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Karasu Tülay T Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Bldg, Leicester Royal Infirmary, Leicester, Leicestershire, LE2 7LX, United - - 2013
Introduction: High anandamide (AEA) concentrations are detrimental for implantation and early pregnancy. Progesterone, essential for pregnancy, may keep AEA levels low by increasing fatty acid amide hydrolase (FAAH) expression. Here the effect of RU486, a P4 antagonist used to initiate medical termination of pregnancy (MTOP), on plasma AEA concentrations and ...
Matar Kamal M KM Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, 13110 Safat, - - 2013
Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in this study. The ...
Fernandes da Silva M O MO Department of Obstetrics of the Universidade Federal de São Paulo, Brazil. - - 2013
This study evaluated serum vascular endothelial growth factor (VEGF) concentrations in women with ectopic pregnancy (EP), miscarriage, and normal pregnancy (NP). This was a case-control study comparing serum VEGF concentrations among 72 women with ectopic pregnancy (n = 35), miscarriage (n = 15), and normal pregnancy (n = 22) matched ...
Kim Hyesook - - 2012
OBJECTIVE: To evaluate the relation between maternal serum folate status and blood mercury in pregnant Korean women. METHODS: The nutritional status of folate and the blood mercury concentration were measured in pregnant Korean women who participated in a multicenter prospective study from 2006 through 2011. We analyzed existing blood mercury ...
Giebułtowicz Joanna - - 2012
OBJECTIVE: The aim of the present study was to describe the changes in the activity of ALDH3A1 in saliva in relation to the menstrual cycle and pregnancy. We also measured major salivary antioxidants, salivary peroxidase (SPO) activity and uric acid (UA) concentration. DESIGN: Fasting saliva samples were collected from 63 ...
Patterson Kristine B - - 2012
OBJECTIVE:: To investigate the intraindividual pharmacokinetics of total (protein bound + unbound) and unbound lopinavir/ritonavir (LPV/RTV) and to assess whether the pediatric formulation (100mg/25mg) can overcome any pregnancy-associated changes. Design: Prospective longitudinal pharmacokinetic (PK) study METHODS:: HIV-infected pregnant antiretroviral therapy-naïve and experienced women receiving LPV/RTV 400mg/100mg tablets twice daily. Intensive ...
Günzel-Apel A - - 2012
Progesterone profiles of individual bitches may vary considerably both between and within individuals during pregnancy and non-pregnancy. Suspected luteal deficiency is commonly purported but is difficult to evaluate in clinical cases when progesterone is supplemented because this masks the underlying hormone changes. Therefore, in this study, suspected cases of luteal ...
Zheng Songmao S Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7630, - - 2012
Information on the pharmacokinetics of tacrolimus during pregnancy is limited to case reports despite the increasing number of pregnant women being prescribed tacrolimus for immunosuppression. Blood, plasma, and urine samples were collected over 1 steady-state dosing interval from women treated with oral tacrolimus during early to late pregnancy (n = ...
Ringholm Lene - - 2012
Aims: To explore hormonal counterregulation to biochemical hypoglycaemia during pregnancy. Methods: Observational study of 107 consecutive pregnant women with type 1 diabetes (median duration 16 years (range 1-36), HbA1c 6.6% (4.9-10.5) in early pregnancy) and 22 healthy pregnant women. At 8, 14, 21, 27 and 33 weeks (women with diabetes) ...
Eley Timothy - - 2013
For some antiretroviral therapies, drug concentrations are reduced during pregnancy, potentially compromising effective virological suppression. Data on atazanavir boosted with ritonavir in pregnancy are reviewed. With standard atazanavir/ritonavir 300/100 mg once-daily dosing: atazanavir area-under-the-concentration-time curves were reduced during pregnancy in most studies, but overall interpretation differed according to the data ...
Kim M J - - 2012
OBJECTIVES: To assess whether fetal-derived hypermethylated RASSF1A concentrations in maternal plasma during pregnancy are altered in pregnancies associated with placental dysfunction manifested by intrauterine growth restriction (IUGR), preeclampsia (PE), or placental previa (PP) and whether this alteration can be detected in susceptible subjects before the onset of clinical disease. METHODS: ...
Son Ga Hyun - - 2012
OBJECTIVE: To compare the levels of urinary excretion of nephrin in women experiencing either normotensive or severe preeclamptic pregnancies, and to examine the relationship between urinary nephrin levels and clinical parameters of preeclampsia. STUDY DESIGN: In a case control study we collected serum and urine specimens from women with normal ...
Dey Madhusudan M On Study Leave (Materno-Fetal Medicine), AIIMS, New Delhi, - - 2013
Cervical priming agents mainly prostaglandins in different doses and routes are used during first trimester vaccum aspiration to prevent cervical injury and shorten the abortion procedure. This study was carried out to assess women's acceptability, the efficacy and side effects of oral versus vaginal administration of misoprostol in facilitating cervical ...
Kacerovsky Marian - - 2012
Abstract Objective: To determine amniotic fluid myeloperoxidase concentration in women with preterm prelabor rupture of the membranes with microbial invasion of the amniotic cavity and histological chorioamnionitis. Methods: One hundred eighty-one women with singleton pregnancies with a gestational age between 24+0 and 36+6 weeks were included in this study. Amniocenteses ...
Olagunju Adeniyi - - 2012
Mother-to-child-transmission rates of HIV in the absence of any intervention range between 20 and 45%. However, the provision of antiretroviral drugs (ARVs) during pregnancy, delivery and breastfeeding can reduce HIV transmission to less than 2%. Physiological changes during pregnancy can influence ARV disposition. Associations between SNPs in genes coding for ...
Shiu Jennifer R - - 2012
The pharmacokinetics of methadone is altered during pregnancy, but the most appropriate dosing and monitoring regimen has yet to be identified. To review dosing and monitoring of methadone therapy in pregnancy. A literature search was performed in several databases (PubMed, MEDLINE, Embase, International Pharmaceutical Abstracts, and the Cochrane Database of ...
Allegaert Karel - - 2012
CONTEXT: Pregnancy affects intravenous paracetamol pharmacokinetics, but there are no studies on covariates of intravenous paracetamol pharmacokinetics around delivery. OBJECTIVES: To document the impact of gestational age at delivery on pharmacokinetics of a high intravenous dose of paracetamol. DESIGN: Pharmacokinetic study in women shortly after caesarean delivery. This study is ...
Park Hyun Soo - - 2012
Abstract Aim: The aim of this study was to evaluate the transplacental transfer of clarithromycin, which was used in the treatment of preterm premature rupture of membranes (PPROM) in human pregnancies, by comparing umbilical cord and maternal serum clarithromycin concentrations. Methods: Singleton pregnant women with PPROM (<34 weeks) were prospectively ...
Kaga Maiko - - 2012
AIMS: Liposome-encapsulated hemoglobin (hemoglobin vesicles: HbV; diameter 250nm) is reconstructed from human hemoglobin and developed as an artificial oxygen carrier for use as a transfusion alternative. Previous studies using rodent models closely investigated the safety of daily repeated infusions (DRI) of HbV and reported that the reticuloendothelial system was physiologically ...
Caritis Steve N - - 2012
The purpose of this study was to estimate pharmacokinetic parameters and to evaluate placental transport of 17-hydroxyprogesterone caproate (17-OHPC) in singleton gestation. Sixty-one women who received weekly injections of 17-OHPC underwent 2 pharmacokinetic studies at 20 + 0 to 24 + 6 weeks' gestation (study 1) and 31 + 0 ...
Nagy Gyula R - - 2012
Epignathus is a rare congenital orofacial teratoma. We present a case of a fast-growing tumor, where early prenatal diagnosis was made and where fetopathological examination revealed the reason of the remarkable ultrasonographic signs and underlined the expected poor prognosis. Ultrasonographic examination at 18 weeks' gestation showed that there was a growing ...
Zorrilla C - - 2012
Antiretroviral (ARV) therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission (MTCT). Physiologic changes during pregnancy can affect PK. We present the PK of total and unbound (pharmacologically active) DRV in HIV-1-infected pregnant women receiving twice-daily (bid) DRV/ritonavir (rtv). This Phase IIIb study enrolled HIV-1-infected pregnant women≥18 ...
Else L - - 2012
Purpose of the study: Pregnant women experience physiological changes during pregnancy resulting in clinically significant alterations in antiretroviral pharmacokinetics (PK). Therefore, achieving and maintaining optimal plasma concentrations of antiretroviral drugs is essential for maternal health and minimising the risk of mother-to-child transmission of HIV. The aim of this study is ...
Kouakou F - - 2012
The association of decompensated cirrhosis and pregnancy is rare. Portal hypertension exposure to gastrointestinal bleeding from a ruptured esophageal varix may at any time complicate the course of the disease. We report the case of a 24-year-old patient who delivered at 35 weeks/four days of gestation with decompensated cirrhosis secondary ...
Allegaert K - - 2012
During pregnancy, changes in renal elimination, body composition and metabolic activity occur. Since these important alterations in physiology also affect drug disposition, pregnancy warrants a focused approach. Despite these differences, even commonly administered drugs have not undergone pharmacokinetic evaluation in pregnant women or at delivery. This is also true for ...
Lin Chia-Chun - - 2012
In view of the limited information on the pharmacokinetics of oseltamivir (OSE) during pregnancy, this study aims to evaluate the placental transportation of OSE and its active metabolite oseltamivir carboxylic acid (OCA) in rats. A validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) system coupled to an in vivo transplacental model has ...
Qiu Chunfang - - 2012
Heme oxygenase-1 (HO-1) concentrations have been recently reported to be elevated in impaired glucose tolerance and type 2 diabetes mellitus (T2DM). However, no study has examined the association between HO-1 concentrations and gestational diabetes mellitus (GDM). In a case-control study, nested within a prospective cohort of pregnant women (186 GDM ...
Hoglund Richard M RM Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, University of Gothenburg, Gothenburg, - - 2012
Pregnancy is associated with an increased risk of developing a malaria infection and a higher risk of developing severe malaria. The pharmacokinetic properties of many anti-malarials are also altered during pregnancy, often resulting in a decreased drug exposure. Piperaquine is a promising anti-malarial partner drug used in a fixed-dose combination ...
Govednik-Horny Cara - - 2011
Angiomyolipoma (AML) is a rare, benign tumor composed of fat cells, smooth muscle cells, and blood vessels. They are commonly found in the kidney but have also been reported to occur in the liver, ovary, fallopian tube, spermatic cord, palate, and colon. Most often, they are discovered as an incidental ...
Haward Rebecca N - - 2011
Over 80% of laparoscopic adjustable gastric banding (LAGB) patients are women, and approximately half of these are of reproductive age; therefore, pregnancy post-LAGB is common. It is not known if pregnancy increases the need for revisional procedures. We compare the incidence of revisions in two matched cohorts of LAGB patients, ...
Vujasinovic-Stupar Nada - - 2011
Pregnancy-associated spinal osteoporosis (PPSO) is a rare condition characterized by severe back pain occurring near the end of the first pregnancy or shortly afterward. The aim of this report is to present a 12-year follow-up of a patient with PPSO. Also, the outcomes of patient's two pregnancies and her infants ...
Mallarini G - - 2010
The prevalence of infertility in the United States is 15-20% and this condition represents an important medical problem. The purpose of this work was to evaluate therapeutical efficacy of 2 consecutive hysterosalpingography (HSG) followed each other after 4 week compared with the fallopian tube recanalization (FTR). Two groups of 80 ...
Verhoeve H R - - 2011
Laparoscopy has been claimed to be superior to hysterosalpingography (HSG) in predicting fertility. Whether this conclusion is applicable to a general subfertile population can be questioned as data in support of this claim were collected in third line centres. The aim of this study was to assess the prognostic capacity ...
Kumakiri Jun - - 2010
We investigated the feasibility of linear salpingotomy with suturing for ampullary tubal pregnancy via single incision laparoscopic surgery (SILS). Three patients underwent SILS between April and May 2010 at our hospital due to ampullary tubal pregnancy. A multichannel port was inserted into the umbilicus via a 2.5-cm incision to accommodate ...
Horne Andrew W AW Centre for Reproductive Biology, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom. - - 2011
Tubal ectopic pregnancy is common, but accurate diagnosis is difficult and costly. There is currently no serum test to differentiate tubal from intrauterine implantation, and an effective biomarker of ectopic pregnancy would be a major clinical advance. A key feature of successful intrauterine implantation is the establishment of a supportive ...
Singhal Manphool - - 2010
Heterotopic pregnancy, ie, combined intrauterine and extrauterine (ectopic) pregnancy, is a rare clinical entity that may present with acute abdominal catastrophy. Most of cases reported in literature are a consequence of medical or surgical interventions like assisted reproductive techniques, tubal surgeries, intrauterine contraceptive devices, or pelvic inflammatory disease. Heterotopic pregnancy ...
Swende T Z - - 2010
BACKGROUND: Female sterilization is an important tool in reducing unplanned pregnancy and maternal mortality in our environment. The aim of this study was to determine the incidence, sociodemographic characteristics, technique, effectiveness and complications associated with female sterilization by bilateral tubal ligation at caesarean section. METHOD: This was a retrospective analysis ...
Shaw Julie L V JL Centre for Reproductive Biology, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, - - 2010
Tubal ectopic pregnancy (EP) is the most common cause of maternal mortality in the first trimester of pregnancy; however, its etiology is uncertain. In EP, embryo retention within the Fallopian tube (FT) is thought to be due to impaired smooth muscle contractility (SMC) and alterations in the tubal microenvironment. Smoking ...
Allen C - - 2010
Fallopian tubal disease is a common cause of subfertility. Reproductive surgery or assisted reproduction techniques such as in vitro fertilization (IVF) have been the main treatment options for patients with tubal disease in Ireland, although access to these treatments remains limited. We describe a case of pregnancy following selective salpingography ...
Shao Ruijin - - 2010
Human ectopic pregnancy (EP) remains a common cause of pregnancy-related first trimester death. Nitric oxide (NO) is synthesized from L-arginine by three NO synthases (NOS) in different tissues, including the Fallopian tube. Studies of knockout mouse models have improved our understanding of the function of NOS isoforms in reproduction, but ...
Allahbadia Gautam N - - 2010
Technological advances in fiberoptics and endoscopy have resulted in the development of minimally invasive transcervical tubal catheterization procedures with the potential of improved diagnostic accuracy of tubal disease and transcervical treatment of proximal tubal obstruction (PTO) with reduced risks, costs and morbidity compared with surgical procedures. Fallopian tube recanalization can ...
Arjona José Eduardo - - 2010
A case of uterine perforation by an Essure microinserts placed in proximity to the tubal ostia mimicking proper microinsert placement and bilateral tubal occlusion on imaging techniques is presented. The presence of Essure microinserts did not interfere with implantation and pregnancy, and in this case, no adjacent intraabdominal tissue damage ...
Honest Honest - - 2010
To present a case report of two concurrent ectopic pregnancies (EP), in a disparate distal location within abdominal cavity with potential life-threatening consequences. Case report. In-patient acute hospital admission. A multiparous woman with two children and a previous right tubal pregnancy treated with laparoscopic salpingectomy, who initially presented with an ...
Soriano David - - 2010
STUDY OBJECTIVE: To determine the long-term outcome of intrauterine pregnancies after treatment of heterotopic pregnancies. DESIGN: Retrospective cohort study (Canadian Task Force classification II-3). SETTING: Tertiary center university hospital. PATIENTS: All women who underwent surgery because of heterotopic pregnancy over 12 years. INTERVENTION: Laparoscopic surgery. MEASUREMENTS AND MAIN RESULTS: Infant ...
Svirsky Ran - - 2010
OBJECTIVE: To present four cases of twin tubal pregnancies and discuss possible etiologies. Twin tubal pregnancies are a rare event, with incidence rates estimated as 1 out of 725-1,580 of tubal pregnancies. DESIGN: Case series. SETTING: Department of obstetrics and gynecology at a tertiary health care facility. PATIENT(S): All women ...
Schippert Cordula - - 2010
Tubal infertility mostly results from infections. Conception only is possible through complex treatments (in vitro fertilization or surgery). Success cannot be guaranteed, even after repeated treatments. Unfortunately, many couples are not informed about the prospect for success of tubal reconstruction. Problems of in vitro fertilization are low pregnancy and birth ...
Lantieri Teresa - - 2010
This report describes the first case of superfetation after ovarian stimulation with gonadotrophins and intrauterine insemination (IUI) that were performed in the presence of an undiagnosed tubal pregnancy. A 32-year-old woman who underwent repeated attempts of ovarian stimulation and IUI was hospitalized for severe pelvic pain and submitted to laparoscopic ...
Shaw J L V - - 2010
BACKGROUND An ectopic pregnancy is a pregnancy which occurs outside of the uterine cavity, and over 98% implant in the Fallopian tube. Tubal ectopic pregnancy remains the most common cause of maternal mortality in the first trimester of pregnancy. The epidemiological risk factors for tubal ectopic pregnancy are well established ...
Iyibozkurt A C - - 2010
To investigate whether serum levels of leukemia inhibitory factor (LIF), interleukin 10 (IL-10) and interleukin 11 (IL-11) are different in reference to the site of implantation. Seventeen patients with laparoscopic diagnoses of tubal ectopic pregnancy (EP) and 19 patients with intrauterine pregnancy delivering healthy term neonates (IUP) were prospectively evaluated ...
Tan Heng Hao - - 2010
INTRODUCTION: Women with previous tubal sterilisation seeking fertility are faced with treatment options of reconstructive tubal surgery or in vitro fertilisation (IVF) techniques. The aim was to assess the current viability of tubal anastomosis in a local clinical practice. MATERIALS AND METHODS: A retrospective cohort review of all sterilisation reversal ...
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