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Pérez R R Laboratorio de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, - - 2014
The plasma kinetic profile of moxidectin (MXD) in ewes during the last third of pregnancy was studied after the subcutaneous dose of 0.2 mg/kg of body weight (bw). Two groups of sheep (n = 7) that were equally balanced in body weight were used. Group I (control) was maintained unmated, while Group ...
van Hasselt J G C JG Department of Clinical Pharmacology, Netherlands Cancer Institute, - - 2014
Pregnant patients with cancer are increasingly treated with anti-cancer drugs, although the specific impact of pregnancy-induced physiological changes on the pharmacokinetics (PK) of anti-cancer drugs and associated implications for optimal dose regimens remains unclear. Our objectives were to quantify changes in PK during pregnancy for four frequently used anti-cancer agents ...
Cai Jia J Department of Clinical Laboratory, Beijing Shijitan Hospital, Capital Medical University , Beijing , - - 2014
Abstract It is necessary to regularly monitor thyroid function status during pregnancy. The repeated tests on serum thyroid hormones are invasive and can be uncomfortable. Sampling urine may provide an effective alternative. The primary aim of this study was to investigate if there is a correlation between the serum and ...
Johnson Emily L EL Department of Neurology, and Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, - - 2014
The aims of this study were to characterize the alterations in total and free carbamazepine (CBZ) and in total and free carbamazepine-epoxide (CBZ-EPO) clearances during pregnancy, to calculate the change in free fractions of CBZ and CBZ-EPO during pregnancy, and to determine whether seizure worsening is associated with a low ...
Kao Li-Ting LT Graduate Institute of Life Science, National Defense Medical Center, Taipei, - - 2014
This study aimed to investigate the most prescribed medications and principle diagnoses for category D and X drugs during pregnancy using a population-based dataset in Taiwan. The data for the present study were sourced from the Taiwan Longitudinal Health Insurance Database 2000. We selected 14 125 women who had live singleton ...
Karampas Grigorios G Obstetrics & Gynecology Department, "Konstantopoulio" General Hospital, Athens, Greece; 2nd Dept of Obstetrics & Gynecology, Medical School, University of Athens "Aretaieio" Hospital, Athens, - - 2014
The aim of this study was to determine maternal serum concentrations of NGAL, MMP-9 and MMP-9/NGAL complex longitudinally in pregnancy, in normal pregnancies, in pregnancies that developed preeclampsia and in pregnancies that delivered a small for gestational age infant (SGA). NGAL, MMP-9 and MMP-9/NGAL were determined in the 1(st) , ...
Ryu Rachel J RJ Department of Pharmacy, University of Washington, 1959 NE Pacific Street, H-375 Health Sciences Center, Box 357630, Seattle, WA, 98195-7630, - - 2014
Our objective was to evaluate the pharmacokinetics (PK) of doxorubicin during pregnancy compared to previously published data from non-pregnant subjects. During mid- to late-pregnancy, serial blood and urine samples were collected over 72 h from seven women treated with doxorubicin for malignancies. PK parameters were estimated using non-compartmental techniques. Pregnancy parameters ...
Martin Laura F LF Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, - - 2014
To evaluate the concentration of PTX3 in amniotic fluid (AF) during the final weeks of normal pregnancies and in pregnancies complicated by preterm delivery (PTD). A cross-sectional study was conducted with 95 pregnant women followed to term and 25 who presented with PTD. Samples of AF from all patients were ...
Deligiannidis Kristina M KM From the *Department of Psychiatry and Obstetrics and Gynecology, †Depression Specialty Clinic, ‡Women's Mental Health Specialty Clinic, Center for Psychopharmacologic Research and Treatment, and §Psychosomatic Medicine, Women's Mental Health Specialty Clinic, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester; and ∥Department of Psychiatry, Perinatal and Reproductive Psychiatry Program, Harvard Medical School, Massachusetts General Hospital, Boston, - - 2014
Pharmacotherapy for mood disorders during pregnancy is often complicated by pregnancy-related pharmacokinetic changes and the need for dose adjustments. The objectives of this review are to summarize the evidence for change in perinatal pharmacokinetics of commonly used pharmacotherapies for mood disorders, discuss the implications for clinical and therapeutic drug monitoring ...
Crijns Ineke I University of Groningen, Research Institute for Health Research (SHARE), Department of Pharmacoepidemiology & PharmacoEconomics , Groningen , The - - 2014
Background: Pregnancy prevention programmes (PPP) can be imposed by regulatory authorities to minimise the risk of exposure to teratogenic drugs during pregnancy, thus preventing congenital anomalies. The objective of this study was to explore the reasons to request PPPs in the EU and the elements that they included. Methods: For ...
Rytting Erik E Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0587, USA, - - 2014
Although indomethacin has been widely used for the treatment of preterm labor over the past 40 years, there are few reports regarding its pharmacokinetics in pregnant women. This opportunistic study assessed the steady-state pharmacokinetics of indomethacin in pregnant subjects to whom an oral dose of 25 mg every 6 h was prescribed. Indomethacin ...
Mumford Sunni L SL Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, - - 2014
Phytoestrogens have been associated with subtle hormonal changes, although effects on fecundity are unknown. Our objective was to evaluate the association between male and female urinary phytoestrogen (isoflavone and lignan) concentrations and time to pregnancy (TTP) in a population-based cohort of 501 couples desiring pregnancy and discontinuing contraception. Couples were ...
Ke Alice Ban AB Drug Disposition, Lilly Research Laboratories, Indianapolis, Indiana 46285; email: - - 2014
Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during pregnancy can significantly affect drug pharmacokinetics (PK) and may necessitate dose adjustment. Here, the specific aspects related to the design, execution, and analysis ...
McCormack Shelley A SA Pediatrics Department, School of Medicine, Rady Children's Hospital San Diego, University of California San Diego , San Diego, CA , - - 2014
Use of pharmacotherapy during pregnancy is common and increasing. Physiologic changes during pregnancy may significantly alter the overall systemic drug exposure, necessitating dose changes. A search of PubMed for pharmacokinetic clinical trials showed 494 publications during pregnancy out of 35,921 total pharmacokinetic published studies (1.29%), from the late 1960s through ...
Moon Joonho - - 2013
Progesterone (P4) plays a key role in implantation and pregnancy. Thus, the level of P4 at the time of embryo transfer (ET) is important. P4 concentrations and numbers of corpus lutea were evaluated from 126 surrogate pigs. SCNT embryos were transferred into 126 surrogates, among them, 11 surrogates maintained pregnancy ...
Smith Judith A JA Department of Gynecologic Oncology and , the University of Texas M.D. Anderson Cancer Center, Houston, TX; Division of Pharmacy, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address: - - 2013
The objective of this study was to determine the fetal drug compartment concentrations when various concentrations of carboplatin cross the placental/trophoblastic barrier (PTB) and the effect on the fetal kidneys. An ex vivo human placenta perfusion model was utilized. Term human placentae (N=9) were collected immediately after delivery then, re-perfused ...
West Kristi L - - 2013
This study evaluated circulating concentrations of thyroid hormones in relation to age, sex, pregnancy status, and perinatal loss in bottlenose dolphins (Tursiops truncatus) under human care. A total of 373 blood samples were collected from 60 individual dolphins housed at nine aquariums/oceanariums. Serum concentrations of total and free thyroxine (T4) ...
Fischer James H - - 2013
Labetalol is frequently prescribed for the treatment of hypertension during pregnancy; however, the influence of pregnancy on labetalol pharmacokinetics is uncertain, with inconsistent findings reported by previous studies. This study examined the population pharmacokinetics of oral labetalol during and after pregnancy in women receiving labetalol for hypertension. Data were collected ...
Kajaysri Jatuporn - - 2013
The study was to find patterns of progestagen (progesterone and its metabolite) and glucocorticoid and their metabolite concentrations in serum and feces of pregnant Asian elephants (Elephas maximus). The five female Asian domestic elephants were naturally mated until pregnancy. After that, blood and feces samples were collected monthly during pregnancy ...
Streuli Isabelle I Department of Obstetrics and Gynaecology, University Hospitals of Geneva and the Faculty of Medicine of the Geneva University, Geneva, Switzerland. Electronic address: - - 2013
This study determined whether anti-Müllerian hormone (AMH) concentration influences the time necessary to conceive a live-born child - effective time to pregnancy (eTTP) - in a population of women who conceived naturally. This is an observational study of 87 women with a planned spontaneous pregnancy resulting in a live birth. ...
Odum Lars - - 2013
Abstract Background: Neutrophil gelatinase-associated lipocalin (NGAL) serum values have been shown to increase in preeclampsia. The goal of the present study was to evaluate changes in urinary NGAL concentrations during uncomplicated pregnancy and in cases of preeclampsia and hypertension. Methods: Fifty-one pregnant women who developed preeclampsia and 28 diagnosed with ...
van Gelder Marleen M H J - - 2013
What are the dispensing rates of drugs suspected to be associated with teratogenic mechanisms among pregnant Dutch women? In a substantial proportion of pregnancies in our study population at least one drug associated with a teratogenic mechanism was dispensed in the first trimester of pregnancy. The main teratogenic mechanisms of ...
Howard Brandon - - 2013
To evaluate pregnancy rates with 84/7, 21/7, and 24/4 combined oral contraceptives (COCs). Data were obtained from the i3Invision Data Mart(TM) retrospective claims database. Subjects were 15 to 40 years; first prescribed COCs between January 1, 2006 and April 1, 2011; and continuously insured for ≥1 year. Eighty four over ...
Patel Jignesh P - - 2013
The optimal dosing strategy of low molecular weight heparins (LMWH) for the treatment of antenatal venous thromboembolism (VTE) is not known. The physiological changes associated with pregnancy alter the pharmacokinetic (PK) profile of LMWH, which has led to controversy and subsequent variation in practice, when pregnant women with VTE are ...
Verner Marc-André - - 2013
A recent meta-analysis based on data from more than 7,000 pregnancies reported an association between prenatal PCB-153 exposure and reduced birth weight. Gestational weight gain, which is associated negatively with PCB levels in maternal and cord blood, and positively with birth weight, could substantially confound this association. To estimate the ...
Rossi Alberto - - 2013
In normal pregnancies, a hypoxic intrauterine environment seems necessary for early trophoblast development. In this context, maternal serum levels of ischemia-modified albumin (IMA) are elevated, reflecting the oxidative stress associated with placental development. The aim of this study was to evaluate IMA and pregnancy-associated plasma protein A (PAPP-A) in mothers ...
Ke A B - - 2013
Conducting PK studies in pregnant women is challenging. Therefore, we asked if a physiologically-based pharmacokinetic (PBPK) model could be used to predict the disposition in pregnant women of drugs cleared by multiple CYP enzymes. We expanded and verified our previously published pregnancy PBPK model by incorporating hepatic CYP2B6 induction (based ...
Miranda Jezid - - 2013
Abstract Objective: α-klotho, a protein with anti-aging properties, has been involved in important biological processes, such as calcium/phosphate metabolism, resistance to oxidative stress, and nitric oxide production in the endothelium. Recent studies have suggested a role of α-klotho in endocrine regulation of mineral metabolism and postnatal growth in infants. Yet, ...
Moss John A JA Department of Chemistry, Oak Crest Institute of Science, Pasadena, California, - - 2013
Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This ...
Zorrilla Cd - - 2013
OBJECTIVES: Antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission of HIV and for maternal care management. Physiological changes during pregnancy can affect pharmacokinetics, potentially altering pharmacological activity. We therefore evaluated the pharmacokinetics of twice-daily (bid) darunavir in HIV-1-infected pregnant women. METHODS: HIV-1-infected pregnant women receiving ...
Caritis Steve N - - 2013
Despite widespread use of glyburide to treat pregnancy-related hyperglycemia, the dosing regimen is based in large part on pharmacokinetic and pharmacodynamic studies in men and nonpregnant women. Like many medications used by pregnant women, adequate pharmacokinetic and pharmacodynamic data in pregnancy have been sorely lacking. This lack of information can ...
Abdulah Rizky - - 2013
Selenium is an essential nutrient for human health, and maternal selenium concentration has been reported to be associated with pregnancy outcome. To further investigate the possible role of selenium (Se) in miscarriage, we conducted a case-control study to evaluate the correlations among selenium status, glutathione peroxidase activity, and spontaneous abortion. ...
Kacerovsky Marian - - 2013
Abstract Objective: To determine the amniotic fluid nucleosome concentrations in pregnancies that are complicated by preterm prelabor rupture of membranes and their correlation to microbial invasion of the amniotic cavity (MIAC), histological chorioamnionitis (HCA), and their association with neonatal outcomes. Methods: Eighty-nine women with singleton pregnancies were included in this ...
Rossary Adrien - - 2013
BACKGROUND & AIMS: Oily fish is a good source of n-3 long-chain polyunsaturated fatty acids. Since these fatty acids may change efficiency of amino acid (AA) absorption, we determined whether increased salmon consumption influences plasma AA concentrations in pregnant women and their newborns. METHODS: Pregnant women were randomly allocated to ...
Cespedes Michelle S MS Division of Infectious Diseases and Immunology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA. - - 2013
Steady-state pharmacokinetics in pregnant women prescribed ritonavir-boosted fosamprenavir (FPV) to prevent HIV transmission were assessed in the second trimester, third trimester, and postpartum. Compared with postpartum, geometric mean amprenavir (APV, FPVs active metabolite) area under the plasma concentration-time curves were 35% lower in the second trimester and 25% lower in ...
Hebert Mary F MF Department of Pharmacy, University of Washington, Seattle, WA 98195-7630, - - 2013
Pregnancy after solid organ transplantation, although considered high risk for maternal, fetal, and neonatal complications, has been quite successful. Tacrolimus pharmacokinetic changes during pregnancy make interpretation of whole blood trough concentrations particularly challenging. There are multiple factors that can increase the fraction of unbound tacrolimus, including but not limited to ...
Campbell Sarah C - - 2013
Pregnancy increases the pharmacological management challenge of numerous neurological diseases as a result of complex physiological changes. Understanding pregnancy-induced changes in pharmacokinetic and pharmacodynamic parameters can lead to better outcomes for both the mother and baby. Although the application of pharmacogenomics in maternal-fetal medicine is in its infancy, further research ...
Dawodu Adekunle - - 2013
Background:Vitamin D (vD) deficiency in pregnancy is a global health problem and the amount of vD supplementation to prevent vD deficiency is controversial.Objective:Determine effectiveness and safety of prenatal 2000 IU and 4000 IU/day compared with 400 IU/day vD3 supplementation in a RCT in population where vD deficiency is endemic.Design/Methods:Arab women ...
Ostensen Monika - - 2013
Rheumatic diseases may be active during pregnancy necessitating drug treatment in order to control maternal disease activity and ensure a successful pregnancy outcome. The present literature survey of the last 2 years does not profoundly change the recommendations given in recent reviews: the teratogenic drugs cyclophosphamide, methotrexate, mycophenolate mofetil, and ...
Chaemsaithong Piya - - 2013
Abstract Objective: Pregnancy is characterized by activation of the innate immune response demonstrated by phenotypic and metabolic changes in granulocytes and monocytes. This state of activation has been implicated in the pathophysiology of multiorgan dysfunction of pregnant women with acute viral or bacterial infection. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) ...
Lu Ellen - - 2013
When contemplating a pregnancy, women treated for multiple sclerosis (MS) with a disease-modifying drug must decide to discontinue their medication before conception or risk exposing their unborn child to potential drug toxicity. Few studies exist as reference for patients and physicians, and of those available, the majority are less than ...
Brantsæter A L AL Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403 Oslo, Norway. - - 2013
Perfluoroalkyl substances (PFASs) are widespread pollutants that have been associated with adverse health effects although not on a consistent basis. Diet has been considered the main source of exposure. The aim of the present study was to identify determinants of four plasma PFASs in pregnant Norwegian women. This study is ...
Denny Kerina J - - 2013
Preeclampsia is a leading cause of morbidity and mortality worldwide, encompassing significant short- and long-term health sequelae. Recently, there has been accumulating evidence for a role of the complement system in the pathogenesis of numerous complications of pregnancy, including preeclampsia. The present cross-sectional study compared the plasma concentrations of complement ...
Tomson Torbjörn - - 2013
Pregnancy is a state where pharmacokinetic changes are more pronounced and more rapid than during any other period of life. The consequences of such changes can be far reaching, not least in the management of epilepsy where the risks with uncontrolled seizures during pregnancy need to be balanced against potential ...
Matok Ilan - - 2013
Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described. The objective of this study was to compare the PK of doxylamine/pyridoxine delayed-released combination in pregnant versus nonpregnant women. The apparent clearances (CL) of doxylamine and pyridoxal 5'-phosphate (PLP; the active ...
Cressey Tim R - - 2013
AIM: To describe the pharmacokinetics and safety of indinavir boosted with ritonavir (IDV/r) during the second and third trimesters of pregnancy and in the postpartum period. METHODS: IMPAACT P1026s is an on-going, prospective, non-blinded study of antiretroviral pharmacokinetics (PK) in HIV-infected pregnant women with a Thai cohort receiving IDV/r 400/100 ...
Bołzan E - - 2013
Two independent experiments were performed on cyclic (Experiment I) and pregnant (Experiment II) gilts to examine the effect of human Chorionic Gonadotropin (hCG) administration on day 12 of the estrous cycle/pregnancy on ovarian and endometrial secretory function. Animals were divided into hCG Group (injection of 750 IU hCG) and Control ...
Shibata Katsumi - - 2013
Most Japanese women do not consume the estimated average requirement of vitamin B6 (1.7 mg/d) during pregnancy. Nevertheless, these deficiencies are not reported. We investigated a nutritional biomarker of vitamin B6 in pregnant Japanese women as well as their vitamin B6 intakes. Vitamin B6 intakes in the first, second, and ...
Kaitu'u-Lino Tu'uhevaha J - - 2013
We have recently shown first trimester Macrophage inhibitory cytokine-1 (MIC-1) and Pregnancy Associated Plasma Protein-A (PAPP-A) serum concentrations are depressed among asymptomatic women destined to miscarry. Here we examined whether plasma levels of MIC-1 and PAPP-A are depressed among women presenting to an Early Pregnancy Assessment Unit (EPAU), noted to ...
Zelner Irene - - 2013
Due to its wide range of deleterious effects on the unborn baby, knowledge on the disposition of ethanol in the maternal-fetal unit is critical. This review summarizes and updates the existing evidence on ethanol disposition in the mother, the placenta and the fetus, and relates them to their potential fetal ...
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