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Huang Yifan Y Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P. R. - - 2014
Abstract Objective: To examine whether vitamin supplement before and during pregnancy alters the detrimental effect of maternal obesity on the offspring. Methods: Obese C57BL/6 female mice were randomly divided into 4 groups and fed with the control diet, vitamin D, folic acid or multivitamin supplement before and during pregnancy. Physiologic ...
Seo Heewon - - 2014
Prostaglandins (PGs) are important lipid mediators regulating various reproductive processes in many species. In pigs, the expression pattern of PGE2 and PGF2alpha metabolic enzymes and the regulatory mechanism controlling PGE2 and PGF2alpha levels in the uterus during pregnancy are not completely understood. This study determined endometrial expression of the genes ...
Malek Antoine A University Hospital Zurich, Department of Obstetrics, Research Division Frauenklinikstr. 10, 8091 Zurich, Switzerland. - - 2014
Metabolic diseases induced by metabolic syndrome (MS) have been increased during the past two decades. During healthy pregnancy maternal organs and placenta are challenged to adapt to the increasingly physiological changes. In addition to the increasingly proatherogenic MS, pregnant woman develops a high cardiac output, hypercoagulability, increased inflammatory activity and ...
Mierzyński Radzisław R Department of Obstetrics and Perinatology Medical University of Lublin Ul. Jaczewskiego 8 20-954 Lublin Poland. - - 2014
Pregnancy is an acquired hypercoagulable state related to the increase in procoagulants and to the impaired fibrinolysis. Pregnancy is associated with a 4-fold increase in the risk of venous thromboembolism (VTE) and this risk still increases to 14-fold during puerperium. An association between the metabolic syndrome and the risk of ...
Poniedziałek-Czajkowska Elżbieta - - 2014
This review presents available evidence for possible application of n-3 long chain polyunsaturated fatty acids (PUFAs) in pregnant obese women with metabolic syndrome (MS) and focuses on prophylaxis of pregnancy complications associated with MS such as gestational hypertension, preeclampsia and gestational diabetes. Dietary supplementation with n-3 PUFAs has increased in ...
Nathan Nisha - - 2014
Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive-age women. With very little risk associated with its use, metformin provides many important benefits to women with ...
Berti C C a Unit of Obstetrics & Gynecology and Center for Fetal Research Giorgio Pardi , University of Milan , - - 2014
Abstract Pregnancy is a complex period of human growth, development and imprinting. Nutrition and metabolism play a crucial role for the health and wellbeing of both mother and fetus, as well as for the long-term health of the offspring. Nevertheless, several biological and physiological mechanisms related to nutritive requirements together ...
Garcés María F MF Department of - - 2014
Context: Irisin is a recently discovered adipomyokine that regulates the differentiation and phenotype of adipose tissue. Objective: In this study, we investigated the levels of irisin over the three trimesters of gestation in healthy and preeclamptic women, and during the follicular and luteal phase of the menstrual cycle in a ...
Sachse Daniel D Department of Medical Biochemistry, University of Oslo , Oslo , - - 2014
Background. Modern metabolomic profiling has not yet been applied to human breastfeeding research. A common reason for breastfeeding cessation is perceived insufficient milk production. We investigated broad biochemical profiles in maternal urine collected during and after pregnancy to identify biomarkers related to reduced reported breastfeeding. Methods. Fasting urine was collected ...
Wessel Ann E AE Center for Nutrition, Boston Children's Hospital, Boston, - - 2014
Maple syrup urine disease (MSUD) is an inherited disorder of metabolism of the branched-chain amino acids leucine, isoleucine, and valine. Complications of acute elevation in plasma leucine include ketoacidosis and risk of cerebral edema, which can be fatal. Individuals with MSUD are at risk of metabolic crisis throughout life, especially ...
Ma Yue Y Faculty of Medicine - Endocrinology, Memorial University of Newfoundland, St. John's, NL, - - 2014
Fibroblast growth factor-23 (FGF23) controls serum phosphorus largely through actions on the kidneys to excrete phosphorus and reduce calcitriol. Although these actions are well established in adults and children, the role that FGF23 plays in regulating fetal phosphorus metabolism has not been previously studied. We used several mouse models to ...
Lowe W L WL Jr Center for Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, - - 2014
Maternal glucose metabolism during pregnancy differs from the non-gravid state to allow the mother to meet her own and the growing fetus's energy needs. New insights into the mechanisms underlying maternal metabolism during pregnancy are being gained through the use of new 'omics' technologies. This review focuses on the application ...
Scholtz Elizabeth L EL Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA - - 2014
One of the most widely accepted axioms of mammalian reproductive biology is that pregnancy requires the (sole) support of progesterone, acting in large measure through nuclear progesterone receptors (PRs) in uterine and cervical tissues, without which pregnancy cannot be established or maintained. However, mares lack detectable progesterone in the latter ...
Melzer Katarina K Swiss Federal Institute of Sport Magglingen, - - 2014
Food intake increases to a varying extent during pregnancy to provide extra energy for the growing fetus. Measuring the respiratory quotient (RQ) during the course of pregnancy (by quantifying O2 consumption and CO2 production with indirect calorimetry) could be potentially useful since it gives an insight into the evolution of ...
Li Jie J Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of - - 2014
Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with increased risk of metabolic diseases in adulthood. We hypothesized preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with ...
Hiersch Liran L Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, - - 2014
To address the recent evidence regarding the association between hyperglycemia during pregnancy and adverse short-term and long-term outcome for both mothers and offspring. Recent data suggest a relationship between hyperglycemia during pregnancy and adverse short-term fetal outcomes, mainly those associated with excessive fetal growth. The degree of hyperglycemia plays an ...
Priyadarshini Medha M Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, - - 2014
During the course of pregnancy, dynamic remodeling of the gut microbiota occurs and contributes to maternal metabolic changes through an undefined mechanism. Because short chain fatty acids (SCFAs) are a major product of gut microbiome fermentation, we investigated whether serum SCFA levels during pregnancy are related to key metabolic parameters ...
Luan Hemi - - 2014
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the maternal plasma that are induced by pregnancy ...
Xu Jian J Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China ; Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou, Zhejiang Province, - - 2014
Gestational diabetes mellitus (GDM) is an important complication of pregnancy that poses significant threats to women and their offspring. Telomere length shortens as cellular damage increases and is associated with metabolic diseases. Telomere length in fetal leucocytes was determined in 82 infants of women with GDM (N = 82) and 65 normal ...
Liu Laura X LX Cardiovascular Institute, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical - - 2014
Pregnancy causes dramatic physiological changes in the expectant mother. The placenta, mostly fetal in origin, invades maternal uterine tissue early in pregnancy and unleashes a barrage of hormones and other factors. This fetal "invasion" profoundly reprograms maternal physiology, affecting nearly every organ, including the heart and its metabolism. We briefly ...
Sinclair Marie M Liver Transplant Unit Victoria, Austin Health, Heidelberg, Victoria, - - 2014
Abnormal liver function tests are common in pregnancy; however, liver failure is rare. Pregnancy is a catabolic state that can precipitate illness in patients with underlying metabolic disorders. A 19-year-old woman presented at 14 weeks of gestation with an alanine transaminase of 2,252 international units/L (less than 30), an international ...
Zhang Chun-Mei - - 2014
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder frequently accompanied by obesity and by insulin resistance, and patients with this syndrome suffer from infertility and poor pregnancy outcome. Disturbances in plasma amino acid (AA) metabolism have been implicated in women with PCOS. However, direct evidence on follicular AA metabolic ...
Ferrecchia Iris A IA University of Florida, Gainesville, Florida (Ms Ferrecchia); Bard College at Simon's Rock, Great Barrington, Massachusetts (Ms Guenette); UFHealth, Gainesville, Florida (Ms Potocik); and University of Florida College of Medicine, Gainesville (Dr - - 2014
Over the past 9 decades since glycogen storage disease (GSD) was described, an almost universally fatal disease has become one where women are living well into adulthood and choosing to bear children. This inborn error of metabolism associated with the creation and utilization of glycogen, when untreated, manifests with unrelenting ...
Jacquemyn Yves Y Department of Obstetrics, UZA, Edegem, - - 2014
A 27-year-old woman with vitamin B12 responsive form of methylmalonic acidaemia (MMA) was pregnant with her first child. Treatment was unaltered during pregnancy: a low-protein diet and supplements. Her pregnancy was uncomplicated. She had a spontaneous delivery of a healthy girl with no MMA. The postpartum period was uneventful. MMA ...
Plećas Draga - - 2014
Healthy diet in pregnancy should guarantee proper fetal growth and development, maintain (and promote) maternal health and enable lactation. Nutritional counseling and interventions need to be an integral part of antenatal care and continue during pregnancy in order to reduce the risk of maternal, fetal and neonatal complications, as well ...
Silva Vanessa Cavalcante da VC Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, São Paulo, Brasil; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, São Paulo, - - 2014
Epidemiological and experimental studies indicate that the altered fetal and neonatal environment influences physiological functions and may increase the risk of developing chronic diseases in adulthood. Because homocysteine (Hcy) metabolic imbalance is considered a risk factor for neurodegenerative diseases, we investigated whether maternal Vitamin B deficiency during early development alters ...
Omo-Aghoja L L Department of Obstetrics & Gynecology, Faculty of Clinical Medicine, Delta State University, Abraka, - - 2014
Very small changes in pH may significantly affect the function of various fetal organ systems, such as the central nervous system, and the cardiovascular system with associated fetal distress and poor Apgar score. Review of existing data on maternal-fetal acid-base balance in pregnancy highlight the factors that are associated with ...
Gademan Maaike G J MG Department of Public Health, Academic Medical Center - University of Amsterdam, Amsterdam, The - - 2014
There is growing evidence that disturbances in maternal metabolism and, subsequently, intrauterine conditions affect foetal metabolism. Whether this has metabolic consequences in offspring later in life is not fully elucidated. We investigated whether maternal pre-pregnancy body mass index (pBMI) is associated with offspring's adiposity at age 5-6 years and whether ...
Pazos Patricia P Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Avenida de Barcelona s/n, 15782 Santiago de Compostela, Spain ; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), 15706 Santiago de Compostela, - - 2014
The placenta produces a number of signaling molecules including metabolic and reproductive hormones as well as several inflammatory mediators. Among them, Interleukin-6 (IL-6), a well-known immune and metabolic regulator, acts peripherally modulating metabolic function and centrally increasing energy expenditure and reducing body fat. IL-6 interacts with key hypothalamic neuropeptidergic systems ...
Garcés María F MF Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, - - 2013
Pregnancy is characterized by several metabolic changes that promote fat gain and later onset of insulin resistance. Since BDNF decreases hyperglycemia and hyperphagia, we aimed to investigate the potential role of placental and circulating BDNF levels in these pregnancy-related metabolic changes in rats and humans. We identified the mRNA and ...
Corriveau Stéphanie - - 2013
The aim of the present experimental study was to assess the tocolytic effect of eicosanoids on myometrium from non-pregnant and pregnant rats with or without an induced inflammatory condition. Three hundred myometrial rings were obtained by median laparotomy from 50 Sprague-Dawley rats divided into three groups: (i) non-pregnant (n = 15); (ii) ...
Goyal Ravi - - 2013
Objective: Vitamin D deficiency has been associated with pregnancy complications, such as preeclampsia, gestational diabetes, and recurrent miscarriage. Therefore, we hypothesized differences in vitamin D status between healthy (Sprague-Dawley (SD), and Lewis (LW)) and complicated (Brown Norway (BN)) rat pregnancies. Approach and Results: In SD, LW and BN rats, we ...
Keimpema Erik - - 2013
It is increasingly recognized that maternal exposure to metabolic (nutritional) stimuli, infections, illicit or prescription drugs and environmental stressors during pregnancy can predispose affected offspring to developing devastating postnatal illnesses. If detrimental maternal stimuli coincide with critical periods of tissue production and organogenesis then they can permanently derail key cellular ...
Zielinsky Paulo P are from the Fetal Cardiology Unit, Institute of Cardiology, Porto Alegre, - - 2013
Fetal circulation has characteristic features, being morphologically and functionally different from extrauterine circulation. The ductus arteriosus plays a fundamental role in directing the blood flow to fetal inferior body parts. Basically, the ductus arteriosus directs 80-85% of the right ventricular output arising from the superior vena cava, coronary sinus, and ...
Arias-Álvarez M - - 2013
Disturbing maternal metabolism during the first pregnancy and postpartum period is associated with sub fertility in rabbit does. Nutritional strategies can be used during those periods and its effects to improve reproductive management may affect periconceptional events and early embryo development. Our goal was to elucidate if treatment with a ...
Jost Ted - - 2013
Scarce research has been performed to assess whether the human maternal gut microbiota undergoes changes during the perinatal period. Therefore, in the present study, gut microbiota composition of seven healthy mothers(to-be) was assessed at different time points during the perinatal period (i.e. weeks 3-7 prepartum and days 3-6, 9-14, and ...
Gomes Patricia R - - 2013
Excess of glucocorticoids (GCs) during pregnancy is strongly associated with the programming of glucose intolerance in the offspring. However, the impact of high GCs levels on maternal metabolism is not clearly documented. This study aimed to test the hypothesis that mothers exposed to elevated levels of GCs might also display ...
Helldén Anders - - 2013
It is well-known that profound physiological and biochemical changes occur throughout the course of pregnancy. At the same time, the role of pharmacogenomics in modulating the metabolism and response profile to numerous medications has been elucidated. Yet, the clinical impact of pharmacogenomics during pregnancy is less well understood. We present ...
Danielsen Inge - - 2013
Objective: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during 3rd trimester of pregnancy and markers of MS in adult offspring. Design and Methods: High sensitive C-reactive ...
Gelmann Elyssa R - - 2013
Inorganic arsenic (iAs) exposure is detrimental to birth outcome. We lack information regarding the potential for iAs metabolism to affect fetal growth. Our pilot study evaluated postpartum Romanian women with known birth weight outcome for differences in iAs metabolism. Subjects were chronically exposed to low-to-moderate drinking water iAs. We analyzed ...
Yan Jian - - 2013
Although biomarkers of choline metabolism are altered by pregnancy, little is known about the influence of human pregnancy on the dynamics of choline-related metabolic processes. This study used stable isotope methodology to examine the effects of pregnancy on choline partitioning and the metabolic activity of choline-related pathways. Healthy third-trimester pregnant ...
Tan Eng Kien - - 2013
Pregnant women undergo profound anatomical and physiological changes so that they can cope with the increased physical and metabolic demands of their pregnancies. The cardiovascular, respiratory, haematological, renal, gastrointestinal and endocrine systems all undergo important physiological alterations and adaptations needed to allow development of the fetus and to allow the ...
Sarantopoulou Vasiliki - - 2013
Abstract Objective: The aim of the study was to evaluate the significance of the presence of thyroid peroxidase autoantibodies (anti-TPO Abs) in type 1 diabetes mellitus (DM1) pregnant women relative to the course of pregnancy and, especially, with regard to metabolic control, thyroid function, maternal complications and neonatal outcome. Methods: ...
Bullon Pedro - - 2013
Background: Gestational diabetes mellitus and Metabolic Syndrome has been related to periodontitis. Our objective was to establish the relationship between them in pregnant women affected by Gestational Glucose Metabolism Disorder. Materials and Methods: In 188 positive O´Sullivan test pregnant women, an oral glucose tolerance test was performed to diagnose Gestational-Diabetes-Mellitus. ...
Scolari Childress Katherine M - - 2013
Pica is a commonly underappreciated disorder in pregnancy that can lead to several complications, including severe metabolic derangements and other adverse outcomes. We report a case of baking soda pica in pregnancy associated with both rhabdomyolysis and cardiomyopathy. A multigravid woman at 37 weeks of gestation presented with weakness and ...
Senyavina N V - - 2013
Metabolome analysis of the serum from pregnant patients aimed at detection of low-molecular-weight biomarkers of gestation process disorders indicated a relationship between the metabolic profile of maternal serum and risk of gestosis. In women with pre-eclampsia or preterm delivery, analysis of serum purine metabolites revealed changes in the metabolite concentrations, ...
Vanhees Kimberly - - 2013
The research field of fetal programming has developed tremendously over the years and increasing knowledge suggests that both maternal and paternal unbalanced diet can have long-lasting effects on the health of offspring. Studies implicate that macronutrients play an important role in fetal programming, although the importance of micronutrients is also ...
Gao Xiaolin - - 2013
Sphingosine 1-phosphate (S1P), a product of sphingomyelin metabolism, is generated via phosphorylation of sphingosine by sphingosine kinases (SphK). It acts via a family of G protein-coupled receptors or as an intracellular second messenger for agonists acting through the S1P receptors (S1P1-5). In our study, the expression of SphK1 and S1P1 ...
Palliser Hannah K - - 2013
Intrauterine growth restriction (IUGR) is a risk factor for preterm labor; however, the mechanisms of the relationship remain unknown. Prostaglandin (PG), key stimulants of labor, availability is regulated by the synthetic enzymes, prostaglandin endoperoxidases 1 and 2 (PTGS1 and 2), and the metabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (HPGD). We hypothesized that ...
Zhou Qunyan - - 2013
Preadipocyte factor-1(Pref-1), an inhibitor of adipocyte differentiation, is increased in fetal blood of small for gestational age (SGA) and is considered a factor involved in determining adiposity and associated with high risk of metabolic diseases in adulthood. Preeclampsia is a condition closely associated with SGA, however, the alteration of Pref-1 ...
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