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Results 651 - 700 of 980
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Garcia M P - - 1987
This article reports correlations among gamma-glutamyltransferase (GGT), fetal haemoglobin (fH), alpha-fetoprotein, 5'-nucleotidase, ceruloplasmin, and direct, indirect, and total bilirubin in the serum of blood taken from the umbilical cords of 128 newborns delivered after 37-42 weeks of gestation. GGT was significantly correlated with alpha-fetoprotein, but not with direct bilirubin, indirect ...
Haddow J E - - 1987
Very low maternal serum alpha-fetoprotein (MSAFP) levels (less than 10 ng/mL) are known to be associated with non-viable pregnancies, including conditions such as fetal death, molar pregnancies, and non-pregnancies. There has not been agreement, however, as to whether very low MSAFP levels indicate already existing fetal deaths or are actually ...
Bell S C - - 1987
A specific and sensitive radioimmunoassay has been developed for pregnancy-associated endometrial alpha 2-globulin (alpha 2-PEG), the major secretory protein of the human endometrium during the mid- to late-luteal phase of the menstrual cycle and first trimester of pregnancy. This assay enabled alpha 2-PEG to be measured in the cytosolic extracts ...
Lindfors K K - - 1987
Eight pregnancies with open neural tube defects were detected in 70 midtrimester patients referred for sonography and amniocentesis because of elevated maternal serum alpha-fetoprotein levels. Two cases of anencephaly were detected by sonography, aborted without amniocentesis, and confirmed by pathologic examination. Six cases of open spina bifida were detected through ...
Tabor A - - 1987
Maternal serum alpha-fetoprotein (AFP) levels were determined before and after genetic amniocentesis (n = 283) or ultrasound scan (n = 268) in a group of women participating in a randomized trial of genetic amniocentesis. Increases in AFP levels were seen significantly more often after amniocentesis than after ultrasound scan (P ...
Penso C - - 1987
We report a sonographic sign which reliably distinguishes those hydrocephalic fetal heads associated with a neural tube defect from those which are not, particularly in the second trimester. This sign involves a "pointed" deformity of the frontal aspect of the skull in fetuses with hydrocephalus, indicating the presence of a ...
Van Regemorter N - - 1987
Glial fibrillary acidic protein (GFAp), an intracellular protein specific to astrocytes of the central nervous system, was determined by 2-site immunoradiometric assay in amniotic fluid from 78 pregnancies with a normal, and 100 with an abnormal outcome. GFAp was not detectable in any of the normal pregnancies, but there were ...
Cuckle H S - - 1987
The risk of an individual woman having a pregnancy associated with Down's syndrome was estimated from her age and her serum alpha-fetoprotein (AFP) level at 14-20 weeks gestation. The estimates were made using published data on the risk of Down's syndrome in relation to maternal age from 4528 affected and ...
Konieczko K M - - 1987
Fifty-three infants with neural tube defects and 97 with other major congenital abnormalities have been reviewed. In only one case did the mother receive an anaesthetic before or during pregnancy and this anaesthetic is unlikely to have played any part in the outcome. The anaesthetic history was recorded for 471 ...
Myrianthopoulos N C - - 1987
In the NIH Collaborative Perinatal Project, a prospective study of over 53,000 pregnant women and their offspring, 71 single-born children (13.33/10,000) were found to have a non-syndromal neural tube defect (NTD). A family history was present in only one case. The group of individuals with NTD was compared to a ...
Ashwood E R - - 1987
A retrospective study of 3,411 women who underwent midtrimester amniocentesis for fetal chromosome analysis between June 1979 and August 1984 was performed to evaluate an association between low maternal serum alpha-fetoprotein (AFP) concentrations and Down syndrome (DS) pregnancies. A total of 71 pregnancies was found with abnormal fetal chromosomes; of ...
Cuckle H - - 1987
Using information derived from the voluntary system of notification of congenital malformations in England and Wales, the birth prevalence of anencephaly and spina bifida was estimated to have declined by 80 per cent from 31.5 to 6.2 per 10,000 between 1964-1972 and 1985. Over the same period, notified terminations of ...
Nelson L H - - 1987
In previous reports on the use of maternal serum alpha-fetoprotein (MSAFP), emphasis was placed on the significance of elevated MSAFP values. The purpose of this paper is to stress the importance of low MSAFP values based on data from 28,285 pregnancies screened. The cutoff value used to define low MSAFP ...
Veszprémi B - - 1987
Priming of uterine cervix with PGF2 alpha has been applied to 253 primigravidae before interruption of first trimester pregnancy. Of them, 140 patients were treated with intracervical PGF2 alpha, while 113 other patients with extraamniotic PGF2 alpha. Spontaneous abortion or complete dilatation occurred in 65% of cases in the first ...
Tsoi M M - - 1987
Thirty pregnant women with raised serum alpha fetoprotein (AFP) were interviewed before and after they received real-time ultrasound scanning to further diagnose fetal abnormalities. Thirty pregnant mothers receiving routine ultrasound scanning for dates served as the controls. The 'at risk' group were more anxious and concerned about the fetus before ...
Di Rocco C - - 1987
Recent developments in the field of experimentally induced neural tube defects (NTD) indicate that specific substances, namely the glycosaminoglycans (GAGs) may play a role in the genesis of spinal malformations. The authors report the results obtained by evaluating the GAGs in rat fetuses with NTD, secondary to the administration of ...
Halmesmäki E - - 1987
No diagnostic measures exist for the fetal alcohol syndrome (FAS). Therefore, maternal serum alpha-fetoprotein (AFP), human placental lactogen (HPL) and pregnancy specific beta-1-glycoprotein (SP 1) were followed in 35 pregnant problem drinkers and 14 abstinent control women throughout pregnancy. Thirteen women gave birth to infants with FAS. These women had ...
Polgar K - - 1987
Amniotic fluid cells from 31 pregnancies with fetuses having open neural tube defects (NTDs) and from 43 pregnancies with fetuses free of NTDs were studied with the use of the immunoperoxidase method for alpha-fetoprotein (AFP) and glial fibrillary acidic protein (GFAP). The authors also used cytochemical stains for endogenous peroxidase ...
Wajner M - - 1987
The immunoregulatory processes operating during pregnancy that allow the survival of the semiallogeneic conceptus are at present far from understood. alpha-fetoprotein (AFP) is a biological component of the body produced in high amounts during pregnancy mainly by the fetal liver, and in certain clinical pathological states. The biological function of ...
Martin J T - - 1987
Pregnant rats treated during the last third of pregnancy with a continuous infusion of alpha-melanocyte-stimulating hormone (alpha-MSH) produced offspring that weighed less at birth and in adulthood. These offspring of the alpha-MSH treated mothers were less sensitive to pain and as adults showed a reduced analgesic response to morphine. Male ...
Papp Z - - 1987
The recurrence risk for neural tube defects in pregnancies of women with a family history of neural tube defects greatly exceeds the general population risk. In these high risk pregnancies, we used a prenatal diagnostic method differing from that usually employed, relying mainly on the results of maternal serum alpha-fetoprotein ...
Van Leuven F - - 1986
Pregnancy zone protein (PZP) was isolated from late pregnancy serum and examined for binding to normal skin fibroblasts in culture. A high-affinity binding site on these cells is demonstrated for PZP reacted with methylamine. Experiments with alpha 2-macroglobulin (alpha 2M) and PZP, both modified by methylamine, showed this receptor to ...
Winsor E J - - 1986
A survey of the records of all hospitals with obstetric services in Nova Scotia revealed that during 1980-84 there were 122 pregnancies involving a neural tube defect. The mean rate was 2/1000 births. Of the affected fetuses or infants 54% had spina bifida, 35% had anencephaly and 11% had encephalocele. ...
Kricker A - - 1986
Maternal factors in pregnancy were examined in a case-control study of 155 children with limb deficiencies (longitudinal and transverse) born 1970-1981 inclusive and 274 matched normal controls. Vomiting of pregnancy was associated with an increased risk of longitudinal limb reduction defects. Gestational bleeding has long been known for its association ...
Blakemore K J - - 1986
Maternal serum alpha-fetoprotein concentrations were determined by radioimmunoassay in 72 patients immediately before and after chorionic villus sampling for prenatal diagnosis. Fifty percent showed a rise of greater than or equal to 5 ng/ml. Assuming such rises represent fetal blood crossing the intervillous space, in 14% of the cases greater ...
Macri J N - - 1986
Various methods of adjusting maternal serum alpha-fetoprotein levels based on maternal weight have been recommended in order to more appropriately assign risk in maternal serum alpha-fetoprotein screening. These adjustments may, however, result in a larger proportion of pregnancies designated as having increased risk and reduction in detection accuracy.
Hayashida K - - 1986
Rat alpha 2-macroglobulin (alpha 2M) is a typical acute phase protein, the concentration of which in serum increases more than 100-fold after inflammation. It is also known that the protein increases during pregnant (and neonatal) stages. Using a specific cDNA probe, expression of the alpha 2M gene during pregnancy was ...
Bell S C - - 1986
The levels of pregnancy-associated endometrial alpha 1- and alpha 2-globulins (alpha 1- and alpha 2-PEG), the two major proteins synthesized and secreted by the endometrium in vitro, have been assayed in 210 amniotic fluid specimens obtained at termination of pregnancy or by amniocentesis, or at delivery. alpha 1-PEG was undetectable ...
Magnus P - - 1986
In an attempt to identify biochemical components of the genetic predisposition to neural tube defects (NTDs), levels of folate, cobalamin, apo-transcobalamins I and II and alpha-fetoprotein were studied in midtrimester amniotic fluid from 24 pregnant women who had previously had a child with NTD. The control group consisted of 76 ...
Boyd P A - - 1986
Ten placentae from pregnancies proceeding to term from mothers who on routine screening at 16-18 weeks gestation were found to have raised serum AFP but no increase in amniotic fluid AFP and no fetal abnormality, were studied using morphometric techniques. The results were compared with 20 placentae from normal term ...
Tam P K - - 1986
Recent works have shown that the neuropeptide, substance P, is an important element of the central nervous system, functioning as a neurotransmitter as well as moderating neural development. In a previous communication, we provided indirect evidence that substance P played a role in the pathogenesis and pathophysiology of spina bifida ...
Hershey D W - - 1986
Twenty-eight cases of Down syndrome with maternal serum alpha-fetoprotein (AFP) measured at second trimester were added to 137 previously reported cases. Seventy-eight percent of affected pregnancies had levels at or below the median AFP value, compared with 50% of unaffected pregnancies. Maternal age at delivery and serum AFP levels by ...
Bell S C - - 1986
Pregnancy-associated endometrial alpha 2-globulin (alpha 2-PEG), the major secretory protein as assessed by in-vitro synthesis and secretion by the endometrium during the luteal phase of the menstrual cycle and early first trimester of pregnancy, has been purified from the cytosolic fraction of pregnancy endometrium. The purification schedule involved anion exchange ...
Sadovnick A D - - 1986
Rates of fetal mortality in sibships of probands with neural tube defects (NTDs) may reflect liability to NTDs. Expectations from the multifactorial model predict that fetal loss should be higher in sibships of male probands; in multiplex sibships; and sibships where the proband had no additional malformations. This was analysed ...
Crandall B F - - 1986
Of 40,000 initial amniotic fluid samples, 0.7% had an alphafetoprotein (AFP) level greater than or equal to +3 standard deviations above the mean. The risk of an open neural tube defect (NTD) or other serious fetal abnormality was 61% when AFP levels measured greater than or equal to +3 and ...
Bragg L E - - 1986
Several factors might affect the growth of neomucosa after serosal patching of small intestinal defects. Often only short segments of small intestine can be patched because of limited serosal surface and anatomic factors. The purpose of this study was to determine the influence of patch size on neomucosal growth. Twenty ...
Patten R M - - 1986
Limb-Body Wall Complex is a complicated fetal malformation with the essential features of neural-tube defects, body-wall disruption, and limb abnormalities. This complex should be distinguished from other body-wall defects including omphalocele and gastroschisis since the prognosis for limb-body wall complex is uniformly poor. For 13 cases of this unusual fetal ...
Barlow R D - - 1986
An enzyme-linked immunosorbent assay (ELISA) was evaluated for serum alpha-fetoprotein determination in the antenatal screening for fetal open neural tube defects. The ELISA was used concurrently with an existing radioimmunoassay (RIA) method until serum specimens from 5000 pregnant women, between 15 and 20 weeks gestation, had been tested. The accuracy ...
Legum C - - 1986
A pilot project to detect neural tube defects (NTD) of the fetus by maternal serum alpha-fetoprotein (MSAFP) screening of women in early pregnancy was initiated in Tel Aviv in 1982 at the instigation of the Israel Ministry of Health. The program was designed to be an extension of routine pregnancy ...
Ghosh A - - 1986
A prospective study of maternal serum alphafetoprotein (alpha-FP) screening of 9838 women in an area with low prevalence of neural tube defects and predominance of anencephalics revealed that an intervention point of single serum alpha-FP level above 2.8 times the median was appropriate for this population. Ninety per cent of ...
Wilson G N - - 1986
The clinical efficacy of rocket immunoelectrophoresis (RIE) and radioimmunoassay (RIA) methods for the measurement of amniotic fluid alpha-fetoprotein (AFP) were compared in separate series of over 1,000 pregnancies each. Using a mean +3 SD limit, 21 of 1,414 pregnancies monitored with RIE and 21 of 1,006 monitored with RIA were ...
Muñoz W P - - 1986
A pregnant black woman was found to have extremely high serum alpha-fetoprotein (AFP) concentrations on several occasions between 18 and 28 weeks of gestation; the amniotic fluid total AFP level was borderline at 22 weeks, and the concanavalin-A non-reactive fraction was below normal. At this stage termination of pregnancy was ...
Doran T A - - 1986
Maternal serum alpha-fetoprotein values in 61 patients with fetal autosomal trisomies diagnosed at 6581 genetic amniocenteses were significantly lower than those in an equal number of matched control subjects. The genetic risk of fetal autosomal trisomies for women less than age 35 offered amniocentesis with maternal serum alpha-fetoprotein values less ...
Horne C H - - 1986
The serum concentrations of "pregnancy-associated" alpha 2-glycoprotein (alpha 2-PAG) were measured in 129 healthy women and 141 healthy men to establish a normal range, using a sensitive enzyme linked immunosorbent assay. In the normal population 2.8% of men and 5.4% of women had low serum alpha 2-PAG concentrations. Low concentrations ...
Russ P D - - 1986
Ultrasonography has made it possible to evaluate the fetal spine in utero. Vertebral ossifications are demonstrable by ultrasonography in the early second trimester. Most spinal defects are apparent by 20-22 weeks menstrual age. Early detection of spinal anomalies allows for parental counseling and appropriate obstetrical management. Real-time equipment allows the ...
Seller M J - - 1986
Detailed investigations were made on 150 fetuses with neural tube defects (NTD). After eliminating those with recognised causes, the rest were found to consist of fetuses with both isolated NTD and NTD with other developmental abnormalities. On evaluation of reproductive history, type and frequencies of NTD in pregnancies before conception, ...
Taubert H D - - 1986
Serum Alpha-Fetoprotein (AFP) was found to rise to exceedingly high levels in a case of triplet pregnancy after two fetuses died in the 21st week of gestation. The surviving infant was born in the 36th week accompanied by the two fetus papyracei. By the time the process of mummification of ...
Bass H N - - 1986
Intrauterine fetal demise (IUFD) in one of twins at 12 weeks of gestation was accompanied by markedly elevated maternal serum alpha-fetoprotein (AFP) at 17 and 18 weeks. Amniotic fluid AFP from the healthy surviving twin's sac at 18.5 and 23 weeks was also greatly increased along with a positive acetylcholinesterase ...
Wajner M - - 1986
Alpha-fetoprotein (AFP) quantitation in maternal blood has been used for prenatal diagnosis of anencephaly, spina bifida and some other congenital abnormalities. The levels of AFP in pregnancy serum are greatly dispersed within each gestational period, what makes the test of difficult interpretation mainly in border line cases. The factors which ...
Brambati B - - 1986
Feto-maternal transfusion following chorionic villus sampling (CVS) in the first trimester of pregnancy was evaluated by alpha-fetoprotein (AFP) level determination in maternal serum before and after sampling. Some fetal haemorrhage was suggested in 72% of 283 continuing pregnancies by a significant increase of maternal AFP level. Fetal bleeding appeared to ...
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