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Hiersch Liran L Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Abstract Objective: Limited data exists regarding uterine contraction intensity prior to membrane rupture. Using a novel technique of Electrical Uterine Myography (EUM) we aimed to determine which factors affect myometrial activity during active phase of labor. Methods: EUM was prospectively measured in 37 women with singleton pregnancy at term during ...
Yang Gayoung G Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, - - 2014
There is no current consensus on the best treatment modality for cesarean scar pregnancy (CSP) with favorable reproductive and pregnancy outcome. We treated 3 cases of symptomatic CSP with fetal cardiac activity. The first case underwent laparoscopic repair at 6 weeks' gestational age of unruptured CSP. The second patient underwent ...
Sun Lu-Ming LM School of Public Health, Fudan University, Shanghai, China; Fetal Medicine Unit, Division of Maternal-Fetal Medicine, Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Shanghai, China; OMNI Research Group, Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa - - 2014
To assess whether singleton pregnancies conceived by assisted reproductive technology (ART) are associated with an increased use of intrapartum interventions when compared with spontaneous singleton pregnancies. In total, 1327 ART pregnancies and 5222 spontaneous pregnancies during the period 2004 to 2008 were extracted from BORN (Better Outcomes Registry and Network) ...
Ulkumen Burcu A BA Obstetrics and Gynecology Department, School of Medicine, Celal Bayar University, Manisa 45210, Turkey. Tel. +90 (236) 4144162. Fax. +90 (236) 4652434. E-mail. - - 2014
Placental invasion anomalies are rare obstetrical complications. They cause severe third trimester hemorrhage, severe postpartum bleeding, and maternal morbidity and mortality unless they are diagnosed antenatally. We present a rare case with placenta percreta leading to spontaneous uterine rupture during the second trimester with an acute abdomen and hypovolemia. 
Tørring Niels N Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, - - 2014
Objectives: To validate the performance of first-trimester screening for fetal aneuploidy employing blood samples drawn in gestational weeks 6-13. Methods: Prospective combined first-trimester screening for fetal aneuploidy in Denmark was validated in two large datasets: (1) a dataset from the Central Denmark Region including 147,768 pregnancies from October 2003 to ...
Zanello Margherita M Division of Prenatal Medicine, Department of Medicine and Surgery DIMEC, University of Bologna, Bologna, - - 2014
Objective: To develop a model for prediction of late preeclampsia (PE; which develops at or after 34 weeks' gestation) based on maternal history and characteristics, mean arterial pressure (MAP), and circulating levels of mRNA for the placenta-specific 1 (PLAC1) gene in maternal plasma at 14-18 weeks' gestation. Method: This was ...
Spencer Kevin K Prenatal Research Unit, Department of Clinical Biochemistry, Barking Havering & Redbridge University Hospitals NHS Trust, King George Hospital , Goodmayes , - - 2014
Abstract Screening for Down Syndrome was initially only related to maternal age and has successively developed by introducing biochemical markers and algorithms to estimate the risk for particularly trisomy 21 and 18. We now have a long experience of screening with four biochemical markers, alpha-fetoprotein, total hCG, unconjugated estriol and ...
Alphonse Jennifer J Faculty of Health Sciences, The University of Sydney, Lidcombe, N.S.W., - - 2014
Objective: To assess 2D and 3D frontomaxillary facial angle (FMFA) measurements in euploid and trisomy 21 fetuses. Materials and Methods: Over a 2-year period, women with singleton pregnancies attending a private prenatal screening and diagnosis practice in Sydney, Australia, were invited to participate in this study where 2D images and ...
Santos Mariana Mouraz Lopes Dos MM Department of Obstetrics and Gynecology, Hospital Dr. José de Almeida, Cascais, - - 2014
Renal angiomyolipoma is a benign tumor, composed of adipocytes, smooth muscle cells and blood vessels. The association with pregnancy is rare and related with an increased risk of complications, including rupture with massive retroperitoneal hemorrhage. The follow-up is controversial because of the lack of known cases, but the priorities are: ...
Gitsels van der Wal Janneke T - - 2014
In the Netherlands, prenatal screening follows an opting in system and comprises two non-invasive tests: the combined test to screen for trisomy 21 at 12 weeks of gestation and the fetal anomaly scan to detect structural anomalies at 20 weeks. Midwives counsel about prenatal screening tests for congenital anomalies and ...
Roman Ashley S AS Department of Obstetrics and Gynecology, New York University School of Medicine, New York, N.Y., - - 2014
Introduction: To evaluate whether maternal serum α-fetoprotein (MSAFP) improves the detection rate for open neural tube defects (ONTDs) and ventral wall defects (VWD) in patients undergoing first-trimester and early second-trimester fetal anatomical survey. Material and Methods: A cohort of women undergoing screening between 2005 and 2012 was identified. All patients ...
Li Qing Q Department of Epidemiology & Biostatistics, Michigan State University. Electronic address: - - 2014
Routine second-trimester transvaginal ultrasonographic (TVU) screening for short cervical length (CL) predicts spontaneous preterm delivery (SPTD), albeit with limited sensitivity (35-40%) and moderate positive likelihood ratio (LR+: 4-6). However, CL describes one of multidimensional changes associated with precocious cervical ripening (PCCR), which also include cervical softening, cervical funneling (CF), and ...
Ogu Rosemary N RN Senior Lecturer, Department of Obstetrics and Gynaecology, University of Port Harcourt, Port Harcourt , Rivers State, Nigeria - - 2014
Ectopic pregnancy is the greatest mimic in gynaecology. Ruptured ectopic gestation usually presents with syncope and severe anaemia. We report the clinical dilemma exposed by the management of a 22-year-old student who presented with syncope and severe anaemia due to a small solitary submucous uterine fibroid.
Li Qing Q Department of Epidemiology & Biostatistics, Michigan State University. Electronic address: - - 2014
Routine second-trimester transvaginal ultrasonographic (TVU) screening for short cervical length (CL) predicts spontaneous preterm delivery (SPTD), albeit with limited sensitivity (35-40%) and moderate positive likelihood ratio (LR+: 4-6). However, CL describes one of multidimensional changes associated with precocious cervical ripening (PCCR), which also include cervical softening, cervical funneling (CF), and ...
Teixeira João L G JL Programa de Pós-Graduação em Ciências Cirúrgicas, Universidade Federal do Rio Grande do Sul Departamento e Serviço de Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, - - 2014
To evaluate the performance of a commercial urinary test to screen for abnormal first trimester pregnancies in women presenting to an emergency room. In this prospective observational cohort, women with a confirmed first trimester pregnancy (gestational age < 12 weeks) provided a urine sample for diagnosing the viability of their ...
Iliescu D G DG Department of Obstetrics and Gynecology, Prenatal Diagnostic Unit, University of Medicine and Pharmacy Craiova, - - 2014
To evaluate the potential of first trimester (FT) screening in the diagnosis of agenesis of the ductus venosus (ADV), and to study its prevalence in a low-risk population, the associated conditions and pregnancy outcome. Prospective, sequential screening study at two tertiary units with morpho-functional evaluation of the ductus venosus (DV) ...
Karsli Mehmet Fatih MF Dr. Sami Ulus Women's and Children's Health and Research Teaching Hospital, Department of Obstetrics and Gynecology, Ankara, - - 2014
The aim of this study was to determine whether polycystic ovary syndrome (PCOS) affects the biochemical components of first trimester combined aneuploidy screening test. A case-control study was performed at a tertiary referral hospital between years 2007-2013. Singleton pregnancies in the first trimester (11(+0) -13(+6)  week) who had a history ...
Tosun A A Department of Radiology, Giresun University School of Medicine, Giresun, Turkey, - - 2014
The aim of this study was to assess the relationship between the maternal superior mesenteric artery Doppler, pancreatic size and gestational diabetes mellitus (GDM). Two hundred and fifty-eight consecutive, pregnant women between 20 and 22 weeks of gestation underwent routine fetal anomaly screening. All subjects underwent maternal superior mesenteric artery Doppler ...
Chambers Anne E - - 2014
Previous studies showed that soluble LHCGR/hCG-sLHCGR concentrations in serum or plasma combined with PAPP-A and free betahCG significantly increased the sensitivity of Down's syndrome screen at early pregnancy without altering the false positive rate. The goal of the present study was to further examine the role of sLHCGR forms as ...
Thombs Brett D BD Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Psychiatry, McGill University, Montréal, Québec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Québec, Canada; Department of Psychology, McGill University, Montréal, Québec, Canada; Department of Educational and Counselling Psychology, McGill University, Montréal, Québec, Canada; School of Nursing, McGill University, Montréal, Québec, Canada. Electronic address: - - 2014
Clinical practice guidelines disagree on whether health care professionals should screen women for depression during pregnancy or postpartum. The objective of this systematic review was to determine whether depression screening improves depression outcomes among women during pregnancy or the postpartum period. Searches included the CINAHL, EMBASE, ISI, MEDLINE, and PsycINFO ...
Chang Grace G Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Psychiatry, VA Boston Healthcare System, 940 Belmont Street, Brockton, MA 02301, USA. Electronic address: - - 2014
The use of alcohol and other substances is not infrequent during pregnancy and may be associated with adverse effects on pregnancy outcome. Many pregnant women may continue these practices throughout pregnancy and even after delivery, unless they are recognized and assessed. Screening may be one way to achieve consistent and ...
Connery Hilary Smith HS Division of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Substance use among adolescents increases the risk of unplanned pregnancies, which then increases the risk of fetal exposure to addictive, teratogenic substances. Specific interventions are necessary to target pregnancy planning and contraception among reproductive-age substance users. Screening for substance use using the CRAFFT is recommended in all health care settings ...
Lindqvist Maria - - 2014
Although associated adverse pregnancy outcomes, no international or Swedish consensus exists that identifies a cut-off value or what screening method to use for definition of gestational diabetes mellitus. This study investigates the following: i) guidelines for screening of GDM; ii) background and risk factors for GDM and selection to OGTT; ...
Garcia-Tizon Larroca Santiago S Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
Objective: To assess the risk for preeclampsia (PE) by maternal characteristics, uterine artery pulsatility index (Ut-PI), mean arterial pressure (MAP), serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) at 30-33 weeks' gestation. Methods: This was a screening study in singleton pregnancies including 2,140 that developed PE and ...
De Clippel Dorien D Blood Service, Belgian Red Cross-Flanders, Gent, - - 2014
Transfusion-related acute lung injury (TRALI) is known as a life-threatening complication of transfusion. HLA and HNA antibodies have been associated with the immune pathway of TRALI. Since donors with a history of transfusion and/or pregnancy are presumed to have an increased risk of carrying such antibodies, we investigated the association ...
Ekin A A Department of Perinatology, Izmir Tepecik Training and Research Hospital , Izmir , - - 2014
The aim of our study was to evaluate the incidences and chromosomal abnormality detection rates of various indications for genetic amniocentesis. We retrospectively analysed 6,142 amniocentesis cases performed in a single centre between January 2007 and April 2013. We assessed the indications for prenatal diagnosis, fetal karyotypes, maternal ages, fetal ...
Banch Clausen F F Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, - - 2014
Prenatal and postnatal RhD prophylaxis reduces the risk of RhD immunization in pregnancies of RhD-negative women. Based on the result from prenatal screening for the fetal RHD gene, prenatal RhD prophylaxis in Denmark is targeted to RhD-negative women who carry an RhD-positive fetus. Here, we present a 2-year evaluation of ...
Halscott Torre L TL Division of Maternal-Fetal Medicine, MedStar Washington Hospital Center, MedStar Georgetown University Hospital, Washington, DC, - - 2014
The use of first trimester screening to detect aneuploidy has become an integral part of prenatal care. The application of similar screening algorithms to identify women at the highest risk for other adverse pregnancy outcomes in the first trimester could potentially have a major clinical impact. There has been much ...
Lai Jonathan J Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
Objective: To assess the risk for preeclampsia (PE) by maternal characteristics, serum placental growth factor (PIGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) at 30-33 weeks' gestation. Methods: This was a screening study in singleton pregnancies including 2,140 that subsequently developed PE and 83,615 that were unaffected by PE, gestational hypertension ...
Cohen Daniel N DN Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, - - 2014
RhIG is used worldwide to reduce the incidence of alloimmunization to D during pregnancy. We report a case of clinically significant neonatal hemolysis mediated by maternally administered RhIG. A 25-year-old, O-, primigravid mother with a negative antenatal antibody screen delivered a 6-lb 4-oz, blood group A, D+ baby girl at ...
Azizi Fereidoun F Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Maternal hypothyroidism in pregnancy is associated with several adverse outcomes. The American Thyroid Association and the Endocrine Society Guidelines for the management of thyroid diseases in pregnancy were published in 2011 and 2012, respectively; however, impact of the guidelines in routine clinical practice is unknown. We therefore carried out a ...
Simon Emmanuel G EG University Hospital Center of Tours, Department of Obstetrics, Gynecology and Fetal Medicine, 2, boulevard Tonnellé, 37044 Tours Cedex 9, France; Inserm U930, François Rabelais University, 2 boulevard Tonnellé, 37044 Tours Cedex 9, - - 2014
In the first trimester of pregnancy, a biparietal diameter (BPD) below the 5(th) percentile is a simple marker that makes it possible to detect half of all cases of open spina bifida. We hypothesized that relating the BPD measurement to the transverse abdominal diameter (TAD) might be another simple and ...
Guzel Ali Irfan AI Burak Women's Health Research and Education Hospital, Department of Obstetrics and Gynecology; - - 2014
Objective: To evaluate the diagnostic value of screening laboratory tests in women who had recurrent pregnancy loss (RPL). Methods: A total of 252 women with RPL managed in our tertiary referral research and education hospital were included in the study. Risk factors recorded involved age, gravidity, parity, number of prior ...
Goldfarb Ilona T IT Massachusetts General Hospital, Boston, - - 2014
Obstructive sleep apnea (OSA) as diagnosed by polysomnography has been associated with preeclampsia and intrauterine growth restriction (IUGR). The use of validated screening tools in pregnancy is unknown. We sought to examine the association between a positive screen on one validated OSA tool, the STOP-BANG Questionnaire, and preeclampsia or IUGR. ...
Ozdamar Ozkan O Ozkan Ozdamar, Department of Obstetrics and Gynecology, Golcuk Military Hospital, Golcuk, Kocaeli, - - 2014
We aimed to detect whether maternal serum free β-hCG and PAPP-A levels and NT measurements vary between normal pregnancies and those that subsequently develop pre-eclampsia and to evaluate the role of these screening serum analytes in the prediction of pre-eclampsia. Using a case-control study design, we identified all women who ...
Poon Leona C LC Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
Preeclampsia (PE), which affects about 2% of pregnancies, is a major cause of maternal and perinatal morbidity and mortality. PE can be subdivided into early onset PE, requiring delivery <34 weeks' gestation and late onset PE with delivery >34 weeks. Early onset PE is associated with a higher incidence of adverse outcome. ...
Kagan K O KO Department of obstetrics and gynaecology, University of - - 2014
In the last decades, prenatal screening for aneuploidy has become increasingly effective. While first trimester combined screening is considered to be the current gold standard, the use of cell-free fetal DNA (cffDNA), which is also called noninvasive prenatal testing (NIPT), will result in a change of paradigm. Respective studies indicate ...
He Sheng S Prenatal Diagnostic Center, Guangxi Zhuang Automonous Region Women and Children Care Hospital, 59 Xiangzhu Road, Naning 530000, People's Republic of - - 2014
To demonstrate the performance of Hb Bart's Disease prevention in Guangxi Zhuang Autonomous Region, China. A prenatal control program for Hb Bart's disease was conducted from January 2006 to December 2012. A total of 17,555 pregnant women were screened for α-thalassemia in our prenatal screening program. Pregnancy at-risk for Hb ...
Sayres Lauren C LC Duke University School of Medicine, Durham, NC, - - 2014
This study seeks to inform clinical application of cell-free fetal DNA (cffDNA) screening as a novel method for prenatal trisomy detection by investigating public attitudes towards this technology and demographic and experiential characteristics related to these attitudes. Two versions of a 25-item survey assessing interest in cffDNA and existing first-trimester ...
Marren Anthony J AJ RPA Women and Babies, Royal Prince Alfred Hospital, Sydney, New South Wales, - - 2014
Using a fixed cut-off of ≤25 mm, ultrasound assessment of cervical length during the 18-23 week anomaly scan has been shown to identify approximately 50% of pregnancies that would deliver prior to 34 weeks. To determine whether a policy of reverting to transvaginal cervical assessment only if the cervix appears short (≤25 mm) on ...
Gebeile Rémi R Service d'hématologie et microbiologie, Laboratoire de biologie médicale, Centre hospitalier de Chambéry, - - 2014
The aim of the study is to specify the pre-analytical conditions required for Down's syndrome screening in first trimester by maternal serum markers. The concentration variation of both markers, hCGβ and PAPP-A, was analyzed at room temperature, at 4°C and during freezing-thawing cycles. Serum can be kept during 72h between ...
Chambers Christina D - - 2014
Fetal alcohol spectrum disorders are thought to be a leading cause of developmental disabilities worldwide. However, data are lacking on alcohol use among pregnant women in many countries. The purpose of this study was to evaluate the prevalence and predictors of alcohol consumption by pregnant women in Ukraine. Cross-sectional screening ...
Belahcen Amina A Mohammed V University - Souissi, Faculty of Medicine and Pharmacy, Rabat, Morocco; Tératovigilance Research Team, Mohammed V University - - - 2014
Abortion is prohibited and penalized in Morocco. On the other hand, there is no strategy or consensus for prenatal screening for Down syndrome (PSDS) included into the Moroccan pregnancy monitoring national program. This study aims to explore the awareness and attitudes of women who have a child with DS regarding ...
Goetzinger Katherine R KR Department of Obstetrics & Gynecology, Washington University in St. - - 2014
Second-trimester biomarkers were initially introduced with the intent of screening for neural tube defects, and then subsequently for Down syndrome. It was soon realized that these markers can be indirect evidence of abnormal placentation and, therefore, can be used for screening for adverse pregnancy outcomes. Several new biomarkers have subsequently ...
Debost-Legrand Anne - - 2014
Congenital malformations occur in 3-4% of live births. Their prenatal detection is performed by ultrasound screening. Any announcement about a suspected malformation is a source of stress for the parents, and misdiagnosis during ultrasound screening can lead to expensive and sometimes iatrogenic medical interventions. In this study, we aim to ...
Papastefanou Ioannis I Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, University of Athens, 'Attikon' University Hospital, Athens, - - 2014
To predict small for gestational age (SGA, at or below the 5(th) birthweight centile) and large for gestational age (LGA, at or above the 95(th) birthweight centile) fetuses by using maternal and fetal parameters from the second and third trimester ultrasound examinations. Retrospective cohort study on 1979 singleton pregnancies that ...
Blumenfeld Yair J YJ Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address: - - 2014
To examine the association between placental abruption, maternal characteristics, and routine first and second trimester aneuploidy screening analytes. Analysis of 1,017 women with and 136,898 women without placental abruption who had first and second trimester prenatal screening results, linked birth certificate, and hospital discharge records for a live born singleton. ...
Taché Véronique V Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of California, Davis, Sacramento, CA. Electronic address: - - 2014
To examine the relationship between second trimester maternal serum biomarkers and the development of early- and late-onset severe preeclampsia in euploid pregnancies. Included were 136,139 pregnancies participating in second trimester prenatal screening through the California Prenatal Screening Program with live births in 2006 through 2008. We identified severe preeclampsia diagnoses ...
Sonek Jiri J *Fetal Medicine Foundation, Dayton †Department of Obstetrics and Gynecology, Wright State University, Dayton, - - 2014
Although it is widely accepted that the best time to screen for chromosomal abnormalities is the first trimester, ultrasound evaluation of the fetus in the second trimester has also been shown to be useful for this purpose. A multitude of markers of varying strength has been developed over the past ...
Moon-Grady Anita J AJ Fetal Cardiovascular Program, Department of Pediatrics, Division of Cardiology, The Fetal Treatment Center, University of California, Benioff Children's Hospital, San Francisco, - - 2014
Advances in both imaging technology and understanding of fetal cardiac disease have contributed to a dramatic increase in the sensitivity and specificity of fetal echocardiography over the last few decades. Fetal echocardiography now plays an important role in the prenatal evaluation of fetuses with known or suspected aneuploidy. In this ...
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