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Philippat Claire C From the aInserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; bUniversity of Grenoble Alpes, IAB, Grenoble, France; cInserm, Center for research in Epidemiology and Population Health, U1018, Team Epidemiology of Diabetes, Obesity and Renal Disease: Lifelong Approach, Villejuif, France; dUniversité Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France; and eCenters for Disease Control and Prevention, Atlanta, - - 2014
Phenols interact with nuclear receptors implicated in growth and adipogenesis regulation. Only a few studies have explored their effects on growth in humans. We studied the associations of maternal exposure to phenols during pregnancy with prenatal and postnatal growth of male newborns. Within a cohort of women recruited during pregnancy, ...
Rasmussen Anne Staub AS MR Research Centre, Aarhus University Hospital, Skejby, Aarhus N, 8200, Aarhus, Denmark, - - 2014
While intrauterine growth restriction is often associated with placental dysfunction or abnormal morphology, the link between fetal weight and the placental delivery capacity of blood has not been studied in detail. The purpose of this study was to investigate the relationship between the fetal placental blood volume (FPBV) and fetal ...
Reynolds Simone A SA Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA, 15261, USA, - - 2014
The objective of this study is unknown if fetal sex and race modify the impact of maternal pre-pregnancy body mass index (BMI), and smoking on fetal growth. The authors studied markers of fetal growth in singleton offspring of 8,801 primiparous, normotensive women, enrolled in the Collaborative Perinatal Project. The authors ...
Hoyer M J MJ Artis Royal Zoo, Amsterdam, the - - 2014
This study was conducted to establish representative curves that allow evaluation of fetal growth and estimation of gestational age from measurement of fetal structures by ultrasound in Malayan tapirs (Tapirus indicus). Three pregnancies (i.e. 3 fetuses) were examined in one female Malayan tapir. Transabdominal ultrasonographic examination was performed without anesthesia ...
Veerbeek J H W JH University Medical Center Utrecht, Division of Perinatology, Department of Obstetrics, The Netherlands. Electronic address: - - 2014
To identify key pathological characteristics of placentas from pregnancies complicated by early intrauterine growth restriction, and to examine their relations with maternal hypertensive disease and umbilical artery Doppler waveform abnormalities. Single-center retrospective cohort study of singleton pregnancies with abnormal umbilical artery Doppler flow patterns resulting in a live birth <34 ...
Papageorghiou Aris T AT Nuffield Department of Obstetrics & Gynaecology and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, - - 2014
There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations. The INTERGROWTH-21(st) Project aimed to produce the first, international standards for early fetal size and ultrasound dating of pregnancy based on CRL measurement. Urban areas in eight ...
Karadeniz O O Department of Obstetrics and Gynecology, Akdeniz University , Antalya , - - 2014
Intrauterine growth restriction (IUGR) is one of the most common problems in obstetrics. Ischaemia-modified albumin (IMA), a product deriving from albumin as a result of the modification by oxidative free radicals in response to hypoxia, was previously used as a marker of ischaemia in acute coronary syndrome. We performed this ...
Herraiz Ignacio I Fetal Medicine Unit-SAMID, Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Madrid, Spain; and the Department of Obstetrics, Charité University Medicine, Berlin, - - 2014
To characterize the values of the soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio in pregnancies with fetal growth restriction with or without concurrent preeclampsia or hemolysis, elevated liver enzymes and low platelets syndrome (HELLP) and in pregnancies with normally grown fetuses with or without concurrent preeclampsia ...
Prossler J J Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address: - - 2014
During the first trimester of human pregnancy, specialised placental cells called extravillous trophoblasts (EVTs) grow out from anchoring villi, invade the maternal decidua and remodel the uterine spiral arteries. Inadequate EVT invasion is associated with pregnancy complications including intrauterine growth restriction (IUGR) and pre-eclampsia. During early pregnancy, the placenta exists ...
Araujo Júnior Edward E Referral Center for Teaching of Diagnostic Imaging, São Paulo, Brazil (E.A.J., C.R., S.M.Z.F.); Department of Obstetrics, Paulista School of Medicine, São Paulo Federal University, São Paulo, Brazil (E.A.J., E.F.M.S., J.E.J.); Department of Obstetrics and Gynecology, School of Medicine of Ribeirão Preto, São Paulo University, Ribeirão Preto, Brazil (W.P.M.); Ultrasonography and Retraining Medical School of Ribeirão Preto, Ribeirão Preto, Brazil (W.P.M.); and Department of Gynecology and Obstetrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas USA - - 2014
The purpose of this study was to establish reference charts of fetal biometric parameters measured by 2-dimensional sonography in a large Brazilian population. A cross-sectional retrospective study was conducted including 31,476 low-risk singleton pregnancies between 18 and 38 weeks' gestation. The following fetal parameters were measured: biparietal diameter, head circumference, ...
Bloise Enrrico E Laboratory of Molecular Endocrinology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
The number of children conceived using assisted reproductive technologies (ART) has reached >5 million worldwide and continues to increase. Although the great majority of ART children are healthy, many reports suggest a forthcoming risk of metabolic complications, which is further supported by the Developmental Origins of Health and Disease hypothesis ...
Bowman Zachary S ZS Department of Obstetrics & Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT; Intermountain Healthcare, Salt Lake City, UT. Electronic address: - - 2014
The placenta forms the interface between the mother and the fetus and is essential to fetal growth and development. In addition to the exchange of gases and nutrients, it serves immunologic and endocrine functions that protect the fetus and support physiological changes in pregnancy. Although often largely ignored during routine ...
Dhobale Madhavi M Bharati Vidyapeeth University, Pune-411043, India. Electronic address: - - 2014
Proper placental development is essential during pregnancy since it forms the interface between the maternal-fetal circulations and is critical for fetal nutrition and oxygenation. Neurotrophins such as nerve growth factor (NGF), brain derived neurotrophin (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) are naturally occurring molecules that regulate development of the placenta ...
Deter Russell L RL Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, - - 2014
Abstract Objective: To evaluate the impact of late 3(rd) trimester fetal growth cessation on anatomical birth characteristic predictions used in classifying SGA neonates. Methods: A prospective longitudinal study was performed in 119 pregnancies with normal neonatal growth outcomes. Seven biometric parameters were measured at 3-4 week intervals using 3D ultrasonography. ...
Crimmins S S Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of - - 2014
To evaluate the surveillance characteristics that precede stillbirth in growth restricted fetuses (FGR) that receive integrated Doppler and biophysical profile scoring. 987 singleton pregnancies complicated by FGR had multi-vessel Doppler (umbilical (UA), middle cerebral (MCA) arteries, ductus venosus (DV), umbilical vein (UV)) and biophysical profile scoring (BPS). Surveillance findings were ...
Straley M E ME The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland; Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, - - 2014
During pregnancy, maternal infection at different stages of gestation increases the risk of developing several psychiatric and neurological disorders later in life for affected offspring. As placental health is intrinsically linked to neurodevelopmental outcome, maternal infection may adversely affect the placenta at or before the gestational stages it affects fetal ...
Myers Jenny E JE Maternal & Fetal Heath Research Centre, Manchester Academic Health Science Centre, University of Manchester, Central Manchester NHS Trust, Manchester, United Kingdom - - 2014
An overrepresentation of adverse pregnancy outcomes has been observed in pregnancies associated with a male fetus. We investigated the association between fetal gender and candidate biomarkers for preeclampsia. Proteins were quantified in samples taken at 20 weeks from women recruited to the SCreening fOr Pregnancy Endpoints (SCOPE) study (preeclampsia n ...
Frey Heather A HA Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, - - 2014
To estimate the risk of stillbirth among pregnancies complicated by a major isolated congenital anomaly detected by antenatal ultrasonography and the influence of incidental growth restriction. A retrospective cohort study of all consecutive singleton pregnancies undergoing routine anatomic survey between 1990 and 2009 was performed. Stillbirth rates among fetuses with ...
Galthen-Sørensen Mathias M Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, - - 2014
Vitamin D deficiency or insufficiency in pregnancy is widespread worldwide. Associations between maternal vitamin D levels and anthropometrics of the newborn have been demonstrated in some, but not all studies. The role of maternal vitamin D levels on fetal bone growth is sparsely studied. Our objective was to perform a ...
Izquierdo Luis A LA Division of Maternal Fetal Medicine, University of New Mexico School of Medicine, MSC 105580, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: - - 2014
During early gestation, drugs have teratogenic effects and can be associated with structural anomalies in the fetus. Substance abuse can also have physiologic effects on the mother and fetus, including decreased uterine blood flow, increased vascular resistance, and an increase in fetal blood pressure. Women at increased risk for stillbirth ...
Kong K L KL 1 Department of Food Science and Human Nutrition, Iowa State University, Ames, - - 2014
Few studies have investigated the impact of lifestyle interventions during pregnancy on post-partum weight retention and infant growth. Thirty seven previously non-exercising, overweight or obese pregnant women were randomly assigned to a walking intervention or non-intervention control. For the follow-up study, weight of the mother and weight, length and body ...
Barbero A A 1 Universidad Complutense de Madrid, Facultad de Veterinaria, Madrid, - - 2014
The main role of early nutritional programming in the current rise of obesity and associated diseases is well known. However, translational studies are mostly based in postnatal food excess and, thus, there is a paucity of information on the phenotype of individuals with prenatal deficiencies but adequate postnatal conditions. Thus, ...
Giddings S S Perinatal Institute, Birmingham, - - 2014
Small for gestational age (SGA) birthweight has an increased association with perinatal mortality when defined by a customised instead of a population based standard.(1) We wanted to examine whether this applies also to ultrasound estimated fetal weight (EFW) in a South Asian cohort. The data were extracted from an NHS ...
Southam M M Perinatal Institute, Birmingham, - - 2014
Previous delivery of a small for gestational age (SGA) baby is an accepted indication for increased surveillance in subsequent pregnancies. We sought to quantify the effectiveness of the various serial scan protocols which were in operation in our NHS Region. The cohort consisted of 5281 singleton, normally formed pregnancies with ...
Imcha M M Queen Elizabeth the Queen Mother Hospital, Margate, Kent, Margate, - - 2014
PAPP-A is a biochemical marker in first trimester screening undertaken at 11-13 weeks gestation. Studies have shown that low levels of it (<0.4 MoM) are descriptive of poor early placentation and can be an independent risk factor of complications associated with adverse obstetric outcomes. Review existing management and pregnancy outcome ...
Shajpal A A Leicester Royal Infirmary, Leicester, - - 2014
: Fetal growth restriction (FGR) affects around 5% of pregnancies. Failing to detect and manage pregnancies with FGR increases the risk of stillbirth. There are two main challenges to detecting these fetuses. Firstly identifying the group of pregnancies that need growth scans, secondly using growth charts appropriate for the population ...
Williams M M Perinatal Institute, Birmingham, - - 2014
We wanted to quantify the association between decreased fetal movements (DFM), fetal growth restriction (FGR) and stillbirth in a maternity population which routinely receives reminders throughout pregnancy about the significance of DFM. The database was collected between 2009 and 2012 from the national hand held maternity record, which contains auditable ...
Mohadeb D D Royal Victoria Infirmary, NUTH NHS Foundation Trust, Newcastle Upon Tyne, - - 2014
Thrombophilia has been linked to adverse pregnancy outcomes; however the timing and role of thrombophilia testing following pregnancy loss remains controversial. The RCOG guideline on late pregnancy loss advises thrombophilia testing at delivery whereas BSH guidance states the evidence for this is limited and conflicting. The aim of this study ...
Sefe Dk D Royal Free London NHS Foundation Trust, London, - - 2014
: Fetal/Placental weight ratio (FPWR) is a useful tool for assessing fetal growth, which is consistent across ethnic groups (Perry, 1995). The FPWR increases during gestation (Pardi, 2002) but IUGR pregnancies have been shown to be associated with reduced FPWR compared to normal singleton pregnancies of the same gestation (Heinenon, ...
James Cp C Fetal Medicine Unit, University College London Hospital, London, - - 2014
Gastroschisis is associated with low birthweight, which is thought to be due to protein leakage into the amniotic fluid from herniated bowel, bowel inflammation, placental chorangiosis and villous oedema. Little is known about the growth trajectories of fetuses affected with gastroschisis compared to those of normal fetuses. A retrospective review ...
Fidanza Antonella - - 2014
To evaluate how Assisted Reproduction Technologies (ART) affect vasculogenesis of the developing conceptus, we analyzed placental and fetal development of sheep embryos produced in vitro (IVP). Pregnancies produced by ART carry increased risk of low birth weight, although what causes this risk remains largely unknown. We recently reported that developmental ...
Neubert Hendrik H aPfizer Inc., Pharmacokinetics Dynamics and Metabolism, Andover, Massachusetts bPfizer Inc., Pharmacokinetics Dynamics and Metabolism, Groton, Connecticut cPfizer Inc., Clinical Statistics, San Diego, California, - - 2014
Serum β-nerve growth factor (NGF) concentrations were determined in pregnant female, nonpregnant female, and male cynomolgus monkeys using a highly selective and sensitive immunoaffinity liquid chromatography-tandem mass spectrometry assay. NGF was significantly higher in pregnant monkeys than in nonpregnant female and male monkeys. NGF increased over pregnancy (mean NGF±SD: 541±448, ...
Cotechini T T Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada. Electronic address: - - 2014
Evidence links alterations in placental shape and size to fetal growth restriction (FGR). Here we determined whether alterations in placental morphometrics are linked to FGR induced by abnormal maternal inflammation. We used an inflammation-induced model of FGR in which pregnant rats receive lipopolysaccharide (LPS) on gestational days (GD) 13.5-16.5. Fetal ...
Schumann K K Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany. Electronic address: - - 2014
Fetal growth during pregnancy has previously been studied in the domesticated guinea pig (Cavia aperea f. porcellus) after dissecting pregnant females, but there are no studies describing the fetal growth in their wild progenitor, the wild guinea pig (C aperea). In this study, 50 pregnancies of wild guinea pig sows ...
Beckett Evan M EM E Beckett, Pediatrics, University of Michigan, Ann Arbor, United - - 2014
Gestational testosterone (T) treatment causes maternal hyperinsulinemia, intra-uterine growth retardation (IUGR), low birth weight, and adult reproductive and metabolic dysfunctions. Sheep models of IUGR demonstrate placental insufficiency as an underlying cause of IUGR. Placental compromise is likely the cause of fetal growth retardation in gestational T-treated sheep. This study tested ...
Aurioles-Garibay Alma A Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Md. and Detroit, Mich., - - 2014
The lesion termed 'placental infarction hematoma' is associated with fetal death and adverse perinatal outcome. Such a lesion has been associated with a high risk of fetal death and abruption placentae. The fetal and placental hemodynamic changes associated with placental infarction hematoma have not been reported. This paper describes a ...
Figueras Francesc F Barcelona Center of Maternal-Fetal Medicine and Neonatology (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, - - 2014
FGR is among the obstetrical entities with the greatest variation in clinical practice. The first clinically relevant step in the management of fetal growth restriction (FGR) is the distinction of "true" FGR, associated with signs of abnormal feto-placental function and poorer perinatal outcome, from small-for-gestational age (SGA) fetuses, which do ...
Elhddad Agzail S AS Academic Unit of Reproductive and Developmental Medicine, Human Metabolism Department, Medical School, University of Sheffield, - - 2014
To assess the pattern of gestational weight gain (GWG) and its effect on fetal growth among normogylycemic obese and lean mothers. Prospective longitudinal study. Teaching hospitals, Sheffield, UK. 46 euglycemic obese and 30 lean mothers and their offspring. The contrast slope of GWG was calculated and its impact on fetal ...
Rosner Mara - - 2014
To compare 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space (UPCS) in the first trimester between women who subsequently deliver growth restricted versus normally grown neonates. This was a prospective observational study of singleton pregnancies at 11-14 weeks gestation. The 3DPD indices, Vascularization Index (VI), Flow Index (FI) and ...
O'Tierney-Ginn Perrie F PF Center for Reproductive Health, MetroHealth Medical Center at Case Western Reserve U, Cleveland, OH, - - 2014
Invasion of extravillous trophoblast cells (EVTs) into the maternal tissues is a key step in the development of a successful pregnancy, excessive and insufficient EVT invasion being associated with pregnancy complications. These pregnancy complications include preeclampsia and fetal growth restriction, both of which are associated with maternal and fetal morbidity ...
Jensen A B AB Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales CF10 3AX, - - 2014
In utero growth restriction is the failure of a fetus to achieve its genetic growth potential during gestation. Elevated expression of the maternally expressed imprinted gene PHLDA2, has been reported in the human placenta of growth restricted pregnancies. A mouse modelling this alteration has been generated and also displays fetal ...
Ferguson Kelly K KK Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, - - 2014
Previous studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy. We explored longitudinal changes in plasma cytokines, including IL-1β, IL-6, IL-10, and TNF-α, as well as C-reactive protein in pregnant women from a nested ...
Gao Feng F College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China. Electronic address: - - 2014
This study investigated the effects of maternal undernutrition during late pregnancy on the development and function of ovine fetal liver. Eighteen ewes with singleton fetuses were allocated to three groups at d 90 of pregnancy: Restricted Group 1 (RG1, 0.175MJMEkgBW(-0.75)d(-1), n=6), Restricted Group 2 (RG2, 0.33MJMEkgBW(-0.75)d(-1), n=6) and a Control ...
Canavan Timothy P TP Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Ultrasound, Magee-Womens Hospital, University of Pittsburgh, 300 Halket Street, Pittsburgh, PA, - - 2014
To determine the effect of maternal body mass index on fetal growth using individualized growth assessment and two-level linear modeling. A retrospective review of biometry in the second and third trimesters from 246 normal, term singleton fetuses was performed. Four to eight biparietal diameter (BPD), head circumference (HC), abdominal circumference ...
Spencer R N RN Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E - - 2014
Poor placentation, which manifests as pre-eclampsia and fetal growth restriction, is a major pregnancy complication. The underlying cause is a deficiency in normal trophoblast invasion of the spiral arteries, associated with placental inflammation, oxidative stress and an anti-angiogenic state. Peripartum therapies, such as antenatal maternal corticosteroids and magnesium sulphate, can ...
Merialdi Mario - - 2014
In 2006 WHO presented the infant and child growth charts suggested for universal application. However, major determinants for perinatal outcomes and postnatal growth are laid down during antenatal development. Accordingly, monitoring fetal growth in utero by ultrasonography is important both for clinical and scientific reasons. The currently used fetal growth ...
Gupta Megha M Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, - - 2014
Fetal growth restriction is associated with poor perinatal outcomes. Unfortunately, only approximately 25% of children who are born growth restricted are identified prenatally. This underidentification of fetal growth restriction by standard measures is thought to be even higher in obese patients. The low sensitivity of outdated standardized fetal growth curves ...
Orzechowski Kelly K Thomas Jefferson University/Jefferson Medical College, Philadelphia, - - 2014
Small placental volumes are associated with adverse pregnancy outcomes such as intrauterine growth restriction. Normative growth curves for the fetus exist but not for normal placental growth. This study examines longitudinal placental growth pattern in a healthy cohort. This prospective longitudinal cohort study of placental volume enrolled 12 gravidas with ...
Nelson David B DB University of Texas Southwestern Medical Center at Dallas, Dallas, - - 2014
To characterize the consequences of growth restriction according to birth weight in pregnancies complicated by fetal gastroschisis. This was a population-based, retrospective study of all singleton pregnancies with fetal gastroschisis that underwent prenatal sonography and delivered at our institution between August 1997 and December 2012. Pregnancies were identified from an ...
Horowitz Kari M KM University of Connecticut Health Center, Farmington, - - 2014
Fetal growth restriction is associated with intrauterine fetal demise, neonatal morbidity, and death. Late-term delivery is optimal for isolated fetal growth restriction without other risk factors. Fetal growth restriction alone is not an indication for cesarean delivery unless there is a nonreassuring fetal heart rate tracing. These patients may undergo ...
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