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Tuuri A L AL Department of Obstetrics and Gynecology, Hospital District of Helsinki and Uusimaa, FIN-00029 Helsinki, Finland. Electronic address: - - 2014
The insulin-sensitivity regulator adipocyte fatty acid-binding protein 4 (FABP4) integrates metabolic and inflammatory responses. We hypothesize that there is relationship between FABP4 and factors related to metabolic syndrome in pregnancy-induced hypertension (PIH). In this prospective observational study, among the 72 relatively overweight (BMI ≥24 kg/m(2)) nulliparous women, 14 developed non-proteinuric PIH ...
Gupta Madhu M Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, United States The Feinstein Institute for Medical Research, The Center for Immunology and Inflammation, Manhasset, NY, United - - 2014
Inadequate magnesium (Mg) intake is a widespread problem, with over 50% of women of reproductive age consuming less than the Recommended Daily Allowance (RDA). Because pregnancy increases the requirement for Mg and the beneficial effects of magnesium sulfate for pre-eclampsia/eclampsia, and fetal neuroprotection are well-described, we examined the outcomes of ...
Correia-Branco Ana A Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, - - 2014
An adequate maternal nutrition during pregnancy is crucial for the health outcome of offspring in adulthood. Maternal undernutrition during critical periods of fetal development can program the fetus for metabolic syndrome (MetS) later in life, especially when postnatally challenged with a hypernutritive diet. Adipogenesis, which begins in utero and accelerates ...
Vinter C A CA Department of Gynecology and Obstetrics, Odense University Hospital, - - 2014
The Lifestyle in Pregnancy intervention in obese pregnant women resulted in significantly lower gestational weight gain compared with the control group, but without improvement in rates of clinical pregnancy complications. The impact of the lifestyle intervention on metabolic variables in the study participants is now reported. The Lifestyle in Pregnancy ...
Arabin B B Clara Angela Foundation, Witten and Berlin ; Phillips University Marburg, Centre for Mother and Child ; Department of Obstetrics, University Hospital Charité - - 2014
Overweight and obesity have become a global health problem. Obesity and excessive weight gain during pregnancy have a serious impact on maternal, fetal and neonatal outcomes. Pre-conceptional obesity and excessive weight gain during pregnancy are associated with weight gain in women following childbirth leading to associated risks such as metabolic ...
Baynouna Al Ketbi Latifa Mohammad - - 2014
Maternal diet restriction might be associated with adverse maternal and perinatal outcomes due to metabolic changes. This study aimed to investigate the prevalence of changes in glucose levels due to Ramadan fasting in Emirati pregnant women. We conducted a cross-sectional observational study of 150 women from the United Arab Emirates, ...
Li Si-Ming SM School of Life Science, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin, 150030, - - 2014
Fibroblast growth factor 21 (FGF21), a recently discovered regulatory factor, plays an important role in glucose and lipid metabolism. In this study, we firstly found the FGF21 expression in white blood cells (WBCs). Then, we enrolled 51 women with gestational diabetes mellitus (GDM) and 50 pregnant women with normal blood ...
Capobianco Giampiero G Gynaecologic and Obstetric Clinic, Department of Surgical, Microsurgical and Medical - - 2014
The aim of this study was to assess the influence of glucose metabolism on the expression of glycosaminoglycans (GAGs) and proteoglycans (PGs) in pregnant women. Seventy-six women in the first trimester of pregnancy (10-13 weeks) attending the Gynecologic and Obstetric Clinic, University of Sassari, were enrolled and gave early morning ...
Knight Ba B NIHR Exeter Clinical Research Facility, University of Exeter, Exeter, UK Royal Devon and Exeter NHS Foundation Trust, Exeter, - - 2014
In euthyroid healthy adults thyroid function is known to be associated with obesity, insulin resistance, glycaemia, and dyslipidaemia. Little is known of similar associations in pregnancy, where maternal subclinical hypothyroidism or hypothyroxinaemia can have a detrimental effect on both mother and fetus.(1) AIMS: To assess the associations between reduced thyroid ...
Bromfield John J JJ Department of Animal Sciences, University of Florida, PO Box 110910, Gainesville, FL, 32611-0910, USA, - - 2014
The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre- ...
Zivi Einat E IVF Unit, Dept. of OB & GYN, Hadassah University Hospital, P. O. Box 12000, Jerusalem, 91120, - - 2014
To identify an association between amino acids (AAs) metabolism and reproductive outcome. Prospective collection, observational study, in patients undergoing fresh, double embryo transfer (ET), in a tertiary hospital referral IVF unit. Spent day 1 and day 3 media were collected. Concentrations of taurine, aspartic acid, proline, and serine in the ...
Barrett Helen L HL Corresponding author: Helen L. Barrett, - - 2014
Outcomes in pregnancies complicated by preexisting diabetes (type 1 and type 2) and gestational diabetes mellitus have improved, but there is still excess morbidity compared with normal pregnancy. Management strategies appropriately focus on maternal glycemia, which demonstrably improves pregnancy outcomes for mother and infant. However, we may be reaching the ...
Feillet François F Department of Pediatrics, Hôpital d'Enfants Brabois, CHU Nancy, Vandoeuvre les Nancy, France, - - 2014
Sapropterin dihydrochloride (SD) is the first drug treatment for phenylketonuria (PKU), but due to the lack of data, its use in maternal PKU must be undertaken with caution as noted in the FDA and EMEA labels. We collected data from eight pregnancies in PKU women treated with SD and we ...
Dickinson Hayley - - 2014
While the use of creatine in human pregnancy is yet to be fully evaluated, its long-term use in healthy adults appears to be safe, and its well documented neuroprotective properties have recently been extended by demonstrations that creatine improves cognitive function in normal and elderly people, and motor skills in ...
Yap Constance C Diabetes and Endocrinology, Westmead Hospital, Sydney, New South Wales, - - 2014
OBJECTIVEVitamin D deficiency in pregnancy is associated with an increased risk of gestational diabetes mellitus (GDM) and neonatal vitamin D deficiency. We conducted a double-blind, randomized controlled trial of low-dose (LD) versus high-dose (HD) vitamin D supplementation to investigate the effects of vitamin D supplementation on glucose metabolism during pregnancy.RESEARCH ...
Huang Yifan Y Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P. R. - - 2014
Abstract Objective: To examine whether vitamin supplement before and during pregnancy alters the detrimental effect of maternal obesity on the offspring. Methods: Obese C57BL/6 female mice were randomly divided into 4 groups and fed with the control diet, vitamin D, folic acid or multivitamin supplement before and during pregnancy. Physiologic ...
Seo Heewon - - 2014
Prostaglandins (PGs) are important lipid mediators regulating various reproductive processes in many species. In pigs, the expression pattern of PGE2 and PGF2alpha metabolic enzymes and the regulatory mechanism controlling PGE2 and PGF2alpha levels in the uterus during pregnancy are not completely understood. This study determined endometrial expression of the genes ...
Fidchenko Yu M YM Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, - - 2014
We studied the possibility of prolactin involvement in the regulation of water-salt metabolism in female rats in the model of cholestasis of pregnancy. For simulation of the prolactin level during pregnancy, hyperprolactinemia was simulated by transplantation the pituitary under the renal capsule of the recipient; for modeling cholestasis of pregnancy, ...
Malek Antoine A University Hospital Zurich, Department of Obstetrics, Research Division Frauenklinikstr. 10, 8091 Zurich, Switzerland. - - 2014
Metabolic diseases induced by metabolic syndrome (MS) have been increased during the past two decades. During healthy pregnancy maternal organs and placenta are challenged to adapt to the increasingly physiological changes. In addition to the increasingly proatherogenic MS, pregnant woman develops a high cardiac output, hypercoagulability, increased inflammatory activity and ...
Mierzyński Radzisław R Department of Obstetrics and Perinatology Medical University of Lublin Ul. Jaczewskiego 8 20-954 Lublin Poland. - - 2014
Pregnancy is an acquired hypercoagulable state related to the increase in procoagulants and to the impaired fibrinolysis. Pregnancy is associated with a 4-fold increase in the risk of venous thromboembolism (VTE) and this risk still increases to 14-fold during puerperium. An association between the metabolic syndrome and the risk of ...
Poniedziałek-Czajkowska Elżbieta - - 2014
This review presents available evidence for possible application of n-3 long chain polyunsaturated fatty acids (PUFAs) in pregnant obese women with metabolic syndrome (MS) and focuses on prophylaxis of pregnancy complications associated with MS such as gestational hypertension, preeclampsia and gestational diabetes. Dietary supplementation with n-3 PUFAs has increased in ...
Nathan Nisha - - 2014
Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive-age women. With very little risk associated with its use, metformin provides many important benefits to women with ...
Berti C C a Unit of Obstetrics & Gynecology and Center for Fetal Research Giorgio Pardi , University of Milan , - - 2014
Abstract Pregnancy is a complex period of human growth, development and imprinting. Nutrition and metabolism play a crucial role for the health and wellbeing of both mother and fetus, as well as for the long-term health of the offspring. Nevertheless, several biological and physiological mechanisms related to nutritive requirements together ...
Garcés María F MF Department of - - 2014
Context: Irisin is a recently discovered adipomyokine that regulates the differentiation and phenotype of adipose tissue. Objective: In this study, we investigated the levels of irisin over the three trimesters of gestation in healthy and preeclamptic women, and during the follicular and luteal phase of the menstrual cycle in a ...
Sachse Daniel D Department of Medical Biochemistry, University of Oslo , Oslo , - - 2014
Background. Modern metabolomic profiling has not yet been applied to human breastfeeding research. A common reason for breastfeeding cessation is perceived insufficient milk production. We investigated broad biochemical profiles in maternal urine collected during and after pregnancy to identify biomarkers related to reduced reported breastfeeding. Methods. Fasting urine was collected ...
Wessel Ann E AE Center for Nutrition, Boston Children's Hospital, Boston, - - 2014
Maple syrup urine disease (MSUD) is an inherited disorder of metabolism of the branched-chain amino acids leucine, isoleucine, and valine. Complications of acute elevation in plasma leucine include ketoacidosis and risk of cerebral edema, which can be fatal. Individuals with MSUD are at risk of metabolic crisis throughout life, especially ...
Ma Yue Y Faculty of Medicine - Endocrinology, Memorial University of Newfoundland, St. John's, NL, - - 2014
Fibroblast growth factor-23 (FGF23) controls serum phosphorus largely through actions on the kidneys to excrete phosphorus and reduce calcitriol. Although these actions are well established in adults and children, the role that FGF23 plays in regulating fetal phosphorus metabolism has not been previously studied. We used several mouse models to ...
Lowe W L WL Jr Center for Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, - - 2014
Maternal glucose metabolism during pregnancy differs from the non-gravid state to allow the mother to meet her own and the growing fetus's energy needs. New insights into the mechanisms underlying maternal metabolism during pregnancy are being gained through the use of new 'omics' technologies. This review focuses on the application ...
Melzer Katarina K Swiss Federal Institute of Sport Magglingen, - - 2014
Food intake increases to a varying extent during pregnancy to provide extra energy for the growing fetus. Measuring the respiratory quotient (RQ) during the course of pregnancy (by quantifying O2 consumption and CO2 production with indirect calorimetry) could be potentially useful since it gives an insight into the evolution of ...
Scholtz Elizabeth L EL Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA - - 2014
One of the most widely accepted axioms of mammalian reproductive biology is that pregnancy requires the (sole) support of progesterone, acting in large measure through nuclear progesterone receptors (PRs) in uterine and cervical tissues, without which pregnancy cannot be established or maintained. However, mares lack detectable progesterone in the latter ...
Li Jie J Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of - - 2014
Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with increased risk of metabolic diseases in adulthood. We hypothesized preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with ...
Hiersch Liran L Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, - - 2014
To address the recent evidence regarding the association between hyperglycemia during pregnancy and adverse short-term and long-term outcome for both mothers and offspring. Recent data suggest a relationship between hyperglycemia during pregnancy and adverse short-term fetal outcomes, mainly those associated with excessive fetal growth. The degree of hyperglycemia plays an ...
Priyadarshini Medha M Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation, we investigated whether serum SCFA levels during pregnancy are related to key metabolic parameters ...
Luan Hemi - - 2014
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the maternal plasma that are induced by pregnancy ...
Xu Jian J Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China ; Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang Province, - - 2014
Gestational diabetes mellitus (GDM) is an important complication of pregnancy that poses significant threats to women and their offspring. Telomere length shortens as cellular damage increases and is associated with metabolic diseases. Telomere length in fetal leucocytes was determined in 82 infants of women with GDM (N = 82) and 65 normal ...
Liu Laura X LX Cardiovascular Institute, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical - - 2014
Pregnancy causes dramatic physiological changes in the expectant mother. The placenta, mostly fetal in origin, invades maternal uterine tissue early in pregnancy and unleashes a barrage of hormones and other factors. This fetal "invasion" profoundly reprograms maternal physiology, affecting nearly every organ, including the heart and its metabolism. We briefly ...
Sinclair Marie M Liver Transplant Unit Victoria, Austin Health, Heidelberg, Victoria, - - 2014
Abnormal liver function tests are common in pregnancy; however, liver failure is rare. Pregnancy is a catabolic state that can precipitate illness in patients with underlying metabolic disorders. A 19-year-old woman presented at 14 weeks of gestation with an alanine transaminase of 2,252 international units/L (less than 30), an international ...
Zhang Chun-Mei - - 2014
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder frequently accompanied by obesity and by insulin resistance, and patients with this syndrome suffer from infertility and poor pregnancy outcome. Disturbances in plasma amino acid (AA) metabolism have been implicated in women with PCOS. However, direct evidence on follicular AA metabolic ...
Ferrecchia Iris A IA University of Florida, Gainesville, Florida (Ms Ferrecchia); Bard College at Simon's Rock, Great Barrington, Massachusetts (Ms Guenette); UFHealth, Gainesville, Florida (Ms Potocik); and University of Florida College of Medicine, Gainesville (Dr - - 2014
Over the past 9 decades since glycogen storage disease (GSD) was described, an almost universally fatal disease has become one where women are living well into adulthood and choosing to bear children. This inborn error of metabolism associated with the creation and utilization of glycogen, when untreated, manifests with unrelenting ...
Jacquemyn Yves Y Department of Obstetrics, UZA, Edegem, - - 2014
A 27-year-old woman with vitamin B12 responsive form of methylmalonic acidaemia (MMA) was pregnant with her first child. Treatment was unaltered during pregnancy: a low-protein diet and supplements. Her pregnancy was uncomplicated. She had a spontaneous delivery of a healthy girl with no MMA. The postpartum period was uneventful. MMA ...
Plećas Draga - - 2014
Healthy diet in pregnancy should guarantee proper fetal growth and development, maintain (and promote) maternal health and enable lactation. Nutritional counseling and interventions need to be an integral part of antenatal care and continue during pregnancy in order to reduce the risk of maternal, fetal and neonatal complications, as well ...
Silva Vanessa Cavalcante da VC Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, São Paulo, Brasil; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, São Paulo, - - 2014
Epidemiological and experimental studies indicate that the altered fetal and neonatal environment influences physiological functions and may increase the risk of developing chronic diseases in adulthood. Because homocysteine (Hcy) metabolic imbalance is considered a risk factor for neurodegenerative diseases, we investigated whether maternal Vitamin B deficiency during early development alters ...
Gademan Maaike G J MG Department of Public Health, Academic Medical Center - University of Amsterdam, Amsterdam, The - - 2014
There is growing evidence that disturbances in maternal metabolism and, subsequently, intrauterine conditions affect foetal metabolism. Whether this has metabolic consequences in offspring later in life is not fully elucidated. We investigated whether maternal pre-pregnancy body mass index (pBMI) is associated with offspring's adiposity at age 5-6 years and whether ...
Pazos Patricia P Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Avenida de Barcelona s/n, 15782 Santiago de Compostela, Spain ; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), 15706 Santiago de Compostela, - - 2014
The placenta produces a number of signaling molecules including metabolic and reproductive hormones as well as several inflammatory mediators. Among them, Interleukin-6 (IL-6), a well-known immune and metabolic regulator, acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. IL-6 interacts with key hypothalamic neuropeptidergic systems ...
Omo-Aghoja L L Department of Obstetrics & Gynecology, Faculty of Clinical Medicine, Delta State University, Abraka, - - 2014
Very small changes in pH may significantly affect the function of various fetal organ systems, such as the central nervous system, and the cardiovascular system with associated fetal distress and poor Apgar score. Review of existing data on maternal-fetal acid-base balance in pregnancy highlight the factors that are associated with ...
Sinha Nupur N 0000-0001-8573-3809 Division of Pulmonary and Critical Care Medicine, Bronx Lebanon Hospital Center and Albert Einstein College of Medicine, Bronx, NY 10457, - - 2014
Pregnancy is a diabetogenic state characterized by relative insulin resistance, enhanced lipolysis, elevated free fatty acids and increased ketogenesis. In this setting, short period of starvation can precipitate ketoacidosis. This sequence of events is recognized as "accelerated starvation." Metabolic acidosis during pregnancy may have adverse impact on fetal neural development ...
Maitre Léa - - 2014
Preterm birth (PB) and fetal growth restriction (FGR) convey the highest risk of perinatal mortality and morbidity, as well as increasing the chance of developing chronic disease in later life. Identifying early in pregnancy the unfavourable maternal conditions that can predict poor birth outcomes could help their prevention and management. ...
Costa Aurelio A General Surgery Division, Ospedali Riuniti Valdichiana Senese Hospital, Montepulciano, 53040 Siena, - - 2014
Endometriosis causes rare complications in pregnancy, such as obstetrical bleeding, preterm birth, spontaneous haemoperitoneum, and intestinal perforation. The prevalence of spontaneous perforation due to intestinal endometriosis is unknown in pregnancy. A recent review of the literature indicated 15 bowel complications caused by endometriosis during pregnancy or at the immediate postpartum ...
Garcés María F MF Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, - - 2013
Pregnancy is characterized by several metabolic changes that promote fat gain and later onset of insulin resistance. Since BDNF decreases hyperglycemia and hyperphagia, we aimed to investigate the potential role of placental and circulating BDNF levels in these pregnancy-related metabolic changes in rats and humans. We identified the mRNA and ...
Corriveau Stéphanie - - 2013
The aim of the present experimental study was to assess the tocolytic effect of eicosanoids on myometrium from non-pregnant and pregnant rats with or without an induced inflammatory condition. Three hundred myometrial rings were obtained by median laparotomy from 50 Sprague-Dawley rats divided into three groups: (i) non-pregnant (n = 15); (ii) ...
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