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Cohen Rana R Motherisk Israel, Unit of Clinical Pharmacology, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Ondansetron use for nausea and vomiting during pregnancy has increased in the last years, although its maternal and fetal safety is not conclusive. We describe a case of intestinal obstruction in a pregnant woman with severe nausea and vomiting of pregnancy treated with ondansetron, which is known to slow gut ...
de Seymour Jamie V JV Liggins Institute, The University of Auckland, Building 505, 85 Park Road, Grafton, Auckland, New Zealand, - - 2014
Current early pregnancy screening tools to identify women at risk of developing gestational diabetes mellitus lack both specificity and sensitivity. As a result, the foetus and mother are often subjected to insult during disease progression, prior to diagnosis and treatment in later pregnancy. Metabolomics is an analytical approach, which allows ...
Surampudi Kameswari K Department of Gynaecology, Fernandez Hospital, Fernandez Hospital Unit 1, 4-1-1230, Bogulkunta, Hyderabad, Andhra Pradesh, 500001, - - 2014
Adnexal masses in pregnancy are often incidentally detected during sonography and most resolve spontaneously by early second trimester. This study aimed to look at the prevalence and management of adnexal masses in pregnancy at a tertiary care referral perinatal hospital. This is a retrospective study of all women with adnexal ...
Harrod Curtis S CS Department of Epidemiology, Colorado School of Public Health, Aurora, - - 2014
To examine the dose-dependent and time-specific relationships of prenatal smoking with neonatal body mass, fat mass (FM), fat-free mass (FFM), and FM-to-FFM ratio, as measured by air-displacement plethysmography (PEA POD system). We analyzed 916 mother-neonate pairs participating in the longitudinal prebirth cohort Healthy Start study. Maternal prenatal smoking information was ...
Dietrich Jennifer E JE Division of Pediatric and Adolescent Gynecology, Department of OBGYN, Baylor College of Medicine, Houston, - - 2014
The nonobstructive group of anatomic variants involving the reproductive tract includes vaginal agenesis as well as the congenital anomalies of the vagina and uterus, occurring without pain during the pubertal years. The objective is to discuss the non-obstructive morphologic variations in anatomy of the uterus and vagina. Systematic review using ...
Matson B C BC Departments of Cell Biology & Physiology, University of North Carolina at Chapel Hill, NC 27599, USA. Electronic address: - - 2014
Levels of the peptide hormone adrenomedullin (AM) are elevated during normal pregnancy, but whether this differs during complications of pregnancy remains unresolved. AM can be quantified by measuring its pre-prohormone byproduct, midregional pro-adrenomedullin (MR-proADM). MR-proADM has shown prognostic value as a biomarker of heart failure, sepsis, and community-acquired pneumonia. Given ...
Bondt Albert A Erasmus University Medical Center, - - 2014
The N-linked glycosylation of the constant fragment (Fc) of Immunoglobulin G has been shown to change during pathological and physiological events and to strongly influence antibody inflammatory properties. In contrast, little is known about Fab-linked N-glycosylation carried by approximately 20% of IgG. Here we present a high-throughput workflow to analyze ...
Shore Eliane M EM Departments of Obstetrics and Gynaecology, Laboratory Medicine, and Medical Imaging, St. Michael's Hospital, and the Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, - - 2014
Uterine lymphangiomas are rare benign tumors of the lymphatic system that are commonly congenital. A 36-year-old woman was diagnosed with an asymptomatic cystic mass of unclear etiology before pregnancy. It was thought to be an adnexal mass and managed conservatively during the antepartum period with ultrasonography and magnetic resonance imaging. ...
Gürsoy Mervi M 1 Department of Periodontology, Institute of Dentistry, University of Turku , Turku, Finland - - 2014
Abstract Pregnancy-associated gingivitis is a bacterial-induced inflammatory disease with a remarkably high prevalence ranging from 35% to 100% across studies. Yet little is known about the attendant mechanisms or diagnostic biomarkers that can help predict individual susceptibility for rational personalized medicine. We aimed to define inflammatory proteins in saliva, induced ...
Luna Russo Miguel A MA From the Department of Obstetrics and Gynecology, Divisions of Maternal-Fetal Medicine and Gynecologic Oncology, The Winfred L. Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS 39211, - - 2014
Abstract Choriocarcinoma in the second trimester with a normal appearing live fetus is rare. A primigravida presented at 24 weeks gestation with 5 days of worsening dyspnea and multiple widespread small lung nodules. Pelvic ultrasound revealed a normal intrauterine live singleton fetus with an extrauterine mass. Gestational hypertension progressed to ...
Okubo Hitomi H From the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom (HO, SRC, NCH, KMG, HMI, CC, and SMR); the Department of Social and Preventive Epidemiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (HO); the National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom (NCH, KMG, SMR, and CC); and the NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Nuffield Orthopedic Centre, Oxford, United Kingdom - - 2014
Maternal hyperglycemia in pregnancy is associated with greater adiposity in offspring. The glycemic index (GI) and glycemic load (GL) describe the glycemic response to carbohydrate ingestion. However, the influence of maternal dietary GI and GL in pregnancy on childhood adiposity is unknown.OBJECTIVE: We examined relations of maternal dietary GI and ...
Pasternak Monica C MC Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA. Electronic address: - - 2014
The urachus is a remnant of the urogenital sinus and allantois, which persists after antenatal involution. Despite its rudimentary postnatal presence, it can undergo metaplasia and tumor formation. Malignant transformation of the urachus is rare. However, these tumors can recur and develop pseudomyxoma peritonei. Thus, they should remain on the ...
Trivedi Drupad K DK Eric Leonard Kruse Foundation for Health Research, UK; Biomedical Sciences, Middlesex University, Hendon, NW4 4BT, UK; Manchester Institute of Biotechnology and School of Chemistry, University of Manchester, M1 7DN, - - 2014
In this data-rich age it is no longer necessary to methodically isolate, characterize and measure specific molecules. What is important is to identify which of the hundreds or thousands of resolved and measured 'unknown' molecules are potentially associated with the pathophysiology of interest. We have taken LC-MS data from pregnancy ...
Santana Eduardo Felix Martins EF Department of Obstetrics, Federal University of São Paulo (UNIFESP), São Paulo-SP, Brazil. - - 2014
A 20-year-old nulliparous woman was referred due a cervical mass in the fetus in an ultrasound examination performed in the 25th week of pregnancy. The exam revealed an irregular, solid-cystic heterogeneous mass measuring 75x54 mm that came to the exterior through the mouth of the fetus. Three-dimensional ultrasound and magnetic ...
Goyal Prashant P Department of Pathology, Swami Dayanand Hospital , Dilshad Garden, Delhi, - - 2014
Aggressive angiomyxoma (AA) is a rare, slow-growing mesenchymal neoplasm of vulvo-perineal region. Although AA is common in females of reproductive age, only a few cases during pregnancy have been documented in the English literature. It carries a high risk of local recurrence but rarely metastasizes. The high recurrence rate can ...
Gholson Ryan R University of Oklahoma Tulsa, Tulsa, - - 2014
Adnexal mass in pregnancy is a common finding with now routine ultrasound use. Incidence of adnexal mass=1-2% with malignancy complicating is reported in 2-3% of cases. We sought to determine if the size of persistent adnexal mass can be used as a predictor of patients requiring surgical intervention. We performed ...
Zhu Lei L Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, P.R. - - 2014
Preeclampsia (PE) is considered to be a potentially fatal complication during pregnancy. However, no effective laboratory assessment has been developed to enable early diagnosis and monitoring of PE. The present study aimed to identify differentially expressed transthyretin (TTR) during severe PE and evaluate TTR as a possible biomarker of this ...
Azpiazu Rubén R Human Genetics Research Group, IDIBAPS, Faculty of Medicine, University of Barcelona, Casanova 143, Barcelona 08036, - - 2014
Are there quantitative alterations in the proteome of normozoospermic sperm samples that are able to complete IVF but whose female partner does not achieve pregnancy? Normozoospermic sperm samples with different IVF outcomes (pregnancy versus no pregnancy) differed in the levels of at least 66 proteins. The analysis of the proteome ...
Yamamoto Eiko E Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, - - 2014
•Gestational trophoblastic neoplasia can arise during the first trimester originating from trophoblasts of concurrent pregnancy.•Intraplacental choriocarcinoma can be developed from trophoblasts of a previous pregnancy.
Ciborowski Michal M Clinical Research Centre, Medical University of Bialystok, - - 2014
Macrosomia and low birth weight (LBW) can be associated with pregnancy complications and may affect the long term health of the child. The aim of this study was to evaluate the metabolomic serum profiles of healthy pregnant women to identify early biomarkers of macrosomia and LBW, and to understand mechanisms ...
Goh William W aHawaii Permanente Medical Group, Honolulu, Hawaii bUniversity of Wisconsin School of Medicine, Madison, Wisconsin cJohn A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, - - 2014
With the increased use of ultrasonography in the first trimester, up to 1% of all pregnancies are diagnosed with an adnexal mass. Yet, the management of asymptomatic adnexal masses in pregnancy continues to be controversial as management guidelines are mainly based on case-control or observational studies. The purpose of this ...
Bahado-Singh Ray O RO Department of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Kings College Hospital, London, - - 2014
To identify metabolomic markers in maternal first-trimester serum for the detection of fetal congenital heart defects (CHD). Mass spectrometry (Direct Injection (DI)/LC-MS/MS) and nuclear magnetic resonance spectrometry (NMR) based metabolomic analyses were performed between 11 weeks and 13 weeks 6 days gestation on maternal serum. A total of 27 CHD ...
Swiatecka Jolanta - - 2014
IVF-ICSI procedures are accompanied by a continuous search for predictors of ART outcome. The properties of zona pellucida (ZP) have been believed to reflect the history of oocyte cytoplasmic maturation. The meiotic spindle (MS) is crucial for chromosomal alignment and proper separation of the maternal chromosomes. There is data suggesting ...
Karippaliyil Balakumar B Department of Ultrasonography, Balku's Scan Centre, PVS Hospital, Calicut 2, Kerala, - - 2014
Second trimester fetal ultrasonography (USG) occasionally reveals an echogenic intragastric mass. These masses are usually small due to the organized debris from swallowed amniotic fluid, and they normally disappear in the third trimester. This report shows a fetal intragastric echogenic mass detected at 30 weeks of gestation that persisted as ...
Zera Chloe A CA Division of Maternal-Fetal Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: - - 2014
As obesity is a risk factor for placental dysfunction, we hypothesized that maternal body mass index (BMI) would be associated with alterations in serum angiogenic markers. We included 2399 singleton pregnancies with and without placental dysfunction in a prospective longitudinal cohort study of angiogenic markers. We modeled the relationship between ...
Shanthi Vissa V Department of Pathology, Narayana Medical College, Nellore, ANDHRA PRADESH, - - 2014
Placental polyp is the retained fragment of placental tissue after the parturition or abortion for indefinite period which forms a polypoidal mass in the uterus. It is predominantly composed of necrotic and hyalinized chorionic villi (ghost chorionic villi). We report a case of 26-year-old G2P2 woman presenting with vaginal bleeding. ...
Smid Marcela C MC Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina at Chapel Hill School of Medicine , NC, USA ; Department of Obstetrics and Gynecology, Chicago Lying in Hospital, University of Chicago Medicine , IL, - - 2014
Actinomyces israelii is a gram-positive, filamentous anaerobic bacteria colonizing the oral and gastrointestinal tracts. Retroperitoneal actinomycotic abscess is uncommon and its rare presentation as a hemorrhagic mass may be confused with malignancy. We present a case of this unusual infection complicating pregnancy. Increased awareness of actinomycotic abscess in the differential ...
Rapino Cinzia C Faculty of Veterinary Medicine, University of Teramo, Teramo, - - 2014
BACKGROUNDInfertility is a condition of the reproductive system that affects ∼10-15% of couples attempting to conceive a baby. More than half of all cases of infertility are a result of female conditions, while the remaining cases can be attributed to male factors, or to a combination of both. The search ...
Scott Andrew R AR Department of Otolaryngology - Head & Neck Surgery and Facial Plastic Surgery, Floating Hospital for Children - Tufts Medical Center, Boston, MA, United States. Electronic address: - - 2014
To examine the spectrum of fetal head and neck anomalies that may prompt prenatal referral and to determine the frequency of these consultations. Case series with chart review. The billing databases of two urban pediatric otolaryngology practices were queried for ICD-9 codes corresponding to fetal anomalies between January 2010 and ...
Lu E E Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, - - 2014
We linked several population-based clinical and health administrative databases in British Columbia, Canada. We identified and compared birth outcomes of pregnancies fathered by men with multiple sclerosis (MS) (n=202) and men from a frequency-matched general population cohort (n=981) between 1996 and 2010. Using multivariate models, we analyzed the association of ...
Coyle Patricia K - - 2014
This article reviews the current understanding of the interactions between multiple sclerosis (MS) and pregnancy, and implications for reproductive counseling. This is a key topic in MS because the typical patient is a young woman of childbearing age. It has been known for some time that MS disease activity markedly ...
Mikołajczyk Mateusz - - 2014
Infertility remains a challenge to modern medicine. Despite extensive diagnostic and therapeutic procedures, the achievement of pregnancy remains an elusive goal in some patients. The endometrium is one of the key factors in embryo implantation. Older methods of describing endometrial receptivity like histology or ultrasound, did not bring noticeable improvement ...
Sugiyama Takashi T Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980-8574, - - 2014
The aim of this study was to determine the effects of pre-gestational body mass index on pregnancy outcomes of women with gestational diabetes in Japan. A multi-institutional retrospective study was performed. We examined pregnant women who met the former criteria for gestational diabetes in Japan, receiving dietary intervention with self-monitoring ...
Forde Niamh N N Forde, School of Agriculture and Food Science, University College Dublin, Dublin, - - 2014
The aims of this study were: (i) to characterise the global changes in the composition of the uterine luminal fluid (ULF) from pregnant heifers during pregnancy recognition (Day 16) using nano-LC MS/MS; (ii) to describe quantitative changes in selected proteins in the ULF from Day 10, 13, 16 and 19 ...
Noguchi Daito D Departments of Obstetrics and Gynecology, Surgery, and Pathology, Fukaya Red Cross Hospital, Fukaya City, Saitama, and the Department of Obstetrics and Gynecology, Tatedebari Sato Hospital, Takasaki City, Gunma, - - 2014
A cyst of the canal of Nuck is a rare cause of inguinal swelling in adult women. Ectopic pregnancies that implant to rare regions are sometimes challenging to diagnose. A 45-year-old woman presented with painful swelling in her right groin with a positive urine pregnancy test. Ultrasonography, magnetic resonance imaging, ...
Ni Xiaobei X State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China ; Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, - - 2014
Many pregnant women suffer miscarriages during early gestation, but the description of these early pregnancy losses (EPL) can be somewhat confusing because of the complexities of early development. Thus, the identification of proteins with different expression profiles related to early pregnancy loss is essential for understanding the comprehensive pathophysiological mechanism. ...
Baña A A Servicio de Neonatología, Departamento de Pediatria, Hospital Clínico Universitario de Santiago, Santiago de Compostela, - - 2014
Alcohol consumption during pregnancy, even when moderate, implies a risk of impaired neurodevelopment, physical impairments and malformations. Its early identification is essential for establishing preventive measures to diminish disabilities among newborns. To determine the frequency of consumption of substance use in pregnant women, we have used the techniques of gas ...
Wundes Annette A 0000-0001-8633-6848 Department of Neurology, Multiple Sclerosis Center, University of Washington, McMurry Building, 1536 N. 115th Street, Seattle, WA 98113, - - 2014
Pregnancy in multiple sclerosis (MS) is considered safe for both the woman and the child. Nevertheless, pregnancy issues in MS are complex both from a patient's and a provider's perspective. In an anonymous survey, 28 healthcare providers in the United States reported on the management of multiple sclerosis (MS) during ...
Red-Horse Kristy K Department of Biological Sciences, Stanford University, Stanford, CA, - - 2014
Susan Fisher has spent her career studying human development, proteomics, and the intersection between the two. When she began studying human placentation, there had been extensive descriptive studies of this fascinating organ that intertwines with the mother’s vasculature during pregnancy. Susan can be credited with numerous major findings on the ...
Iles Ray K RK Williamson Laboratory for Molecular Oncology, St Bartholomews Hospital, London EC1A 7BE, UK. - - 2014
The analysis of human chorionic gonadotropin (hCG) in clinical chemistry laboratories by specific immunoassay is well established. However, changes in glycosylation are not as easily assayed and yet alterations in hCG glycosylation is associated with abnormal pregnancy. hCGβ-core fragment (hCGβcf) was isolated from the urine of women, pregnant with normal, ...
Drakopoulos P P Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, - - 2014
A 34-year-old woman without any medical history presented to our hospital emergency unit with a history of 4 days of progressively increasing pain in the left iliac fossa, fever and vaginal bleeding for the past 3 weeks. Urine pregnancy test and serum bhCG were negative. CT scan showed a left pelvic mass ...
Harvey Nicholas C NC Medical Research Council Lifecourse Epidemiology Unit (N.C.H., R.J.M., A.A.S., G.N., S.M.R., K.M.G., H.M.I., C.C.), University of Southampton, Southampton SO16 6YD, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre (N.C.H., K.M.G., C.C.), University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom; Paediatric Endocrinology (R.J.M., J.H.D.), University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom; and National Institute for Health Research Musculoskeletal Biomedical Research Unit (M.K.J., C.C.), University of Oxford, Nuffield Orthopedic Centre, Headington, Oxford OX3 7HE, United - - 2014
Maternal 25-hydroxyvitamin D [25(OH)D] status in pregnancy has been associated with offspring bone development and adiposity. Vitamin D has also been implicated in postnatal muscle function, but little is known about a role for antenatal 25(OH)D exposure in programming muscle development. We investigated the associations between maternal plasma 25(OH)D status ...
Navaratnam Kate - - 2013
5% of the first time pregnancies are complicated by pre-eclampsia, the leading cause of maternal death in Europe. No clinically useful screening test exists; consequentially clinicians are unable to offer targeted surveillance or preventative strategies. IMPROvED Consortium members have pioneered a personalised medicine approach to identifying blood-borne biomarkers through recent ...
Low Hoi Pang - - 2013
Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this protective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and ...
Zheng Jianhua - - 2013
Progress in the fields of protein separation and identification technologies has accelerated research into biofluids proteomics for protein biomarker discovery. Urine has become an ideal and rich source of biomarkers in clinical proteomics. Here we performed a proteomic analysis of urine samples from pregnant and non-pregnant patients using gel electrophoresis ...
Karthikeyan G - - 2013
Citrullinemia type 1 was diagnosed by tandem mass spectrometry in a full term male neonate who presented with an acute catastrophic collapse on the 3rd day of life. Both parents were identified to be carriers for the exon 15 p Gly390Arg mutation in the argininosuccinate synthetase gene located at chromosome ...
Angelico Roberta - - 2013
Adrenal pseudocysts are rare cystic masses usually nonfunctional and asymptomatic, discovered incidentally during diagnostic imaging or when complicated by rupture and hemorrhage or infection. Few cases of hemorrhagic adrenal pseudocyst during pregnancy are reported, but a causal relationship between pregnancy and pseudocyst formation has not been shown. We describe a ...
Zhu Yong - - 2013
To identify biochemical markers in men with idiopathic infertility and normal sperm counts. We obtained proteomic profiling proteins in human spermatozoa following successful or unsuccessful pregnancy via assisted reproductive technology (ART) using 6-plex tandem mass tag (TMT) isobaric mass spectrometry. Our study design consisted of two groups: 1. The semen ...
Jäntti Sirkku E - - 2013
An ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-MS/MS) method was developed for the analysis of steroids and their glucuronides in urine samples. The method provides high sensitivity and fast analysis, as both steroids and their glucuronides can be analyzed directly without hydrolysis or complex sample preparation. The method was ...
Janda Gregory M - - 2013
Intra-abdominal prenatally detected testicular neoplasms are rare; however, increased use of prenatal ultrasonography has led to the discovery of these uncommon neoplasms. We report the fifth case of a prenatally detected intra-abdominal testicular teratoma, which, in this instance, was detected early in pregnancy as a cystic mass within the fetal ...
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