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Velauthar L L Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Women's Health Unit, Barts Health NHS Trust, London, - - 2013
Pre-eclampsia and fetal growth restrictions are associated with adverse pregnancy outcomes, especially with an early onset. Clinical risk assessment of women is done in the first trimester to identify women for preventative treatment. To determine the accuracy with which uterine artery Doppler in the first trimester of pregnancy predicts pre-eclampsia ...
Leventakou Vasiliki V Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece (VL, TR, and LC); the Centre for Research in Environmental Epidemiology, Barcelona, Spain (DM, MC, JS, MK, and MV); the Hospital del Mar Medical Research Institute, Barcelona, Spain (DM, MC, JS, MK, and MV); the Department of Clinical Epidemiology, Predictive Medicine and Public Health and Cardiovascular Research & Development Unit, University of Porto Medical School, Porto, Portugal (HB and AO); the Public Health Institute, University of Porto, Portugal (HB and AO); the Department for Genes and Environment (ME) and Department of Chronic Diseases (HS), Division of Epidemiology, and the Division of Environmental Medicine (A-LB, MH, and HMH), Norwegian Institute of Public Health, Oslo, Norway; the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain (MC, M Murcia, JS, MK, and MV); the Institut National de la Santé et de la Recherche Médicale (INSERM), Centre for Research in Epidemiology and Population Health, U1018, Lifelong Epidemiology of Obesity, Diabetes and Renal Disease Team, Villejuif, France (M-AC and BH); the University Paris-Sud, UMRS 1018, le Kremlin Bicêtre, France (M-AC and BH); the INSERM UMR 1085, Institut de Recherche Santé Environnement & Travail, Université de Rennes 1, Rennes Cedex, France (SC and, FP); the Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, Amsterdam, Netherlands (MvE); the Department of Epidemiology, Lazio Regional health System, Rome, Italy (FF and DP); the Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (UG); the Environmental Risk and Health, Flemish Institute for Technological Research, Mol, Belgium (EG); the Maternal Nutrition Group, Centre for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark (TIH, SFO, and MS); the Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland (TIH); the Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland (WH and KP); The Generation R Study Group (DHMH and VWVJ) and the Departments of Epidemiology (DHMH) and Pediatrics (VWVJ), Erasmus Medical Center, Rotterdam, Netherlands; the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom (HMI and SMR); the Faculty of Health, Medicine and Life Sciences, Department of Health Services Research, Caphri (MJ) and the School for Public Health and Primary Care, Department of Epidemiology (C-MP, M Mommers, and CT), Maastricht University, Maastricht, Netherlands; the Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, Geleen, Netherlands (MJ); the School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland (CK and KV); the Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy (FM and LR); the Centre for Public Health Research, Valencia, Spain (M Murcia); the Department of Nutrition, Harvard School of Public Health, Boston, MA (SFO); the University Pompeu Fabra, Barcelona, Spain (JS); the Department of Public Health, Academic Medical Centre-University of Amsterdam, Amsterdam, Netherlands (TGMV); the Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands (AHW); and the National School of Public Health, Athens, Greece - - 2013
Fish is a rich source of essential nutrients for fetal development, but in contrast, it is also a well-known route of exposure to environmental pollutants. We assessed whether fish intake during pregnancy is associated with fetal growth and the length of gestation in a panel of European birth cohort studies. ...
Weissgerber Tracey L TL Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA (T.L.W.), Beth Israel Deaconess Medical Center, Boston, MA, USA (A.R.), Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh PA, USA (A.M., L.R.E., R.W.P., J.M.R., R.E.G, C.A.H.), Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh PA, USA (R.W.P., J.M.R., C.A.H.), Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA, USA (R.E.G., C.A.H.), Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA, USA (J.M.R.), Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA - - 2013
Context: Research examining the source of excess sFLT1 in preeclampsia has focused on the placenta. The potential contribution of the releasable store of sFLT1 in the systemic vasculature is unknown. Objective: We asked if the non-placental releasable store of sFLT1 is larger in women with previous preeclampsia than in women ...
Dodson R Blair RB Department of Mechanical Engineering, University of Colorado, Boulder, - - 2014
Intrauterine growth restriction (IUGR) is a fetal complication of pregnancy epidemiologically linked to cardiovascular disease in the newborn later in life. However, the mechanism is poorly understood with very little research on the vascular structure and function during development in healthy and IUGR neonates. Previously, we found vascular remodeling and ...
Unterscheider Julia J Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: - - 2013
To evaluate opinions among Irish obstetricians and obstetric trainees regarding the optimal definition, assessment and management of pregnancies affected by intrauterine growth restriction (IUGR). An anonymous, structured, web-based survey that comprised 14 questions was sent to 200 obstetricians and obstetric trainees in Ireland. Of the 113 participants (57% response rate), ...
Oben Jolien - - 2013
Abstract Objective - In this study we determine whether maternal cardiovascular profiling can detect first trimester differences between women with uncomplicated pregnancies (UP) and those who will develop gestational hypertensive disorders (GHD) or normotensive fetal growth retardation (FGR). Methods - Cardiac, arterial, and venous function were evaluated in 242 pregnant ...
Cetin Irene - - 2013
As more women breastfeed for longer, it is increasingly likely that women may be still breastfeeding when they become pregnant again. The Italian Society of Perinatal Medicine (SIMP) Working Group on Breastfeeding has reviewed the literature to determine the medical compatibility of pregnancy and breastfeeding. We found no evidence indicating ...
Julian Colleen G - - 2013
Chronic exposure to hypoxia raises the risk of pregnancy disorders characterized by maternal vascular dysfunction and diminished fetal growth. In an effort to identify novel pathways for these hypoxia-related effects, we assessed gene expression profiles of peripheral blood mononuclear cells (PBMCs) obtained from 43 female, high-altitude or sea-level residents in ...
Pecks U - - 2013
Reduced serum LDL concentrations have been observed in pregnancies complicated by intrauterine growth restriction (IUGR) as compared to healthy pregnant women. Since increased oxidative stress has been suggested to play a major role in IUGR we now hypothesized that the lower LDL concentrations are accompanied by an accumulation of oxidized ...
Peugnet P - - 2013
In equids, placentation is diffuse and the nutrient supply to the fetus is determined by uterine size, which is correlated with maternal size. The size of the mare affects fetal development as shown by embryo transfer (ET) between Ponies and Thoroughbreds. In turn, insulin sensitivity in the newborn foal and ...
Hankins Gary D V - - 2013
Assessments of gestational age are critical in dealing with the pregnancy at the limits of viability, 22-25-weeks gestation, where neonatal outcomes reveal very significant differences from week to week. The obstetrical team can estimate gestational age within a window of 7-10 days during this critical threshold at the window of ...
Norris T T 1 Centre for Global Health and Human Development, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, - - 2013
Theories regarding the relationship between pre- and postnatal growth and programming of health have been based on characteristics at birth, with little or no reference to the patterns of growth occurring in utero. Review of the literature to identify studies using ultrasonographically obtained fetal dimensions to track prenatal growth and ...
Wright E C - - 2013
Placental development is important for fetal development and nutrient and waste transport. The pig, a litter bearing animal, has an epitheliochorial placenta that forms a noninvasive attachment with the uterine endometrium. Insufficient placental development is one of the primary causes of fetal death and reduced fetal growth after 35 days ...
O'Higgins Amy C - - 2013
Abstract The aim of this article is to review the current evidence on gestational weight gain (GWG). Maternal obesity has emerged as one of the great challenges in modern obstetrics as it is becoming increasingly common and is associated with increased maternal and fetal complications. There has been an upsurge ...
Ca─člar Mete - - 2013
Abstract The aim of this study was to compare decorin (DCN) levels between pregnancies complicated by idiopathic fetal growth restriction (FGR) and uncomplicated pregnancies and to determine the relationship between DCN levels and clinical parameters. The study population consisted of two groups: control group consisted of 13 women with uncomplicated ...
Dias Monike Lourenço - - 2013
The interaction between pregnancy and acromegaly has only been studied retrospectively. We prospectively assessed those interactions. Prospective, interventional, multicentric. Ten pregnancies in 8 acromegalics were included according to criteria: previous diagnosis of acromegaly; active acromegaly before pregnancy; sellar MRI, GH and IGF1 measurements before pregnancy. Exclusion criterion: radiotherapy. Withdrawal of ...
Gårdebjer E M - - 2013
Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. Sprague-Dawley rats were exposed to ...
Pollheimer J - - 2013
During pregnancy, the extravillous trophoblast (EVT) invades the maternal decidua and remodels spiral arteries reaching as far as the inner third of the myometrium. This process is mandatory to a successful pregnancy since EVTs regulate spiral artery remodeling to achieve maximal vasodilation and thus an adequate nutrient supply to the ...
Mikovic Zeljko - - 2013
Abstract Objective: To determine if there is any difference in amniotic fluid erythropoietin (EPO) concentration between fetuses small for gestational age (SGA) and appropriate for gestational age (AGA), and between the constitutionally small (CSF) and growth-restricted (GRF) fetuses. Methods: EPO concentrations in the amniotic fluid samples were determined by EpoELISA ...
Arleo Elizabeth Kagan - - 2013
Objective The objective of this study was to use two-dimensional (2D) ultrasound (US) during routine prenatal surveillance to develop normative estimated placental volume (EPV) growth curves.Study Design Patients ≥ 18 years old with singleton pregnancies were prospectively followed from 11 weeks gestational age (GA) until delivery. At routine US visits, ...
Lewis R M - - 2013
Offspring of obese and diabetic mothers are at increased risk of being born with excess adiposity as a consequence of their intrauterine environment. Excessive fetal fat accretion reflects additional placental nutrient transfer, suggesting an effect of the maternal environment on placental function. High plasma levels of particular nutrients in obese ...
Wang Yanfei - - 2013
Mycotoxins are chemicals produced by fungus and many of them are toxic to humans. Zeranol is a mycotoxin used to promote growth in cattle in North America; yet such a practice draws concern about the residual compound in meat in European countries. In the present study, the toxicity of zeranol ...
van Uitert E M - - 2013
Are maternal characteristics and lifestyle factors associated with human embryonic growth trajectories? Periconception maternal age is associated with increased, and smoking and alcohol use with decreased embryonic growth trajectories, estimated with crown-rump length (CRL) measurements. Fetal weight is associated with health and disease in later life. Maternal characteristics and lifestyle ...
Roje Damir - - 2013
To investigate whether there is difference in trophoblast apoptosis between infants with asymmetrical idiopathic intrauterine growth retardation (IUGR) and those with symmetrical fetal growth appropriate for gestational age (AGA). Data and placentas from 52 singleton term pregnancies with idiopathic IUGR, from which a subgroup of 33 (63.4%) infants with asymmetrical ...
Hagelstein Claudia - - 2013
To investigate individual changes in fetal lung volume (FLV) in fetuses with isolated congenital diaphragmatic hernia (CDH) and to calculate weekly growth rates of the FLV using serial MR examinations during pregnancy. MR-FLV was measured in 89 fetuses with CDH. All fetuses received two MRIs. A mean weekly growth rate ...
Zamudio S - - 2013
Pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are associated with reduced blood flow, contributing to placental and fetal hypoxia. Placental hypoxia is thought to cause altered production of angiogenic growth effectors (AGEs), reflected in the circulation of mother and fetus. Vascular endothelial growth factor (VEGF), placental ...
Kim C H - - 2013
The desired objective of controlled ovarian stimulation (COS) is to allow the growth of a cohort of follicles and to facilitate the recovery of a large number of fertilizable oocytes. However, poor responders with diminished ovarian reserve often fail to respond adequately despite the maximal dose of gonadotropins administered, with ...
Meyer-Gesch Katie M - - 2013
Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development and metabolism were studied in an ovine space-restriction model by ...
Erol Onur - - 2013
Background: Triploidy is a highly lethal condition, and is thus very rarely observed in live births. It may result in significant medical risk to the pregnant woman. Case: A 32-year-old multigravid woman presented for prenatal care. Ultrasound examination at 14+3 weeks of gestation revealed a viable fetus with appropriate fetal ...
Gao Xing - - 2013
To investigate the effect of Soothing liver therapy on infertile women undergoing in vitro fertilization and embryo transfer (IVF-ET) and to explore its mechanism. Fifty-eight women with tubal infertility were randomized into two groups: 30 in an experimental group treated with Xiaoyao powder (Shugan) plus gonadotropin-releasing hormone analog (GnRHa)/follicle-stimulating hormone ...
Neves Haroldo Millet - - 2013
To measure fetal renal volume in normoglycemic and hyperglycemic pregnancies. A longitudinal prospective study was conducted and included 92 hyperglycemic and 339 normoglycemic pregnant women attended at the prenatal service of a hospital from Rio de Janeiro State. Ultrasound examinations were performed to estimate gestational age at baseline and the ...
Tongprasert Fuanglada - - 2013
To compare the levels of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) between pregnancies with fetal Hb Bart's disease and unaffected pregnancies. 91 pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the study. Maternal serum ...
Crisci Angelica - - 2013
Although donkey breeding has gained new interest in the past two decades, knowledge about donkey reproduction is still scarce, particularly on jenny pregnancy. The aim of this study was to describe the ultrasonographic and endocrine profiles of the physiological pregnancy in the jenny. The study was performed on 12 pregnancies ...
Lyall Fiona - - 2013
Failure to transform uteroplacental spiral arteries is thought to underpin disorders of pregnancy, including preeclampsia and fetal growth restriction (FGR). In this study, spiral artery remodeling and extravillous-cytotrophoblast were examined in placental bed biopsies from normal pregnancy (n=25), preeclampsia (n=22), and severe FGR (n=10) and then compared with clinical parameters. ...
Radulescu L - - 2013
Context. The prevalence of maternal obesity has been increasing dramatically in the recent years (body mass index ≥ 30 kg/m2). Maternal obesity is associated with an unequivocal increase in maternal and fetal complications of pregnancy and more than that, these complications also extend beyond fetal life in childhood and adulthood. ...
Rutkowski Joseph M JM Institute of Bioengineering, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, - - 2013
Lymphatic vessels surround follicles within the ovary, but their roles in folliculogenesis and pregnancy, as well as the necessity of lymphangiogenesis in follicle maturation and health, are undefined. We used systemic delivery of mF4-31C1, a specific antagonist vascular endothelial growth factor receptor 3 (VEGFR-3) antibody to block lymphangiogenesis in mice. ...
Jones Megan Louise - - 2013
Placental oxidative stress plays a key role in the pathophysiology of several placenta-related disorders. Oxidative stress occurs when excess reactive oxygen species (ROS) damages cellular components, an outcome limited by antioxidant enzymes; mitochondrial uncoupling protein-2 (UCP2) also limits ROS production. We recently reported maternal dietary omega-3 polyunsaturated fatty acid (n-3 ...
Nagamatsu Takeshi - - 2013
Clinical outcome of confined placental mosaicism (CPM) is varied, from normal pregnancy to intrauterine fetal death. It has been suggested that CPM for trisomy 2 is less likely to cause serious adverse effect on pregnancy. We hereby report a case of CPM for trisomy 2, which presented severe fetal growth ...
Iñiguez Carmen - - 2013
In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the association of maternal smoking with fetal biometry in different stages of pregnancy. The study population comprised ...
Yusuf K - - 2013
Abstract Objective: To measure nitric oxide (NO) levels, as assessed by methemoglobin (MetHb), in the umbilical cord arterial blood of women with preeclampsia (PE), normotensive pregnancies with intrauterine growth restriction (IUGR, < 10(th) percentile for birth weight) and normotensive pregnancies with appropriate for gestational age (AGA) infants. Design/Methods: Prospective analysis ...
Hantush Zadeh Sedigheh - - 2013
To determine whether maternal urinary findings in the first trimester of pregnancy are associated with fetal growth restriction. The prevalence of urinary findings in singleton pregnancies complicated by fetal growth restriction were compared with a low-risk control group of pregnancies who gave birth to normal weight babies, in the same ...
Thornburg Kent L - - 2013
Although blood flow in the placental vasculature is governed by the same physiological forces of shear, pressure and resistance as in other organs, it is also uniquely specialized on the maternal and fetal sides. At the materno-fetal interface, the independent uteroplacental and umbilicoplacental circulations must coordinate sufficiently to supply the ...
Ahmed Asif A Vascular Medicine Unit, Aston University, Birmingham B4 7ET, - - 2013
The exact aetiology of preeclampsia is unknown, but there is a good association with an imbalance in angiogenic growth factors and abnormal placentation [1]. Hydrogen sulphide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is pro-angiogenic vasodilator [2,3]. We hypothesized that a reduction in CSE activity may alter ...
Chen Chih-Ping - - 2013
To present prenatal diagnosis of partial monosomy 5p (5p14.1 → pter) and partial monosomy 14q (14q32.31 → qter). A 33-year-old woman underwent amniocentesis at 20 weeks of gestation because of abnormal fetal ultrasound. Amniocentesis revealed a dicentric chromosome of dic(5;14). Level II ultrasound at 23 weeks of gestation revealed a fetus with intrauterine growth ...
Landres Inna V - - 2013
Objectives- The purpose of this study was to evaluate whether the use of customized fetal reference standards improves the prenatal detection of intrauterine growth restriction. Methods- We conducted a retrospective cohort study. Singleton pregnancies with a diagnosis of a small-for-gestational-age (SGA) fetus based on the in utero reference standard of ...
Jansson Thomas T Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA. - - 2013
Altered maternal nutrition and metabolism, restricted utero-placental blood flow, and other perturbations in the maternal compartment may disturb critical periods of fetal development resulting in increased susceptibility to develop disease in childhood and adult life. In response to these perturbations, changes in placental structure and function occur, which influence the ...
Apostolakis-Kyrus Katherine - - 2013
Mature teratoma is a common complication of pregnancy. To the best of the authors' knowledge this is the largest teratoma in pregnancy documented in the literature. A 19-year-old woman, gravida 1, at 14 weeks' gestational age with a 37-cm fundal height, was found to have a 30 x 28 x ...
Ferland Suzanne - - 2013
Objectives: It has been suggested that physical activity (PA) can influence the development of the placenta and the risk of placenta-mediated complications of pregnancy. We evaluated the association between PA and early markers of placental development. Methods: Ninety-four nulliparous women were invited to participate in a prospective observational cohort study. ...
Tomic Vlatka - - 2013
Aim. To assess the effect of maternal physical activity during pregnancy on abnormal fetal growth. Methods. The study group of 166 women in gestational week 6-8 exercised regularly three days per week at submaximal intensity during their entire pregnancy and the control group of 168 women received standard antenatal care. ...
Chen Dong-Bao - - 2013
Ample interest has been evoked in using placental angiogenesis as a target for the development of diagnosis tools and potential therapeutics for pregnancy complications based on the knowledge of placental angiogenesis in normal and aberrant pregnancies. Although these goals are still far from reach, one would expect that two complementary ...
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