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Fauchet Floris F EA 08 Université Paris Descartes, Sorbonne Paris Cité, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France - - 2014
For the first time, a population approach was used to describe abacavir pharmacokinetics in HIV infected pregnant and non-pregnant women. A total of 266 samples were obtained from 150 women. No covariate effect (age, bodyweight, pregnancy, gestational age) was found on abacavir pharmacokinetics. Thus, it seems not necessary to adapt ...
Szafarowska Monika M Department of Gynecology and Oncological Gynecology, Military Institute of Medicine, Warsaw, - - 2014
This study was conducted to determine serum anti-Müllerian hormone (AMH) concentration influence on pregnancy outcome. In this study we investigated sixty one infertile women (aged 27 to 44 years) who were diagnosed and treated between 2011 and 2013. We determine ovarian reserve measured by AMH concentration. Patients were divided in ...
Valade Elodie E EA08, Université Paris Descartes, Sorbonne Paris Cité, France; Unité de Recherche Clinique Paris Centre, AP-HP, France; DHU Risques et Grossesse, Paris, - - 2014
The aims were to describe emtricitabine (FTC) pharmacokinetics in a large population of pregnant women during the different trimesters of pregnancy, and to explain FTC pharmacokinetic variability during pregnancy. FTC plasma concentrations were measured in 103 non-pregnant and 83 pregnant women, including women in the different trimesters of pregnancy and ...
Ter Horst P G J PG Department of Clinical Pharmacy, Isala, Zwolle, The - - 2014
Depression during pregnancy is common and includes risks for mother and child. Pharmacokinetics of venlafaxine may be changed during pregnancy. This study aimed to describe changes in metabolic ratios and concentrations of venlafaxine and its main metabolite O-desmethylvenlafaxine during and after pregnancy. To study this, we used data from our ...
Muñoz M M Centro de Biotecnología Animal-Servicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Camino de Rioseco 1225, La Olla - Deva, 33394 Gijón, Asturias, - - 2014
We analyzed embryo culture medium (CM) and recipient blood plasma using Fourier transform infrared (FTIR) metabolomics to predict pregnancy outcome. Individually cultured, in vitro-produced (IVP) blastocysts were transferred to recipients as fresh and vitrified-warmed. Spent CM and plasma samples were evaluated using FTIR. The discrimination capability of the classifiers was ...
Shuster Diana L DL University of - - 2014
Gestational diabetes mellitus is a major complication of human pregnancy. The oral clearance (CL) of glyburide, an oral anti-diabetic drug, increases 2-fold in pregnant women during late gestation versus non-pregnant controls. In this study, we examined gestational age-dependent changes in maternal-fetal pharmacokinetics (PK) of glyburide and metabolites in a pregnant ...
Valea Innocent I Unité de Recherche Paludisme et Maladies Tropicales Négligées, Centre Muraz, Bobo-Dioulasso, Burkina Faso Institut de Recherche en Sciences de la Santé, Unité de Recherche Clinique de Nanoro, Nanoro, Burkina Faso - - 2014
Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/carboxymefloquine and artesunate/dihydroartemisinin in pregnant and non-pregnant women ...
Mosha Dominic D Ifakara Health Institute, Rufiji HDSS, Rufiji, Tanzania Swiss Tropical and Public Health Institute, University of Basel, Switzerland - - 2014
Artemether-Lumefantrine (AL) is the first line treatment for uncomplicated malaria in second and third trimester of pregnancy. Its efficacy has recently been challenged in pregnancy due to altered pharmacokinetic (PK) properties in this vulnerable group. The aim of this study was to determine the PK profile of AL in pregnant ...
Meinert M M Department of Obstetrics and Gynaecology, Aarhus University Hospital, 8200 Aarhus N, Denmark. Electronic address: - - 2014
The proteoglycan decorin stabilizes collagen whereas biglycan and hyaluronan disrupt well-organized collagen. The aim was to determine the concentrations of these constituents in fetal membranes in relation to gestational age, preterm labour, PPROM and chorioamnionitis. Preterm fetal membranes (24-34 weeks gestation) were obtained from elective caesarean deliveries (N = 4), from PPROM ...
Perucca Emilio E Department of Internal Medicine and Therapeutics, University of Pavia, and C. Mondino National Neurological Institute, Pavia, - - 2014
The purpose of this review is to discuss gender-related aspects in the, pharmacokinetics, effects, selection and use of antiepileptic drugs (AED). In general, there are few known gender related differences in pharmacokinetics or efficacy of AEDs. Conversely, gender has a significant influence on the susceptibility to certain adverse effects, not ...
Murphy N N INFANT centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, Ireland; Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Cork, - - 2014
To establish a gestation-specific reference range for D-dimer in healthy pregnant women with a singleton pregnancy using the Auto-Dimer assay. Cross-sectional study SETTING: Cork University Maternity Hospital, Ireland. Healthy pregnant women attending for routine antenatal care. Simultaneous-quantile regression was performed to construct a median, 5th percentile, and 95th percentile, model ...
Else Lj L Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, - - 2014
Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring optimal plasma concentrations of antiretrovirals is essential for maternal health and to minimize the risk of vertical transmission. Here we describe atazanavir/ritonavir (ATV/r) plasma concentrations in a cohort of pregnant women undergoing routine ...
Garrity Lisa C LC Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
The use of levetiracetam for the treatment of epilepsy in women of childbearing age has increased as more evidence of teratogenicity of other broad-spectrum antiepileptic medications becomes available. Levetiracetam appears to be associated with a low incidence of major congenital malformations based on data from pregnancy registries. Major pregnancy-related changes ...
Bapat Priya P Motherisk Program, Division of Clinical Pharmacology, the Hospital for Sick Children, the Departments of Pharmacology and Toxicology and Pediatrics, University of Toronto, and the Department of Obstetrics and Gynecology, St Michael's Hospital, Toronto, Ontario, - - 2014
To assess the transplacental pharmacokinetics at term of the oral thrombin inhibitor, dabigatran, and its prodrug, dabigatran etexilate mesylate, to estimate fetal drug exposure. Placentae were obtained with informed consent after cesarean delivery of healthy term pregnancies in Toronto, Ontario, Canada. The transplacental transfer of dabigatran and dabigatran etexilate mesylate ...
Abhilashini G D GD Junior Resident, Department of Obstetrics and Gynaecology, JIPMER , Pondicherry, India - - 2014
The aim of this study was to compare the efficacy and safety of intravenous iron sucrose and oral iron administration for the treatment of iron deficiency anaemia in pregnancy. Hundred women with gestational age between 30 and 34 weeks with established iron deficiency anaemia with Haemoglobin-6-8g/dL were randomised to receive ...
Hubalek Michael M Department of Gynecology and Obstetrics, Innsbruck Medical University, Innsbruck, - - 2014
Afamin is a liver-derived plasma glycoprotein with vitamin E-binding properties and a putative function in fertility. This study evaluated serum afamin concentrations during and postpartum to uncomplicated pregnancies and investigated a potential association between afamin concentrations and pregnancy outcome. Afamin serum concentrations were measured in women with uncomplicated pregnancies in ...
Pérez R R Laboratorio de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, - - 2014
The plasma kinetic profile of moxidectin (MXD) in ewes during the last third of pregnancy was studied after the subcutaneous dose of 0.2 mg/kg of body weight (bw). Two groups of sheep (n = 7) that were equally balanced in body weight were used. Group I (control) was maintained unmated, while Group ...
van Hasselt J G C JG Department of Clinical Pharmacology, Netherlands Cancer Institute, - - 2014
Pregnant patients with cancer are increasingly treated with anti-cancer drugs, although the specific impact of pregnancy-induced physiological changes on the pharmacokinetics (PK) of anti-cancer drugs and associated implications for optimal dose regimens remains unclear. Our objectives were to quantify changes in PK during pregnancy for four frequently used anti-cancer agents ...
Rivera Del Álamo Maria Montserrat MM Reproduction Service, Hospital Clínic Veterinari Foundation, Autonomous University of Barcelona, Barcelona, Spain; Animal Medicine and Surgery Department, Veterinary College, Autonomous University of Barcelona, Barcelona, - - 2014
Changes in coagulation parameters depending on reproductive status and pregnancy have been previously reported in both human and other veterinary species. The objective of this study was to determine if different reproductive status affects coagulation parameters in queens. Blood samples from 66 queens submitted to spay surgery were obtained. A ...
Cai Jia J Department of Clinical Laboratory, Beijing Shijitan Hospital, Capital Medical University , Beijing , - - 2014
Abstract It is necessary to regularly monitor thyroid function status during pregnancy. The repeated tests on serum thyroid hormones are invasive and can be uncomfortable. Sampling urine may provide an effective alternative. The primary aim of this study was to investigate if there is a correlation between the serum and ...
Johnson Emily L EL Department of Neurology, and Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, - - 2014
The aims of this study were to characterize the alterations in total and free carbamazepine (CBZ) and in total and free carbamazepine-epoxide (CBZ-EPO) clearances during pregnancy, to calculate the change in free fractions of CBZ and CBZ-EPO during pregnancy, and to determine whether seizure worsening is associated with a low ...
Kao Li-Ting LT Graduate Institute of Life Science, National Defense Medical Center, Taipei, - - 2014
This study aimed to investigate the most prescribed medications and principle diagnoses for category D and X drugs during pregnancy using a population-based dataset in Taiwan. The data for the present study were sourced from the Taiwan Longitudinal Health Insurance Database 2000. We selected 14 125 women who had live singleton ...
Karampas Grigorios G Obstetrics & Gynecology Department, "Konstantopoulio" General Hospital, Athens, Greece; 2nd Dept of Obstetrics & Gynecology, Medical School, University of Athens "Aretaieio" Hospital, Athens, - - 2014
The aim of this study was to determine maternal serum concentrations of NGAL, MMP-9 and MMP-9/NGAL complex longitudinally in pregnancy, in normal pregnancies, in pregnancies that developed preeclampsia and in pregnancies that delivered a small for gestational age infant (SGA). NGAL, MMP-9 and MMP-9/NGAL were determined in the 1(st) , ...
Ryu Rachel J RJ Department of Pharmacy, University of Washington, 1959 NE Pacific Street, H-375 Health Sciences Center, Box 357630, Seattle, WA, 98195-7630, - - 2014
Our objective was to evaluate the pharmacokinetics (PK) of doxorubicin during pregnancy compared to previously published data from non-pregnant subjects. During mid- to late-pregnancy, serial blood and urine samples were collected over 72 h from seven women treated with doxorubicin for malignancies. PK parameters were estimated using non-compartmental techniques. Pregnancy parameters ...
Martin Laura F LF Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, - - 2014
To evaluate the concentration of PTX3 in amniotic fluid (AF) during the final weeks of normal pregnancies and in pregnancies complicated by preterm delivery (PTD). A cross-sectional study was conducted with 95 pregnant women followed to term and 25 who presented with PTD. Samples of AF from all patients were ...
Deligiannidis Kristina M KM From the *Department of Psychiatry and Obstetrics and Gynecology, †Depression Specialty Clinic, ‡Women's Mental Health Specialty Clinic, Center for Psychopharmacologic Research and Treatment, and §Psychosomatic Medicine, Women's Mental Health Specialty Clinic, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester; and ∥Department of Psychiatry, Perinatal and Reproductive Psychiatry Program, Harvard Medical School, Massachusetts General Hospital, Boston, - - 2014
Pharmacotherapy for mood disorders during pregnancy is often complicated by pregnancy-related pharmacokinetic changes and the need for dose adjustments. The objectives of this review are to summarize the evidence for change in perinatal pharmacokinetics of commonly used pharmacotherapies for mood disorders, discuss the implications for clinical and therapeutic drug monitoring ...
Crijns Ineke I University of Groningen, Research Institute for Health Research (SHARE), Department of Pharmacoepidemiology & PharmacoEconomics , Groningen , The - - 2014
Background: Pregnancy prevention programmes (PPP) can be imposed by regulatory authorities to minimise the risk of exposure to teratogenic drugs during pregnancy, thus preventing congenital anomalies. The objective of this study was to explore the reasons to request PPPs in the EU and the elements that they included. Methods: For ...
Rytting Erik E Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0587, USA, - - 2014
Although indomethacin has been widely used for the treatment of preterm labor over the past 40 years, there are few reports regarding its pharmacokinetics in pregnant women. This opportunistic study assessed the steady-state pharmacokinetics of indomethacin in pregnant subjects to whom an oral dose of 25 mg every 6 h was prescribed. Indomethacin ...
Polepally Akshanth R AR Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, - - 2014
The objective of the study was to characterize changes in the oral clearance (CL/F) of lamotrigine (LTG) over the course of pregnancy and the postpartum period through a model-based approach incorporating clinical characteristics that may influence CL/F, in support of developing clinical management guidelines. Women receiving LTG therapy who were ...
Mumford Sunni L SL Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, - - 2014
Phytoestrogens have been associated with subtle hormonal changes, although effects on fecundity are unknown. Our objective was to evaluate the association between male and female urinary phytoestrogen (isoflavone and lignan) concentrations and time to pregnancy (TTP) in a population-based cohort of 501 couples desiring pregnancy and discontinuing contraception. Couples were ...
Ke Alice Ban AB Drug Disposition, Lilly Research Laboratories, Indianapolis, Indiana 46285; email: - - 2014
Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during pregnancy can significantly affect drug pharmacokinetics (PK) and may necessitate dose adjustment. Here, the specific aspects related to the design, execution, and analysis ...
Muñoz Marta M 0000-0002-9832-3523 Centro de Biotecnología Animal-SERIDA, Camino de Rioseco 1225, La Olla-Deva, Gijón, 33394 Asturias, - - 2014
We analyzed embryo culture medium (CM) and recipient blood plasma using Fourier transform infrared spectroscopy (FTIR) metabolomics to identify spectral models predictive of pregnancy outcome. Embryos collected on Day 6 from superovulated cows in 2 countries were individually cultured in synthetic oviduct fluid medium with BSA for 24 h before embryo ...
McCormack Shelley A SA Pediatrics Department, School of Medicine, Rady Children's Hospital San Diego, University of California San Diego , San Diego, CA , - - 2014
Use of pharmacotherapy during pregnancy is common and increasing. Physiologic changes during pregnancy may significantly alter the overall systemic drug exposure, necessitating dose changes. A search of PubMed for pharmacokinetic clinical trials showed 494 publications during pregnancy out of 35,921 total pharmacokinetic published studies (1.29%), from the late 1960s through ...
Costantine Maged M MM Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, TX, - - 2014
Physiologic changes in pregnancy induce profound alterations to the pharmacokinetic properties of many medications. These changes affect distribution, absorption, metabolism, and excretion of drugs, and thus may impact their pharmacodynamic properties during pregnancy. Pregnant women undergo several adaptations in many organ systems. Some adaptations are secondary to hormonal changes in ...
Moon Joonho - - 2013
Progesterone (P4) plays a key role in implantation and pregnancy. Thus, the level of P4 at the time of embryo transfer (ET) is important. P4 concentrations and numbers of corpus lutea were evaluated from 126 surrogate pigs. SCNT embryos were transferred into 126 surrogates, among them, 11 surrogates maintained pregnancy ...
Smith Judith A JA Department of Gynecologic Oncology and , the University of Texas M.D. Anderson Cancer Center, Houston, TX; Division of Pharmacy, The University of Texas M.D. Anderson Cancer Center, Houston, TX. Electronic address: - - 2013
The objective of this study was to determine the fetal drug compartment concentrations when various concentrations of carboplatin cross the placental/trophoblastic barrier (PTB) and the effect on the fetal kidneys. An ex vivo human placenta perfusion model was utilized. Term human placentae (N=9) were collected immediately after delivery then, re-perfused ...
West Kristi L - - 2013
This study evaluated circulating concentrations of thyroid hormones in relation to age, sex, pregnancy status, and perinatal loss in bottlenose dolphins (Tursiops truncatus) under human care. A total of 373 blood samples were collected from 60 individual dolphins housed at nine aquariums/oceanariums. Serum concentrations of total and free thyroxine (T4) ...
Fischer James H - - 2013
Labetalol is frequently prescribed for the treatment of hypertension during pregnancy; however, the influence of pregnancy on labetalol pharmacokinetics is uncertain, with inconsistent findings reported by previous studies. This study examined the population pharmacokinetics of oral labetalol during and after pregnancy in women receiving labetalol for hypertension. Data were collected ...
Kajaysri Jatuporn - - 2013
The study was to find patterns of progestagen (progesterone and its metabolite) and glucocorticoid and their metabolite concentrations in serum and feces of pregnant Asian elephants (Elephas maximus). The five female Asian domestic elephants were naturally mated until pregnancy. After that, blood and feces samples were collected monthly during pregnancy ...
Streuli Isabelle I Department of Obstetrics and Gynaecology, University Hospitals of Geneva and the Faculty of Medicine of the Geneva University, Geneva, Switzerland. Electronic address: - - 2013
This study determined whether anti-Müllerian hormone (AMH) concentration influences the time necessary to conceive a live-born child - effective time to pregnancy (eTTP) - in a population of women who conceived naturally. This is an observational study of 87 women with a planned spontaneous pregnancy resulting in a live birth. ...
Odum Lars - - 2013
Abstract Background: Neutrophil gelatinase-associated lipocalin (NGAL) serum values have been shown to increase in preeclampsia. The goal of the present study was to evaluate changes in urinary NGAL concentrations during uncomplicated pregnancy and in cases of preeclampsia and hypertension. Methods: Fifty-one pregnant women who developed preeclampsia and 28 diagnosed with ...
van Gelder Marleen M H J - - 2013
What are the dispensing rates of drugs suspected to be associated with teratogenic mechanisms among pregnant Dutch women? In a substantial proportion of pregnancies in our study population at least one drug associated with a teratogenic mechanism was dispensed in the first trimester of pregnancy. The main teratogenic mechanisms of ...
Howard Brandon - - 2013
To evaluate pregnancy rates with 84/7, 21/7, and 24/4 combined oral contraceptives (COCs). Data were obtained from the i3Invision Data Mart(TM) retrospective claims database. Subjects were 15 to 40 years; first prescribed COCs between January 1, 2006 and April 1, 2011; and continuously insured for ≥1 year. Eighty four over ...
Patel Jignesh P - - 2013
The optimal dosing strategy of low molecular weight heparins (LMWH) for the treatment of antenatal venous thromboembolism (VTE) is not known. The physiological changes associated with pregnancy alter the pharmacokinetic (PK) profile of LMWH, which has led to controversy and subsequent variation in practice, when pregnant women with VTE are ...
Verner Marc-André MA Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2013
A recent meta-analysis based on data from > 7,000 pregnancies reported an association between prenatal polychlorinated biphenyl (PCB)-153 exposure and reduced birth weight. Gestational weight gain, which is associated negatively with PCB levels in maternal and cord blood, and positively with birth weight, could substantially confound this association. We sought ...
Rossi Alberto - - 2013
In normal pregnancies, a hypoxic intrauterine environment seems necessary for early trophoblast development. In this context, maternal serum levels of ischemia-modified albumin (IMA) are elevated, reflecting the oxidative stress associated with placental development. The aim of this study was to evaluate IMA and pregnancy-associated plasma protein A (PAPP-A) in mothers ...
Ke A B - - 2013
Conducting PK studies in pregnant women is challenging. Therefore, we asked if a physiologically-based pharmacokinetic (PBPK) model could be used to predict the disposition in pregnant women of drugs cleared by multiple CYP enzymes. We expanded and verified our previously published pregnancy PBPK model by incorporating hepatic CYP2B6 induction (based ...
Miranda Jezid - - 2013
Abstract Objective: α-klotho, a protein with anti-aging properties, has been involved in important biological processes, such as calcium/phosphate metabolism, resistance to oxidative stress, and nitric oxide production in the endothelium. Recent studies have suggested a role of α-klotho in endocrine regulation of mineral metabolism and postnatal growth in infants. Yet, ...
Moss John A JA Department of Chemistry, Oak Crest Institute of Science, Pasadena, California, - - 2013
Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This ...
Zorrilla Cd - - 2013
OBJECTIVES: Antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission of HIV and for maternal care management. Physiological changes during pregnancy can affect pharmacokinetics, potentially altering pharmacological activity. We therefore evaluated the pharmacokinetics of twice-daily (bid) darunavir in HIV-1-infected pregnant women. METHODS: HIV-1-infected pregnant women receiving ...
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