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Adair Linda S LS Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, - - 2014
Maternal nutritional deficiencies and excesses during pregnancy, and faster infant weight gain in the first 2 years of life are associated with increased risk of noncommunicable diseases (NCDs) in adulthood. The first 1,000 days of life (from conception until the child reaches age 2 years) represent a vulnerable period for ...
Miller Laura L LL School of Social and Community Medicine, University of Bristol, Bristol, United - - 2014
There are animal data that indicate that prenatal environmental exposures have sex-specific effects on subsequent generations. In humans, an increase in birthweight has been reported if the maternal grandmother had smoked in the pregnancy giving rise to the mother. Here we assess whether prenatal exposure of either parent to cigarette ...
Roland Marie Cecilie Paasche MC Department of Obstetrics, Oslo University Hospital, Oslo, - - 2014
Maternal nutritional and metabolic factors influence the developmental environment of the fetus. Virtually any nutritional factor in the maternal blood has to pass the placental membranes to reach the fetal blood. Placental weight is a commonly used measure to summarize placental growth and function. Placental weight is an independent determinant ...
Unterscheider Julia J Obstetrics & Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland. - - 2014
Intrauterine growth restriction (IUGR) is the single largest contributing factor to perinatal mortality in non-anomalous fetuses. Advances in antenatal and neonatal critical care have resulted in a reduction in neonatal deaths over the past decades, while stillbirth rates have remained unchanged. Antenatal detection rates of fetal growth failure are low, ...
Janisse James J JJ a Department of Family Medicine and Public Health Sciences, School of Medicine , Wayne State University , Detroit , Michigan , - - 2014
ABSTRACT. Background: Pregnancy substance use is linked to low birth weight. However, less is known about relative contributions of various substances and whether effects are due to decreased gestational duration, restriction of fetal growth, or both. The study goal was to use causal modeling to evaluate the individual impact of ...
Pizzi Costanza C Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy ; Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, London, United - - 2014
Studying prenatal influences of early life growth is relevant to life-course epidemiology as some of its features have been linked to the onset of later diseases. We studied the association between prenatal maternal characteristics (height, age, parity, education, pre-pregnancy body mass index (BMI), smoking, gestational diabetes and hypertension) and offspring ...
Nørgaard Lone Nikoline LN Department of Obstetrics and Gynecology, Hillerød Hospital, Copenhagen University Hospital, Hillerød, - - 2014
To describe early and late fetal growth in pregnancies conceived after gastric bypass surgery in relation to time from surgery to conception of pregnancy. National cohort study on 387 Danish women, who had laparoscopic or open gastric bypass surgery prior to a singleton pregnancy in which first trimester screening was ...
Qi Wei W Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, - - 2014
The mechanism by which nanoparticles cross the placental barrier was studied by using isotopic tracers. The abortion rates and other related data were counted and analysed in pregnant mice with different pregnancy times. Results showed that oxidised multi-walled carbon nanotubes (oMWCNTs) crossed the placental barrier and entered the foetus body. ...
Pike Katharine C KC 1] Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK [2] NIHR Southampton Respiratory Biomedical Research Unit - - 2014
Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought ...
Linzke Nadja N Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, - - 2013
Heme Oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) promote implantation and placentation. Pregnancy disorders such as preeclampsia and intrauterine growth restriction are linked to both HO-1 diminution and impaired remodeling of maternal spiral arteries (SAs). Here, we investigated whether CO is able to prevent preeclampsia and intrauterine growth restriction ...
Galjaard Sander S KU Leuven Department of Development and Regeneration: Pregnancy, Fetus and Neonate, Gynaecology and Obstetrics, University Hospitals Leuven, - - 2013
to evaluate the application of a pocket-sized ultrasound machine (PUM) in a routine ante-natal third trimester scan compared to high specification ultrasound machines (HSUM). An observational cohort study on 53 unselected patients, who came for their routine third trimester ultrasound scan. First scan was performed by an experienced ultra-sonographer (SB) ...
Suzuki Kohta K Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of - - 2013
Background: Maternal smoking during pregnancy is a major cause of intrauterine growth restriction and childhood obesity, but only a few studies have examined the association of smoking cessation before and during pregnancy with fetal and childhood growth. We examined this association in a prospective cohort study in Japan.Methods: Our study ...
Al-Jameil Noura N Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi - - 2014
Preeclampsia (PE) is a leading cause of maternal mortality and morbidity worldwide. It occurs in women with first or multiple pregnancies and is characterized by new onset hypertension and proteinuria. Improper placentation is mainly responsible for the disease. If PE remains untreated, it moves towards more serious condition known as ...
Velauthar L L Women's Health Research Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Women's Health Unit, Barts Health NHS Trust, London, - - 2013
Pre-eclampsia and fetal growth restrictions are associated with adverse pregnancy outcomes, especially with an early onset. Clinical risk assessment of women is done in the first trimester to identify women for preventative treatment. To determine the accuracy with which uterine artery Doppler in the first trimester of pregnancy predicts pre-eclampsia ...
Leventakou Vasiliki V Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece (VL, TR, and LC); the Centre for Research in Environmental Epidemiology, Barcelona, Spain (DM, MC, JS, MK, and MV); the Hospital del Mar Medical Research Institute, Barcelona, Spain (DM, MC, JS, MK, and MV); the Department of Clinical Epidemiology, Predictive Medicine and Public Health and Cardiovascular Research & Development Unit, University of Porto Medical School, Porto, Portugal (HB and AO); the Public Health Institute, University of Porto, Portugal (HB and AO); the Department for Genes and Environment (ME) and Department of Chronic Diseases (HS), Division of Epidemiology, and the Division of Environmental Medicine (A-LB, MH, and HMH), Norwegian Institute of Public Health, Oslo, Norway; the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain (MC, M Murcia, JS, MK, and MV); the Institut National de la Santé et de la Recherche Médicale (INSERM), Centre for Research in Epidemiology and Population Health, U1018, Lifelong Epidemiology of Obesity, Diabetes and Renal Disease Team, Villejuif, France (M-AC and BH); the University Paris-Sud, UMRS 1018, le Kremlin Bicêtre, France (M-AC and BH); the INSERM UMR 1085, Institut de Recherche Santé Environnement & Travail, Université de Rennes 1, Rennes Cedex, France (SC and, FP); the Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, Amsterdam, Netherlands (MvE); the Department of Epidemiology, Lazio Regional health System, Rome, Italy (FF and DP); the Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (UG); the Environmental Risk and Health, Flemish Institute for Technological Research, Mol, Belgium (EG); the Maternal Nutrition Group, Centre for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark (TIH, SFO, and MS); the Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland (TIH); the Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland (WH and KP); The Generation R Study Group (DHMH and VWVJ) and the Departments of Epidemiology (DHMH) and Pediatrics (VWVJ), Erasmus Medical Center, Rotterdam, Netherlands; the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom (HMI and SMR); the Faculty of Health, Medicine and Life Sciences, Department of Health Services Research, Caphri (MJ) and the School for Public Health and Primary Care, Department of Epidemiology (C-MP, M Mommers, and CT), Maastricht University, Maastricht, Netherlands; the Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, Geleen, Netherlands (MJ); the School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland (CK and KV); the Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy (FM and LR); the Centre for Public Health Research, Valencia, Spain (M Murcia); the Department of Nutrition, Harvard School of Public Health, Boston, MA (SFO); the University Pompeu Fabra, Barcelona, Spain (JS); the Department of Public Health, Academic Medical Centre-University of Amsterdam, Amsterdam, Netherlands (TGMV); the Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, Netherlands (AHW); and the National School of Public Health, Athens, Greece - - 2013
Fish is a rich source of essential nutrients for fetal development, but in contrast, it is also a well-known route of exposure to environmental pollutants. We assessed whether fish intake during pregnancy is associated with fetal growth and the length of gestation in a panel of European birth cohort studies. ...
Weissgerber Tracey L TL Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA (T.L.W.), Beth Israel Deaconess Medical Center, Boston, MA, USA (A.R.), Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh PA, USA (A.M., L.R.E., R.W.P., J.M.R., R.E.G, C.A.H.), Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh PA, USA (R.W.P., J.M.R., C.A.H.), Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA, USA (R.E.G., C.A.H.), Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA, USA (J.M.R.), Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA - - 2013
Context: Research examining the source of excess sFLT1 in preeclampsia has focused on the placenta. The potential contribution of the releasable store of sFLT1 in the systemic vasculature is unknown. Objective: We asked if the non-placental releasable store of sFLT1 is larger in women with previous preeclampsia than in women ...
Whitehead Clare - - 2013
Hypoxia in utero can lead to stillbirth and severe perinatal injury. While current prenatal tests can identify fetuses that are hypoxic, none can determine the severity of hypoxia/acidaemia. We hypothesized a hypoxic/acidaemic fetus would upregulate and release hypoxia-induced mRNA from the fetoplacental unit into the maternal circulation, where they can ...
Dodson R Blair RB Department of Mechanical Engineering, University of Colorado, Boulder, - - 2014
Intrauterine growth restriction (IUGR) is a fetal complication of pregnancy epidemiologically linked to cardiovascular disease in the newborn later in life. However, the mechanism is poorly understood with very little research on the vascular structure and function during development in healthy and IUGR neonates. Previously, we found vascular remodeling and ...
Unterscheider Julia J Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: - - 2013
To evaluate opinions among Irish obstetricians and obstetric trainees regarding the optimal definition, assessment and management of pregnancies affected by intrauterine growth restriction (IUGR). An anonymous, structured, web-based survey that comprised 14 questions was sent to 200 obstetricians and obstetric trainees in Ireland. Of the 113 participants (57% response rate), ...
Oben Jolien - - 2013
Abstract Objective - In this study we determine whether maternal cardiovascular profiling can detect first trimester differences between women with uncomplicated pregnancies (UP) and those who will develop gestational hypertensive disorders (GHD) or normotensive fetal growth retardation (FGR). Methods - Cardiac, arterial, and venous function were evaluated in 242 pregnant ...
Julian Colleen G - - 2013
Chronic exposure to hypoxia raises the risk of pregnancy disorders characterized by maternal vascular dysfunction and diminished fetal growth. In an effort to identify novel pathways for these hypoxia-related effects, we assessed gene expression profiles of peripheral blood mononuclear cells (PBMCs) obtained from 43 female, high-altitude or sea-level residents in ...
Cetin Irene - - 2013
As more women breastfeed for longer, it is increasingly likely that women may be still breastfeeding when they become pregnant again. The Italian Society of Perinatal Medicine (SIMP) Working Group on Breastfeeding has reviewed the literature to determine the medical compatibility of pregnancy and breastfeeding. We found no evidence indicating ...
Hankins Gary D V - - 2013
Assessments of gestational age are critical in dealing with the pregnancy at the limits of viability, 22-25-weeks gestation, where neonatal outcomes reveal very significant differences from week to week. The obstetrical team can estimate gestational age within a window of 7-10 days during this critical threshold at the window of ...
Pecks U - - 2013
Reduced serum LDL concentrations have been observed in pregnancies complicated by intrauterine growth restriction (IUGR) as compared to healthy pregnant women. Since increased oxidative stress has been suggested to play a major role in IUGR we now hypothesized that the lower LDL concentrations are accompanied by an accumulation of oxidized ...
O'Higgins Amy C - - 2013
Abstract The aim of this article is to review the current evidence on gestational weight gain (GWG). Maternal obesity has emerged as one of the great challenges in modern obstetrics as it is becoming increasingly common and is associated with increased maternal and fetal complications. There has been an upsurge ...
Ca─člar Mete - - 2013
Abstract The aim of this study was to compare decorin (DCN) levels between pregnancies complicated by idiopathic fetal growth restriction (FGR) and uncomplicated pregnancies and to determine the relationship between DCN levels and clinical parameters. The study population consisted of two groups: control group consisted of 13 women with uncomplicated ...
Dias Monike Lourenço - - 2013
The interaction between pregnancy and acromegaly has only been studied retrospectively. We prospectively assessed those interactions. Prospective, interventional, multicentric. Ten pregnancies in 8 acromegalics were included according to criteria: previous diagnosis of acromegaly; active acromegaly before pregnancy; sellar MRI, GH and IGF1 measurements before pregnancy. Exclusion criterion: radiotherapy. Withdrawal of ...
Gårdebjer E M - - 2013
Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. Sprague-Dawley rats were exposed to ...
Pollheimer J - - 2013
During pregnancy, the extravillous trophoblast (EVT) invades the maternal decidua and remodels spiral arteries reaching as far as the inner third of the myometrium. This process is mandatory to a successful pregnancy since EVTs regulate spiral artery remodeling to achieve maximal vasodilation and thus an adequate nutrient supply to the ...
Mikovic Zeljko - - 2013
Abstract Objective: To determine if there is any difference in amniotic fluid erythropoietin (EPO) concentration between fetuses small for gestational age (SGA) and appropriate for gestational age (AGA), and between the constitutionally small (CSF) and growth-restricted (GRF) fetuses. Methods: EPO concentrations in the amniotic fluid samples were determined by EpoELISA ...
Arleo Elizabeth Kagan - - 2013
Objective The objective of this study was to use two-dimensional (2D) ultrasound (US) during routine prenatal surveillance to develop normative estimated placental volume (EPV) growth curves.Study Design Patients ≥ 18 years old with singleton pregnancies were prospectively followed from 11 weeks gestational age (GA) until delivery. At routine US visits, ...
van Uitert E M - - 2013
Are maternal characteristics and lifestyle factors associated with human embryonic growth trajectories? Periconception maternal age is associated with increased, and smoking and alcohol use with decreased embryonic growth trajectories, estimated with crown-rump length (CRL) measurements. Fetal weight is associated with health and disease in later life. Maternal characteristics and lifestyle ...
Lewis R M - - 2013
Offspring of obese and diabetic mothers are at increased risk of being born with excess adiposity as a consequence of their intrauterine environment. Excessive fetal fat accretion reflects additional placental nutrient transfer, suggesting an effect of the maternal environment on placental function. High plasma levels of particular nutrients in obese ...
Wang Yanfei - - 2013
Mycotoxins are chemicals produced by fungus and many of them are toxic to humans. Zeranol is a mycotoxin used to promote growth in cattle in North America; yet such a practice draws concern about the residual compound in meat in European countries. In the present study, the toxicity of zeranol ...
Roje Damir - - 2013
To investigate whether there is difference in trophoblast apoptosis between infants with asymmetrical idiopathic intrauterine growth retardation (IUGR) and those with symmetrical fetal growth appropriate for gestational age (AGA). Data and placentas from 52 singleton term pregnancies with idiopathic IUGR, from which a subgroup of 33 (63.4%) infants with asymmetrical ...
Hagelstein Claudia - - 2013
To investigate individual changes in fetal lung volume (FLV) in fetuses with isolated congenital diaphragmatic hernia (CDH) and to calculate weekly growth rates of the FLV using serial MR examinations during pregnancy. MR-FLV was measured in 89 fetuses with CDH. All fetuses received two MRIs. A mean weekly growth rate ...
Zamudio S - - 2013
Pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR) are associated with reduced blood flow, contributing to placental and fetal hypoxia. Placental hypoxia is thought to cause altered production of angiogenic growth effectors (AGEs), reflected in the circulation of mother and fetus. Vascular endothelial growth factor (VEGF), placental ...
Kim C H - - 2013
The desired objective of controlled ovarian stimulation (COS) is to allow the growth of a cohort of follicles and to facilitate the recovery of a large number of fertilizable oocytes. However, poor responders with diminished ovarian reserve often fail to respond adequately despite the maximal dose of gonadotropins administered, with ...
Meyer-Gesch Katie M - - 2013
Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development and metabolism were studied in an ovine space-restriction model by ...
Erol Onur - - 2013
Background: Triploidy is a highly lethal condition, and is thus very rarely observed in live births. It may result in significant medical risk to the pregnant woman. Case: A 32-year-old multigravid woman presented for prenatal care. Ultrasound examination at 14+3 weeks of gestation revealed a viable fetus with appropriate fetal ...
Neves Haroldo Millet - - 2013
To measure fetal renal volume in normoglycemic and hyperglycemic pregnancies. A longitudinal prospective study was conducted and included 92 hyperglycemic and 339 normoglycemic pregnant women attended at the prenatal service of a hospital from Rio de Janeiro State. Ultrasound examinations were performed to estimate gestational age at baseline and the ...
Gao Xing - - 2013
To investigate the effect of Soothing liver therapy on infertile women undergoing in vitro fertilization and embryo transfer (IVF-ET) and to explore its mechanism. Fifty-eight women with tubal infertility were randomized into two groups: 30 in an experimental group treated with Xiaoyao powder (Shugan) plus gonadotropin-releasing hormone analog (GnRHa)/follicle-stimulating hormone ...
Tongprasert Fuanglada - - 2013
To compare the levels of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) between pregnancies with fetal Hb Bart's disease and unaffected pregnancies. 91 pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the study. Maternal serum ...
Crisci Angelica - - 2013
Although donkey breeding has gained new interest in the past two decades, knowledge about donkey reproduction is still scarce, particularly on jenny pregnancy. The aim of this study was to describe the ultrasonographic and endocrine profiles of the physiological pregnancy in the jenny. The study was performed on 12 pregnancies ...
Lyall Fiona - - 2013
Failure to transform uteroplacental spiral arteries is thought to underpin disorders of pregnancy, including preeclampsia and fetal growth restriction (FGR). In this study, spiral artery remodeling and extravillous-cytotrophoblast were examined in placental bed biopsies from normal pregnancy (n=25), preeclampsia (n=22), and severe FGR (n=10) and then compared with clinical parameters. ...
Radulescu L - - 2013
Context. The prevalence of maternal obesity has been increasing dramatically in the recent years (body mass index ≥ 30 kg/m2). Maternal obesity is associated with an unequivocal increase in maternal and fetal complications of pregnancy and more than that, these complications also extend beyond fetal life in childhood and adulthood. ...
Rutkowski Joseph M - - 2013
Lymphatic vessels surround follicles within the ovary, but their roles in folliculogenesis and pregnancy, as well as the necessity of lymphangiogenesis in follicle maturation and health, are undefined. We used systemic delivery of mF4-31C1, a specific antagonist vascular endothelial growth factor receptor 3 (VEGFR-3) antibody to block lymphangiogenesis in mice. ...
Jones Megan Louise - - 2013
Placental oxidative stress plays a key role in the pathophysiology of several placenta-related disorders. Oxidative stress occurs when excess reactive oxygen species (ROS) damages cellular components, an outcome limited by antioxidant enzymes; mitochondrial uncoupling protein-2 (UCP2) also limits ROS production. We recently reported maternal dietary omega-3 polyunsaturated fatty acid (n-3 ...
Iñiguez Carmen - - 2013
In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the association of maternal smoking with fetal biometry in different stages of pregnancy. The study population comprised ...
Nagamatsu Takeshi - - 2013
Clinical outcome of confined placental mosaicism (CPM) is varied, from normal pregnancy to intrauterine fetal death. It has been suggested that CPM for trisomy 2 is less likely to cause serious adverse effect on pregnancy. We hereby report a case of CPM for trisomy 2, which presented severe fetal growth ...
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