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Muraro Ana Paula - - 2014
There is strong evidence of an association between maternal smoking during pregnancy and restriction of intrauterine growth, but the effects of this exposure on postnatal linear growth are not well defined. Furthermore, few studies have investigated the role of tobacco smoke exposure also after pregnancy on linear growth until adolescence. ...
Boutsikou Theodora T Department of Neonatology, Athens University Medical School , Athens , Greece - - 2014
Abstract Objective: To determine levels of the possible angioregulatory molecules netrin-1 and -4, in intrauterine-growth-restricted (IUGR), large for gestational age (LGA) (both groups characterized by altered angiogenic mechanisms) and appropriate-for-gestational-age (AGA) pregnancies. Methods: Cord blood (UC) netrin-1 and -4 concentrations were measured in 30 IUGR, 30 LGA and 20 AGA ...
Boutsikou Theodora - - 2014
Abstract Objective: To determine levels of galectins (gal)-1 and -3 (implicated in angiogenesis/immunologic mechanisms) in intrauterine growth restricted (IUGR), large (LGA) and appropriate for gestational age (AGA) pregnancies, as these groups differ in fat mass, angiogenic patterns and immune responses. Methods: Cord-blood (UC) gal-1 and -3 concentrations were measured in ...
Li Wei W Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery,Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts - - 2014
Preeclampsia is a complication of pregnancy manifested as maternal hypertension and often fetal growth restriction. Placental ischemia could be an initiating event, but the linking mechanisms leading to hypertension and growth restriction are unclear. We have shown an upregulation of matrix metalloproteinases (MMPs) during normal pregnancy (Norm-Preg). To test the ...
Higgins Stephen T ST Vermont Center on Behavior and Health, University of Vermont, USA; Department of Psychiatry, University of Vermont, USA; Department of Psychology, University of Vermont, USA. Electronic address: - - 2014
To examine whether an efficacious voucher-based incentives intervention for decreasing smoking during pregnancy and increasing fetal growth could be improved without increasing costs. The strategy was to redistribute the usual incentives so that higher values were available early in the quit attempt. 118 pregnant smokers in greater Burlington, Vermont (studied ...
Walsh Jennifer M JM UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, - - 2014
Interrogation of the association between leptin, insulin resistance and fetal growth may provide a biological link for the fetal programming of later metabolic health. Our aim was to clarify the relationship between maternal and fetal leptin, insulin resistance and fetal growth. Maternal leptin, glucose and insulin were measured in early ...
Herrera Emilio - - 2014
More glucose crosses the placenta than any other substrate, but correlations between its concentration in maternal plasma and fetal growth are not found consistently. The accumulation of maternal fat depots and hyperlipidemia are the two principal changes in lipid metabolism during pregnancy. Although lipids cross the placenta with difficulty, maternal ...
Arcos-Machancoses Jose Vicente JV Department of Pediatrics, University & Polytechnic Hospital La Fe, Valencia, - - 2014
The presence of a single umbilical artery (SUA) is a fetal soft marker of congenital abnormalities. Among the most common related malformations, there are cardiological, nephrourological and digestive anomalies, most of which are considered to have a vascular etiology. There is an association between increased incidence of intrauterine growth retardation ...
Murase Harutaka H Equine Science Division, Hidaka Training and Research Center, Japan Racing - - 2014
It has not been common to perform regular ultrasound examination of the fetus in equine practice, due to the increasing volume of the uterus caused by fetal development. The convex three-dimensional transducer is bulb-shaped, and is able to observe wide areas. In addition, its operation is simple, making it easy ...
Forhead Alison J AJ A Forhead, University of Cambridge, Dept of Physiology, Cambridge, CB2 3EG, United - - 2014
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are essential for normal growth and development of the fetus. Their bioavailability in utero depends on development of the fetal hypothalamic-pituitary-thyroid gland axis and the abundance of thyroid hormone transporters and deiodinases that influence tissue levels of bioactive hormone. Fetal T4 and ...
Nucci Marta M Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, - - 2014
Objective: To compare the maternal serum concentrations of placental growth factor (PlGF)-1 and PlGF-2 in the first, second and third trimesters in normal pregnancies and in those complicated by pre-eclampsia (PE) or the delivery of small for gestational age (SGA) neonates after 37 weeks. Methods: Serum PlGF-1 and PlGF-2 were ...
Bahr B B Department of Physiology and Developmental Biology, Brigham Young University, 595 WIDB, Provo, UT 84602, - - 2014
Intrauterine growth restriction (IUGR) has been documented to increase placental apoptosis at term. HSP27 has been shown to be involved in the control of apoptosis. Our objective is to determine the expression of phosphorylated HSP27 (p-HSP27) in human IUGR, and to determine the role of HSP27 during gestation in an ...
Salam Rehana A RA aDivision of Woman and Child Health, Aga Khan University, Karachi, Pakistan bProgram for Global Pediatric Research, Hospital for Sick Children, Toronto, Ontario, - - 2014
Intrauterine growth restriction (IUGR) is responsible for the higher rates of fetal, perinatal, and neonatal morbidity and mortality. This review details the IUGR risk factors, its short and long-term sequel, the mechanism underlying the long-term consequences, and the strategies to tackle IUGR burden. Short-term consequences of IUGR involve metabolic, thermal, ...
Belluscio Laura M LM Laboratorio de Biología Molecular, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón II, 1428 Ciudad de Buenos Aires, - - 2014
Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth ...
Gaillard Romy R Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The - - 2014
Fetal growth characteristics are used to identify influences of several maternal characteristics and to identify individuals at increased risk of adverse outcomes. The extent to which fetal growth characteristics track in different trimesters is not known. In a population-based prospective cohort study among 8636 pregnant women, we examined the extent ...
Laskowska Marzena M Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, - - 2014
Objective: The aim of present study was to assess the maternal serum eNOS, NOSTRIN and ADMA levels in pregnancies with intrauterine growth restriction in the presence or absence of preeclampsia and to compare the results with preeclamptic pregnant women with appropriate-for-gestational-age weight infants. Patients and methods: The study was performed ...
Carr David D University College London, UCL Institute for Women's Health, 86-96 Chenies Mews, London, United Kingdom, WC1E 6HX, University of Aberdeen, Rowett Institute of Nutrition and Health, Greenburn Lane, Bucksburn, Aberdeen, United Kingdom, AB21 9SB ; - - 2014
Introduction: Fetal growth restriction (FGR) occurs in ~8% of pregnancies and is a major cause of perinatal mortality and morbidity. There is no effective treatment. FGR is characterised by reduced uterine blood flow (UBF). In normal sheep pregnancies, local uterine artery (UtA) adenovirus (Ad) mediated over-expression of vascular endothelial growth ...
Jerabek-Klestil Susanne S Department of Gynecology and Obstetrics, Innsbruck Medical University Hospital, Anichstrasse 35, 6020 Innsbruck, Austria. - - 2014
The incidence of fetal portosystemic anastomoses is unknown, and it is presumed that many cases remain undetected, as visualization of the hepatic vasculature is not part of the routine 20-week sonographic scan in pregnancy. However, portosystemic anastomoses are associated with fetal growth restriction due to a diminished oxygen supply to ...
Ashraf Tasneem T Department of Obstetrics and Gynaecology, Bolan Medical College, - - 2014
Aggressive angiomyxoma is a locally aggressive soft tissue tumour mainly arises from perineal, vulval and bladder connective tissue. As it has a tendency for local infiltration and recurrence so long-term follow-up and treatment is required. A case of 24 years old primigravida, 16 weeks pregnant with huge pedunculated lobulated growth ...
de Steenwinkel Florentien D O FD Department of Rheumatology, Erasmus MC, Rotterdam, The - - 2014
Objective Active rheumatoid arthritis (RA) during pregnancy and the presence of rheumatoid factor (RF) or anti-citrullinated protein antibody (ACPA) are related with a lower birth weight. Prednisone reduces the gestational age. Rapid catch-up in weight for length during the first year of life has been related to worse cardiovascular and ...
Pinar Halit H a Women and Infants Hospital, Division of Perinatal and Pediatric - - 2014
Abstract ABSTRACT Identifying growth abnormalities in stillbirths is clinically useful, but complicated by maceration. This is an observational study of consecutive postmortem examinations where femur lengths and gestational age at delivery were collected, along with associated congenital anomalies and extent of fetal maceration. Between 2005 and 2012, 1,530 consecutive postmortem ...
Rogne Tormod T Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, - - 2014
To evaluate how different levels of increase in maternal blood glucose from a fasting state to two hours after an oral glucose challenge in late pregnancy is associated with fetal growth, with special emphasis on those with a low increase. Prospective cohort study. We followed 855women, of whom 70% had ...
Chawla Reeti R Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, - - 2014
Small for gestational age (weight for gestational age <10th percentile, SGA) birth status and adulthood susceptibility to diabetes is well established, but the relationship to diabetes during pregnancy is incompletely understood. The authors investigated the association between women's impaired fetal growth (as measured by SGA status) and diabetes mellitus (DM) ...
Mifsud William W Department of Paediatric Histopathology, Great Ormond Street Hospital, London, - - 2014
Several histopathological features are found more frequently in placentas from pregnancies complicated by fetal growth restriction (FGR), including villous infarction, maternal vascular changes and villous morphological alterations, although around one quarter of placentas associated with FGR lack any morphological abnormality on routine examination. Since similar changes may also affect clinically ...
Smith Nicole A NA Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, - - 2014
Fetal growth restriction is a strong risk factor for stillbirth. We aimed to compare the performance of three fetal growth curves: customized, ultrasound (Hadlock), and population, in identifying abnormally grown fetuses at risk of stillbirth. We performed a case-control study of singleton stillbirths (2000-2010) at one center. Four liveborn controls ...
Tran Melanie M The University of - - 2014
Adverse conditions in utero can have transgenerational effects, in the absence of a subsequent insult. We aimed to investigate the contribution of the maternal pregnancy environment vs. germ-line effects in mediating alterations to cardio-renal and metabolic physiology in offspring from mothers born small. Uteroplacental insufficiency was induced by bilateral uterine ...
Gutaj Paweł - - 2014
Abstract Aim: To analyze the role of maternal placental growth factor (PlGF) in the prediction of small for gestational age (SGA) birth weight in pregnancy complicated by type 1 diabetes mellitus (T1DM). Methods: A prospective observational study on 59 normotensive T1DM pregnant women, assessing maternal PlGF concentrations between the 10th-14th ...
Georgiadis L L Department of Obstetrics and Gynaecology, Kuopio University Hospital, P.O Box 100, 70029 Kuopio, Finland; University of Eastern Finland, Department of Clinical Medicine, P.O Box 1627, 70211 Kuopio, Finland. Electronic address: - - 2014
Many complications of pregnancy and delivery are associated with umbilical cord length. It is important to examine the variation in length, in order to identify normal and abnormal conditions. Moreover, the factors influencing cord growth and development are not precisely known. The main objectives were to provide updated reference charts ...
Miyamoto A A Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, - - 2014
The establishment of pregnancy requires well-balanced regulation of the endocrine and immune systems and involves interactions among the conceptus, oviduct-uterus, and corpus luteum (CL). In particular, a rapid increase in plasma progesterone during the first week after ovulation is critical for the growth of the conceptus and successful pregnancy in ...
Dierickx I I Department of Obstetrics and Gynaecology, U.Z. Gasthuisberg , KU Leuven , - - 2014
Background: Fetal/neonatal hyperthyroidism is a well-known complication of maternal Graves' disease with high concentrations of TSH-receptor antibodies (TRAb). Few data are available on the management of fetal hyperthyroidism in surgically treated Graves' disease. Methods: Clinical, ultrasound and biochemical data are reported in a fetus/neonate whose mother underwent a thyroidectomy > ...
Vesce F F Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Italy. - - 2014
To assess the eventual influence of low dose betamethasone throughout pregnancy on fetal growth. 320 patients - admitted to the Section of Obstetrics and Gynecology of Ferrara University from January 2005 to December 2010 - were subdivided in two groups: 160 patients affected by recurrent spontaneous abortion (Group A), treated ...
Morales-Roselló José J Fetal Medicine Unit, Academic Department of Obstetrics and Gynecology, St George's University of London, - - 2014
To evaluate whether changes in the middle cerebral artery (MCA), umbilical artery (UA) and cerebroplacental ratio (CPR) Doppler indices at term might be used to select those appropriate for gestational age (AGA) fetuses, failing to reach their growth potential (FRGP). This was a retrospective cohort study in a single tertiary ...
Borras D D Department of Obstetrics and Gynecology, Hospital Universitario La Fe , Valencia , - - 2014
The aim of this paper was to study if soluble fms-like tyrosine kinase 1 (sFlt-1), free vascular endothelial growth factor (f-VEGF) and the f-VEGF/sFlt-1 quotient in singleton pregnancies complicated with intrauterine growth restriction (IUGR) are different from controls. This was a case-control study between 18 pregnancies with IUGR and 24 ...
Grazul-Bilska Anna T AT A Grazul-Bilska, Animal Sciences, North Dakota State University, Fargo, 58108, United - - 2014
Utero-placental growth and vascular development are critical for pregnancy establishment that may be altered by various factors including assisted reproductive technologies (ART), nutrition, or others, leading to compromised pregnancy. We hypothesized that placental vascularization and expression of angiogenic factors are altered early in pregnancies after transfer of embryos created using ...
Visser Gerard H A GH Departments of Obstetrics, University Medical Center, Utrecht, The - - 2014
The outcome of early small-for-gestational age and/or intrauterine growth-restricted fetuses is reviewed. In these fetuses the outcome appears to be considerably poorer than that of appropriately grown fetuses and this seems mainly to be caused by intrauterine malnutrition rather than by hypoxemia. Active management of intrauterine growth restriction at the ...
Miller Suzanne L SL The Ritchie Centre, Monash Institute of Medical Research, Monash University, 27-31 Wright St, 3168, Clayton, Victoria, Australia; Department of Obstetrics & Gynaecology, Southern Clinical School, Monash University, 3800, Clayton, Victoria, - - 2014
Fetal intrauterine growth restriction (IUGR) is a serious pregnancy complication associated with increased rates of perinatal morbidity and mortality, and ultimately with long-term neurodevelopmental impairments. No intervention currently exists that can improve the structure and function of the IUGR brain before birth. Here we investigated whether maternal antenatal melatonin administration ...
Figueras Francesc F Barcelona Center of Maternal-Fetal Medicine and Neonatology (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, - - 2014
Small fetuses are defined as those with an ultrasound estimated weight below a threshold, most commonly the 10th centile. The first clinically relevant step is the distinction of 'true' fetal growth restriction (FGR), associated with signs of abnormal fetoplacental function and poorer perinatal outcome, from constitutional small-for-gestational age, with a ...
Nucci Marta M Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, - - 2014
Objective: To compare the maternal serum concentration of placental growth factor-1 (PlGF-1) and PlGF-2 at 11-13 weeks' gestation in normal pregnancies and in those complicated by preeclampsia (PE), delivery of small for gestational age (SGA) neonates and fetal trisomies 21, 18 and 13. Methods: Serum PlGF-1 and PlGF-2 were measured ...
Frančišković Vedran V Department of Gynecology and Obstetrics, Perinatology Unit, Clinical Hospital Center Rijeka, Rijeka, - - 2014
Abstract Objective. To test if secular growth acceleration occurs during fetal life. Methods. ANOVA Kruskal-Wallis and Mann-Whitney U test have been used for the biometric characteristics comparison of nowadays fetal population with those three decades ago and to test the hypothesis about the existence of secular growth acceleration during fetal ...
Jones Megan Louise ML M Jones, School of Anatomy, Physiology & Human Biology, The University of Western Australia, Perth, - - 2014
The developing fetus requires substantial amounts of fatty acids to support rapid cellular growth and activity. Although the fatty acid composition delivered to the fetus is largely determined by maternal circulating levels, the placenta preferentially transfers physiologically important long chain polyunsaturated fatty acids (LC-PUFAs), particularly omega-3 (n-3) PUFAs. Maternal dietary ...
Reid Rosemary A RA Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New - - 2014
Context. C-type Natriuretic Peptide (CNP), a vasoactive product of the endothelium, is markedly increased during placentation in ovine pregnancy, and is further stimulated by nutrient restriction. Whether CNP products change in human pregnancy is unknown. Objectives. To compare serial changes in maternal plasma CNP peptides during normal pregnancy with changes ...
Leibovitz Zvi Z Unit of Fetal Neurology and Prenatal Diagnosis, Department of Obstetrics and Gynecology Wolfson Medical Center, Holon, Israel. Sackler School of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Construction of nomograms for fetal midbrain (MB) and hindbrain (HB) dimensions, assessed by 3D-MPR sonographic imaging in the mid-sagittal cranial plane and application of the nomograms to fetuses with posterior fossa malformations. A prospective cross-sectional study of 334 healthy fetuses of low-risk singleton pregnancies between 16 and 35 weeks was performed. ...
Benaglia Laura L Obstet-Gynecol Dept, Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, - - 2014
Several studies aimed to disentangle whether pregnancy influences the growth of uterine fibroids but results were inconsistent. In this study, we speculated that fibroid enlargement during pregnancy may not be linear and we hypothesized that this phenomenon may mainly occur during initial pregnancy. To test this hypothesis, we set up ...
Sullivan L L Leeds Teaching Hospitals NHS Trust, Leeds, - - 2014
PurposeThe use of intravitreal vascular endothelial growth factor (VEGF) inhibitor medications has widened considerably to include indications affecting females of reproductive age.Patients and methodsWe present our experiences following intravitreal injection of bevacizumab during the first trimester of unrecognised pregnancies in four women.ResultsAll our patients were inadvertently exposed to bevacizumab within ...
Santos Juliana J University of São Paulo, São Paulo, Sao Paulo, Brazil. Electronic address: - - 2014
Measurements on the growth process and placental development of the embryo and fetuses of Cavia porcellus were carried out using ultrasonography. Embryo, fetus, and placenta were monitored from Day 15 after mating day to the end of gestation. Based on linear and quadratic regressions, the following morphometric analysis showed a ...
Maruotti G M GM High Risk Pregnancy Centre - Department of Gynaecology and Obstetrics, University Federico II, Via Pansini, 5, 80100 Naples, - - 2014
Abstract Objective: To establish whether there are relationships between umbilical artery Pulsatility Index (PI) and fetal macrosomia in pregnancies complicated by type I diabetes. Methods: In a retrospective observational study 102 singleton pregnant women with type-1 diabetes were considered. Umbilical artery PI was measured by Doppler ultrasonography within one week ...
Alahakoon Thushari I TI Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, Sydney, NSW, - - 2014
Abstract Objective: To evaluate the plasma levels of angiogenic factors in preeclampsia (PE) and intrauterine fetal growth restriction (IUGR) and their potential as biomarkers to distinguish normal from pathological pregnancies. Methods: Case control study included singleton pregnancies in 4 categories: (1) Normal (n=29), (2) PE (n = 15), (3) PE ...
Godoy Guilherme A F GA Departments of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Departments of Paediatrics, Erasmus Medical Center-Sophia Children`s Hospital, Rotterdam, the - - 2014
Variation in maternal thyroid function during early pregnancy may permanently affect childhood growth and cardiovascular development. We examined the associations of early pregnancy maternal TSH and free T4 (FT4) levels with childhood growth, body composition and cardiovascular characteristics. We performed a population-based prospective cohort study among 5,646 mothers and their ...
Bazer Fuller W FW Departments of Animal Science, Texas A&M University, College Station, TX 77843, United States. Electronic address: - - 2014
The litter-bearing pig is an invaluable model for research in reproductive biology. Spherical pig blastocysts on Day 10 of pregnancy undergo rapid morphological changes to tubular and then filamentous forms by Day 12 and a filamentous conceptus of almost 1m in length by Day 16 of pregnancy. Thus, trophectoderm of ...
Christian Parul P Department of International Health, Center for Human Nutrition, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, - - 2014
In 2010, 171 million children under 5 years old were estimated to be stunted globally, with 98% being from low- and middle-income countries. Low birthweight including fetal growth restriction is also common in these regions and may contribute to childhood undernutrition. As part of the Child Health Reference Group (CHERG) ...
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