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Leach Lopa - - 2011
This Spotlight Issue of Microcirculation contains six current perspectives on the role of the intrauterine environment, especially maternal nutritional status and maternal diabetes in influencing fetal growth and cardiovascular heath in the offspring in later life. The reviews address issues such as the existence of a commonality of mechanism following ...
Thaman Rajesh - - 2011
Aims The natural history and outcome of pregnancy in patients with a pacemaker or those presenting with atrioventricular conduction block in pregnancy are unknown with only a limited number of case reports published. Methods and results This study examines the progress and outcome of 25 pregnancies in 18 women who ...
Ajslev T A - - 2011
Objective:To investigate whether delivery mode (vaginal versus by caesarean section), maternal pre-pregnancy body mass index (BMI) and early exposure to antibiotics (<6 months of age) influence child's risk of overweight at age 7 years, hence supporting the hypotheses that environmental factors influencing the establishment and diversity of the gut microbiota ...
Dawson Paul Anthony - - 2011
Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1-/-) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during pregnancy and to determine the physiological consequences of maternal hyposulfataemia on fetal, placental and postnatal ...
Geelhoed Jjm - - 2011
Please cite this paper as: Geelhoed J, el Marroun H, Verburg B, van Osch-Gevers L, Hofman A, Huizink A, Moll H, Verhulst F, Helbing W, Steegers E, Jaddoe V. Maternal smoking during pregnancy, fetal arterial resistance adaptations and cardiovascular function in childhood. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.02900.x. Objective  To unravel the ...
Nicolaides Kypros H - - 2011
The current approach to prenatal care, which involves visits at 16, 24, 28, 30, 32, 34 and 36 weeks and then weekly until delivery, was established 80 years ago. The high concentration of visits in the third trimester implies, firstly, that most complications occur at this late stage of pregnancy ...
Giambona Antonino - - 2011
At 5-12 weeks of gestation the amniotic sac is surrounded by celomic fluid, which contains cells of fetal origin. This fluid can be sampled by celocentesis, which involves the ultrasound-guided insertion of a needle through the vagina. The aim of this study was to examine the feasibility of prenatal diagnosis of ...
Srisupundit Kasemsri - - 2011
Objective: To determine the accuracy of splenic circumference in predicting hemoglobin (Hb) Bart's disease among fetuses at risk at midpregnancy. Materials and Methods: Women with singleton pregnancies with a fetal risk of Hb Bart's disease were enrolled in the study at 18-22 weeks of gestation. All underwent splenic circumference measurement ...
Romero Roberto - - 2011
Failure of physiologic transformation of the spiral arteries has been studied using placental bed biopsies in several obstetrical syndromes. Contrary to what was originally believed, this lesion is not restricted to preeclampsia and/or intrauterine growth restriction. A review of published evidence indicates that failure of physiologic transformation can be observed ...
Petersen Irene I Department of Primary Care & Population Health, University College London, Rowland Hill St, London NW3 2PF, UK. - - 2011
Potential adverse effects of antidepressants during pregnancy have caused concern about their use. There are, however, very limited detailed data on patterns of antidepressant prescribing in pregnancy. To examine secular trends in prescribing during pregnancy, to assess whether pregnancy is a major determinant for stopping antidepressants, and to identify characteristics ...
Veas Carlos J - - 2011
Objectives. To evaluate the association between endothelial activation markers in the maternal circulation with nitric oxide (NO) synthesis in human umbilical endothelial cells. Study design. This is a case-control study of normal and pre-eclamptic pregnancies. The levels of sE-selectin, soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble fms-like tyrosine kinase 1 ...
Fitzgerald B - - 2011
Elevated levels of the maternal prenatal screening markers hCG and inhibin-A, measured at 15-20 weeks gestation, increase the subsequent risk of severe pre-eclampsia and intra-uterine growth restriction (IUGR). Since both markers are produced by syncytiotrophoblast, we tested the hypothesis that these elevations were due to accelerated differentiation of the villous ...
Solheim Karla N - - 2011
Objective. The overall annual incidence rate of caesarean delivery in the United Sates has been steadily rising since 1996, reaching 32.9% in 2009. Primary cesareans often lead to repeat cesareans, which may lead to placenta previa and placenta accreta. This study's goal was to forecast the effect of rising primary and ...
Diouf Ibrahima - - 2011
Diouf I, Charles MA, Blondel B, Heude B, Kaminski M. Discordant time trends in maternal body size and offspring birthweight of term deliveries in France between 1972 and 2003: data from the French National Perinatal Surveys. Paediatric and Perinatal Epidemiology 2011; 25: 210-217. We investigated time trends in maternal weight ...
Alves Júlio Augusto Gurgel - - 2011
Interstitial pregnancy sometimes is mistakenly referred to as cornual pregnancy and is frequently confused with angular pregnancy. A strict distinction among these three conditions is clinically important because their findings, management and outcomes are different. We report an unusual case of pregnancy where interstitial pregnancy was diagnosed at 6 weeks of ...
Bussani Cecilia - - 2011
Aims:  The aim of this study was to evaluate possible procedure-related variations in the levels of cell-free fetal DNA (fDNA) in maternal plasma of women undergoing genetic amniocentesis. Materials and Methods:  Blood samples were collected at 16-18 weeks' gestation from 33 pregnant women attending the Fetal Medicine Unit for genetic ...
Takimoto Hidemi - - 2011
Aim:  Greater antenatal weight or body mass index (BMI) gains may lead to larger fetuses and thus increase the risk for operative deliveries, such as cesarean deliveries. In order to examine the effect of weekly maternal weight and BMI changes on large-for-gestational-age (LGA) infants and cesarean delivery, delivery records from ...
Papageorgiou Elisavet A EA Cytogenetics and Genomics Department, The Cyprus Institute of Neurology and Genetics, Nicosia, - - 2011
The trials performed worldwide toward noninvasive prenatal diagnosis (NIPD) of Down's syndrome (or trisomy 21) have shown the commercial and medical potential of NIPD compared to the currently used invasive prenatal diagnostic procedures. Extensive investigation of methylation differences between the mother and the fetus has led to the identification of ...
Larkin Jacob C - - 2011
OBJECTIVE: The purpose of this study was to determine whether a customized standard of large-for-gestational age (LGA) identifies pregnancies with increased perinatal risk. STUDY DESIGN: We evaluated 7510 estimates of fetal weight to generate a fetal growth curve. Next, we analyzed the gestational age at delivery, physiologic and pathological variables ...
Clifford Gari - - 2011
We sought to evaluate the accuracy of a novel system for measuring fetal heart rate (FHR) and ST-segment changes using noninvasive electrodes on the maternal abdomen. Fetal electrocardiograms were recorded using abdominal sensors from 32 term laboring women who had a fetal scalp electrode (FSE) placed for a clinical indication. ...
Colvin Lyn - - 2011
BACKGROUND: The safety of selective serotonin reuptake inhibitors (SSRIs) during pregnancy remains uncertain. The purpose of this study was to investigate dispensing patterns and pregnancy outcomes for women dispensed an SSRI in pregnancy. METHODS: Using data linkage of population-based health datasets from Western Australia and a national pharmaceutical claims dataset, ...
Loane Maria - - 2011
BACKGROUND: As part of EUROCAT's surveillance of congenital anomalies in Europe, a statistical monitoring system has been developed to detect recent clusters or long-term (10 year) time trends. The purpose of this article is to describe the system for the identification and investigation of 10-year time trends, conceived as a ...
Gulsun Serda - - 2011
This study was undertaken in order to evaluate the effect of brucellosis in pregnancy. The serum agglutination test, Coombs and/or blood culture systems were used in the diagnosis of brucellosis. From July 2003 to September 2010, the clinical and delivery patterns of 40 healthy pregnant women were compared with 39 ...
Woodham Padmashree Chaudhury - - 2011
Thrombophilias have been implicated in complications related to ischemic placental disease including recurrent pregnancy loss, intrauterine fetal demise, preeclampsia, fetal growth restriction, placental abruption, and preterm delivery. Maternal screening and treatment may lower the recurrence of these outcomes. Our objective was to estimate if antenatal screening for thrombophilias with the ...
Paule Sarah - - 2011
The uterus undergoes dramatic remodelling in preparation for embryo implantation and pregnancy establishment. A receptive uterus is pivotal for embryo attachment, implantation and the eventual formation of a hemochorial placenta. We have previously identified by proteomics that tropomyosin alpha-4 chain (TPM4), protein disulfide isomerase A1 (PDIA1) and src substrate cortactin ...
Umbers Alexandra J - - 2011
Placental malaria is hypothesized to lead to placental insufficiency, which causes fetal growth restriction (FGR). In this review, recent discoveries regarding the mechanisms of pathogenesis by which malaria causes FGR are discussed in the wider context of placental function and fetal growth. Placental malaria and associated host responses can induce ...
Elovitz Michal A - - 2011
Exposure to prenatal inflammation is a known risk factor for long term neurobehavioral disorders including cerebral palsy, schizophrenia, and autism. Models of systemic inflammation during pregnancy have demonstrated an association with an immune response an adverse neurobehavioral outcomes for the exposed fetus. Yet, the most common route for an inflammatory ...
Morris R Katie - - 2011
OBJECTIVES: To determine the effectiveness of fetal cystoscopy in the prenatal diagnosis and intervention for congenital lower urinary tract obstruction. METHODS: Literature search using Medline, Embase, Cochrane Library, MEDION, Web of Science reference lists, and contact with experts. All studies reporting on fetal cystoscopy in lower urinary tract obstruction with ...
Gorincour Guillaume - - 2011
Objective: To explicate the ontological statuses of both the fetus and neonate as a basis for clinical ethical judgments about the obligations of both physicians and pregnant women to protect the life and health of both the fetus and the neonate. Methods: Despite drastic changes in perinatology, there is still ...
Cecati Monia - - 2011
There is growing evidence that pregnancy complications such as preeclampsia, recurrent pregnancy loss (RPL), IUGR, and premature birth could be associated with abnormal immunologic interactions at the fetal-maternal interface. The restricted expression of HLA-G to the subpopulation of trophoblast cells which invade the uterus has generated much interest. The alternative ...
Mayeur Sylvain - - 2011
Numerous data highlight the importance of a fine regulation of the fetal growth for the individual's subsequent susceptibility to diseases. Recent evidence suggests that neurotrophins may have important functions during pregnancy and that they could modulate fetal growth. We hypothesize that neurotrophins may participate in fetal growth by different pathways: ...
Gyllstrom M Elizabeth - - 2011
To examine the association between mental health factors with smoking cessation during pregnancy and postpartum relapse. We used data from 1,416 women who participated in the Minnesota Pregnancy Risk Assessment Monitoring System survey in 2004-2006 and reported smoking immediately prior to pregnancy. Maternal mood during pregnancy, stressful life events and ...
Matijasevich Alicia - - 2011
To explore the effects of maternal smoking during pregnancy on offspring growth using three approaches: (1) multiple adjustments for socioeconomic and parental factors, (2) maternal-paternal comparisons as a test of putative intrauterine effects and (3) comparisons between two birth cohort studies. Population-based birth cohort studies were carried out in Pelotas, ...
Blackmore Emma Robertson ER Department of Psychiatry, University of Rochester Medical Center, New York, NY 14642-8409, USA. - - 2011
Prenatal loss, the death of a fetus/child through miscarriage or stillbirth, is associated with significant depression and anxiety, particularly in a subsequent pregnancy. This study examined the degree to which symptoms of depression and anxiety associated with a previous loss persisted following a subsequent successful pregnancy. Data were derived from ...
Tarrant R C - - 2011
Background/Objectives:To examine the prevalence and combined occurrence of peri-conceptional folic acid (FA) supplement use, smoking and alcohol consumption during pregnancy in a sample of women in Dublin, and determine the factors associated with these health behaviours.Subjects/Methods:A prospective observational study (2004-2006) involving the recruitment of 491 pregnant women from antenatal clinics ...
Parodi Emilia - - 2011
Due to the low occurrence of cancer during pregnancy, limited data are available about outcome of infants exposed to chemotherapy in utero. We report the case of a newborn who developed transient ventricular hypocinesia and late-onset infection after in utero exposure to four epirubicin cycles for pregnancy-associated breast cancer. Moreover, ...
Ganzevoort Wessel - - 2011
Pre-eclampsia has a strong association with adverse outcomes: high incidences at term, and low incidences of morbidity; low incidences remote from term, high incidences of morbidity. The ultimate cure for pre-eclampsia is delivery of the placenta, but gestational age at delivery has an effect on perinatal outcome. We review aspects ...
Henry Melissa - - 2011
Background: Cancer occurs during one in 1000-5000 of the approximately 6 million yearly US pregnancies identified by the American Pregnancy Association. Although a newly diagnosed cancer is associated with substantial distress, little is known about cancer's emotional impact on women when diagnosed during pregnancy, and no studies have been conducted ...
Reuss Annette - - 2011
We report on the prenatal and postnatal cytogenetic, molecular genetic and clinical findings in monochorionic diamniotic twins discordant for trisomy 18. For prenatal diagnosis sampling of both sacs is recommended in monochorionic diamniotic twin pregnancy, especially if one twin has structural anomalies on ultrasound scan. Copyright © 2011 ISUOG. Published ...
Mocarski M - - 2011
The purpose of the study was to examine ethnic variation in the impact of Gestational Diabetes Mellitus (GDM) on birth outcome. The authors examined the association between GDM and pregnancy-induced hypertension, macrosomia, primary Cesarean delivery, and preterm birth, using New York City Birth Certificate data from 2001-2006. Logistic regression was ...
Roman Ashley S - - 2011
Objective.?To examine the impact of maternal obesity on maternal and neonatal outcomes in pregnancies complicated with gestational diabetes mellitus (GDM). Methods.?Women with singleton pregnancies and GDM enrolled in an outpatient GDM education, surveillance and management program were identified. Maternal and neonatal pregnancy outcomes were compared for obese (pre-pregnancy BMI???30?kg/m(2)) and ...
Lee Yong-Taek - - 2011
The etiology of congenital muscular torticollis (CMT) remains controversial. Ultrasonographically, severe fibrosis involving the entire sternocleidomastoid muscle (SCM; type 3 or 4) fibrosis has been associated with poor clinical outcomes and indicates a chronic state of the condition. The purpose of this study was to test whether or not type ...
Combs C Andrew - - 2011
We sought to determine whether prophylactic treatment with 17-alpha-hydroxyprogesterone caproate (17Pc) in twin pregnancy will reduce neonatal morbidity (primary outcome) by prolonging pregnancy (secondary outcome). This was a double-blind, randomized clinical trial. Mothers carrying dichorionic-diamniotic twins were randomly assigned (in a 2:1 ratio) to weekly injections of 250 mg of ...
Nomura Roseli Mieko Yamamoto - - 2011
To describe pregnancies with conjoined twins according to the request for legal termination of pregnancy. Retrospective review of pregnancies with conjoined twins, with no possibility of extrauterine survival or postnatal surgical separation, observed at a tertiary teaching hospital, between 1998 and 2010. Amongst 30 cases seen during the study period, ...
Gaudet Laura M - - 2011
Objective: Misclassification of body mass index (BMI) by pregnant women could be a significant barrier to minimizing weight-related adverse pregnancy outcomes and improving the short- and long-term health of mother and child. The primary objective in this study was to determine the proportion of a group of pregnant women who ...
Belfort Michael A - - 2011
Fetal electrocardiogram (ECG) ST segment analysis (STAN) was approved in 2005 in the United States as an adjunct to electronic fetal heart rate monitoring to determine whether obstetrical intervention is warranted when there is an increased risk for developing metabolic acidosis. STAN has utility in the reduction of fetal acidosis ...
van der Post Joris A M - - 2011
Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is unknown, placental factors released into the ...
Stout Molly J - - 2011
Electronic fetal monitoring (EFM) using cardiotocography is a common tool used during labor and delivery for assessment of fetal well-being. It has largely replaced the use of intermittent auscultation and fetal scalp pH sampling. However, data suggesting improved clinical outcomes with the use of EFM are sparse. In this review, ...
Jones Kenneth Lyons - - 2011
Prenatal exposure to alcohol has profound effects on many aspects of fetal development. Although alterations of somatic growth and specific minor malformations of facial structure are most characteristic, the effects of alcohol on brain development are most significant in that they lead to substantial problems with neurobehavioral development. Since the ...
Hutti Marianne H - - 2011
To evaluate the influence of previous perinatal loss, anxiety, depressive symptoms, impact of the previous loss, and maternal investment in the baby on mothers' healthcare utilization (HCU) during the subsequent pregnancy and postpartum periods. A longitudinal, cohort study design gathered telephone interview data from 36 mothers with a history of ...
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