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Sayres Lauren C LC Duke University School of Medicine, Durham, NC, - - 2014
This study seeks to inform clinical application of cell-free fetal DNA (cffDNA) screening as a novel method for prenatal trisomy detection by investigating public attitudes towards this technology and demographic and experiential characteristics related to these attitudes. Two versions of a 25-item survey assessing interest in cffDNA and existing first-trimester ...
Marren Anthony J AJ RPA Women and Babies, Royal Prince Alfred Hospital, Sydney, New South Wales, - - 2014
Using a fixed cut-off of ≤25 mm, ultrasound assessment of cervical length during the 18-23 week anomaly scan has been shown to identify approximately 50% of pregnancies that would deliver prior to 34 weeks. To determine whether a policy of reverting to transvaginal cervical assessment only if the cervix appears short (≤25 mm) on ...
Gebeile Rémi R Service d'hématologie et microbiologie, Laboratoire de biologie médicale, Centre hospitalier de Chambéry, - - 2014
The aim of the study is to specify the pre-analytical conditions required for Down's syndrome screening in first trimester by maternal serum markers. The concentration variation of both markers, hCGβ and PAPP-A, was analyzed at room temperature, at 4°C and during freezing-thawing cycles. Serum can be kept during 72h between ...
Belahcen Amina A Mohammed V University - Souissi, Faculty of Medicine and Pharmacy, Rabat, Morocco; Tératovigilance Research Team, Mohammed V University - - - 2014
Abortion is prohibited and penalized in Morocco. On the other hand, there is no strategy or consensus for prenatal screening for Down syndrome (PSDS) included into the Moroccan pregnancy monitoring national program. This study aims to explore the awareness and attitudes of women who have a child with DS regarding ...
Goetzinger Katherine R KR Department of Obstetrics & Gynecology, Washington University in St. - - 2014
Second-trimester biomarkers were initially introduced with the intent of screening for neural tube defects, and then subsequently for Down syndrome. It was soon realized that these markers can be indirect evidence of abnormal placentation and, therefore, can be used for screening for adverse pregnancy outcomes. Several new biomarkers have subsequently ...
Debost-Legrand Anne - - 2014
Congenital malformations occur in 3-4% of live births. Their prenatal detection is performed by ultrasound screening. Any announcement about a suspected malformation is a source of stress for the parents, and misdiagnosis during ultrasound screening can lead to expensive and sometimes iatrogenic medical interventions. In this study, we aim to ...
Papastefanou Ioannis I Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, University of Athens, 'Attikon' University Hospital, Athens, - - 2014
To predict small for gestational age (SGA, at or below the 5(th) birthweight centile) and large for gestational age (LGA, at or above the 95(th) birthweight centile) fetuses by using maternal and fetal parameters from the second and third trimester ultrasound examinations. Retrospective cohort study on 1979 singleton pregnancies that ...
Blumenfeld Yair J YJ Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address: - - 2014
To examine the association between placental abruption, maternal characteristics, and routine first and second trimester aneuploidy screening analytes. Analysis of 1,017 women with and 136,898 women without placental abruption who had first and second trimester prenatal screening results, linked birth certificate, and hospital discharge records for a live born singleton. ...
Taché Véronique V Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of California, Davis, Sacramento, CA. Electronic address: - - 2014
To examine the relationship between second trimester maternal serum biomarkers and the development of early- and late-onset severe preeclampsia in euploid pregnancies. Included were 136,139 pregnancies participating in second trimester prenatal screening through the California Prenatal Screening Program with live births in 2006 through 2008. We identified severe preeclampsia diagnoses ...
Sonek Jiri J *Fetal Medicine Foundation, Dayton †Department of Obstetrics and Gynecology, Wright State University, Dayton, - - 2014
Although it is widely accepted that the best time to screen for chromosomal abnormalities is the first trimester, ultrasound evaluation of the fetus in the second trimester has also been shown to be useful for this purpose. A multitude of markers of varying strength has been developed over the past ...
Moon-Grady Anita J AJ Fetal Cardiovascular Program, Department of Pediatrics, Division of Cardiology, The Fetal Treatment Center, University of California, Benioff Children's Hospital, San Francisco, - - 2014
Advances in both imaging technology and understanding of fetal cardiac disease have contributed to a dramatic increase in the sensitivity and specificity of fetal echocardiography over the last few decades. Fetal echocardiography now plays an important role in the prenatal evaluation of fetuses with known or suspected aneuploidy. In this ...
Wright Lydia L Emory University School of Medicine, Atlanta, GA, USA, - - 2014
Although fetal echocardiography is a useful tool for earlier detection of congenital heart disease (CHD), no clear, evidence-based appropriate use criteria exist. This study aimed to determine those referral indications most predictive of CHD. A retrospective cohort study of fetal echocardiograms was conducted at a single tertiary care center. Binomial ...
Jørgensen J M JM Department of Biochemistry, Immunology and Genetics, Statens Serums Institut, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address: - - 2014
Recent efforts to develop reliable and efficient early pregnancy screening programmes for pre-eclampsia have focused on combining clinical, biochemical and biophysical markers. The same model has been used for first-trimester screening for fetal aneuploidies i.e. prenatal diagnosis (PD), which is routinely offered to all pregnant women in many developed countries. ...
Hsiao Ching-Hua CH Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, Taipei, Taiwan, - - 2014
Objective: To examine the performance of first-trimester screening test combining several fetal sonographic and maternal biochemical markers for major aneuploidy in a Chinese population. Methods: This was a prospective study performed over 5 years between January 2005 and December 2010 in Taiwan, with 20,586 cases that had a combination of ...
Baer Rebecca J RJ Genetic Disease Screening Program, California Department of Public Health, Richmond, and the Division of Maternal Fetal Medicine, University of California, San Francisco, and the Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California; and the Division of Maternal Fetal Medicine, University of Hawaii, Honolulu, - - 2014
To assess the risk of adverse obstetric, perinatal, and fetal outcomes for pregnant women participating in prenatal sequential integrated screening through the California Prenatal Screening Program who had a false-positive screening result. Women who underwent first- and second-trimester prenatal integrated screening plus nuchal translucency measurement with outcome information available were ...
Halawa S S Department of Obstetrics and - - 2014
This audit was performed in the obstetrics and gynaecology department of a tertiary referral hospital, to investigate the use and results of TORCH screening. St Michael's Hospital delivers approximately 6,000 women from South Bristol a year and receives tertiary referrals from the South West of England and South Wales. It ...
Michie Lucy L Department of Reproductive and Developmental Sciences, University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 5SU, United Kingdom; Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, United Kingdom. Electronic address: - - 2014
The objective was to determine if simplified follow-up after early medical abortion, consisting of a telephone call 2 weeks after the procedure plus a self-performed low-sensitivity urine pregnancy (LSUP) test, was successful for screening for ongoing pregnancies in the year following its introduction as standard service. A retrospective computerized database ...
Martineau Marcus M Division of Obstetric & Consultative Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI 02905, USA; Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Imperial College, London W12 0NN, United Kingdom. Electronic address: - - 2014
To evaluate the association between intrahepatic cholestasis of pregnancy (ICP) and gestational diabetes mellitus (GDM). A retrospective case-control study of pregnancy outcomes in 57,724 women managed at a university teaching hospital in Rhode Island, USA, in whom universal screening for GDM had been performed and who were assessed for the ...
Hyett Jon J *RPA Women and Babies, Royal Prince Alfred Hospital †Discipline of Obstetrics, Gynaecology and Neonatology, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia ‡Fetal Medicine Foundation USA §Division of Maternal Fetal Medicine, Wright State University, Dayton, - - 2014
Screening tests for trisomy 21 have gradually become more refined and now involve complex statistical models that combine demographic, biophysical, and biochemical parameters to produce individualized risk estimates for pregnant women. An understanding of the evolution of the principles, methods, and statistical techniques applied to Down syndrome screening is valuable ...
Rebarber Andrei A Maternal-Fetal Medicine Associates, PLLC, 70 East 90th St, New York, NY 10128 USA. - - 2014
Objectives- The purpose of this study was to estimate the prevalence and persistence rate of vasa previa in at-risk pregnancies using a standardized screening protocol. Methods- We conducted a descriptive study of patients with a diagnosis of vasa previa from a single ultrasound unit between June 2005 and June 2012. ...
Alexandre Isabel - - 2014
Neonatal conjunctivitis or ophthalmia neonatorum (ON) is an acute bacterial conjunctivitis contracted by newborns during delivery. In non-industrialized countries, detection of the etiological agent is difficult due to the unavailability of modern diagnostic resources. Therefore, we analyzed the effectiveness of Gram and methylene blue staining techniques, which are simple microbiological ...
Rocha Luciane Alves LA Fetal Cardiology Unit, Department of Obstetrics, Federal University of São Paulo (UNIFESP), 05303-000 São Paulo, SP, - - 2014
Objective. To describe the experience of a tertiary center in Brazil to which patients are referred whose fetuses are at increased risk for congenital heart diseases (CHDs). Methods. This was a cross-sectional observational study. The data was collected prospectively, during the year 2012, through a screening protocol of the fetal ...
Köşüş Nermin N Department of Obstetrics and Gynecology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey. - - 2014
To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results. Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART due to ...
Hudecova Irena I Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China ; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, - - 2014
Recently published international guidelines recommend the clinical use of noninvasive prenatal test (NIPT) for aneuploidy screening only among pregnant women whose fetuses are deemed at high risk. The applicability of NIPT to aneuploidy screening among average risk pregnancies requires additional supportive evidence. A key determinant of the reliability of aneuploidy ...
Mathad Jyoti S JS Division of Infectious Diseases, Weill Cornell Medical College, New York, New York, United States of - - 2014
Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The sensitivity of the widely-used tuberculin skin test (TST), however, may ...
Hannan Natalie J NJ Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, - - 2014
We have previously shown in two independent cohorts that circulating first trimester Macrophage Inhibitory Cytokine-1 (MIC-1) levels are lower in women in early pregnancy who are destined to miscarriage. While promising, the diagnostic performance of measuring MIC-1 alone was not sufficient for it to be a useful predictive test for ...
Gagnon Alain A University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: - - 2013
Prenatal screening for aneuploidy has changed significantly over the last 30 years, from being age-based to maternal serum and ultrasound based techniques. Multiple pregnancies present particular challenges with regards to screening as serum-based screening techniques are influenced by all feti while ultrasound-based techniques can be fetus specific. Tests currently available ...
Stirnemann Julien J JJ Obstetrics and Maternal-Fetal Medicine, GHU Necker - Enfants Malades, AP-HP, Université Paris Descartes, - - 2013
To compare the performance of traditional growth charts for estimated fetal weight (EFW) and a validated pragmatic probabilistic approach using biometry at 31-34 weeks to screen for late pregnancy small-for-gestational age (SGA) in a low-risk population. Records of ultrasound biometry at 31-34 weeks were reviewed in 7755 consecutive low-risk women between 2002 ...
Wright D D Centre for Medical Statistics and Bioinformatics, University of Exeter, Exeter, - - 2013
Objective: To examine the performance of screening for trisomies 21, 18 and 13 at 11-13 weeks' gestation using specific algorithms for these trisomies based on combinations of fetal nuchal translucency thickness (NT), fetal heart rate (FHR), ductus venosus pulsatility index for veins (DV PIV), and serum free β-human chorionic gonadotropin ...
Chervenak Frank A FA *Department of Obstetrics and Gynecology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York †Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, - - 2013
Noninvasive first-trimester fetal aneuploidy screening provides pregnant women with risk assessment information early in pregnancy. Noninvasive first-trimester aneuploidy screening includes imaging of the fetus and maternal serum analyte and assessment of fetal genetic material in the maternal circulation. The ethical challenges of noninvasive first-trimester fetal aneuploidy screening concern the physician's ...
Kirkegaard I I Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus N, - - 2013
The aim of this study was to investigate whether sub-fertility, measured as longer time-to-pregnancy (TTP) in spontaneously conceived pregnancies, affects the first trimester levels of PAPP-A and free β-hCG and hence the risk estimates in Down syndrome screening. The study included a cohort of 10,469 singleton pregnant women who underwent ...
Russo Melissa L ML Maternal Fetal Medicine, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. Electronic address: - - 2013
There have been tremendous advancements over the past three decades in prenatal screening for aneuploidy and we have changed our practice from screening by maternal age alone to 'combined' first trimester screening and circulating cell-free fetal DNA. We currently use the nuchal translucency and biochemical markers of free β-hCG and ...
Kawamura Makoto - - 2013
We measured fibrin monomer complex (FMC) levels in all subjects who gave birth at our hospital and evaluated the feasibility of using FMC for screening for venous thromboembolism (VTE) in patients during late pregnancy and the post-partum period. From August 2010 to January 2012, all women who gave birth at ...
Davenport William B WB Department of Obstetrics and Gynecology, University of Vermont, 89 Beaumont Avenue, Given C262, Burlington, VT 05406, - - 2014
Historically, much controversy has existed regarding the association of inherited thrombophilias with adverse pregnancy outcomes. The current guidelines do not recommend screening unless a personal history of venous thromboembolism is present, but the authors' survey of physician screening patterns has suggested that up to 40% of physicians may screen contrary ...
Petersen Ob O Fetal Medicine Unit, Department of Obstetrics, Rigshospitalet, - - 2013
Non-invasive prenatal testing (NIPT) could be an alternative to traditional karyotyping. NIPT tests for trisomies 21, 18 and 13 and sex chromosome aneuploidies. We aimed to determine the risk of missing other abnormal karyotypes of likely phenotypic significance by NIPT. A retrospective population-based analysis of all singleton pregnancies booked for ...
Blaas Harm-Gerd Karl HG Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, National Center for Fetal Medicine, Norway; Department of Obstetrics and Gynecology, University Hospital Trondheim, Norway. Electronic address: - - 2013
During the past 25 years, embryonic and early fetal ultrasound and diagnosis have increasingly gained attention in pregnancy care. Modern high-frequency ultrasound transducers make it possible to obtain detailed images of the early conceptus and its organs, and thus move part of the anatomy and anomaly scan from the second ...
Dmitrovic Bojana Kitanovic - - 2013
To screen 212 women for depression symptoms during pregnancy and postpartum in Serbia. Questionnaires that covered key demographic and obstetric information and Edinburgh Postnatal Depression Scale (EPDS) were administered at the third trimester of pregnancy and at 8 weeks postpartum. In all, 21% of the sample was screened as depression ...
Lee Fa-Kung FK Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, - - 2013
To analyze the performance of the first trimester Down syndrome screening in a single medical center in Northern Taiwan. From April 1999 to June 2012, a total of 25,104 pregnant women at gestational age of 10 weeks to 13 weeks 6 days received first trimester "combined test" for Down syndrome ...
Kristjansdottir Hildur H University of Iceland, Faculty of Nursing, Department of Midwifery, Iceland; Directorate of Health, Iceland. Electronic address: - - 2013
we aimed to gain insights into women's reflection on their experience of receiving a false-positive screening result for fetal anomalies, more than 11 months from birth. the women constituted a subgroup of participants in a larger cohort study (n=1111) where the purpose was to explore women's experience of maternity services, ...
Pásztor Norbert - - 2013
The autopsy and placental histopathological examination results following fetal deaths were analyzed retrospectively in an attempt to explain the stillbirths that occurred from 1996 to 2010 at the Department of Obstetrics and Gynecology, University of Szeged. One hundred and forty fetal deaths were recorded in that period, i.e. a rate ...
Karahasanovic Azra - - 2013
Abstract Background: The aim of this study was to compare pregnancy-associated plasma protein A (PAPP-A) and the β-subunit of human chorionic gonadotropin (hCGβ) measured in maternal plasma at the first trimester screening, in women who later developed early or late pre-eclampsia (PE) to women with normal pregnancies. Methods: In the ...
Ben-Ami Ido - - 2013
Objective: The objective of this study was to provide a critical analysis of the impact of assisted conception on prenatal screening for Down syndrome (DS) in twin pregnancies and the value of various screening modalities for early detection of anomalies. Methods: The literature was searched using PubMed and the Cochrane ...
Stenman Ulf-Håkan - - 2013
Determination of human chorionic gonadotropin (hCG) is used for diagnosis and monitoring of pregnancy, pregnancy related disorders, for trophoblastic and some nontrophoblastic tumors. In addition, hCG is determined for doping control in males. Assay of hCG is complicated by the occurrence of different molecular forms, which are detected to various ...
Pils S - - 2013
To review our experience with a screening programme that included four sequential cervical length (CL) measurements from 16 to 22( ) weeks of gestation. Historical cohort study. Tertiary-care centre in a university hospital. There were 312 singleton pregnancies in 321 women with a previous large loop excision of the transformation zone ...
Prutsky Gabriela J - - 2013
Context:Gestational diabetes mellitus (GDM) is defined as any degree of hyperglycemia with first recognition during pregnancy. The optimal time to screen for GDM that would maximize the yield and benefits remains unclear.Objective:Our objective was to appraise the evidence regarding screening for GDM (accuracy, correlation with adverse outcomes, and harms).Data Sources:We ...
Al-Allawi Nasir As - - 2013
To evaluate the feasibility and effectiveness of a preventive programme for haemoglobinopathies in a single centre in Northeastern Iraq. Premarital screening, genetic counselling and prenatal diagnosis (PND) were implemented over a 5 year period. Among a total of 108,264 screened individuals (54,132 couples), β-thalassaemia trait, δβ-thalassaemia trait, and sickle cell ...
Vila Lluís - - 2013
There is a well-known controversy between scientific societies regarding the recommendation to screen for thyroid dysfunction (DT) during pregnancy. Although several studies have shown an association between maternal subclinical hypothyroidism and/or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, there is only limited evidence on the possible positive ...
O'Leary Peter - - 2013
To analyse the cost-effectiveness and performance of noninvasive prenatal testing (NIPT) for high-risk pregnancies following first-trimester screening compared with current practice. A decision tree analysis was used to compare the costs and benefits of current practice of first-trimester screening with a testing pathway incorporating NIPT. We applied the model to ...
Elkins Donnay - - 2013
Pregnancies complicated by both obesity and gestational diabetes mellitus (GDM) increase the risk of maternal and fetal complications, including but not limited to gestational hypertension, cesarean surgical birth, fetal macrosomia and postpartum hemorrhage. Because of the increased maternal and fetal risks associated with maternal obesity and GDM, the development of ...
Kou K O - - 2013
The authors present 2 unusual cases of haemoglobin (Hb) Bart's hydrops fetalis and highlight the problem of a screening system for α-thalassaemia which focuses on maternal and paternal mean corpuscular volume (MCV) alone. Normal paternal MCV may not preclude fetal Hb Bart's disease because of the rare occurrence of maternal ...
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