoblastic neoplasia. ...
Kleemann D O - - 1994
Two experiments were conducted to determine whether administration of progesterone during early pregnancy affects fetal growth in sheep and if any effect is specific to the days of treatment. In the first experiment, Merino ewes were randomly allocated to four treatment groups and inseminated at a synchronized oestrus. Three groups ...
Johnson M R - - 1994
The aim of the study was to investigate the circulating levels of human chorionic gonadotrophin (hCG), oestradiol (OE2) and progesterone in multifetal pregnancies before and after embryo reduction. The levels of hCG, OE2 and progesterone were measured in plasma samples obtained from two groups of pregnant women: (i) singleton (n ...
Gobbetti A - - 1994
To delineate endocrine mechanisms regulating equine luteal function and the possible functional differences between one month and three month corpora lutea of pregnancy (CL), the in vitro basal releases of prostaglandin F (PGF), prostaglandin E2 (PGE2), progesterone, and 17 beta-estradiol by one and three month CL of pregnant mares were ...
Anttila M - - 1994
Diabetic pregnancies are risk pregnancies with increased perinatal mortality and perinatal morbidity. The purpose of this study was to evaluate retrospcctively the outcome of 567 diabetic pregnancies in the area of Oulu University Hospital periodically from 1967 to 1987.
Winn R J - - 1994
Marked growth and softening of the uterine portion of the cervix occur during the last third of the 115-day gestation period in the gilt. These changes in the cervix are temporally correlated with elevated blood levels of relaxin, estrogen, and progesterone. We recently demonstrated that relaxin plays a major role ...
Raber-Durlacher J E - - 1994
The purpose of this study was to assess whether an intensive oral hygiene regimen practised during pregnancy results in a clinically healthy gingival state, and to assess whether experimentally-induced gingivitis differs in severity during pregnancy as compared to post-partum. In addition, levels of black-pigmented Gram negative anaerobes at subgingival and ...
Allrich R D - - 1994
During proestrus, gonadotropins induce final follicular maturation, resulting in increased secretion of estradiol. Estradiol, in the relative absence of progesterone, acts on the hypothalamus to induce estrous behavior. The mean duration of estrus is 12 to 16 h and ranges from 3 to 28 h. The effects of estradiol appear ...
de Gasparo M - - 1994
Samples of human myometrium have been collected during pregnancy and from non-pregnant women. Binding studies revealed the presence of a 50-fold higher density of angiotensin II AT2 receptor in the non-pregnant state than during gestation. Low levels of the AT1 receptor subtype (approx. 20 fmol/mg protein) were detected in both ...
Muramatsu Y - - 1994
The purpose of this study was to investigate oral health status in relation to subgingival microflora and sex hormone concentrations in saliva during pregnancy. Oral health examinations were performed on 39 subjects: of 19 pregnant women (mean age 28.5), and 8 women in the fifth post-partum month (mean age 27.1), ...
Goldberger SG - - 1994
Laparoscopic surgery is currently the preferred diagnostic and treatment modality for ectopic pregnancy (EP). Cornual pregnancy, a rare and dangerous form of EP, is usually treated by cornual resection or hysterectomy. We report the first case to be treated by laparoscopic surgery. A 27 year old, gravida 3 para 2, ...
Daily C A - - 1994
OBJECTIVE: Our purpose was to determine whether serum progesterone, with or without quantitative beta-human chorionic gonadotropin, is predictive of pregnancy outcome within the first 8 weeks of gestation in asymptomatic women. STUDY DESIGN: Asymptomatic patients at < 8 menstrual weeks' gestation were prospectively evaluated. The enrollment protocol included history, physical ...
Elwardy-Mérézak J - - 1994
Previous studies from our laboratory have suggested that post-receptor events at the level of beta-adrenergic receptor-adenylate cyclase interaction could be altered in myometrium by steroid hormones or pregnancy. In this study, we have addressed this question by performing a direct evaluation of rat myometrial Gs proteins at various stages of ...
Zamudio S - - 1994
OBJECTIVE: Intrauterine growth retardation and preeclampsia are more common at high than at low altitude. Because altered hormonal profiles have been linked with these disorders, we asked whether placental steroid hormone concentrations were altered during pregnancy at high altitude. METHODS: We measured progesterone, unconjugated estradiol, and estriol (by radioimmunoassay) at ...
Ziai N - - 1994
OBJECTIVE: To determine whether the altered hormonal milieu of pregnancy is associated with changes in the dynamics of aqueous humor formation and drainage. DESIGN: Nineteen women were studied during each trimester of a single pregnancy and post partum. Measures of aqueous dynamics included intraocular pressure, aqueous flow, facility of outflow, ...
Wisel M S - - 1994
OBJECTIVE: To compare effects of various anti-estrogens on early pregnancy. METHODS: Fifty regularly cycling guinea pigs were divided into five groups (five animals/group), of which three groups received 3 mg/kg body weight Nafoxidine, Centchroman, or Tamoxifen, respectively, on the 1st, 2nd, or 3rd day of pregnancy. The rest of the ...
Ohno Y - - 1994
Our objective was to clarify the mechanism of uterine contraction induced in pregnant women by intrauterine bacterial infection. The concentration of interleukin 2 (IL-2) was measured in amniotic fluids that had been obtained by amniocentesis, transvaginal amniotomy or by transuterine amniocentesis performed at cesarean section in 50 pregnant women. The ...
Renouf D - - 1994
Concentrations of circulating progesterone were monitored in a captive breeding group of harp seals. Five females were monitored for 2 years, over which time they either became pregnant (four instances) or displayed an overt pseudopregnancy (five instances). Only one female exhibited consecutive pseudopregnancies. In all pseudopregnancies, serum progesterone values were ...
Yallampalli C - - 1994
Previously, we demonstrated the presence of an L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the rat uterus and that NO inhibits contractility during pregnancy but not during delivery. In the present study, we investigated the possible role of sex steroid hormones in the regulation of NO synthesis and cGMP ...
Nomura K - - 1994
Cystic endometrial hyperplasia resembling that of normal early pregnancy was induced by the insertion of a silk suture into diestrous bitches. Intraluminal trauma (wire scratching) induced a similar but moderate change. Intraluminal olive oil and saline had little or no effect. Maternal decidual response in rodentia produced by mechanical means ...
Errickson C V - - 1994
Skin disorders of pregnancy fall into three major groups: disorders due to physiologic changes, specific skin disorders of pregnancy, and skin tumors. Elevated levels of estrogen and progesterone stimulate melanogenesis, which causes hyperpigmentation, including melasma; high levels of circulating hormones also cause vascular changes and alter hair growth cycles. Specific ...
Nephew K P - - 1994
A series of four experiments with 258 ewes was conducted to determine whether blastocyst size could be altered before normal luteolysis and, if so, how this affected fertility. In Exp. 1 and 2, nonmated and mated ewes, respectively, were treated with hCG (100 IU), progesterone (12 mg), or vehicle on ...
Sauer M V - - 1994
In conclusion, these three functionally agonadal patients illustrate that discontinuing hormone support may have disastrous effects upon early pregnancy. Patients should be educated as to the importance of utilizing medications correctly. In cases where compliance is an issue, embryo transfer should be delayed. If compliance is questioned, a serum progesterone ...
Burns W N - - 1994
PURPOSE: In gonadotropin-releasing hormone analogue-pretreated in vitro fertilization-embryo transfer cycles, pregnancy rates are inversely related to serum progesterone levels on the day of administration of human chorionic gonadotropin. The relationship of the progesterone concentration on other days in the periovulatory period to pregnancy rates in such cycles is little studied. ...
Meyer H H - - 1994
Placenta and corpus luteum (CL) have acquired different functions for progesterone synthesis and maintenance of pregnancy in the course of placentalia evolution. In the cow and pig, progesterone is produced by the same CL during the entire gestation period with minor or no contribution from the placenta. In the case ...
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