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Gardosi Jason J Perinatal Institute, Birmingham, - - 2014
Customized growth charts reduce complexity in antenatal care for the expectant mother and her clinicians by improving the distinction between physiological and pathological variation in fetal size. Their application in large databases has improved our understanding of the importance of intrauterine growth restriction and its antenatal recognition. Their implementation into ...
Prior Tomas T Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, London, UK; Institute for Reproductive and Developmental Biology, Imperial College London, London, UK; Mater Research Institute, South Brisbane, Queensland, - - 2014
The incidence of cerebral palsy in term infants has not changed over the last 30 years. Current intrapartum monitoring techniques are limited by their inherent poor specificity. Changes in fetal haemodynamics in the term fetus, similar to those seen in fetal growth restriction, have been associated with an increased risk of ...
Harper Lorie M LM The Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health at the University of Alabama at Birmingham, Birmingham, AL. Electronic address: - - 2014
To evaluate the utility of ultrasound surveillance in obese women. Retrospective cohort of all obese women undergoing sonography at a single center from 2005-2013. Inclusion criteria were: body mass index ≥30 kg/m(2), singleton, ≥1 ultrasound performed <20 weeks, and ≥1 ultrasound performed ≥24 weeks. Pregnancies with medical complications, fetal anomalies ...
Caserta Donatella - - 2014
A unicornuate uterus accounts for 2.4 to 13% of all Mullerian anomalies. A unicornuate uterus with a non-communicating rudimentary horn may be associated with gynecological and obstetric complications such as infertility, endometriosis, hematometra, urinary tract anomalies, abortions, and preterm deliveries. It has a poor reproductive outcome and pregnancy management is ...
Sanders Tessa R TR Centre for Neuroendocrinology, Edgar National Centre for Diabetes and Obesity Research, Gravida: National Research Centre for Growth and Development, Department of Anatomy, University of Otago School of Medical Sciences, Dunedin, New - - 2014
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the pro-inflammatory cytokine interleukin 6 (IL6), but whether it is present in the fetal circulation, and how it acts on the developing fetus is unclear. We firstly observed that ...
Wang N N National Centre for Chronic and Non-communicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China; Murdoch Children's Research Institute, c/o Royal Children Hospital, Melbourne, Australia. Electronic address: - - 2014
Maternal influence on fetal growth is mediated through the placenta and this influence may have an implication for the offspring's long-term health. The placenta-to-birth weight ratio has been regarded as an indicator of placental function. However, few studies have examined the effect of maternal lifestyle exposures on the placenta-to-birth weight ...
Calcaterra F F Department of Medical Biotechnologies and Translational Medicine, University of Milan, Italy; Lab of Clinical and Experimental Immunology, Humanitas Clinical and Research Center, Rozzano, MI, - - 2014
Circulating endothelial progenitor cells (EPCs) may play a crucial role during pregnancy by sustaining adequate placentation and fetal growth. Unambiguous demonstration of EPC increase during pregnancy has been hampered so far by lack of standardized methods for EPC quantification. In this study we used the currently most accepted phenotype for ...
Giannubilo Stefano Raffaele SR Polytechnic University of Marche, Clinical Sciences, Salesi Hospital, Ancona, Italy, 60123, +39 71 36745, +39 71 36575 ; - - 2014
Coenzyme Q10 (CoQ10 or ubiquinone) is an essential component of the mitochondrial electron transport chain and is also present in various cellular membranes and in plasma lipoproteins. Diabetes, cardiovascular neurodegenerative and preeclampsia diseases are all associated with an alteration of CoQ10 level or its redox status. During pregnancy we note ...
Curtis Simon S Myerscough College, St Michael's Rd, Bilsborrow, Preston PR3 0RY, UK; School of Sport, Tourism and the Outdoors, University of Central Lancashire, Darwin Building, DB201, Preston PR1 2HE, UK. Electronic address: - - 2014
A circumferential ring in the hoof horn of foals occurs at birth and grows down to the distal border as the fetal hoof is replaced. Horn growth and complete hoof capsule renewal have not been measured in Thoroughbred foals but the determination of time of hoof renewal may allow accurate ...
Vassena Rita R Department of Assisted Reproduction, Clinica EUGIN, Barcelona 08029, Spain. Electronic address: - - 2014
The menstrual cycle is a finely tuned biological process comprising a precisely orchestrated sequence of events: follicular growth, selection and ovulation, extensive endometrial changes, corpus luteum (CL) growth and maturation, and luteolysis. Differences in the length of the menstrual cycle (MCL) have been associated with variable female fecundity. However, the ...
Muraro Ana Paula - - 2014
There is strong evidence of an association between maternal smoking during pregnancy and restriction of intrauterine growth, but the effects of this exposure on postnatal linear growth are not well defined. Furthermore, few studies have investigated the role of tobacco smoke exposure also after pregnancy on linear growth until adolescence. ...
Boutsikou Theodora T Department of Neonatology, Athens University Medical School , Athens , Greece - - 2014
Abstract Objective: To determine levels of the possible angioregulatory molecules netrin-1 and -4, in intrauterine-growth-restricted (IUGR), large for gestational age (LGA) (both groups characterized by altered angiogenic mechanisms) and appropriate-for-gestational-age (AGA) pregnancies. Methods: Cord blood (UC) netrin-1 and -4 concentrations were measured in 30 IUGR, 30 LGA and 20 AGA ...
Boutsikou Theodora - - 2014
Abstract Objective: To determine levels of galectins (gal)-1 and -3 (implicated in angiogenesis/immunologic mechanisms) in intrauterine growth restricted (IUGR), large (LGA) and appropriate for gestational age (AGA) pregnancies, as these groups differ in fat mass, angiogenic patterns and immune responses. Methods: Cord-blood (UC) gal-1 and -3 concentrations were measured in ...
Li Wei W Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery,Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts - - 2014
Preeclampsia is a complication of pregnancy manifested as maternal hypertension and often fetal growth restriction. Placental ischemia could be an initiating event, but the linking mechanisms leading to hypertension and growth restriction are unclear. We have shown an upregulation of matrix metalloproteinases (MMPs) during normal pregnancy (Norm-Preg). To test the ...
Higgins Stephen T ST Vermont Center on Behavior and Health, University of Vermont, USA; Department of Psychiatry, University of Vermont, USA; Department of Psychology, University of Vermont, USA. Electronic address: - - 2014
To examine whether an efficacious voucher-based incentives intervention for decreasing smoking during pregnancy and increasing fetal growth could be improved without increasing costs. The strategy was to redistribute the usual incentives so that higher values were available early in the quit attempt. 118 pregnant smokers in greater Burlington, Vermont (studied ...
Walsh Jennifer M JM UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, - - 2014
Interrogation of the association between leptin, insulin resistance and fetal growth may provide a biological link for the fetal programming of later metabolic health. Our aim was to clarify the relationship between maternal and fetal leptin, insulin resistance and fetal growth. Maternal leptin, glucose and insulin were measured in early ...
Bukowski Radek R University of Texas Medical Branch at Galveston, United States of - - 2014
Stillbirth is strongly related to impaired fetal growth. However, the relationship between fetal growth and stillbirth is difficult to determine because of uncertainty in the timing of death and confounding characteristics affecting normal fetal growth. We conducted a population-based case-control study of all stillbirths and a representative sample of live ...
Parker Samantha E SE Slone Epidemiology Center, Boston University, Boston, MA 02215. Electronic address: - - 2014
Preeclampsia, placental abruption, and intrauterine growth restriction (IUGR) have collectively been termed ischemic placental disease (IPD) due to a suspected common biological pathway involving poor placentation in early pregnancy and subsequent placental insufficiency. Despite decades of research, the etiologies of these conditions remain largely unknown and preventive and therapeutic strategies ...
Herrera Emilio - - 2014
More glucose crosses the placenta than any other substrate, but correlations between its concentration in maternal plasma and fetal growth are not found consistently. The accumulation of maternal fat depots and hyperlipidemia are the two principal changes in lipid metabolism during pregnancy. Although lipids cross the placenta with difficulty, maternal ...
Arcos-Machancoses Jose Vicente JV Department of Pediatrics, University & Polytechnic Hospital La Fe, Valencia, - - 2014
The presence of a single umbilical artery (SUA) is a fetal soft marker of congenital abnormalities. Among the most common related malformations, there are cardiological, nephrourological and digestive anomalies, most of which are considered to have a vascular etiology. There is an association between increased incidence of intrauterine growth retardation ...
Murase Harutaka H Equine Science Division, Hidaka Training and Research Center, Japan Racing - - 2014
It has not been common to perform regular ultrasound examination of the fetus in equine practice, due to the increasing volume of the uterus caused by fetal development. The convex three-dimensional transducer is bulb-shaped, and is able to observe wide areas. In addition, its operation is simple, making it easy ...
Forhead Alison J AJ A Forhead, University of Cambridge, Dept of Physiology, Cambridge, CB2 3EG, United - - 2014
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are essential for normal growth and development of the fetus. Their bioavailability in utero depends on development of the fetal hypothalamic-pituitary-thyroid gland axis and the abundance of thyroid hormone transporters and deiodinases that influence tissue levels of bioactive hormone. Fetal T4 and ...
Nucci Marta M Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, - - 2014
Objective: To compare the maternal serum concentrations of placental growth factor (PlGF)-1 and PlGF-2 in the first, second and third trimesters in normal pregnancies and in those complicated by pre-eclampsia (PE) or the delivery of small for gestational age (SGA) neonates after 37 weeks. Methods: Serum PlGF-1 and PlGF-2 were ...
Bahr B B Department of Physiology and Developmental Biology, Brigham Young University, 595 WIDB, Provo, UT 84602, - - 2014
Intrauterine growth restriction (IUGR) has been documented to increase placental apoptosis at term. HSP27 has been shown to be involved in the control of apoptosis. Our objective is to determine the expression of phosphorylated HSP27 (p-HSP27) in human IUGR, and to determine the role of HSP27 during gestation in an ...
Salam Rehana A RA aDivision of Woman and Child Health, Aga Khan University, Karachi, Pakistan bProgram for Global Pediatric Research, Hospital for Sick Children, Toronto, Ontario, - - 2014
Intrauterine growth restriction (IUGR) is responsible for the higher rates of fetal, perinatal, and neonatal morbidity and mortality. This review details the IUGR risk factors, its short and long-term sequel, the mechanism underlying the long-term consequences, and the strategies to tackle IUGR burden. Short-term consequences of IUGR involve metabolic, thermal, ...
Khandaker Shamim S Department of Gynaecology & Obstetrics, North Bengal Medical College, Sushrutanagar, Darjeeling, 734 012 India ; Flat A4, Pratima Apartments, Anandapuri Block A, 45 Jessore Road, Barasat, 700 124 Kolkata - - 2014
To study the antepartum fetal growth between customized "GROW" curves and noncustomized growth curves with neonatal growth pattern. Fetal growth scans are performed between 30 and 35 weeks to singleton mother. Estimated fetal weights (EFWs) were determined using ultrasound variables (biparietal diameter, head circumference, abdominal circumference, and femur length). This EFW ...
Belluscio Laura M LM Laboratorio de Biología Molecular, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón II, 1428 Ciudad de Buenos Aires, - - 2014
Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth ...
Gaillard Romy R Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The - - 2014
Fetal growth characteristics are used to identify influences of several maternal characteristics and to identify individuals at increased risk of adverse outcomes. The extent to which fetal growth characteristics track in different trimesters is not known. In a population-based prospective cohort study among 8636 pregnant women, we examined the extent ...
Laskowska Marzena M Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, - - 2014
Objective: The aim of present study was to assess the maternal serum eNOS, NOSTRIN and ADMA levels in pregnancies with intrauterine growth restriction in the presence or absence of preeclampsia and to compare the results with preeclamptic pregnant women with appropriate-for-gestational-age weight infants. Patients and methods: The study was performed ...
Carr David D University College London, UCL Institute for Women's Health, 86-96 Chenies Mews, London, United Kingdom, WC1E 6HX, University of Aberdeen, Rowett Institute of Nutrition and Health, Greenburn Lane, Bucksburn, Aberdeen, United Kingdom, AB21 9SB ; - - 2014
Introduction: Fetal growth restriction (FGR) occurs in ~8% of pregnancies and is a major cause of perinatal mortality and morbidity. There is no effective treatment. FGR is characterised by reduced uterine blood flow (UBF). In normal sheep pregnancies, local uterine artery (UtA) adenovirus (Ad) mediated over-expression of vascular endothelial growth ...
Jerabek-Klestil Susanne S Department of Gynecology and Obstetrics, Innsbruck Medical University Hospital, Anichstrasse 35, 6020 Innsbruck, Austria. - - 2014
The incidence of fetal portosystemic anastomoses is unknown, and it is presumed that many cases remain undetected, as visualization of the hepatic vasculature is not part of the routine 20-week sonographic scan in pregnancy. However, portosystemic anastomoses are associated with fetal growth restriction due to a diminished oxygen supply to ...
Ashraf Tasneem T Department of Obstetrics and Gynaecology, Bolan Medical College, - - 2014
Aggressive angiomyxoma is a locally aggressive soft tissue tumour mainly arises from perineal, vulval and bladder connective tissue. As it has a tendency for local infiltration and recurrence so long-term follow-up and treatment is required. A case of 24 years old primigravida, 16 weeks pregnant with huge pedunculated lobulated growth ...
de Steenwinkel Florentien D O FD Department of Rheumatology, Erasmus MC, Rotterdam, The - - 2014
Objective Active rheumatoid arthritis (RA) during pregnancy and the presence of rheumatoid factor (RF) or anti-citrullinated protein antibody (ACPA) are related with a lower birth weight. Prednisone reduces the gestational age. Rapid catch-up in weight for length during the first year of life has been related to worse cardiovascular and ...
Pinar Halit H a Women and Infants Hospital, Division of Perinatal and Pediatric - - 2014
Abstract ABSTRACT Identifying growth abnormalities in stillbirths is clinically useful, but complicated by maceration. This is an observational study of consecutive postmortem examinations where femur lengths and gestational age at delivery were collected, along with associated congenital anomalies and extent of fetal maceration. Between 2005 and 2012, 1,530 consecutive postmortem ...
Rogne Tormod T Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, - - 2014
To evaluate how different levels of increase in maternal blood glucose from a fasting state to two hours after an oral glucose challenge in late pregnancy is associated with fetal growth, with special emphasis on those with a low increase. Prospective cohort study. We followed 855women, of whom 70% had ...
Chawla Reeti R Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA, - - 2014
Small for gestational age (weight for gestational age <10th percentile, SGA) birth status and adulthood susceptibility to diabetes is well established, but the relationship to diabetes during pregnancy is incompletely understood. The authors investigated the association between women's impaired fetal growth (as measured by SGA status) and diabetes mellitus (DM) ...
Mifsud William W Department of Paediatric Histopathology, Great Ormond Street Hospital, London, - - 2014
Several histopathological features are found more frequently in placentas from pregnancies complicated by fetal growth restriction (FGR), including villous infarction, maternal vascular changes and villous morphological alterations, although around one quarter of placentas associated with FGR lack any morphological abnormality on routine examination. Since similar changes may also affect clinically ...
Saunders Lauren L Team of Epidemiological Research on Environment, Reproduction and Development, National Institute for Health and Medical Research (INSERM U1085), Rennes, - - 2014
Recent studies suggest that a Mediterranean dietary pattern during pregnancy may influence pregnancy outcomes. The aim of this study was to evaluate the effect of adherence to a Mediterranean diet (MD) during pregnancy on fetal growth restriction (FGR) and preterm delivery (PTD) in a French Caribbean island where the population ...
Smith Nicole A NA Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, - - 2014
Fetal growth restriction is a strong risk factor for stillbirth. We aimed to compare the performance of three fetal growth curves: customized, ultrasound (Hadlock), and population, in identifying abnormally grown fetuses at risk of stillbirth. We performed a case-control study of singleton stillbirths (2000-2010) at one center. Four liveborn controls ...
Gutaj PaweĊ‚ - - 2014
Abstract Aim: To analyze the role of maternal placental growth factor (PlGF) in the prediction of small for gestational age (SGA) birth weight in pregnancy complicated by type 1 diabetes mellitus (T1DM). Methods: A prospective observational study on 59 normotensive T1DM pregnant women, assessing maternal PlGF concentrations between the 10th-14th ...
Tran Melanie M Department of Physiology, The University of Melbourne, Parkville, - - 2014
Adverse conditions in utero can have transgenerational effects, in the absence of a subsequent insult. We aimed to investigate the contribution of the maternal pregnancy environment vs. germ line effects in mediating alterations to cardiorenal and metabolic physiology in offspring from mothers born small. Uteroplacental insufficiency was induced by bilateral ...
Georgiadis L L Department of Obstetrics and Gynaecology, Kuopio University Hospital, P.O Box 100, 70029 Kuopio, Finland; University of Eastern Finland, Department of Clinical Medicine, P.O Box 1627, 70211 Kuopio, Finland. Electronic address: - - 2014
Many complications of pregnancy and delivery are associated with umbilical cord length. It is important to examine the variation in length, in order to identify normal and abnormal conditions. Moreover, the factors influencing cord growth and development are not precisely known. The main objectives were to provide updated reference charts ...
Miyamoto A A Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, - - 2014
The establishment of pregnancy requires well-balanced regulation of the endocrine and immune systems and involves interactions among the conceptus, oviduct-uterus, and corpus luteum (CL). In particular, a rapid increase in plasma progesterone during the first week after ovulation is critical for the growth of the conceptus and successful pregnancy in ...
Dierickx I I Department of Obstetrics and Gynaecology, U.Z. Gasthuisberg , KU Leuven , - - 2014
Background: Fetal/neonatal hyperthyroidism is a well-known complication of maternal Graves' disease with high concentrations of TSH-receptor antibodies (TRAb). Few data are available on the management of fetal hyperthyroidism in surgically treated Graves' disease. Methods: Clinical, ultrasound and biochemical data are reported in a fetus/neonate whose mother underwent a thyroidectomy > ...
Vesce F F Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Italy. - - 2014
To assess the eventual influence of low dose betamethasone throughout pregnancy on fetal growth. 320 patients - admitted to the Section of Obstetrics and Gynecology of Ferrara University from January 2005 to December 2010 - were subdivided in two groups: 160 patients affected by recurrent spontaneous abortion (Group A), treated ...
Morales-Roselló José J Fetal Medicine Unit, Academic Department of Obstetrics and Gynecology, St George's University of London, - - 2014
To evaluate whether changes in the middle cerebral artery (MCA), umbilical artery (UA) and cerebroplacental ratio (CPR) Doppler indices at term might be used to select those appropriate for gestational age (AGA) fetuses, failing to reach their growth potential (FRGP). This was a retrospective cohort study in a single tertiary ...
Borras D D Department of Obstetrics and Gynecology, Hospital Universitario La Fe , Valencia , - - 2014
The aim of this paper was to study if soluble fms-like tyrosine kinase 1 (sFlt-1), free vascular endothelial growth factor (f-VEGF) and the f-VEGF/sFlt-1 quotient in singleton pregnancies complicated with intrauterine growth restriction (IUGR) are different from controls. This was a case-control study between 18 pregnancies with IUGR and 24 ...
Grazul-Bilska Anna T AT A Grazul-Bilska, Animal Sciences, North Dakota State University, Fargo, 58108, United - - 2014
Utero-placental growth and vascular development are critical for pregnancy establishment that may be altered by various factors including assisted reproductive technologies (ART), nutrition, or others, leading to compromised pregnancy. We hypothesized that placental vascularization and expression of angiogenic factors are altered early in pregnancies after transfer of embryos created using ...
Visser Gerard H A GH Departments of Obstetrics, University Medical Center, Utrecht, The - - 2014
The outcome of early small-for-gestational age and/or intrauterine growth-restricted fetuses is reviewed. In these fetuses the outcome appears to be considerably poorer than that of appropriately grown fetuses and this seems mainly to be caused by intrauterine malnutrition rather than by hypoxemia. Active management of intrauterine growth restriction at the ...
Miller Suzanne L SL The Ritchie Centre, Monash Institute of Medical Research, Monash University, 27-31 Wright St, 3168, Clayton, Victoria, Australia; Department of Obstetrics & Gynaecology, Southern Clinical School, Monash University, 3800, Clayton, Victoria, - - 2014
Fetal intrauterine growth restriction (IUGR) is a serious pregnancy complication associated with increased rates of perinatal morbidity and mortality, and ultimately with long-term neurodevelopmental impairments. No intervention currently exists that can improve the structure and function of the IUGR brain before birth. Here we investigated whether maternal antenatal melatonin administration ...
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