Search Results
Results 451 - 500 of 1341
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De Vivo Antonio - - 2010
BACKGROUND: Pregnancy influences thyroid function and may bring to light mild and latent disorders. Thyroid dysfunction has been related to obstetrical complications such as premature delivery, gestational hypertension, preeclampsia, and placental abruption. The aim of our study was to evaluate whether the occurrence and timing of pregnancy loss could be ...
Soldin Offie P OP Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC, USA. - - 2010
The diagnosis and monitoring of thyroid disease necessitates the knowledge of thyroid pathophysiology and of the technical limitations of current thyroid-related biochemical tests. Thyroid disease diagnosis and monitoring are further complicated during pregnancy and lactation, due to pregnancy-related changes in thyroid hormone metabolism. Dramatic changes that occur in thyroxine and ...
Luetic Ana Tikvica - - 2010
Thyroid changes are considered to be normal events that happen as a large maternal multiorganic adjustment to pregnancy. However, hyperthyroidism occurs in pregnancy with clinical presentation similar to hyperemesis gravidarum (HG) and pregnancy itself. Moreover, 10% of women with HG will continue to have symptoms throughout the pregnancy suggesting that ...
Yassa Leila - - 2010
BACKGROUND: Thyroid hormone requirement increases 20-40% during gestation. Women with treated hypothyroidism must increase their l-T(4) in pregnancy to prevent maternal hypothyroidism, although how this should be accomplished is unclear. METHODS: We prospectively enrolled 60 women with treated hypothyroidism seeking pregnancy. Once pregnant, women were randomized to increase l-T(4) by ...
Weetman Anthony P - - 2010
Pregnancy and the postpartum period have a profound effect on autoimmune thyroid disease. Graves disease ameliorates during pregnancy, only to relapse postpartum, whereas postpartum thyroiditis is caused by destructive thyroiditis during the first few months after delivery. The immunology of pregnancy underlies these changes: the mother must maintain tolerance of ...
Ertek Sibel - - 2010
Although the incidence of postpartum autoimmune disorders of endocrine glands are not rare, the presence of two different entities in the same patient with two different pregnancies is uncommon. We present a 35-year-old woman whose story starts with her first pregnancy when she was 29 years old, she had the ...
Raymond Jennifer - - 2010
PURPOSE OF REVIEW: The purpose of this review is to briefly summarize current knowledge of fetal and neonatal thyroid function, and then to summarize the most significant new findings over the last year that add to our knowledge of the cause, diagnosis, and management of fetal and neonatal thyroid disorders. ...
M?nnist? Tuija - - 2010
Context: Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to pregnancy complications/later maternal morbidity. Objective: The aim of this study was to evaluate the association between maternal thyroid dysfunction/antibodies during pregnancy and pregnancy complications or later maternal hypertension, diabetes, and thyroid disease. Design and Setting: ...
Tran Phuong - - 2010
Graves' disease is a thyroid-specific autoimmune disorder in which the body makes antibodies to the thyroid-stimulating hormone receptor leading to hyperthyroidism. Therapeutic options for the treatment of Graves' disease include medication, radioactive iodine ablation, and surgery. Radioactive iodine is absolutely contraindicated in pregnancy as exposure to I-131 to the fetal ...
Ohira Satoshi - - 2010
Most fetal goitrous hypothyroidisms are reportedly caused by the maternal use of an antithyroid drug or fetal dyshormonogenesis. However, fetal goitrous hypothyroidism due to the transplacental passage of maternal thyroid stimulation-blocking antibody (TSBAb) is extremely rare. A woman at 28 weeks of gestation was found to have a fetal goiter ...
Patil-Sisodia Komal - - 2010
OBJECTIVE: To provide a clinical update on Graves' hyperthyroidism and pregnancy with a focus on treatment with antithyroid drugs. METHODS: We searched the English-language literature for studies published between 1929 and 2009 related to management of hyperthyroidism in pregnancy. In this review, we discuss differential diagnosis of hyperthyroidism, management, importance ...
Nor Azlin M I - - 2010
This study was undertaken to determine the presence of thyroid autoantibodies and associated pregnancy complications from 49 pregnant women with thyroid disease. There were 31 (63%) women with Graves' disease (GD) and 18 (37%) with primary hypothyroidism (PHT). A total of 26 (53.1%) women, 19 (61%) with GD and seven ...
Holt Elizabeth H - - 2010
PURPOSE OF REVIEW: Thyroid cancer is the fastest rising type of cancer among women in North America. Care of the pregnant patient with thyroid cancer is, therefore, of concern to obstetricians, internists and endocrine specialists. Guidelines for the care of the pregnant patient with thyroid disease were released by the ...
Polak Michel - - 2010
Recent advances in fetal imaging techniques and fetal hormonology allow the identification in the fetus of thyroid function disorders that can potentially be treated in utero by giving drugs to the mother. In women with Graves' disease (when fetal hyperthyroidism is present), it can generally be treated in a noninvasive ...
Rebagliato Marisa - - 2010
BACKGROUND: An adequate iodine intake during pregnancy is essential for the synthesis of maternal thyroid hormones and normal brain development in the fetus. Scant evidence is available on the effects and safety of iodine supplementation during pregnancy in areas with adequate or mildly deficient iodine intake. We examined the association ...
Check J H - - 2010
To evaluate the role of infection as a cause of pregnancy loss. Studies concerning the risk factor of certain microorganisms for first trimester miscarriage and premature rupture of membranes are reviewed. The microorganisms especially considered were ureaplasma/mycoplasma, the potpourri of organisms causing bacterial vaginosis and chlamydia trachomatis. The consensus is ...
Ashoor Ghalia - - 2010
The aim of this study in pregnant women with hypothyroidism treated by levothyroxine is to examine the interrelations between thyroid-stimulating hormone (TSH), free thyroxine (FT(4)) and free tri-iodothyronine (FT(3)), and examine whether in such patients the treatment is adequate. This was a retrospective cross-sectional study. Maternal serum concentrations of FT(3), ...
Ceccaldi Pierre-François - - 2010
Fetal thyroid is essential for normal fetus development. Echography of fetuses from mothers with Graves' disease is extremely specific for detecting an intrauterine thyroid dysfunction. We report the first correlation of two cases between color Doppler and histologic study of fetal thyroid goiters.
Dorizzi Romolo M - - 2010
Reference values for thyrotropin (TSH) from weeks 5 to 17 of pregnancy in women living in a moderately iodine-deficient area in Italy have never been calculated using the Advia Centaur analyzer. TSH was measured in surplus blood samples drawn from 657 pregnant women: 101 in weeks 5-6 (group I), 333 ...
Hefnawy Abd-Elghany AE Department of Internal Medicine, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736, - - 2010
Pregnancy toxemia was induced in nine pregnant goat does with twins by the stress of fasting with access to water in late pregnancy to investigate the effect of pregnancy toxemia on immunoglobulins (IgA, IgM, and IgG), cortisol, insulin, thyroid, and growth hormones and their correlations with the plasma levels of ...
Moskovitz Joshua B - - 2010
BACKGROUND: Molar pregnancy is a rare form of pregnancy, affecting approximately 1 in 1000 pregnancies in the United States. Hyperthyroidism is a rare complication of molar pregnancy; thyroid storm occurs even less frequently. OBJECTIVES: To discuss a rare cause of thyroid storm in a woman of reproductive age. CASE REPORT: ...
G?rtner Roland - - 2009
PURPOSE OF REVIEW: Thyroid disorders are common in pregnancy and affect maternal and fetal outcome. RECENT FINDINGS: The reference values for normal thyroid function during first and second trimester had been re-evaluated recently. Hypothyroxinemia affects the neuropsychological development of the child. Maternal thyroid dysfunction or only the presence of thyroid-specific ...
Zamperini P - - 2009
Thyroid cancer is the most common endocrine malignancy, more frequently diagnosed in young women during childbearing age and approximately 10% of all thyroid cancers are diagnosed during pregnancy or in the early post-partum period. Thyroid cancer in young people has generally an excellent prognosis, and survival among women with thyroid ...
Hamm Michele P - - 2009
To determine whether maternal hypothyroxinemia during early pregnancy is associated with adverse perinatal outcomes. Serum samples of a prospective cohort of 879 women collected at 15-16 weeks of pregnancy were analyzed for thyroid-stimulating hormone (TSH) and free thyroxine (T4) concentrations. Women with TSH levels within the normal reference range (0.15-4.0 ...
Galofre Juan C - - 2009
The maternal physiological changes that occur in normal pregnancy induce complex endocrine and immune responses. During a normal pregnancy, thyroid gland volume may enlarge, and thyroid hormone production increases. Hence, the interpretation of thyroid function during gestation needs to be adjusted according to pregnancy-specific ranges. The elevated prevalence of gestation-related ...
Alvarez-Pedrerol Mar - - 2009
The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa (n = 570), Spain. Thyroid hormones (free T4 and total ...
Vannucchi Guia - - 2010
OBJECTIVE: Pregnancy represents a favorable condition for the development of thyroid nodules, likely due to the secretion of hormones with stimulatory activity. In particular, differentiated thyroid cancer (DTC) represents the second most frequent tumor among those diagnosed during pregnancy. However, few and discordant data are available about the impact of ...
Shields Beverley M - - 2009
BACKGROUND: Maternal subclinical hypothyroidism is associated with a number of adverse outcomes in pregnancy. The Endocrine Society's recent consensus guidelines have recommended treatment with T(4) for this condition in pregnancy. The single nucleotide polymorphism rs4704397 in the phosphodiesterase 8B (PDE8B) gene has been found to be associated with altered serum ...
Rosenfeld Hila - - 2009
Propylthiouracil (PTU) is presently considered to be the treatment of choice for hyperthyroidism in pregnancy. It is known to cross the human placenta, and therefore may affect the fetus. The major aims of this study were to evaluate the rate of major anomalies and to report the rate of fetal ...
Boas Malene - - 2009
BACKGROUND: Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE: The aim of the study was the assessment of the intra-individual variation as well as the longitudinal course of ...
Ribault Virginie - - 2009
CONTEXT: Nonimmune fetal goitrous hypothyroidism is a rare condition that can induce obstetrical and/or neonatal complications and neurodevelopmental impairments such as those still seen in some patients with congenital hypothyroidism. Prenatal treatment to prevent these adverse outcomes is appealing, but experience is limited and the risk to benefit ratio controversial. ...
Bori? Marta - - 2009
People of all ages can be affected by iodine deficiency, however, pregnant women and children are especially at a high risk. Because of changes that occur in maternal thyroid hormone economy during pregnancy and the potential unfavorable effects of iodine deficiency on the offspring, an adequate dietary iodine intake throughout ...
Laurberg Peter - - 2009
Exposure of the fetus to low levels of thyroid hormones for extended periods during pregnancy can lead to irreversible brain damage and potential delays in neurological and behavioral development. What are the exact mechanisms behind this abnormality, and can prompt initiation of maternal iodine supplementation prevent this adverse effect?
Alexander Erik K - - 2009
Uncertainty exists about the best approach to manage levothyroxine dosage in women with hypothyroidism, once they become pregnant. The etiology of an individual's hypothyroidism might be a key determinant of the optimal time and duration of dose adjustments, say the authors of a retrospective review published in the journal Thyroid.
Bunevicius Robertas - - 2009
Background. Depression and thyroid dysfunction are prevalent in women, including pregnant women. The aim of this study was to assess the relationship between depression and thyroid function during pregnancy. Methods. One hundred and ninety-nine pregnant women three times during pregnancy were assessed for depressive disorder and for thyroid stimulating hormone ...
Suzuki Shunji - - 2009
Although urinary retention caused by the retroverted gravid uterus is uncommon, acute urinary retention is an emergency condition. We present here two cases of acute urinary retention at 12 weeks' gestation secondary to retroverted gravid uterus. Although some preventive measures were suggested to the patients, recurrences of urinary retention occurred ...
Landek-Salgado Melissa A - - 2010
Autoimmune diseases comprise a group of about 85 heterogeneous conditions that can affect virtually any organ and tissue in the body. Many autoimmune diseases change significantly during pregnancy: some ameliorate, some worsen, and others are unaffected. Two autoimmune diseases present prominently in relation to pregnancy: postpartum autoimmune thyroiditis and autoimmune ...
Toulis Konstantinos A - - 2009
The mechanism explaining the association between first-trimester spontaneous miscarriages and the presence of thyroid autoimmunity remains unclear. Glycoprotein hormone receptors form a receptor subfamily, in which significant structural similarity is observed. Cross-reactivity between chorionic gonadotropin (hCG), thyroid-stimulating hormone (TSH) and their receptors (R) is suggested by the thyrotropic action of ...
Sezer Kerem - - 2009
OBJECTIVE: Abortus is a common problem and is observed approximately in one third of all pregnancies. In this study, we aimed to evaluate in euthyroid pregnant population the effect of thyroid autoantibodies of both first trimester and postpartum period on abortus incidence. DESIGN AND METHOD: Euthyroid 128 pregnant women were ...
Zimmermann Michael B - - 2009
Iodine deficiency has multiple adverse effects in humans, termed iodine deficiency disorders, due to inadequate thyroid hormone production. Globally, it is estimated that 2 billion individuals have an insufficient iodine intake, and South Asia and sub-Saharan Africa are particularly affected. However, about 50% of Europe remains mildly iodine deficient, and ...
Sahu Meenakshi Titoria - - 2010
PURPOSE: Thyroid disorders are among the common endocrine problems in pregnant women. It is now well established that not only overt, but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. There are few data from India about the prevalence of thyroid dysfunction in pregnancy. With this ...
Sloter E - - 2009
Methyl iodide (MeI) induces fetotoxicity in New Zealand White (NZW) rabbits when maternal exposure occurs during a susceptible window late in gestation (gestation days [GD] 23-26). To identify the possible mode of action, comprehensive maternal and fetal bioanalysis and thyroid structure/function assessments were conducted in MeI-exposed (25 ppm by whole-body ...
Fister Petja - - 2009
OBJECTIVE: Literature data concerning thyroid enlargement during pregnancy are not conclusive. Our aim was to systematically follow the thyroid volume changes during pregnancy and after delivery in an iodine-sufficient area. STUDY DESIGN: Prospective study of healthy pregnant women living in an iodine-sufficient area. We followed 118 pregnant women with the ...
Tanda M L - - 2009
Autoimmune thyroid disorders (AITDs) are the result of a complex interplay between genetic and environmental factors, the former account for about 70-80% of liability to develop AITDs. However, at least 20-30% is contributed by environmental factors, which include certainly smoking (at least for Graves' disease and orbitopathy), probably stress, iodine ...
Hallengren Bengt - - 2009
BACKGROUND: Thyroid hormones are important for normal fetal development. Maternal hypothyroidism during early pregnancy is associated with impaired neuropsychological development of children and other adverse outcomes. The primary aim of this prospective study was to determine whether thyroxine-treated pregnant women with hypothyroidism are adequately thyroxine substituted in early pregnancy. A ...
Huel C - - 2009
OBJECTIVES: To determine whether sonography can be used to distinguish hyperthyroidism from hypothyroidism in pregnancies with fetal goiter. METHODS: This was a retrospective study of 39 cases of fetal goiter. The majority of the mothers had Graves' disease. Fetuses were scanned for the existence of a hypertrophic thyroid gland (goiter) ...
Orito Yoshiko - - 2009
CONTEXT: The effect of constant rich iodine intake, especially during pregnancy, has not been well understood. OBJECTIVE: The objective was to examine urinary iodine excretion and thyroid function in early pregnancy in Japanese healthy women. We also studied fetal maturation and child development in these women. DESIGN AND SETTING: This ...
Gyamfi Cynthia - - 2009
Maternal hypothyroidism is known to result in neurodevelopmental disorders in offspring, but whether subclinical hypothyroidism results in lower intelligence quotient (IQ) performance in progeny is an area of debate. Animal studies have shown that fetal thyroxine and triiodothyronine are primarily maternally derived before mid gestation. Other animal data reveal that ...
Garsi Jérôme-Philippe - - 2009
Context and objectives  Radiation is known to be mutagenic. The present study analyses birth outcomes and the health of offspring from men previously exposed to (131) I treatment for thyroid carcinoma. Methods  Data on 493 pregnancies (356 from 173 untreated fathers, 23 from 17 patients who have undergone surgery alone ...
Springer Drahomira - - 2009
BACKGROUND: Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for ...
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