Search Results
Results 251 - 300 of 1349
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Jiang Y - - 2013
PURPOSE: The aim of this study was to determine whether laterality of an absent umbilical artery (AUA) is associated with fetal growth in fetuses with isolated single umbilical artery (SUA). METHODS: Fifty singleton pregnancies were studied, including 26 cases with a right AUA and 24 cases with a left AUA ...
Probyn Megan E - - 2013
High levels of alcohol consumption during pregnancy can lead to growth deficits in early postnatal life. However, the effects of low to moderate alcohol consumption during pregnancy are less clearly defined. The aim of this study was to determine if low-moderate ethanol (EtOH) consumption throughout pregnancy in the rat alters ...
Ghosh Sanjib Kumar - - 2013
AIM: To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20-22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR). MATERIAL AND METHODS: A prospective cohort study was conducted on 722 women with singleton pregnancies, screened ...
Radulescu L - - 2013
One of the most important causes of perinatal mortality and morbidity complicating significant percentage pregnancies is intrauterine growth restriction (IUGR). Fetal growth restriction is the main cause of intrauterine fetal death and the second leading cause of death in the neonatal period. Numerous studies in different populations reveal an association ...
Vasudeva Akhila - - 2013
OBJECTIVES: We aimed to measure early fetal growth velocity and to correlate this with the birth weight, gestational age at delivery, and with the incidence of adverse pregnancy outcomes specifically preeclampsia and perinatal mortality. METHODS: A data based prospective observational study, wherein sonographic biometry data and specific pregnancy outcome related ...
Mazzucco María Belén - - 2013
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. Aims: to study the effect of a saturated-fat-rich diet on growth, lipid accretion, and lipases, leptin and leptin receptor expression in the placenta and fetal liver. We also ...
Haedersdal Sofie - - 2013
Low-grade inflammation has been associated with pregnancy complications including preeclampsia (PE), intrauterine growth restriction (IUGR), and spontaneous preterm birth (SPB). In an unmatched, nested case-control study, we assessed the possible predictive association of maternal C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), and soluble urokinase plasminogen activator receptor (suPAR) in second ...
Shyamsundar - - 2013
Uterine myomas are being observed in pregnancy more frequently now than in the past, because many women are delaying child bearing till their late thirties, which is the time for the greatest risk of the myoma growth. Traditionally, obstetricians are trained to avoid myomectomies during caesarean sections as severe haemorrhages ...
Braun T - - 2013
Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET ...
Simón-Muela Inmaculada - - 2013
OBJECTIVE: To analyze the role of cord blood adiponectin and its multimeric forms in neonatal adiposity and fetal growth (FGV) during the third trimester of pregnancy according to fetal gender. STUDY DESIGN: Prospective analytical observational study conducted at the Diabetes and Pregnancy unit, University Hospital Joan XXIII, Tarragona. Ninety-six healthy ...
Konieczny Andrzej - - 2013
Preeclampsia is a disorder occurring during pregnancy typically after 20 weeks of gestation. It affects both mother and unborn baby in at least 5-8% of all pregnancies. It is a rapidly progressive condition characterized by high blood pressure and the presence of protein in the urine. The symptoms, such as ...
Ouyang Fengxiu F MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2013
Elevated pre-pregnancy BMI, excessive gestational weight gain (GWG), and gestational diabetes mellitus (GDM) are known determinants of fetal growth. The role of placental weight is unclear. We aimed to examine the extent to which placental weight mediates the associations of pre-pregnancy BMI, GWG, and GDM with birth weight-for-gestational age, and ...
Smith R - - 2013
Unexplained antepartum stillbirth is a major obstetric health problem. Data demonstrate a rapid rise in risk per 1000 continuing pregnancies as gestation advances beyond 40 weeks. We review the evidence that such stillbirths are a consequence of aging related changes in the late gestation placenta. We suggest that the relatively ...
Vermeer N - - 2013
OBJECTIVES: To analyze the outcomes of fetuses referred because of short femur length. METHODS: This was a retrospective study of all singleton pregnancies referred to a tertiary care referral hospital with a femur length below the 5(th) percentile. All ultrasound scan reports, including Doppler, fetal karyotyping, pregnancy outcome and neonatal ...
Mossa Francesca - - 2013
Severe prenatal under nutrition is usually associated with low birth weights in offspring and disorders including hypertension, obesity and diabetes. Whether alterations in maternal nutrition insufficient to impair birth weight or prenatal growth impact the cardiovascular, stress or metabolic systems is unknown. In addition, little is known about the effects ...
Dallaire Renée R School of Psychology, Laval University and CHUQ Research Center, Quebec, - - 2013
Several studies have reported negative associations of polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and mercury (Hg) with duration of gestation and fetal growth in fish eating populations. Docosahexaenoic acid (DHA) from fish, seafood and marine mammal intake has been reported to be positively related with pregnancy duration and fetal growth. So ...
Chitty Lyn S LS Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, UK. - - 2013
To improve the prenatal diagnosis of thanatophoric dysplasia by defining the change in fetal size across gestation and the frequency of sonographic features, and developing non-invasive molecular genetic diagnosis based on cell-free fetal DNA (cffDNA) in maternal plasma. Fetuses with a confirmed diagnosis of thanatophoric dysplasia were ascertained, records reviewed, ...
Conroy Andrea L - - 2013
Placental malaria (PM) is a major cause of fetal growth restriction, yet the underlying mechanism is unclear. Complement C5a and C5a receptor levels are increased with PM. C5a is implicated in fetal growth restriction in non-infection-based animal models. In a case-control study of 492 pregnant Malawian women, we find that ...
Regnault Timothy Rh - - 2013
Background:This study examines the relationship between placental amino acid (AA) transport and fetal AA demand in an ovine fetal growth restriction (FGR) model where placental underdevelopment induces fetal hypoxemia and hypoglycemia.Methods:Umbilical uptakes of AA, oxygen, glucose and lactate were measured near term in eight experimental ewes (FGR group) and in ...
Cetin Irene - - 2013
PURPOSE OF REVIEW: Intrauterine growth restriction (IUGR) occurs when fetal growth rate falls below the genetic potential and affects a significant number of pregnancies, but still no therapy has been developed for this pregnancy disease. This article reviews the most recent findings concerning maternal characteristics and behaviours predisposing to IUGR ...
Chow Michelle S - - 2013
: Meningiomas are slow-growing tumors that may present in pregnancy because of accelerated growth. We present the case of a recurrent meningioma in two separate pregnancies in the same woman. : A 35-year-old woman presented at 30 weeks of gestation with limb weakness, vomiting, and a progressive decreased level of ...
Szentpéteri Imre - - 2013
Abstract Objective: In this study, we describe changes in gene expression pattern of VEGF-A in human placenta obtained from pregnancies with intrauterine growth restriction using placenta from normal pregnancies as control. Methods: We compared gene expression of VEGF-A in placental samples from IUGR pregnancies vs. placenta obtained from normal pregnancies. ...
Higashijima Ai - - 2013
OBJECTIVE: The aim of this study was to characterize placenta-specific microRNAs in fetal growth restriction (FGR) pregnancy. METHOD: Placenta-specific miRNAs were identified by next-generation sequencing analysis. Subsequently, quantitative real-time reverse-transcription polymerase chain reaction was used to identify FGR placenta-specific miRNAs whose level of expression was significantly decreased in FGR placenta ...
Vrachnis Nikolaos - - 2013
Abstract The needs of the uterus and the fetus for provision of nutrients and oxygen, supplied by the blood flow, are understandably extremely high, with the circulatory system playing the most important role in this action. Abnormal vascular growth and transformation that create a high vessel resistance network have been ...
Whitten Amy E AE Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, - - 2013
Massive perivillous fibrin deposition (MPFD) is associated with serious complications of pregnancy including recurrent spontaneous abortion, fetal growth restriction, and fetal demise. The aim of this study was to determine whether maternal plasma concentrations of angiogenic/antiangiogenic factors in MPFD differ from those of uncomplicated pregnancies. This retrospective longitudinal case-control study ...
Cipolla Marilyn J MJ Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA. - - 2013
The adaptation of the cerebral circulation to pregnancy is unique from other vascular beds. Most notably, the growth and vasodilatory response to high levels of circulating growth factors and cytokines that promote substantial hemodynamic changes in other vascular beds is limited in the cerebral circulation. This is accomplished through several ...
Simonazzi G - - 2013
OBJECTIVE: To evaluate the outcome of pregnancies complicated by placental insufficiency and abnormal umbilical artery Doppler prior to viability. DESIGN: A retrospective cohort study. SETTING: Italy. POPULATION: Singleton pregnancies with fetal growth restriction and absence of end-diastolic velocities (AEDVs) in the umbilical arteries prior to 24 weeks. METHODS: A retrospective cohort ...
Hillman Sara S Institute for Women’s Health, University College London, London, - - 2013
Fathers of low-birth weight offspring are more likely to have type 2 diabetes and cardiovascular disease in later life. We investigated whether paternal insulin resistance and cardiovascular risk factors were evident at the time that fetal growth-restricted offspring were born. We carried out a case-control study of men who fathered ...
Anderson Brenna L BL Division of Maternal-Fetal Medicine, Women & Infants' Hospital, Warren Alpert Medical School of Brown University, Providence, RI, - - 2013
Both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition. The objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy. This prospective cohort enrolled low-risk pregnant ...
Soto Eleazar - - 2013
Substance abuse remains a major concern in pregnancy. The current review summarizes the best available literature on the subject. The findings of most studies are confounded by multiple drug use and environmental and social factors that by themselves are known to adversely affect the pregnancy outcomes of interest. Overall, however, ...
Collins S L - - 2013
Fetal growth restriction (FGR) is a major cause of perinatal morbidity and mortality, even in term babies. An effective screening test to identify pregnancies at risk of FGR, leading to increased antenatal surveillance with timely delivery, could decrease perinatal mortality and morbidity. Placental volume, measured with commercially available packages and ...
Pedersen N G - - 2013
OBJECTIVES: To investigate if fetuses with first trimester growth restriction have poorer perfusion of the placenta compared to a control group, and to investigate whether first trimester growth restriction in combination with poor flow in the uterine arteries in the second trimester can be used to predict poor outcome. STUDY ...
Nawathe A - - 2013
Syndrome of inappropriate antidiuretic hormone (SIADH) is rarely encountered in pregnancy. We report a case of severe hyponatraemia with idiopathic SIADH. A total of 18 cases of hyponatraemia in pregnancy have been reported; seven fit the criteria of SIADH. Unlike our case, none were diagnosed before pregnancy. Of the cases, ...
Prior Tomas - - 2013
The incidence of several adverse pregnancy outcomes including fetal growth restriction are higher in pregnancies where the fetus is male, leading to suggestions that placental insufficiency is more common in these fetuses. Placental insufficiency associated with fetal growth restriction may be identified by multi-vessel Doppler assessment, but little evidence exists ...
Sato Y - - 2013
Intrauterine growth restriction (IUGR) is the leading cause of fetal mortality and morbidity. As an etiology, each of placental findings, maternal factors and fetal factors has been reported to be associated with IUGR, although a comprehensive approach to examine all of these parameters as a cause of IUGR has not ...
Gootwine E - - 2013
A meta-analysis was performed to study the relationship between ovine fetal BW and body length during the last month of pregnancy in sheep gestated under normal conditions and under different natural and experimental maternal- placental- and fetal- directed constraints. Means of crown-rump length (CRL) and BW records, as well as ...
Toutain Jérôme - - 2013
Recent studies have shown that telomere length was significantly reduced in placentas collected at delivery from pregnancies complicated by intrauterine growth restriction secondary to placental insufficiency. Placental telomere length measurement during ongoing pregnancies complicated by intrauterine growth restriction has never been reported. This was the main objective of our study. ...
Schmiegelow Christentze - - 2013
Pregnancy associated malaria is associated with decreased birth weight, but in-utero evaluation of fetal growth alterations is rarely performed. The objective of this study was to investigate malaria induced changes in fetal growth during the 3(rd) trimester using trans-abdominal ultrasound. An observational study of 876 pregnant women (398 primi- and ...
Colleoni Francesca - - 2013
Fetal growth is critically dependent on energy metabolism in the placenta, which drives active exchange of nutrients. Placental oxygen levels are therefore vital, and chronic hypoxia during pregnancy impairs fetal growth. Here we tested the hypothesis that placental hypoxia alters mitochondrial electron transport chain (ETS) function, and sought to identify ...
Shao Ruijin - - 2013
More than 98% of ectopic pregnancies occur in the Fallopian tube. Because many facets of tubal ectopic pregnancy remain unclear, prediction, prevention and treatment of tubal ectopic pregnancy are still a major clinical challenge. Compelling evidence suggests that angiogenic growth factors are involved in normal and abnormal implantation. While acknowledging ...
Galjaard Sander - - 2013
Abstract The environment in utero and in early neonatal life may induce a permanent response in the fetus and the newborn, leading to enhanced susceptibility to later diseases. This review concentrates on the role and mechanisms of events during the antenatal and immediate postnatal period resulting in later life diseases, ...
Kovo Michal - - 2013
Inadequate placental development results in pregnancy complications. The extent and the degree of defective deep placentation may explain why a similar insult would result in different clinical presentations. The relative new categorization of the placental lesions, separating the non-infectious lesions into lesions that are consistent with maternal and fetal circulation ...
Melamed Nir - - 2013
Objectives- To analyze the effect of fetal sex on intrauterine growth patterns during the second and third trimesters. Methods- We conducted a cross-sectional study of women with uncomplicated singleton pregnancies who underwent sonographic fetal weight estimation during the second and third trimesters in a single tertiary center. The effect of ...
Daniel-Spiegel Etty - - 2013
Objectives- Fetal growth evaluation is an essential component of pregnancy surveillance. There have been several methods used to construct growth charts. The conventional charts used in current daily practice are based on small numbers and traditional statistical methods. The purpose of this study was to improve fetal biometric charts based ...
Cisse Ouma - - 2013
Mild gestational hyperglycemia is often associated with fetal overgrowth that can predispose the offspring to metabolic diseases later in life. We hypothesized that unfavorable intrauterine environment may compromise the development of placenta and contribute to fetal overgrowth. Therefore, we developed a rat model and investigated the effects of maternal dysglycemia ...
Babovic I - - 2013
The relation between biophysical profile (BPP), cerebroplacental (C/P) ratio, and lecithin/sphingomyelin (L/S) ratio as a predictor perinatal outcome in term intrauterine growth restricted (IUGR) neonates was evaluated. A retrospective study of the perinatal outcome of 77 term monofetal pregnancies complicated with IUGR fetuses (< 10 percentile) who were terminated by ...
Hua Ying - - 2013
Outcome of a pregnancy is dependent on high-quality ovulation, successful fertilization, normal embryonic and fetal development, and homeostasis of amniotic fluid. Throughout pregnancy, aquaporins are expressed in the placenta, uterus, adnexa, brain, urinary system, and the lacrimal gland. The regional and temporal regulation of aquaporins play important roles in normal ...
Gardosi Jason - - 2013
To assess the main risk factors associated with stillbirth in a multiethnic English maternity population. Cohort study. National Health Service region in England. 92,218 normally formed singletons including 389 stillbirths from 24 weeks of gestation, delivered during 2009-11. Risk of stillbirth. Multivariable analysis identified a significant risk of stillbirth for ...
Laskowska Marzena - - 2013
The aim of this study was to show differences of maternal serum sP-selectin levels in pregnancies complicated by intrauterine fetal growth restriction (IUGR) in the course of preeclampsia and to compare the results with normotensive pregnant women with isolated IUGR. These studies were also conducted on preeclamptic pregnancies with appropriate-for-gestational-age ...
Langridge Amanda T - - 2013
As well as being highly comorbid conditions, autism spectrum disorders (ASD) and intellectual disability (ID) share a number of clinically-relevant phenomena. This raises questions about similarities and overlap in diagnosis and aetiological pathways that may exist for both conditions. To examine maternal conditions and perinatal factors for children diagnosed with ...
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