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Ciborowski Michal M Clinical Research Centre, Medical University of Bialystok, - - 2014
Macrosomia and low birth weight (LBW) can be associated with pregnancy complications and may affect the long term health of the child. The aim of this study was to evaluate the metabolomic serum profiles of healthy pregnant women to identify early biomarkers of macrosomia and LBW, and to understand mechanisms ...
Goh William W aHawaii Permanente Medical Group, Honolulu, Hawaii bUniversity of Wisconsin School of Medicine, Madison, Wisconsin cJohn A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, - - 2014
With the increased use of ultrasonography in the first trimester, up to 1% of all pregnancies are diagnosed with an adnexal mass. Yet, the management of asymptomatic adnexal masses in pregnancy continues to be controversial as management guidelines are mainly based on case-control or observational studies. The purpose of this ...
Bahado-Singh Ray O RO Department of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Kings College Hospital, London, - - 2014
To identify metabolomic markers in maternal first-trimester serum for the detection of fetal congenital heart defects (CHD). Mass spectrometry (Direct Injection (DI)/LC-MS/MS) and nuclear magnetic resonance spectrometry (NMR) based metabolomic analyses were performed between 11 weeks and 13 weeks 6 days gestation on maternal serum. A total of 27 CHD ...
Zera Chloe A CA Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: - - 2014
As obesity is a risk factor for placental dysfunction, we hypothesized that maternal body mass index (BMI) would be associated with alterations in serum angiogenic markers. We included 2399 singleton pregnancies with and without placental dysfunction in a prospective longitudinal cohort study of angiogenic markers. We modeled the relationship between ...
Shanthi Vissa V Department of Pathology, Narayana Medical College, Nellore, ANDHRA PRADESH, - - 2014
Placental polyp is the retained fragment of placental tissue after the parturition or abortion for indefinite period which forms a polypoidal mass in the uterus. It is predominantly composed of necrotic and hyalinized chorionic villi (ghost chorionic villi). We report a case of 26-year-old G2P2 woman presenting with vaginal bleeding. ...
Rapino Cinzia C Faculty of Veterinary Medicine, University of Teramo, Teramo, - - 2014
BACKGROUNDInfertility is a condition of the reproductive system that affects ∼10-15% of couples attempting to conceive a baby. More than half of all cases of infertility are a result of female conditions, while the remaining cases can be attributed to male factors, or to a combination of both. The search ...
Scott Andrew R AR Department of Otolaryngology - Head & Neck Surgery and Facial Plastic Surgery, Floating Hospital for Children - Tufts Medical Center, Boston, MA, United States. Electronic address: - - 2014
To examine the spectrum of fetal head and neck anomalies that may prompt prenatal referral and to determine the frequency of these consultations. Case series with chart review. The billing databases of two urban pediatric otolaryngology practices were queried for ICD-9 codes corresponding to fetal anomalies between January 2010 and ...
Lu E E Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, - - 2014
We linked several population-based clinical and health administrative databases in British Columbia, Canada. We identified and compared birth outcomes of pregnancies fathered by men with multiple sclerosis (MS) (n=202) and men from a frequency-matched general population cohort (n=981) between 1996 and 2010. Using multivariate models, we analyzed the association of ...
Coyle Patricia K - - 2014
This article reviews the current understanding of the interactions between multiple sclerosis (MS) and pregnancy, and implications for reproductive counseling. This is a key topic in MS because the typical patient is a young woman of childbearing age. It has been known for some time that MS disease activity markedly ...
Sugiyama Takashi T Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980-8574, - - 2014
The aim of this study was to determine the effects of pre-gestational body mass index on pregnancy outcomes of women with gestational diabetes in Japan. A multi-institutional retrospective study was performed. We examined pregnant women who met the former criteria for gestational diabetes in Japan, receiving dietary intervention with self-monitoring ...
Forde Niamh N N Forde, School of Agriculture and Food Science, University College Dublin, Dublin, - - 2014
The aims of this study were: (i) to characterise the global changes in the composition of the uterine luminal fluid (ULF) from pregnant heifers during pregnancy recognition (Day 16) using nano-LC MS/MS; (ii) to describe quantitative changes in selected proteins in the ULF from Day 10, 13, 16 and 19 ...
Noguchi Daito D Departments of Obstetrics and Gynecology, Surgery, and Pathology, Fukaya Red Cross Hospital, Fukaya City, Saitama, and the Department of Obstetrics and Gynecology, Tatedebari Sato Hospital, Takasaki City, Gunma, - - 2014
A cyst of the canal of Nuck is a rare cause of inguinal swelling in adult women. Ectopic pregnancies that implant to rare regions are sometimes challenging to diagnose. A 45-year-old woman presented with painful swelling in her right groin with a positive urine pregnancy test. Ultrasonography, magnetic resonance imaging, ...
Harvey Nicholas C NC Medical Research Council Lifecourse Epidemiology Unit (N.C.H., R.J.M., A.A.S., G.N., S.M.R., K.M.G., H.M.I., C.C.), University of Southampton, Southampton SO16 6YD, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre (N.C.H., K.M.G., C.C.), University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom; Paediatric Endocrinology (R.J.M., J.H.D.), University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom; and National Institute for Health Research Musculoskeletal Biomedical Research Unit (M.K.J., C.C.), University of Oxford, Nuffield Orthopedic Centre, Headington, Oxford OX3 7HE, United - - 2014
Maternal 25-hydroxyvitamin D [25(OH)D] status in pregnancy has been associated with offspring bone development and adiposity. Vitamin D has also been implicated in postnatal muscle function, but little is known about a role for antenatal 25(OH)D exposure in programming muscle development. We investigated the associations between maternal plasma 25(OH)D status ...
Navaratnam Kate - - 2013
5% of the first time pregnancies are complicated by pre-eclampsia, the leading cause of maternal death in Europe. No clinically useful screening test exists; consequentially clinicians are unable to offer targeted surveillance or preventative strategies. IMPROvED Consortium members have pioneered a personalised medicine approach to identifying blood-borne biomarkers through recent ...
Low Hoi Pang - - 2013
Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this protective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and ...
Zheng Jianhua - - 2013
Progress in the fields of protein separation and identification technologies has accelerated research into biofluids proteomics for protein biomarker discovery. Urine has become an ideal and rich source of biomarkers in clinical proteomics. Here we performed a proteomic analysis of urine samples from pregnant and non-pregnant patients using gel electrophoresis ...
Liu Linda Y - - 2013
Preeclampsia (PE) is a pregnancy-related vascular disorder which is the leading cause of maternal morbidity and mortality. We sought to identify novel serological protein markers to diagnose PE with a multi-'omics' based discovery approach. Seven previous placental expression studies were combined for a multiplex analysis, and in parallel, two-dimensional gel ...
Karthikeyan G - - 2013
Citrullinemia type 1 was diagnosed by tandem mass spectrometry in a full term male neonate who presented with an acute catastrophic collapse on the 3rd day of life. Both parents were identified to be carriers for the exon 15 p Gly390Arg mutation in the argininosuccinate synthetase gene located at chromosome ...
Angelico Roberta - - 2013
Adrenal pseudocysts are rare cystic masses usually nonfunctional and asymptomatic, discovered incidentally during diagnostic imaging or when complicated by rupture and hemorrhage or infection. Few cases of hemorrhagic adrenal pseudocyst during pregnancy are reported, but a causal relationship between pregnancy and pseudocyst formation has not been shown. We describe a ...
Zhu Yong - - 2013
To identify biochemical markers in men with idiopathic infertility and normal sperm counts. We obtained proteomic profiling proteins in human spermatozoa following successful or unsuccessful pregnancy via assisted reproductive technology (ART) using 6-plex tandem mass tag (TMT) isobaric mass spectrometry. Our study design consisted of two groups: 1. The semen ...
Jäntti Sirkku E - - 2013
An ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-MS/MS) method was developed for the analysis of steroids and their glucuronides in urine samples. The method provides high sensitivity and fast analysis, as both steroids and their glucuronides can be analyzed directly without hydrolysis or complex sample preparation. The method was ...
Janda Gregory M - - 2013
Intra-abdominal prenatally detected testicular neoplasms are rare; however, increased use of prenatal ultrasonography has led to the discovery of these uncommon neoplasms. We report the fifth case of a prenatally detected intra-abdominal testicular teratoma, which, in this instance, was detected early in pregnancy as a cystic mass within the fetal ...
Scheib Stacey A - - 2013
The incidence of adnexal masses in pregnancy is estimated to be 1% to 4%. In select cases, surgical intervention is required. Recent studies have demonstrated that laparoscopy during pregnancy is safe and confers many advantages over laparotomy. Herein we present a series of nine cases collected prospectively that demonstrate the ...
Malek-Mellouli Monia - - 2013
Background: The diagnosis of an adnexal mass associated with pregnancy is increasingly common with the routine use of ultrasound during prenatal care. aim: To assess the feasibility, advantages and limiting factors of laparoscopy in the management of ovarian masses during pregnancy. methods: Rretrospective study of a series of 34 pregnant ...
Ijäs Hilkka - - 2013
Gestational diabetes mellitus (GDM) is associated with an increased risk of subsequent diabetes and metabolic syndrome (MS). The independent significance of overweight, often associated with GDM, is controversial. This study aimed to investigate the prevalence of MS and carotid intima-media thickness (CIMT) values in normal and overweight women with previous ...
McNally Leah - - 2013
Degenerating myomas are common explanations for pain associated with abdominal masses in pregnancy. However, masses arising from other pelvic organs should be included in the differential diagnosis. We present a case of an abdominal mass in pregnancy that was originally misdiagnosed as a uterine leiomyoma. Attention to the patient's history ...
Blankley Richard T - - 2013
Pre-eclampsia (PE) is a serious complication of pregnancy with potentially life threatening consequences for both mother and baby. Presently there is no test with the required performance to predict which healthy first-time mothers will go on to develop PE. The high specificity, sensitivity and multiplexed nature of selected reaction monitoring ...
Vanya Melinda - - 2013
Abstract Objective: The aim of this study was to investigate the connections between MS and fertility, pregnancy. Methods: The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas ...
Jauniaux E - - 2013
To study the effect of maternal smoking on 2D ultrasound measurements and maternal serum (MS) levels of endocrinologic markers of placentation. Prospective population-based cohort study of 32 smokers and 96 non-smoking controls with a normal pregnancy outcome. Placental thickness and 2D-volume and MS levels of pregnancy-associated plasma protein A (PAPP-A) ...
Petla Lakshmi Tanuja - - 2013
Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in ...
Ugboma Ew - - 2013
The spleen is affected by the changes that occur in pregnancy. Ultrasound is the commonest imaging modality used in the evaluation of the abdominal organs in pregnancy; however, there is a paucity of information on the sonographic measurement of the splenic length in normal pregnancy in our environment. To establish ...
Kløverpris S - - 2013
Pregnancy-associated plasma protein-A (PAPP-A) and PAPP-A2, two homologous metzincin metalloproteases, are both tightly linked to regulation within the insulin-like growth factor (IGF) system because of their specific cleavage of IGF binding proteins. Recent studies suggest that PAPP-A may be involved in clinical conditions related to unwanted cellular growth, and the ...
Lopez Jonathan - - 2013
OBJECTIVE: Neural tube defects (NTDs) are usually identified by ultrasonography and confirmed by AFP assay and AchE electrophoresis in amniotic fluid. Yet, both of these biomarkers can be found positive in other etiologies. Here, AF-GFAP (Amniotic-Fluid- Glial Fibrillary Acidic Protein), which was identified by a proteomic study, is shown to ...
Suri S - - 2013
OBJECTIVES: To study the relationships between 2D ultrasound measurements of placentation and maternal serum (MS) levels of PAPP-A, inhibin A and fβhCG in early pregnancy and subsequent fetal growth in pregnancies with a normal and abnormal outcome. STUDY DESIGN: Prospective population-based cohort study of 301 pregnancies with a normal outcome, ...
Houtchens Maria - - 2013
Multiple sclerosis (MS) is a chronic neurological illness affecting adults at the time when they are most likely to consider starting a family. It is known that the risk of MS relapse declines during pregnancy but increases in the first 3 to 6 months postpartum. It is also known that ...
Anderson Joanna - - 2013
Although at any time in the UK there are about 20,000 women with multiple sclerosis (MS) who may be considering having children, very little is known about their experiences or about those who have had children after the onset of disease. Using semi structured interviews, we explored the childbearing experiences ...
Kaplan Megan C - - 2013
The purpose of this series is to describe the grayscale and color Doppler sonographic characteristics as well as the histopathologic features of rare solid posterior neck masses identified on prenatal sonography in pregnant patients. We conducted a retrospective review of detailed fetal sonographic examinations of second- and third-trimester pregnancies referred ...
Polsani Srujana - - 2013
Preeclampsia continues to plague some of the most vulnerable women and fetuses. It is surprisingly prevalent in developing and developed nations. According to the World Health Organization, hypertension during pregnancy is a leading cause of maternal mortality in industrialized countries at 16% and up to 25% in developing countries. As ...
Lim Soyi S Department of Obstetrics and Gynecology, Gil Medical School, Gachon University of Medicine and Science, Incheon, - - 2013
Placenta accreta during the first trimester of pregnancy is rare. Only a few cases of placenta accreta manifesting as a uterine mass have been published. Most patients with placenta accreta present with vaginal bleeding during or after pregnancy. This report describes a patient with placenta accreta that caused vaginal bleeding ...
Kamath-Rayne Beena D - - 2013
Our aim was to review the use of high-dimensional biology techniques, specifically transcriptomics, proteomics, and metabolomics, in amniotic fluid to elucidate the mechanisms behind preterm birth or assessment of fetal development. We performed a comprehensive MEDLINE literature search on the use of transcriptomic, proteomic, and metabolomic technologies for amniotic fluid ...
Turco Edson Guimaraes Lo - - 2013
Endometriosis is a gynecological disease that affects women of reproductive age. The protein profiles of women with endometriosis who were able or unable to achieve pregnancy and women without endometriosis who did achieve pregnancy were compared in this study. The follicular fluid was collected from 21 patients undergoing in vitro-fertilization ...
Fayemi Peter Olutope - - 2013
The objective of the present study was to determine the pregnancy status of Dohne Merino ewes at slaughter. This was done by collecting blood samples from the ewes (n = 60) during exsanguination to assay for pregnancy biomarkers using radio-immunological and TaqMan reverse transcription polymerase chain reaction techniques. The expressions of ovine ...
Patas Konstantinos - - 2013
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system of presumed autoimmune origin. Intriguingly, pregnancy in female MS patients is associated with a substantial decrease in relapse rate. However, post-partum the relapse rate increases in a rebounding fashion above the rate seen before pregnancy. Wide gaps ...
Jelliffe-Pawlowski Laura L - - 2013
OBJECTIVE: To examine the relationship between typically measured prenatal screening biomarkers and early preterm birth in euploid pregnancies. STUDY DESIGN: Included were 345 early preterm cases (< 30 weeks) and 1,725 controls drawn from a population-based sample of California pregnancies that all had both first and second trimester screening results. ...
Zhao Zhen - - 2013
Discovery of circulating miRNAs in maternal blood has not only facilitated the understanding of their role in normal pregnancy, but also paved new avenues for biomarker discovery to detect pregnancy-associated complications, such as preeclampsia, ectopic pregnancy, gestational diabetes mellitus, fetal growth restriction, recurrent pregnancy loss, and preterm delivery. In this ...
Langer-Gould Annette - - 2013
Multiple sclerosis (MS) commonly affects young women of childbearing age. Thus, the challenges of the disease are often faced simultaneously with the challenges of early adult life and family planning. This has led to great interest in the effects of pregnancy and breastfeeding on MS. It is now well known ...
Sweeney Ms Eva M - - 2013
OBJECTIVE(S): Knowledge of the stereology of human myometrium in pregnancy is limited. Uterine contractile performance may be altered in association with maternal obesity and advanced maternal age. The aim of this study was to investigate the stereology of human myometrium in pregnancy, and to evaluate a potential influence of maternal ...
Sreckovic Ivana - - 2013
In human high-density lipoprotein (HDL) represents the major cholesterol carrying lipoprotein class in cord blood, while cholesterol is mainly carried by low-density lipoprotein in maternal serum. Additionally, to carrying cholesterol, HDL also associates with a range of proteins as cargo. We tested the hypothesis that fetal HDL carries proteins qualitatively ...
Josefson J L - - 2013
BACKGROUND: More than 40% of women with a normal pre-pregnancy body mass index (BMI) exceed the 2009 Institute of Medicine (IOM) guidelines' recommended weight gain of 25-35 lb. Excessive gestational weight gain is one modifiable factor that may be contributing to childhood overweight and obesity. OBJECTIVE: The objective of this study ...
Senapati Suneeta S Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, - - 2013
Early pregnancy failure is the most common complication of pregnancy, and 1% to 2% of all pregnancies will be ectopic. As one of the leading causes of maternal morbidity and mortality, diagnosing ectopic pregnancy and determining the fate of a pregnancy of unknown location are of great clinical concern. Several ...
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