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Villar J - - 2013
Please cite this paper as: Villar J, Altman D, Purwar M, Noble J, Knight H, Ruyan P, Cheikh Ismail L, Barros F, Lambert A, Papageorghiou A, Carvalho M, Jaffer Y, Bertino E, Gravett M, Bhutta Z, Kennedy S, for the International Fetal and Newborn Growth Consortium for the 21(st) Century ...
Nelissen Ewka C M - - 2013
STUDY QUESTION: When does a difference in human intrauterine growth of singletons conceived after IVF and embryo culture in two different culture media appear? SUMMARY ANSWER: Differences in fetal development after culture of embryos in one of two IVF media were apparent as early as the second trimester of pregnancy. ...
Alwasel Saleh H SH Fetal Programming of Disease Research Chair, Zoology Department, College of Science and Centre of Excellence in Biotechnology Research, King Saud University, Saudi - - 2013
Studies of the placenta in pregnancies complicated by pre-eclampsia have led to the suggestion that tissue along the length and breadth of its surface has different functions. A recent study in Saudi Arabia showed that the body size of newborn babies was related to the breadth of the surface at ...
Pashaj S - - 2013
OBJECTIVES: The objective of this study is to establish reference ranges of quantitative characteristics of the corpus callosum allowing the accurate diagnosis of corpus callosum pathologies such as hypogenesis, dysgenesis and thick corpus callosum. METHODS: For the present study a total number of 604 pregnant women referred for sonographic examination ...
- - 2013
Fetal growth restriction, also known as intrauterine growth restriction, is a common complication of pregnancy that has been associated with a variety of adverse perinatal outcomes. There is a lack of consensus regarding terminology, etiology, and diagnostic criteria for fetal growth restriction, with uncertainty surrounding the optimal management and timing ...
Bloomfield H - - 2013
Optimal fetal growth is important for a healthy pregnancy outcome and also for lifelong health. Fetal growth is largely regulated by fetal nutrition, and mediated via the maternal and fetal glucose/insulin/insulin-like growth factor axes. Fetal nutrition may reflect maternal nutrition, but abnormalities of placental function can also affect fetal growth, ...
Zong Lu - - 2013
Pre-eclampsia (PE) is the most serious syndrome of human pregnancy and it is potentially life-threatening for both mother and fetus. The aim of the study was to identify the role of high temperature requirement A1 (HtrA1) in pre-eclampsia. One hundred consecutive pregnancies complicated by PE and 100 normal controls were ...
Li Cun C The University of Texas Health Science Center San Antonio, Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology San Antonio, TX 78229, - - 2013
Intrauterine growth restriction (IUGR) is an important fetal developmental problem resulting from 2 broad causes: maternal undernutrition and/or decreased fetal nutrient delivery to the fetus via placental insufficiency. IUGR is often accompanied by up-regulation of the hypothalamo-pituitary-adrenal axis (HPAA). Sheep studies show fetal HPAA autonomy in late gestation. We hypothesized ...
Yelikar Kanan A KA Department of Obstetrics and Gynecology, Government Medical College & Hospital (Ghatti Rugnalaya), Near Panchakki, Aurangabad, - - 2013
To study the efficacy of fetal Doppler and non-stress test (NST) in predicting fetal compromise in preeclampsia and growth-restricted fetuses. ln a prospective study, 189 pregnant women beyond 32 weeks of gestation with preeclampsia or growth-restricted fetuses confirmed by ultrasound were evaluated by Doppler velocimetry (umbilical and middle cerebral artery) and ...
Bouwland-Both Marieke I - - 2013
OBJECTIVE: Fetal growth is dependent on adequate development of the placenta. Impaired angiogenesis and vasculogenesis in early pregnancy compromises placental and embryonic development. The proteins soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and plasminogen activator inhibitor type 2 (PAI-2), and the B-vitamin folate are determinants of placental development. ...
Whitehead Clare L - - 2013
OBJECTIVE: To examine whether mRNA circulating in maternal blood coding genes regulating fetal growth are differentially expressed in 1) severe preterm FGR and 2) at 28 weeks' gestation in pregnancies destined to develop FGR at term. STUDY DESIGN: mRNA coding growth genes were measured in two independent cohorts. The first ...
Mandujano Alicia A Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Advocate Illinois Masonic Medical Center, Chicago, IL 60618, USA. - - 2013
The dawn phenomenon is a transient rise in blood glucose between 4 and 6 am that is attributed to the pulsatile release of pituitary growth hormone (GH). In pregnancy, GH is suppressed by placental GH. Hence, we hypothesize that there is no evidence for the dawn phenomenon in late pregnancy ...
van Uitert Evelyne M - - 2013
STUDY QUESTION: How do human embryonic growth trajectories evolve in the first trimester, and is first-trimester embryonic growth associated with fetal growth and birthweight (BW)? SUMMARY ANSWER: Human embryonic growth rates increase between 9 and 10 weeks of gestation and are associated with mid-pregnancy fetal growth and BW. WHAT IS ...
Gómez Mariel Fajer - - 2013
Maternal nutrient intake in the prenatal period is an important determinant of fetal growth and development and supports maternal health. Many women, however, fail to meet their prenatal nutrient requirements through diet alone and are therefore advised to consume nutrient supplements. The purpose of this study was to describe the ...
Hwang Ji-Yun - - 2013
BACKGROUND: Iron supplementation is a common recommendation for pregnant women to prevent iron deficiency during pregnancy. There is an increasing concern about excessive iron consumption as a general iron prophylaxis by pregnant women without any due consideration about their dietary iron intake or iron status. Our present study investigated the ...
O'Connor C - - 2013
Detecting aberrant fetal growth has long been an important goal of modern obstetrics. Failure to diagnose abnormal fetal growth results in perinatal morbidity or mortality. However, the erroneous diagnosis of abnormal growth may lead to increased maternal anxiety and unnecessary obstetric interventions. We review the aetiology of deviant fetal growth ...
Ulker V - - 2013
Placental mesenchymal dysplasia (PMD) is a rare placental abnormality characterised by placentomegaly and grape-like vesicles resembling partial mole by ultrasonography, but in contrast to partial mole can co-exist with a viable fetus. Although the karyotype is normal, the fetus is at increased risk for intrauterine growth restriction, intrauterine fetal demise ...
Mehta Bindu N - - 2013
Insulin-like growth factor-1 (IGF-1) has been reported to play a role in human follicular and embryonic development. However, earlier studies carried out mostly in animal models or in culture mediums supplemented with IGF-1 have been unable to directly link IGF-1 with embryo quality. Results correlating IGF-1 with pregnancy outcome have ...
Halperin Julia - - 2013
We studied for the first time the mammary gland morphogenesis and its hormonal modulation by immunolocalizing estradiol, progesterone and prolactin receptors (ER, PR and PRLR) in adult females of Lagostomus maximus, a caviomorph rodent which shows a pseudo-ovulatory process at mid-gestation. Mammary ductal system of non-pregnant females lacks expression of ...
Riccardi Daniela - - 2013
In fetal mammals, serum levels of both total and ionized calcium significantly exceed those in the adult. This relative fetal hypercalcemia is crucial for skeletal development and is maintained irrespectively of maternal serum calcium levels. Elegant studies by Kovacs and Kronenberg have previously addressed the role of the CaSR in ...
Jiang Y - - 2013
PURPOSE: The aim of this study was to determine whether laterality of an absent umbilical artery (AUA) is associated with fetal growth in fetuses with isolated single umbilical artery (SUA). METHODS: Fifty singleton pregnancies were studied, including 26 cases with a right AUA and 24 cases with a left AUA ...
Probyn Megan E - - 2013
High levels of alcohol consumption during pregnancy can lead to growth deficits in early postnatal life. However, the effects of low to moderate alcohol consumption during pregnancy are less clearly defined. The aim of this study was to determine if low-moderate ethanol (EtOH) consumption throughout pregnancy in the rat alters ...
Ghosh Sanjib Kumar - - 2013
AIM: To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20-22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR). MATERIAL AND METHODS: A prospective cohort study was conducted on 722 women with singleton pregnancies, screened ...
Radulescu L - - 2013
One of the most important causes of perinatal mortality and morbidity complicating significant percentage pregnancies is intrauterine growth restriction (IUGR). Fetal growth restriction is the main cause of intrauterine fetal death and the second leading cause of death in the neonatal period. Numerous studies in different populations reveal an association ...
Vasudeva Akhila - - 2013
OBJECTIVES: We aimed to measure early fetal growth velocity and to correlate this with the birth weight, gestational age at delivery, and with the incidence of adverse pregnancy outcomes specifically preeclampsia and perinatal mortality. METHODS: A data based prospective observational study, wherein sonographic biometry data and specific pregnancy outcome related ...
- - 2013
Six hundred stillbirths per year in the UK could be prevented by improved detection of fetal growth restriction, a study has suggested.
Mazzucco María Belén - - 2013
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. Aims: to study the effect of a saturated-fat-rich diet on growth, lipid accretion, and lipases, leptin and leptin receptor expression in the placenta and fetal liver. We also ...
Haedersdal Sofie - - 2013
Low-grade inflammation has been associated with pregnancy complications including preeclampsia (PE), intrauterine growth restriction (IUGR), and spontaneous preterm birth (SPB). In an unmatched, nested case-control study, we assessed the possible predictive association of maternal C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), and soluble urokinase plasminogen activator receptor (suPAR) in second ...
Shyamsundar - - 2013
Uterine myomas are being observed in pregnancy more frequently now than in the past, because many women are delaying child bearing till their late thirties, which is the time for the greatest risk of the myoma growth. Traditionally, obstetricians are trained to avoid myomectomies during caesarean sections as severe haemorrhages ...
Braun T - - 2013
Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET ...
Simón-Muela Inmaculada - - 2013
OBJECTIVE: To analyze the role of cord blood adiponectin and its multimeric forms in neonatal adiposity and fetal growth (FGV) during the third trimester of pregnancy according to fetal gender. STUDY DESIGN: Prospective analytical observational study conducted at the Diabetes and Pregnancy unit, University Hospital Joan XXIII, Tarragona. Ninety-six healthy ...
Ouyang Fengxiu - - 2013
Elevated pre-pregnancy BMI, excessive gestational weight gain (GWG), and gestational diabetes mellitus (GDM) are known determinants of fetal growth. The role of placental weight is unclear. We aimed to examine the extent to which placental weight mediates the associations of pre-pregnancy BMI, GWG, and GDM with birth weight-for-gestational age, and ...
Konieczny Andrzej - - 2013
Preeclampsia is a disorder occurring during pregnancy typically after 20 weeks of gestation. It affects both mother and unborn baby in at least 5-8% of all pregnancies. It is a rapidly progressive condition characterized by high blood pressure and the presence of protein in the urine. The symptoms, such as ...
Smith R - - 2013
Unexplained antepartum stillbirth is a major obstetric health problem. Data demonstrate a rapid rise in risk per 1000 continuing pregnancies as gestation advances beyond 40 weeks. We review the evidence that such stillbirths are a consequence of aging related changes in the late gestation placenta. We suggest that the relatively ...
Vermeer N - - 2013
OBJECTIVES: To analyze the outcomes of fetuses referred because of short femur length. METHODS: This was a retrospective study of all singleton pregnancies referred to a tertiary care referral hospital with a femur length below the 5(th) percentile. All ultrasound scan reports, including Doppler, fetal karyotyping, pregnancy outcome and neonatal ...
Mossa Francesca - - 2013
Severe prenatal under nutrition is usually associated with low birth weights in offspring and disorders including hypertension, obesity and diabetes. Whether alterations in maternal nutrition insufficient to impair birth weight or prenatal growth impact the cardiovascular, stress or metabolic systems is unknown. In addition, little is known about the effects ...
Dallaire Renée R School of Psychology, Laval University and CHUQ Research Center, Quebec, - - 2013
Several studies have reported negative associations of polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and mercury (Hg) with duration of gestation and fetal growth in fish eating populations. Docosahexaenoic acid (DHA) from fish, seafood and marine mammal intake has been reported to be positively related with pregnancy duration and fetal growth. So ...
Chitty Lyn S LS Clinical and Molecular Genetics Unit, UCL Institute of Child Health, University College London, UK. - - 2013
To improve the prenatal diagnosis of thanatophoric dysplasia by defining the change in fetal size across gestation and the frequency of sonographic features, and developing non-invasive molecular genetic diagnosis based on cell-free fetal DNA (cffDNA) in maternal plasma. Fetuses with a confirmed diagnosis of thanatophoric dysplasia were ascertained, records reviewed, ...
Conroy Andrea L - - 2013
Placental malaria (PM) is a major cause of fetal growth restriction, yet the underlying mechanism is unclear. Complement C5a and C5a receptor levels are increased with PM. C5a is implicated in fetal growth restriction in non-infection-based animal models. In a case-control study of 492 pregnant Malawian women, we find that ...
Regnault Timothy Rh - - 2013
Background:This study examines the relationship between placental amino acid (AA) transport and fetal AA demand in an ovine fetal growth restriction (FGR) model where placental underdevelopment induces fetal hypoxemia and hypoglycemia.Methods:Umbilical uptakes of AA, oxygen, glucose and lactate were measured near term in eight experimental ewes (FGR group) and in ...
Cetin Irene - - 2013
PURPOSE OF REVIEW: Intrauterine growth restriction (IUGR) occurs when fetal growth rate falls below the genetic potential and affects a significant number of pregnancies, but still no therapy has been developed for this pregnancy disease. This article reviews the most recent findings concerning maternal characteristics and behaviours predisposing to IUGR ...
Chow Michelle S - - 2013
: Meningiomas are slow-growing tumors that may present in pregnancy because of accelerated growth. We present the case of a recurrent meningioma in two separate pregnancies in the same woman. : A 35-year-old woman presented at 30 weeks of gestation with limb weakness, vomiting, and a progressive decreased level of ...
Szentpéteri Imre - - 2013
Abstract Objective: In this study, we describe changes in gene expression pattern of VEGF-A in human placenta obtained from pregnancies with intrauterine growth restriction using placenta from normal pregnancies as control. Methods: We compared gene expression of VEGF-A in placental samples from IUGR pregnancies vs. placenta obtained from normal pregnancies. ...
Higashijima Ai - - 2013
OBJECTIVE: The aim of this study was to characterize placenta-specific microRNAs in fetal growth restriction (FGR) pregnancy. METHOD: Placenta-specific miRNAs were identified by next-generation sequencing analysis. Subsequently, quantitative real-time reverse-transcription polymerase chain reaction was used to identify FGR placenta-specific miRNAs whose level of expression was significantly decreased in FGR placenta ...
Vrachnis Nikolaos - - 2013
Abstract The needs of the uterus and the fetus for provision of nutrients and oxygen, supplied by the blood flow, are understandably extremely high, with the circulatory system playing the most important role in this action. Abnormal vascular growth and transformation that create a high vessel resistance network have been ...
Whitten Amy E AE Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, - - 2013
Massive perivillous fibrin deposition (MPFD) is associated with serious complications of pregnancy including recurrent spontaneous abortion, fetal growth restriction, and fetal demise. The aim of this study was to determine whether maternal plasma concentrations of angiogenic/antiangiogenic factors in MPFD differ from those of uncomplicated pregnancies. This retrospective longitudinal case-control study ...
Cipolla Marilyn J MJ Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA. - - 2013
The adaptation of the cerebral circulation to pregnancy is unique from other vascular beds. Most notably, the growth and vasodilatory response to high levels of circulating growth factors and cytokines that promote substantial hemodynamic changes in other vascular beds is limited in the cerebral circulation. This is accomplished through several ...
Simonazzi G - - 2013
OBJECTIVE: To evaluate the outcome of pregnancies complicated by placental insufficiency and abnormal umbilical artery Doppler prior to viability. DESIGN: A retrospective cohort study. SETTING: Italy. POPULATION: Singleton pregnancies with fetal growth restriction and absence of end-diastolic velocities (AEDVs) in the umbilical arteries prior to 24 weeks. METHODS: A retrospective cohort ...
Hillman Sara - - 2013
OBJECTIVEFathers of low-birth weight offspring are more likely to have type 2 diabetes and cardiovascular disease in later life. We investigated whether paternal insulin resistance and cardiovascular risk factors were evident at the time that fetal growth-restricted offspring were born.RESEARCH DESIGN AND METHODSWe carried out a case-control study of men ...
Anderson Brenna L BL Division of Maternal-Fetal Medicine, Women & Infants' Hospital, Warren Alpert Medical School of Brown University, Providence, RI, - - 2013
Both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition. The objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy. This prospective cohort enrolled low-risk pregnant ...
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