Search Results
Results 451 - 500 of 1266
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Verga Uberta - - 2009
OBJECTIVE: Maternal hyperthyrotropinaemia is associated with an increased risk of adverse maternal and neonatal outcomes. Physiological changes during pregnancy require an increased production of thyroid hormones (or an increase in daily substitutive doses of L-T4 in hypothyroid patients) to meet the maternal and foetal needs. The aim of the study ...
Okosieme Onyebuchi E - - 2008
BACKGROUND: Uncontrolled thyroid dysfunction in pregnancy is associated with adverse fetal and maternal outcomes. OBJECTIVES: To review relevant literature and developments in the medical management of thyroid dysfunction in pregnancy. RESULTS: Hyperthyroidism in pregnancy requires careful control of maternal disease whilst avoiding fetal hypothyroidism. Propylthiouracil is the preferred antithyroid drug ...
Rao V Rama Chandra - - 2008
AIM: To determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the Indian population. SETTINGS AND DESIGN: The study included 163 non-pregnant women with recurrent pregnancy loss in a gestational age up to <or=12 weeks verified by a pregnancy test or ultrasonography, and a ...
Vergani Patrizia - - 2008
OBJECTIVE: To identify the classification protocol for stillbirth that minimizes the rate of unexplained causes. STUDY DESIGN: All stillbirths at > 22 weeks from 1995-2007 underwent a workup inclusive of fetal ultrasonography, amniocentesis for karyotype and cultures, placental histology, fetal autopsy, skin biopsy, total body X-ray, maternal testing for thrombophilias, ...
Gilbert Rhonda M - - 2008
OBJECTIVE: To establish first-trimester-specific reference intervals for thyroid function tests in pregnant Australian women. DESIGN, SETTING AND PARTICIPANTS: Serum samples were collected from 2159 pregnant women (9-13 weeks' gestation) attending a private pathology practice for first-trimester screening during October and November 2006. Levels of serum thyrotropin (TSH), free thyroxine (fT4), ...
Elleuche Skander - - 2008
Cyanase degrades toxic cyanate to NH3 and CO2 in a bicarbonate-dependent reaction. High concentrations of cyanate are fairly toxic to organisms. Here, we characterize a eukaryotic cyanase for the first time. We have isolated the cyn1 gene encoding a cyanase from the filamentous ascomycete Sordaria macrospora and functionally characterized the ...
Liu K S - - 2008
Hulless barley kernels were sequentially abraded to achieve 4%, 8%, 16%, 24%, 32%, and 40% removal. Abraded fines, kernels, and ground kernels were stored at 35 degrees C and 75% relative humidity for 3 wk. Stored samples were extracted and the levels of oil, free phytosterols, tocopherols (Ts), and tocotrienols ...
Wohlgemuth C - - 2008
To investigate whether olfactory performance decreases as a function of the number of pregnancies, previous research having indicated that olfactory function decreases in the course of pregnancy. In a prospective study three groups of women were investigated (total n = 93), women who have given birth to no children (group ...
White Kiley A - - 2008
Metallic nanoparticles of different sizes, shapes and compositions are being avidly explored as materials for next-generation biological labels, therapeutic agents, 'artificial viruses' and diagnostic probes. Gold nanoparticles especially, are making a major impact in these areas, owing in large part to their ease of functionality, low toxicity and unique optical ...
Dhingra Simi - - 2008
BACKGROUND: Resistance to thyroid hormone manifests as high serum levels of free thyroxine and free triiodothyronine, with nonsuppressed thyroid stimulating hormone (TSH) levels. We report a case series of three patients with this condition, the changes in thyroid function tests during their pregnancies, and their obstetric outcome. CASES: Three pregnant ...
Burns Robert - - 2008
BACKGROUND: The distribution of neonatal blood thyroid-stimulating hormone (TSH) concentrations has been used as an index reflecting population dietary iodine intake, with higher concentrations being indicative of lower iodine intake. We examined this distribution in neonates born in Ireland, where the pregnant population has shown a recent decline in urinary ...
Rotondi Mario - - 2008
OBJECTIVE: Pregnancy and the postpartum (PP) period are associated with profound changes of the immune system, which largely influence the clinical activity of autoimmune diseases. The aim of this study was to evaluate the effect of pregnancy and/or the PP period in driving a clinical relapse of hyperthyroidism in patients ...
Sánchez-Vega Javier - - 2008
OBJECTIVE: To evaluate the iodine nutrition of the pregnant women of the Spanish Autonomous Community Extremadura. There are approximately 10,000 births per year in Extremadura, which historically contains areas with endemic goiter (Las Hurdes). DESIGN: Population study in which a representative sample of pregnant women of the general population was ...
Carey Luke C - - 2008
Cyclooxygenase 2 (COX-2) is important for development of the fetal kidney. Precisely how renal COX-2 expression is regulated in fetal life is unclear. The hypothesis that thyroid hormone positively regulates COX-2 and PGE(2) levels in the late gestation fetal kidney cortex was tested. Sham, thyroidectomized (TX), and TX + thyroid ...
Lambert-Messerlian Geralyn - - 2008
OBJECTIVE: The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies. STUDY DESIGN: TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening. RESULTS: ...
Korenek Antonin - - 2008
AIMS: To evaluate the iodine status of patients in early pregnancy and its dependence on level of thyroid-stimulating hormone (TSH). METHODS: Between June 2005 and December 2006, 168 patients with a confirmed vital pregnancy (up to 10(th) week of pregnancy) were included in the study. The entry criteria were no ...
Williams G R - - 2008
For over 100 years, thyroid hormones have been known to be essential for neonatal neurodevelopment but whether they are required by the foetal brain remains a matter of controversy. For decades, the prevailing view was that thyroid hormones are not necessary until after birth because circulating levels in the foetus ...
Larsson A - - 2008
OBJECTIVE: Reference values are usually defined based on blood samples from healthy men or nonpregnant women. This is not optimal as many biological markers changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during ...
Ishikawa Norio - - 2008
OBJECTIVE: Development of the hip joint is complete by 11 weeks of gestation. As triiodothyronine and thyroxine are important regulators of early bone and muscle development, we hypothesized that excessive thyroid hormone in the early fetal period was a congenital risk factor of developmental dysplasia of the hip (DDH). Consequently, ...
Bernardes Lisandra Stein - - 2008
PURPOSE: To build nomograms of fetal thyroid circumference (FTC), fetal thyroid area (FTA), and fetal thyroid transverse diameter (FTTD) throughout gestational age (GA). METHOD: Between January 2006 and July 2006, FTC, FTA, and FTTD were measured once in 196 normal fetuses examined at a GA of 22-35 weeks. Inclusion criteria ...
Gong Yanping - - 2008
OBJECTIVE: To determine using a simplified study design trimester-specific FT4 reference intervals in pregnancy with the Roche Modular immunoassay in routine use. DESIGN AND METHODS: Surplus blood from 300 women in each trimester, drawn at documented times in the gestation, and from 40 age-matched nonpregnant women were assayed for FT4, ...
Lolic Amela - - 2008
OBJECTIVE: A survey related to iodine deficiency in the Republic of Srpska was first conducted in 1999 and resulted in the adoption of regulations concerning the quality of salt for human consumption. In order to reassess iodine status, we conducted the Republic of Srpska Iodine Deficiency Survey in 2006. DESIGN: ...
Bermüller Christian - - 2008
OBJECTIVES: Sensitivity and specificity of active anterior rhinomanometry (RMM) and peak nasal inspiratory flow (PNIF) in the diagnosis of functionally relevant structural nasal deformities should be assessed. The reference standard was clinical judgment based on all clinical data available. STUDY DESIGN: Prospective study of diagnostic accuracy at a tertiary rhinologic ...
Göktolga Umit - - 2008
OBJECTIVE: The diagnosis and management of a fetal neck mass encountered during routine antenatal ultrasound screening, and later diagnosed definitely as a intrauterine fetal goiter, is discussed in this case report. CASE REPORT: A 28-year-old primigravida at 36 weeks' gestation with normal vital findings, normal laboratory values, and no history ...
Gatzioufas Z - - 2008
Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pathophysiology. Pregnancy represents a major alteration in the maternal ...
Cotzias Christina - - 2008
OBJECTIVE: To establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy. STUDY DESIGN: Cross-sectional observational study performed in the Obstetric and Gynaecology department, West Middlesex University Hospital. A single blood sample from 335 pregnant women at various gestations of pregnancy was analysed for thyroid function. FT4, fT3, ...
Stilwell Georgina - - 2008
INTRODUCTION: Median urinary iodine concentration (UIC) is the most commonly used indicator of population iodine nutrition. However, its validity as an indicator of dietary intake relies on a stable relationship between dietary iodine intake and urinary excretion. Physiological alterations in normal pregnancy, such as increased glomerular filtration rate, potentially invalidate ...
Reimer P - - 2008
When contrast agents are approved, the label describes the approved indications and particular circumstances of use such as age, organ function or pregnancy. The use of contrast agents outside their labelled indications is increasing, namely with contrast agents used for MRI. The aim of this paper is to improve the ...
Kyriazopoulou Venetsana - - 2008
Disorders of thyroid function are common among women of childbearing age. It is known that thyroid physiology normally alters during gestation. Clinicians, often, overlook thyroid dysfunction in pregnant women because of nonspecific symptoms and the hypermetabolic state of normal pregnancy. After all, the clinician must consider thyroid dysfunction as a ...
Massey E Wayne - - 2008
Peripheral neuropathy, mononeuropathy and polyneuropathy, are not common in pregnancy. When complaints occur, however, even if minor, they can be bothersome to the pregnant woman. Peripheral nerve function may threaten the mother and fetus in various ways during gestation. Quick recognition and treatment efforts should therefore be the clinician's goal. ...
Will Bruno - - 2008
Although rejected for the most part of the 20th Century, the idea of brain plasticity began to receive wide acceptance from the 1970s. Yet there has been relatively little theoretical comment on the definition and use of "plasticity" in the field of neurobiology. An early exception to this lack of ...
Hirota Kouji - - 2008
Histone acetyltransferases (HATs) and ATP-dependent chromatin remodeling factors (ADCRs) regulate transcription and recombination via alteration of local chromatin configuration. The ade6-M26 allele of Schizosaccharomyces pombe creates a meiotic recombination hotspot that requires a cAMP-responsive element (CRE)-like sequence M26, the Atf1/Pcr1 heterodimeric ATF/CREB transcription factor, the Gcn5 HAT, and the Snf22 ...
Herbstman Julie - - 2008
BACKGROUND: Thyroid function is dynamic during the perinatal period with many factors potentially influencing maternal, fetal and neonatal TSH and thyroid hormone levels. We sought to identify the impact of numerous maternal, fetal and delivery attributes on thyroid parameters in newborns. METHODS: This was a cross sectional study of 300 ...
Wikner Birgitta Norstedt - - 2008
OBJECTIVE: To describe neonatal outcome including the presence of congenital malformations in infants born to women substituted with thyroid hormones, and the maternal characteristics of these women. DESIGN: Register study based on prospectively collected data in relation to delivery. SETTING: Swedish Health Registers. POPULATION: All pregnant women (n=848,468) and all ...
Gurbuz Nilgun - - 2008
In humans androgen decline is presented as a clinical picture which includes decreased sexual interest, diminished erectile capacity, delayed or absent orgasms and reduced sexual pleasure. Additionally, changes in mood, diminished well being, fatigue, depression and irritability are also associated with androgen insufficiency. The critical role of androgens on the ...
Halperin Rabinovich Irene - - 2008
During pregnancy, the body undergoes a major adaptation process as a result of the interaction between mother, placenta and fetus. Major anatomical and histological changes are produced in the pituitary, with an increase of up to 40% in the size of the gland. There are wide variations in the function ...
Berg Gertrud - - 2008
INTRODUCTION: Radioiodine and most cytostatic treatments are contraindicated in pregnancy. Still, inadvertent therapy does occur. Radioiodine was given to two pregnant women with Graves' disease and thyroid cancer respectively, both in their 20th gestational week. Routine pregnancy tests based on urinary beta-hCG had failed to indicate pregnancy in both cases. ...
Kuerschner Lars - - 2008
The biosynthesis and storage of triglyceride (TG) is an important cellular process conserved from yeast to man. Most mammalian cells accumulate TG in lipid droplets, most prominent in adipocytes, which are specialized to store large amounts of the TG over long periods. In this study, we followed TG biosynthesis and ...
Delange Fran?ois - - 2007
OBJECTIVE: This paper re-evaluates the requirements for iodine during pregnancy, lactation and the neonatal period, and formulates original proposals for the median concentrations of urinary iodine (UI) that indicate optimal iodine nutrition during these three critical periods of life. This paper also discusses the measurements that are used to explore ...
Zimmermann Michael B - - 2007
OBJECTIVES: Monitoring of iodine status during pregnancy, lactation and infancy is difficult as there are no established reference criteria for urinary iodine concentration (UI) for these groups; so it is uncertain whether iodized salt programs meet the needs of these life stages.DESIGN AND SUBJECTS: The method used in this paper ...
de Escobar Gabriella Morreale - - 2007
An inadequate supply of iodine during gestation results in damage to the foetal brain that is irreversible by mid-gestation unless timely interventions can correct the accompanying maternal hypothyroxinemia. Even mild to moderate maternal hypothyroxinemia may result in suboptimal neurodevelopment. This review mainly focuses on iodine and thyroid hormone economy up ...
Neale Donna M - - 2007
Twenty-seven million Americans are affected with thyroid disease, yet over half of this population remains undiagnosed. Thyroid disease often manifests itself during the reproductive period of a woman's life and is the second most common endocrinopathy that affects women of childbearing age. The physiologic changes of pregnancy can mimic thyroid ...
Glinoer Daniel - - 2007
OBJECTIVE: To examine the importance of iodine nutrition during pregnancy. DESIGN: Review of existing literature of iodine in pregnancy. SETTING: Population surveys and metabolic studies. SUBJECTS: Pregnant women. RESULTS: The main changes in thyroid function associated with pregnancy are due to an increase in hormone requirements that begin in the ...
Srisupundit Kasemsri - - 2008
INTRODUCTION: Fetal thyrotoxicosis, often caused by maternal Grave's disease, can have adverse effects on fetal outcomes, such as growth impairment or fetal hydrops. Therefore, intrauterine treatment is recommended. Objective: To describe the experience of intrauterine medical treatment of fetal thyrotoxicosis. CASE: A 19-year-old woman with a history of Grave's disease ...
Lamb Matthew R - - 2008
Prenatal and early-life exposure to lead is hypothesized to have a range of adverse effects on childhood health. Drawing on data collected from a population-based prospective cohort study of a highly exposed town and a low exposed town in Kosovo, Yugoslavia we assessed whether elevated maternal blood lead (BPb) concentrations ...
Vela J I - - 2007
PURPOSE: To report two cases of retinal arteriolar occlusion in pregnant women with transient protein S (PS) deficiency. METHODS: Observational case reports. RESULTS: Two pregnant women in their 30s presented with a paracentral scotoma in their right and left eye, respectively. In both cases the only risk factor for vascular ...
McMonnies Charles W - - 2007
PURPOSE: Hypotheses for the varied pathogenesis of the different forms of keratoconus have been outlined. Against this background, the possibility that abnormal rubbing causes or contributes to the development or progression of some forms of keratoconus has been examined. METHODS: Circumstantial evidence that shows an association between abnormal rubbing and ...
Berbel Pere - - 2007
Iodine deficiency remains the most frequent cause worldwide, after starvation, of preventable mental retardation in children. It causes maternal hypothyroxinemia, which affects pregnant women even in apparently iodine-sufficient areas, and often goes unnoticed because L-thyroxine (T4) levels remain within the normal range, and thyroid-stimulating hormone (TSH) is not increased. Even ...
Coimbra A M - - 2007
Aroclor 1254 a polychlorinated biphenyls (PCBs) mixture, when administrated through the diet, was previously found to inhibit adult tilapia (Oreochromis niloticus) reproduction. Since fish larvae can be more sensitive to contaminants, the objectives of this study were to evaluate in adults the impact in gonad development and in thyroid function ...
Mamede da Costa Sheila - - 2007
PROBLEM: To investigate the utility of thyroid peroxidase antibodies (TPOAb) in early pregnancy combined with clinical information for prediction of postpartum thyroid dysfunction (PPTD) within 1 year postpartum. METHOD OF STUDY: We studied 98 pregnant women by determining their TPOAb levels in early pregnancy, as well as their serum thyrotropin ...
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