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Ijäs Hilkka - - 2013
Gestational diabetes mellitus (GDM) is associated with an increased risk of subsequent diabetes and metabolic syndrome (MS). The independent significance of overweight, often associated with GDM, is controversial. This study aimed to investigate the prevalence of MS and carotid intima-media thickness (CIMT) values in normal and overweight women with previous ...
McNally Leah - - 2013
Degenerating myomas are common explanations for pain associated with abdominal masses in pregnancy. However, masses arising from other pelvic organs should be included in the differential diagnosis. We present a case of an abdominal mass in pregnancy that was originally misdiagnosed as a uterine leiomyoma. Attention to the patient's history ...
Blankley Richard T RT Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United - - 2013
Pre-eclampsia (PE) is a serious complication of pregnancy with potentially life threatening consequences for both mother and baby. Presently there is no test with the required performance to predict which healthy first-time mothers will go on to develop PE. The high specificity, sensitivity, and multiplexed nature of selected reaction monitoring ...
Vanya Melinda - - 2013
Abstract Objective: The aim of this study was to investigate the connections between MS and fertility, pregnancy. Methods: The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas ...
Jauniaux E - - 2013
To study the effect of maternal smoking on 2D ultrasound measurements and maternal serum (MS) levels of endocrinologic markers of placentation. Prospective population-based cohort study of 32 smokers and 96 non-smoking controls with a normal pregnancy outcome. Placental thickness and 2D-volume and MS levels of pregnancy-associated plasma protein A (PAPP-A) ...
Petla Lakshmi Tanuja - - 2013
Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in ...
Ugboma Ew - - 2013
The spleen is affected by the changes that occur in pregnancy. Ultrasound is the commonest imaging modality used in the evaluation of the abdominal organs in pregnancy; however, there is a paucity of information on the sonographic measurement of the splenic length in normal pregnancy in our environment. To establish ...
Kløverpris S - - 2013
Pregnancy-associated plasma protein-A (PAPP-A) and PAPP-A2, two homologous metzincin metalloproteases, are both tightly linked to regulation within the insulin-like growth factor (IGF) system because of their specific cleavage of IGF binding proteins. Recent studies suggest that PAPP-A may be involved in clinical conditions related to unwanted cellular growth, and the ...
Lopez Jonathan - - 2013
OBJECTIVE: Neural tube defects (NTDs) are usually identified by ultrasonography and confirmed by AFP assay and AchE electrophoresis in amniotic fluid. Yet, both of these biomarkers can be found positive in other etiologies. Here, AF-GFAP (Amniotic-Fluid- Glial Fibrillary Acidic Protein), which was identified by a proteomic study, is shown to ...
Suri S - - 2013
OBJECTIVES: To study the relationships between 2D ultrasound measurements of placentation and maternal serum (MS) levels of PAPP-A, inhibin A and fβhCG in early pregnancy and subsequent fetal growth in pregnancies with a normal and abnormal outcome. STUDY DESIGN: Prospective population-based cohort study of 301 pregnancies with a normal outcome, ...
Houtchens Maria - - 2013
Multiple sclerosis (MS) is a chronic neurological illness affecting adults at the time when they are most likely to consider starting a family. It is known that the risk of MS relapse declines during pregnancy but increases in the first 3 to 6 months postpartum. It is also known that ...
Anderson Joanna - - 2013
Although at any time in the UK there are about 20,000 women with multiple sclerosis (MS) who may be considering having children, very little is known about their experiences or about those who have had children after the onset of disease. Using semi structured interviews, we explored the childbearing experiences ...
Kaplan Megan C - - 2013
The purpose of this series is to describe the grayscale and color Doppler sonographic characteristics as well as the histopathologic features of rare solid posterior neck masses identified on prenatal sonography in pregnant patients. We conducted a retrospective review of detailed fetal sonographic examinations of second- and third-trimester pregnancies referred ...
Polsani Srujana - - 2013
Preeclampsia continues to plague some of the most vulnerable women and fetuses. It is surprisingly prevalent in developing and developed nations. According to the World Health Organization, hypertension during pregnancy is a leading cause of maternal mortality in industrialized countries at 16% and up to 25% in developing countries. As ...
Lim Soyi S Department of Obstetrics and Gynecology, Gil Medical School, Gachon University of Medicine and Science, Incheon, - - 2013
Placenta accreta during the first trimester of pregnancy is rare. Only a few cases of placenta accreta manifesting as a uterine mass have been published. Most patients with placenta accreta present with vaginal bleeding during or after pregnancy. This report describes a patient with placenta accreta that caused vaginal bleeding ...
Kamath-Rayne Beena D - - 2013
Our aim was to review the use of high-dimensional biology techniques, specifically transcriptomics, proteomics, and metabolomics, in amniotic fluid to elucidate the mechanisms behind preterm birth or assessment of fetal development. We performed a comprehensive MEDLINE literature search on the use of transcriptomic, proteomic, and metabolomic technologies for amniotic fluid ...
Turco Edson Guimaraes Lo - - 2013
Endometriosis is a gynecological disease that affects women of reproductive age. The protein profiles of women with endometriosis who were able or unable to achieve pregnancy and women without endometriosis who did achieve pregnancy were compared in this study. The follicular fluid was collected from 21 patients undergoing in vitro-fertilization ...
Fayemi Peter Olutope - - 2013
The objective of the present study was to determine the pregnancy status of Dohne Merino ewes at slaughter. This was done by collecting blood samples from the ewes (n = 60) during exsanguination to assay for pregnancy biomarkers using radio-immunological and TaqMan reverse transcription polymerase chain reaction techniques. The expressions of ovine ...
Patas Konstantinos - - 2013
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system of presumed autoimmune origin. Intriguingly, pregnancy in female MS patients is associated with a substantial decrease in relapse rate. However, post-partum the relapse rate increases in a rebounding fashion above the rate seen before pregnancy. Wide gaps ...
Jelliffe-Pawlowski Laura L LL Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA. - - 2013
The purpose of this study was to examine the relationship between typically measured prenatal screening biomarkers and early-preterm birth in euploid pregnancies. The study included 345 early-preterm cases (<30 weeks of gestation) and 1725 control subjects who were drawn from a population-based sample of California pregnancies who had both first- ...
Zhao Zhen - - 2013
Discovery of circulating miRNAs in maternal blood has not only facilitated the understanding of their role in normal pregnancy, but also paved new avenues for biomarker discovery to detect pregnancy-associated complications, such as preeclampsia, ectopic pregnancy, gestational diabetes mellitus, fetal growth restriction, recurrent pregnancy loss, and preterm delivery. In this ...
Langer-Gould Annette - - 2013
Multiple sclerosis (MS) commonly affects young women of childbearing age. Thus, the challenges of the disease are often faced simultaneously with the challenges of early adult life and family planning. This has led to great interest in the effects of pregnancy and breastfeeding on MS. It is now well known ...
Sweeney Ms Eva M - - 2013
OBJECTIVE(S): Knowledge of the stereology of human myometrium in pregnancy is limited. Uterine contractile performance may be altered in association with maternal obesity and advanced maternal age. The aim of this study was to investigate the stereology of human myometrium in pregnancy, and to evaluate a potential influence of maternal ...
Sreckovic Ivana - - 2013
In human high-density lipoprotein (HDL) represents the major cholesterol carrying lipoprotein class in cord blood, while cholesterol is mainly carried by low-density lipoprotein in maternal serum. Additionally, to carrying cholesterol, HDL also associates with a range of proteins as cargo. We tested the hypothesis that fetal HDL carries proteins qualitatively ...
Senapati Suneeta S Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, - - 2013
Early pregnancy failure is the most common complication of pregnancy, and 1% to 2% of all pregnancies will be ectopic. As one of the leading causes of maternal morbidity and mortality, diagnosing ectopic pregnancy and determining the fate of a pregnancy of unknown location are of great clinical concern. Several ...
Josefson J L JL Division of Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611-2605, USA. - - 2013
More than 40% of women with a normal pre-pregnancy body mass index (BMI) exceed the 2009 Institute of Medicine (IOM) guidelines' recommended weight gain of 25-35 lb. Excessive gestational weight gain is one modifiable factor that may be contributing to childhood overweight and obesity. The objective of this study was to ...
Brown Jeremy K - - 2013
Ectopic pregnancy (EP) is difficult to diagnose early and accurately. Women often present at emergency departments in early pregnancy with a 'pregnancy of unknown location' (PUL), and diagnosis and exclusion of EP is challenging due to a lack of reliable biomarkers. The objective of this study was to identify novel ...
Mochhoury Latifa - - 2013
To evaluate the impact of the body mass index (BMI) before pregnancy and the weight gain during pregnancy, on the occurrence of maternal and neonatal morbidity in the Moroccan population, as well as to analyze the quality of the weight gain depending on the BMI. A study was carried out ...
Wang Fuqiang - - 2013
Preeclampsia is a serious complication of pregnancy, which affects 2-8% of all pregnancies and is one of the leading causes of maternal and perinatal mortality and morbidity worldwide. To better understand the molecular mechanisms involved in pathological development of placenta in preeclampsia, we used high-resolution LC-MS/MS technologies to construct a ...
Liu Kangsheng K Key Laboratory of Reproductive Medicine, Department of Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jangsu, - - 2013
Prenatal lead exposure could not only affect various organ systems of the mother, but also provide a plumbeous environment for the fetus and newborns, and may affect the fetus in a number of detrimental ways. The aim of this study was to adequately determine the interaction between these factors and ...
Kowal Andrzej A Department of Pediatric - - 2013
Of interest is if factors like maternal diet can influence the risk of hypospadias-affected pregnancy. Increased propionylcarnitine (C3) is regarded as a biomarker of vitamin B12 deficiency. The retrospective study was undertaken to determine whether increased propionylcarnitine and low methionine in newborns are associated with hypospadias. 41 newborns with hypospadias ...
Liu Linda Y - - 2013
Preeclampsia (PE) is a pregnancy-related vascular disorder which is the leading cause of maternal morbidity and mortality. We sought to identify novel serological protein markers to diagnose PE with a multi-'omics' based discovery approach. Seven previous placental expression studies were combined for a multiplex analysis, and in parallel, two-dimensional gel ...
Tambor V - - 2012
INTRODUCTION: The presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) is associated with adverse neonatal outcomes in pregnancies complicated by preterm prelabor rupture of membranes (pPROM). Therefore, there is an urgent need to identify new biomarkers revealing these conditions. The objective of this study is ...
Kent Etaoin - - 2012
OBJECTIVE:: To estimate which maternal body composition parameters measured using multifrequency segmental bioelectric impedance analysis in the first trimester of pregnancy are predictors of increased birth weight. METHODS:: Nondiabetic women were recruited after ultrasonographic confirmation of an ongoing singleton pregnancy in the first trimester. Maternal body composition was measured using ...
Dane C - - 2012
Vaginal leiomyomas are rare benign solid tumours of the vagina. They can cause mechanical dystocia, which is a common problem in obstetrics leading to serious maternal and perinatal complications. Here we describe a patient with a vaginal leiomyoma diagnosed during the mid-trimester that could have caused dystocia. This 22-year-old woman ...
Gharesi-Fard Behrouz - - 2012
PROBLEM: Recurrent pregnancy loss (RPL) is defined as two or more consecutive abortion before the 20th week of gestation. Autoimmune diseases increase the risk and accounts for at least 20% of RPL. Placenta is a pregnancy unique tissue, and proper formation of placenta is key phenomenal for success of a ...
Lee Richard H - - 2012
Objective The total bile acid (TBA) concentration criterion for diagnosing intrahepatic cholestasis of pregnancy varies in the published literature. The purpose of this study was to establish pregnancy-specific reference ranges for the TBA concentration among Latina women.Study Design Self-identified Latina women (n = 211) over 18 years of age with a singleton pregnancy were ...
Moon R J RJ Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, United - - 2013
Maternal diet during pregnancy has been linked to offspring adiposity, but it is unclear whether maternal polyunsaturated fatty acid (PUFA) status during pregnancy affects offspring body composition. We investigated the associations between maternal plasma n-3 and n-6 PUFA status at 34 wk gestation and offspring body composition. A prospective United ...
Thomas Leena Susan - - 2012
Cancer diagnosed during pregnancy is a rare and challenging occurrence, with an incidence of 0.1% of all pregnancies. Thymoma is the most common primary tumour of the anterior mediastinum, accounting for 30% of mediastinal masses in adults. Presentation during pregnancy is rare. We describe a unique case of two successful ...
Flood-Nichols Shannon K SK Madigan Healthcare System, Joint Base Lewis-McChord, Tacoma, Washington 98431, - - 2013
Minimally invasive diagnostic tests are needed in obstetrics to identify women at risk for complications during delivery. The apolipoproteins fluctuate in complexity and abundance in maternal plasma during pregnancy and could be incorporated into a blood test to evaluate this risk. The objective of this study was to examine the ...
Masoura S - - 2012
Pre-eclampsia is a unique disorder of human pregnancy with a great impact on maternal and perinatal morbidity and mortality worldwide and especially in developing countries. The aetiology is still unknown and the pathophysiology of the disease is the subject of extensive investigation. Recently, much of the interest of the investigators ...
Wethington Stephanie L - - 2012
OBJECTIVES: Abdominal radical trachelectomy (ART) is a type C resection (uterine vessels ligated at origin from the hypogastric vessels). Questions arise as to whether fertility is maintained after ART, particularly when uterine vessels are sacrificed. We report an international series on ART to describe fertility and oncologic outcomes. METHODS: Databases ...
Calcagno Angelo - - 2012
Abstract Objective: We sought to study the advantages of laparoscopic conservative treatment and pelvic reproductive surgery in patients with ectopic pregnancy and predisposing factors of tuboperitoneal infertility. Material and methods: Patients who had undergone laparoscopic treatment for ectopic pregnancy were considered, with factors for tuboperitoneal infertility, while patients who underwent ...
Cengiz Hüseyin - - 2012
The reported incidence of adnexal masses during pregnancy vary from 1 in 81 pregnancies to 1 in 8000 pregnancies. There is still a debate on management of incidental adnexal masses during the caesarean section concerning the risk of this additional procedure on postoperative morbidity and mortality. The aim of our ...
Yakasai Ibrahim Adamu - - 2012
Widespread use of ultrasound in early pregnancy has led to the detection of incidental adnexal masses more frequently. This article reviews the diagnosis and management options for adnexal masses in pregnancy. The availability of high-resolution ultrasound has made observation to be a viable option in some cases. However, for those ...
Ozler Ali - - 2012
To investigate long-term postoperative outcomes of conservative and radical surgery in ectopic tubal pregnancies, and evaluate the results of these techniques. A total of 145 patients that operated for tubal pregnancy between January 2006 and January 2009 were reviewed. Data on patient age, reproductive and surgical history history of ectopic ...
Kim C H - - 2012
OBJECTIVE: To report the reproductive outcomes of patients undergoing fertility-preserving radical trachelectomy (RT) for the treatment of early-stage cervical cancer. METHODS: We analyzed data from our institution's first 105 patients who underwent attempted fertility-sparing surgery with radical trachelectomy, pelvic lymphadenectomy, and cerclage from November 2001 to October 2010. RESULTS: Of ...
Reid Shannon S Nepean Hospital, Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit , Penrith, NSW 2747 , Australia +61 2 4734 2312 ; - - 2012
Ectopic pregnancy (EP) remains the leading cause of maternal mortality in the first trimester of pregnancy. In an attempt to expedite the accurate diagnosis of women with EP, research has focused on serum biomarkers that can distinguish EP from other types of pregnancies in women with a pregnancy of unknown ...
Hassan Sarah - - 2012
A young woman in her 20s presented with sudden onset right-sided abdominal pain. On examination she was tender in the right adnexae. Her urine pregnancy test was positive and βHCG value was 1862. Abdominal and pelvic ultrasound revealed evidence of a significant right-sided adnexal mass, a small amount of peritoneal-free ...
Rios Lívia Teresa Moreira - - 2012
Cloacal malformation is an extremely rare fetal pathological condition that presents as a variety of defects. It predominantly affects females, with prevalence of 1 in 50,000 births. Prenatal ultrasonography on a 20-year-old caucasian woman (G4P1A2) at 33 weeks of pregnancy showed the fetus having a large cystic mass in the ...
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