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Results 201 - 250 of 1349
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Yadav Usha - - 2013
The concomitant occurrence of pregnancy and chronic myeloid leukemia is uncommon. We describe the successful management of a 30-year-old G3 P0, A2 woman who was diagnosed to have chronic myelogenous leukemia (CML) in the third trimester of her pregnancy with intra-uterine growth retardation and oligohydroamnios. She was started on hydroxyurea ...
Dubova E A - - 2013
A comparative morphological study of the placentas in spontaneous and induced pregnancy aggravated by placental failure was carried out. Placental failure manifested by shrinkage of the terminal villi, lesser number and section areas of their capillaries, and higher expression of vascular endothelium growth factor and endothelial NO synthase in the ...
Sferruzzi-Perri Amanda N AN 1Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK CB2 3EG. - - 2013
In developed societies, high-sugar and high-fat (HSHF) diets are now the norm and are increasing the rates of maternal obesity during pregnancy. In pregnant rodents, these diets lead to cardiovascular and metabolic dysfunction in their adult offspring, but the intrauterine mechanisms involved remain unknown. This study shows that, relative to ...
Rab Attila - - 2013
In this study, we compared human placental gene expression patterns of epidermal growth factor (EGF) in pregnancies with intrauterine growth restriction (IUGR) vs. normal pregnancies as control. Gene expression of EGF was determined from human placental samples collected from all pregnancies presenting with IUGR at our institution during the study ...
Bulnes Antonio Gonzalez- - - 2013
The present study evaluated the effect of nutritional imbalances during pregnancy, either by excess or deficiency, on fertility and conceptus development in obese-genotype swine (Iberian pig). Twenty-five multiparous sows were fed, from mating to farrowing, with a standard diet fulfilling either 1.6 folds their daily maintenance requirements for pregnancy (overfed ...
Kim Tae-Hee - - 2013
Abstract Fetal thrombotic vasculopathy, a rare condition, is defined as thrombosis in the fetal circulation of placenta causing fibrotic villi and its detection before delivery is difficult. Thrombosis in fetal placenta involves various problems such as uteroplacental insufficiency, central nervous system injury, and even perinatal death. Here, we report a ...
Al-Riyami Nihal - - 2013
Placental tumours include placental chorioangiomas, teratomas, haemangiomas, and haematomas. Placental chorioangiomas are benign vascular tumours and are the most common placental tumours, with a prevalence of 1%. Large placental chorioangiomas are rare and may lead to pregnancy complications and poor perinatal outcomes. These complications include fetal anaemia, hydrops fetalis, fetal ...
Zhu R - - 2013
As one of the key molecules in the extracellular matrix in human conceptus, hyaluronan (HA) has been receiving particular attention. Here, we have investigated the expression and regulation of different molecular weight HA on the biological behaviors of primary human trophoblasts during the first trimester of pregnancy. The expression of ...
Conti E - - 2013
Preeclampsia is the major cause of maternofetal and neonatal morbi-mortality including intrauterine growth retardation, miscarriages and stillbirths. Inadequate vascular dilation and angiogenesis represent the crucial underlying defect of gravidic hypertension, denoting a failed response to the vasodilatory and pro-angiogenic challenge imposed by pregnancy, especially if multifetal. A similar pathogenesis appears ...
Carr Dj - - 2013
Uterus didelphys is a rare congenital abnormality of the reproductive tract. Although it occurs in various species, there are no published reports describing pregnancy outcome in association with this abnormality. Herein we describe a case of successful unilateral singleton pregnancy in a ewe incidentally found to have uterus didelphys during ...
Fleck Shannon - - 2013
Background:Congenital diaphragmatic hernia (CDH) represents a spectrumof lung hypoplasia andconsequent pulmonary hypertension is an important cause of postnatal morbidity and mortality. We studied biomarkers at the maternal-fetal interface to understand factors associated with the persistence of pulmonary hypertension.Methods:Maternal and cord blood samples from fetuseswith CDHand unaffected controls were analyzed using ...
Cnota James F JF Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. - - 2013
Fetal growth abnormalities in hypoplastic left heart syndrome (HLHS) have been documented primarily by birth measurements. Fetal growth trajectory has not been described. We hypothesized that fetal growth trajectory declines across late gestation in this population. Infants with a prenatal diagnosis of HLHS and no history of prematurity or a ...
Nomura Yoko - - 2013
Emerging evidence indicates that maternal medical risk during pregnancy, such as gestational diabetes mellitus (GDM), preeclampsia, and obesity, predisposes the offspring to suboptimal development. However, the underlying biological/epigenetic mechanism in utero is still unknown. The current pilot study (N = 50) compared the levels of global methylation in the placenta ...
van Eijsden M - - 2013
BACKGROUND/OBJECTIVES:Low vitamin D status during pregnancy may be associated with infant skeletal growth. However, evidence on the longer-term effect is limited. This study aims to assess the association between maternal vitamin D status in early pregnancy and markers of linear growth (height, leg length and relative leg length) of the ...
Ananth Cande V - - 2013
OBJECTIVE: Placental abruption is associated with increased risks of preterm birth and fetal growth restriction. Since abruption is apparently a disease of the placenta, the extent to which abruption impacts the growth and development of the placenta remains poorly understood. We reasoned that a study of fetal growth and placental ...
Tenenbaum-Gavish Kinneret - - 2013
The obesity epidemic is a problem of global importance with a profound impact on maternal-fetal health. Maternal overweight and obesity causes pregnancy complications such as gestational diabetes, hypertension and preeclampsia and affects fetal growth. Maternal obesity offers an altered genetic, hormonal and biochemical environment for the developing fetus/embryo and influences ...
Elhddad Agzail S A - - 2013
OBJECTIVE: Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are key regulators of fetal growth. However, the literature is inconsistent. Our objective was to systematically and objectively evaluate the available literature and to develop a balanced opinion on the relation between maternal and fetal IGF-axes and birthweight. DESIGN: A ...
Thame Minerva M - - 2013
OBJECTIVES: To assess fetal growth and whether lower birthweight to mothers with homozygous sickle cell (SS) disease is related to maternal body composition or to clinical events in pregnancy. STUDY DESIGN: A prospective study of 41 pregnant women with SS disease and 41 women with a normal (AA) phenotype attending ...
Wu Guoyao - - 2013
Embryonic loss and intrauterine growth restriction (IUGR) are significant problems in humans and other animals. Results from studies involving pigs and sheep have indicated that limited uterine capacity and placental insufficiency are major factors contributing to suboptimal reproduction in mammals. Our discovery of the unusual abundance of the arginine family ...
Wylie Blair J - - 2013
BACKGROUND: Malaria during pregnancy is associated with an increased risk for low birth weight (<2500 grams). Distinguishing infants that are born premature (< 37 weeks) from those that are growth-restricted (less than the 10th percentile at birth) requires accurate assessment of gestational age. Where ultrasound is accessible, sonographic confirmation of ...
Bojikian Karine Duarte - - 2013
To establish a reference range for normal fetal eye volume (FEV) by three-dimensional ultrasound using Virtual Organ Computer-aided AnaLysis (VOCAL) method and compare the reproducibility between the two trace modes (manual and sphere). This prospective, longitudinal observational study was performed at a single center and involved 71 eyes of 37 ...
Eze Cu - - 2013
Uterine myomas co-existing with pregnancy could cause obstetric complications. To assess sonographically the frequency of occurrence and effect of uterine myomas co-existing with pregnancy. A longitudinal study was conducted during a period of 23 months. A convenience sample of 816 consecutive consenting pregnant women who met the inclusion criteria was ...
Fulford A J C AJ 1 MRC Keneba, MRC Unit, Banjul, The - - 2013
Prenatal events can affect neonatal thymus size and adult immune function. The causal insults are unknown, although fetal nutrient restriction is suspected. We used ultrasound at three time points during pregnancy (14, 19 and 30 weeks) to measure the growth of six fetal dimensions in rural Bangladeshi women participating in ...
Wang Keqing K Vascular Medicine Unit, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United - - 2013
The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is a proangiogenic vasodilator. We hypothesized that a reduction in CSE activity may alter the angiogenic ...
Jansson Thomas - - 2013
Altered maternal nutrition and metabolism, restricted utero-placental blood flow, and other perturbations in the maternal compartment may disturb critical periods of fetal development resulting in increased susceptibility to develop disease in childhood and adult life. In response to these perturbations, changes in placental structure and function occur, which influence the ...
Villar J J Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK Centre for Statistics in Medicine, University of Oxford, Oxford, UK Ketkar Nursing Home, Nagpur, India Department of Engineering Science, University of Oxford, Oxford, UK School of Public Health, Peking University, Beijing, China Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, RS, Brazil Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil Faculty of Health Sciences, Aga Khan University, Nairobi, Kenya Department of Family & Community Health, Ministry of Health, Muscat, Sultanate of Oman Dipartimento di Scienze Pediatriche e dell'Adolescenza, Cattedra di Neonatologia, Università degli Studi di Torino, Torino, Italy University of Washington School of Medicine, Seattle, WA, USA Division of Women & Child Health, The Aga Khan University, Karachi, - - 2013
INTERGROWTH-21(st) is a multicentre, multiethnic, population-based project, being conducted in eight geographical areas (Brazil, China, India, Italy, Kenya, Oman, UK and USA), with technical support from four global specialised units, to study growth, health and nutrition from early pregnancy to infancy. It aims to produce prescriptive growth standards, which conceptually ...
Uauy R R Institute of Nutrition & Food Technology (INTA), University of Chile, Santiago, Chile; Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK; Division of Paediatrics, School of Medicine, Pontifical Universidad Católica de Chile, - - 2013
Healthy growth in utero and after birth is fundamental for lifelong health and wellbeing. The World Health Organization (WHO) recently published standards for healthy growth from birth to 6 years of age; analogous standards for healthy fetal growth are not currently available. Current fetal growth charts in use are not ...
Nelissen Ewka C M - - 2013
STUDY QUESTION: When does a difference in human intrauterine growth of singletons conceived after IVF and embryo culture in two different culture media appear? SUMMARY ANSWER: Differences in fetal development after culture of embryos in one of two IVF media were apparent as early as the second trimester of pregnancy. ...
Alwasel Saleh H SH Fetal Programming of Disease Research Chair, Zoology Department, College of Science and Centre of Excellence in Biotechnology Research, King Saud University, Saudi - - 2013
Studies of the placenta in pregnancies complicated by pre-eclampsia have led to the suggestion that tissue along the length and breadth of its surface has different functions. A recent study in Saudi Arabia showed that the body size of newborn babies was related to the breadth of the surface at ...
Pashaj S - - 2013
OBJECTIVES: The objective of this study is to establish reference ranges of quantitative characteristics of the corpus callosum allowing the accurate diagnosis of corpus callosum pathologies such as hypogenesis, dysgenesis and thick corpus callosum. METHODS: For the present study a total number of 604 pregnant women referred for sonographic examination ...
- - 2013
Fetal growth restriction, also known as intrauterine growth restriction, is a common complication of pregnancy that has been associated with a variety of adverse perinatal outcomes. There is a lack of consensus regarding terminology, etiology, and diagnostic criteria for fetal growth restriction, with uncertainty surrounding the optimal management and timing ...
Bloomfield H - - 2013
Optimal fetal growth is important for a healthy pregnancy outcome and also for lifelong health. Fetal growth is largely regulated by fetal nutrition, and mediated via the maternal and fetal glucose/insulin/insulin-like growth factor axes. Fetal nutrition may reflect maternal nutrition, but abnormalities of placental function can also affect fetal growth, ...
Zong Lu - - 2013
Pre-eclampsia (PE) is the most serious syndrome of human pregnancy and it is potentially life-threatening for both mother and fetus. The aim of the study was to identify the role of high temperature requirement A1 (HtrA1) in pre-eclampsia. One hundred consecutive pregnancies complicated by PE and 100 normal controls were ...
Li Cun C The University of Texas Health Science Center San Antonio, Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology San Antonio, TX 78229, - - 2013
Intrauterine growth restriction (IUGR) is an important fetal developmental problem resulting from 2 broad causes: maternal undernutrition and/or decreased fetal nutrient delivery to the fetus via placental insufficiency. IUGR is often accompanied by up-regulation of the hypothalamo-pituitary-adrenal axis (HPAA). Sheep studies show fetal HPAA autonomy in late gestation. We hypothesized ...
Yelikar Kanan A KA Department of Obstetrics and Gynecology, Government Medical College & Hospital (Ghatti Rugnalaya), Near Panchakki, Aurangabad, - - 2013
To study the efficacy of fetal Doppler and non-stress test (NST) in predicting fetal compromise in preeclampsia and growth-restricted fetuses. ln a prospective study, 189 pregnant women beyond 32 weeks of gestation with preeclampsia or growth-restricted fetuses confirmed by ultrasound were evaluated by Doppler velocimetry (umbilical and middle cerebral artery) and ...
Bouwland-Both Marieke I - - 2013
OBJECTIVE: Fetal growth is dependent on adequate development of the placenta. Impaired angiogenesis and vasculogenesis in early pregnancy compromises placental and embryonic development. The proteins soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and plasminogen activator inhibitor type 2 (PAI-2), and the B-vitamin folate are determinants of placental development. ...
Whitehead Clare L - - 2013
OBJECTIVE: To examine whether mRNA circulating in maternal blood coding genes regulating fetal growth are differentially expressed in 1) severe preterm FGR and 2) at 28 weeks' gestation in pregnancies destined to develop FGR at term. STUDY DESIGN: mRNA coding growth genes were measured in two independent cohorts. The first ...
Mandujano Alicia A Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Advocate Illinois Masonic Medical Center, Chicago, IL 60618, USA. - - 2013
The dawn phenomenon is a transient rise in blood glucose between 4 and 6 am that is attributed to the pulsatile release of pituitary growth hormone (GH). In pregnancy, GH is suppressed by placental GH. Hence, we hypothesize that there is no evidence for the dawn phenomenon in late pregnancy ...
van Uitert Evelyne M - - 2013
STUDY QUESTION: How do human embryonic growth trajectories evolve in the first trimester, and is first-trimester embryonic growth associated with fetal growth and birthweight (BW)? SUMMARY ANSWER: Human embryonic growth rates increase between 9 and 10 weeks of gestation and are associated with mid-pregnancy fetal growth and BW. WHAT IS ...
Gómez Mariel Fajer - - 2013
Maternal nutrient intake in the prenatal period is an important determinant of fetal growth and development and supports maternal health. Many women, however, fail to meet their prenatal nutrient requirements through diet alone and are therefore advised to consume nutrient supplements. The purpose of this study was to describe the ...
Hwang Ji-Yun - - 2013
BACKGROUND: Iron supplementation is a common recommendation for pregnant women to prevent iron deficiency during pregnancy. There is an increasing concern about excessive iron consumption as a general iron prophylaxis by pregnant women without any due consideration about their dietary iron intake or iron status. Our present study investigated the ...
O'Connor C - - 2013
Detecting aberrant fetal growth has long been an important goal of modern obstetrics. Failure to diagnose abnormal fetal growth results in perinatal morbidity or mortality. However, the erroneous diagnosis of abnormal growth may lead to increased maternal anxiety and unnecessary obstetric interventions. We review the aetiology of deviant fetal growth ...
Ulker V - - 2013
Placental mesenchymal dysplasia (PMD) is a rare placental abnormality characterised by placentomegaly and grape-like vesicles resembling partial mole by ultrasonography, but in contrast to partial mole can co-exist with a viable fetus. Although the karyotype is normal, the fetus is at increased risk for intrauterine growth restriction, intrauterine fetal demise ...
Mehta Bindu N - - 2013
Insulin-like growth factor-1 (IGF-1) has been reported to play a role in human follicular and embryonic development. However, earlier studies carried out mostly in animal models or in culture mediums supplemented with IGF-1 have been unable to directly link IGF-1 with embryo quality. Results correlating IGF-1 with pregnancy outcome have ...
Gaccioli F F Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, TX, - - 2013
The mechanisms linking maternal nutrition to fetal growth and programming of adult disease remain to be fully established. We review data on changes in placental transport in response to altered maternal nutrition, including compromized utero-placental blood flow. In human intrauterine growth restriction and in most animal models involving maternal undernutrition ...
Mayeur S S 1 Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, - - 2013
Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in ...
Li S S 1 School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, - - 2013
Antenatal corticosteroids are used to augment fetal lung maturity in human pregnancy. Dexamethasone (DEX) is also used to treat congenital adrenal hyperplasia of the fetus in early pregnancy. We previously reported effects of synthetic corticosteroids given to sheep in early or late gestation on pregnancy length and fetal cortisol levels ...
Parmar P G PG 1 School of Women's and Infants' Health, The University of Western Australia, Perth, WA, - - 2013
Two pregnancy cohorts were used to investigate the association between single-nucleotide polymorphisms (SNPs) in genes within the insulin-like growth factor (IGF)-axis and antenatal and postnatal growth from birth to adolescence. Longitudinal analyses were conducted in the Raine pregnancy cohort (n = 1162) using repeated measures of fetal head circumference (HC), ...
Halperin Julia - - 2013
We studied for the first time the mammary gland morphogenesis and its hormonal modulation by immunolocalizing estradiol, progesterone and prolactin receptors (ER, PR and PRLR) in adult females of Lagostomus maximus, a caviomorph rodent which shows a pseudo-ovulatory process at mid-gestation. Mammary ductal system of non-pregnant females lacks expression of ...
Riccardi Daniela - - 2013
In fetal mammals, serum levels of both total and ionized calcium significantly exceed those in the adult. This relative fetal hypercalcemia is crucial for skeletal development and is maintained irrespectively of maternal serum calcium levels. Elegant studies by Kovacs and Kronenberg have previously addressed the role of the CaSR in ...
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