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Kazerouni N Neely - - 2010
To evaluate the extent of fetal structural abnormalities, other than neural tube and abdominal wall defects (AWDs), identified by California's Prenatal Screening Program. The Quad Marker Prenatal Screening records of 516,172 women were examined for screening interpretation and the diagnosis of structural abnormalities detected via follow-up. Women who were screen-positive ...
Gifford Anne E - - 2010
The objective of this report is to estimate the benefits of universal meconium screening for maternal drinking during pregnancy. Fetal alcohol spectrum disorder (FASD), including its most severe manifestation fetal alcohol syndrome (FAS), is preventable and remains a public health tragedy. The incidences of FAS and FASD have been conservatively ...
Pergament Eugene - - 2010
As first trimester screening has assumed an increasingly dominant role in the obstetric care of prospective parents, the need for genetic counseling has also increased. There are several challenges related to first trimester screening; foremost among them is the need to distinguish between screening and diagnosis. Additional challenges include the ...
Evans Mark I - - 2010
The same principles for diagnosis and screening in singleton pregnancies apply to multiples. However, there can be significant differences in the safety and efficacy of all approaches with multiple gestations. This article deals with specific aspects of screening in multiple pregnancies.
Craig Wendy Y - - 2010
Estimate steroid sulfatase deficiency (STSD) prevalence among California's racial/ethnic groups using data from a previous study focused on prenatal detection of Smith-Lemli-Opitz syndrome (SLOS). SLOS and STSD both have low maternal serum unconjugated estriol (uE3) levels. Prevalence was estimated using three steps: listing clinically identified cases; modeling STSD frequency at ...
Sonek J - - 2010
The first trimester (11-13 +6 weeks) ultrasound examination is useful for several reasons: determination of an accurate date of confinement, diagnostic purposes, and screening for fetal defects. Nuchal translucency measurement combined with maternal serum markers (free b-human chorionic gonadotropin and pregnancy-associated plasma protein A) is the mainstay of first-trimester screening ...
Tuuli Methodius G - - 2010
Preeclampsia and intrauterine growth restriction are major contributors to perinatal mortality and morbidity. Accurate prediction is important for identifying those women who require more intensive monitoring, permitting earlier recognition and intervention, and allowing targeting of potential preventive measures to those at risk. Although different measures of placental dysfunction have been ...
Shamshirsaz Alireza A - - 2010
Considerable advances have been made in identifying women whose pregnancies are at the greatest risk for fetal Down syndrome and other aneuploidies. Maternal serum tests and ultrasonography in either the first or second trimester provide effective prenatal screening. However, the most efficacious protocols are based on the combination of first- ...
Goetzl Laura - - 2010
Women with abnormal results of first trimester screening but with a normal karyotype are at risk for adverse pregnancy outcomes. A nuchal translucency of greater than 3.5 mm is associated with an increased risk of subsequent pregnancy loss, fetal infection, fetal heart abnormalities, and other structural abnormalities. Abnormal levels of ...
Matilainen Maarit - - 2011
The maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) were reduced in hormonally stimulated pregnancies in the in vitro fertilization and intracytoplasmic sperm injection groups (N=176; PAPP-A: 0.82) and in the entire assisted reproduction group (N=282; PAPP-A: 0.83) as compared with controls (N=24,783; PAPP-A: 0.94). However, the false-positive rate of ...
O'Reilly Rebecca - - 2010
Domestic violence (DV) against women during pregnancy affects many women and unborn infants worldwide. Pregnancy presents a window of opportunity for health care providers to identify DV and provide appropriate intervention. The aim of this systematic review was to appraise the effectiveness of DV screening and interventions for women identified ...
Waugh Norman - - 2010
Policy decisions on whether to implement screening programmes depend on whether the proposed programmes meet a set of criteria laid down by the World Health Organization. Screening for hyperglycaemia in pregnancy (HGP) does not meet all the criteria. However the case for screening has been strengthened by a number of ...
Stefansdottir Vigdis - - 2010
OBJECTIVES: To assess pregnant women's knowledge and understanding of first trimester prenatal screening (nuchal translucency, maternal serum free beta-human chorionic gonadotrophin and pregnancy-associated plasma-protein-A), to evaluate the impact of a new information booklet and investigate the effects of education and experiential knowledge of congenital disabilities on the perceived likelihood of ...
Hourrier Sophie - - 2010
In the past two decades second-trimester maternal serum screening for Down syndrome has been the most common strategy for prenatal diagnosis of chromosomal aneuploidies. More recently, screening for and diagnosis of chromosomal abnormalities have increasingly been performed in the first trimester. With improvements and technological advances in ultrasound, it is ...
Cipriano L E - - 2010
OBJECTIVES: To estimate the cost-effectiveness of targeted and universal screening for vasa praevia at 18-20 weeks of gestation in singleton and twin pregnancies. DESIGN: Cost-utility analysis based on a decision-analytic model comparing relevant strategies and life-long outcomes for mother and infant(s). SETTING: Ontario, Canada. POPULATION: A cohort of pregnant women ...
Chasen Stephen T - - 2010
First-trimester aneuploidy screening is associated with very high detection rates for Down syndrome and other chromosomal abnormalities. The clinical implications of early screening relate to prenatal diagnosis of chromosomal abnormalities and important information obtained at screening. Early screening can change the rate of invasive prenatal diagnosis and the gestational age ...
Nhan-Chang Chia-Ling - - 2010
Tuberculosis is known as the great masquerader and the manifestation of the disease can be vague and widespread. Worldwide, TB kills more women each year than any other infection and the greatest burden of disease occurs in those in the reproductive age. Screening strategies in pregnancy provides a unique opportunity ...
Wang Min - - 2010
OBJECTIVE: To estimate the use of maternal serum ADAM12 as a second-trimester Down syndrome serum marker. METHODS: Samples from a total of 46 Down syndrome pregnancies and 184 unaffected singleton pregnancies matched for gestational age and maternal weight were retrieved from storage and measured for ADAM12; 35 false-positive pregnancies were ...
van Heesch Peter N - - 2010
OBJECTIVE: To establish how different methods of estimating gestational age (GA) affect reliability of first-trimester screening for Down syndrome. METHODS: Retrospective single-center study of 100 women with a viable singleton pregnancy, who had first-trimester screening. We calculated multiples of the median (MoM) for maternal-serum free beta human chorionic gonadotropin (free ...
Huang Tianhua - - 2010
OBJECTIVE: To investigate the associations between four defined adverse pregnancy outcomes and levels of first and second trimester maternal serum markers focusing in particular on how well combinations of markers predict these adverse outcomes. METHODS: This was a retrospective review of associations between first and second trimester serum markers and ...
Zhong Yan - - 2010
Preeclampsia and intrauterine growth restriction (IUGR) are major contributors to perinatal mortality and morbidity worldwide. Both are characterized by impaired trophoblastic invasion of the maternal spiral arteries and their conversion from narrow muscular vessels to wide non-muscular channels. Despite improvement in the understanding of the pathophysiology of these conditions, ability ...
Lumbiganon Pisake - - 2010
PURPOSE OF REVIEW: Asymptomatic bacteriuria (ASB) in pregnancy, if left undiagnosed and appropriately treated can lead to acute pyelonephritis in mothers and low birth weight in infants. Urine culture is the gold standard for diagnosing ASB. Unfortunately, urine culture is limitedly available. The present review aims at evaluating performance of ...
Poon Leona C Y - - 2010
OBJECTIVE: To explore if the addition of pregnancy-associated plasma protein-A (PAPP-A) to maternal factors and biophysical markers yields a significant improvement in the detection of hypertensive disorders before the clinical onset of disease. METHODS: Prospective screening study for early preeclampsia (PE), late PE and gestational hypertension (GH) in women attending ...
Olivarez Sofia A - - 2010
OBJECTIVE: Obstructive sleep apnea (OSA) involves episodic nocturnal apneas. Using polysomnography, we examined the predictive capacity of screening questionnaires (Berlin) in pregnancy. Incorporating simultaneous fetal heart rate monitoring (FHM), we examined the association of maternal apnea with FHM abnormalities. STUDY DESIGN: We enrolled 100 pregnant women at 26-39 weeks of ...
- - 2010
Depression is very common during pregnancy and the postpartum period. At this time, there is insufficient evidence to support a firm recommendation for universal antepartum or postpartum screening. There are also insufficient data to recommend how often screening should be done. There are multiple depression screening tools available for use.
Christiansen Michael - - 2010
BACKGROUND: ADAM12 has been shown to be an efficient maternal serum marker for Down syndrome (DS) in the first trimester; but recent studies, using a second generation assay, have not confirmed these findings. We examined the efficiency of a second generation assay for ADAM12. MATERIALS AND METHODS: ADAM12 concentrations were ...
Hedley Paula L - - 2010
BACKGROUND: Prophylaxis with low-dose aspirin may reduce the risk of pre-eclampsia (PE) if introduced in first trimester. The performance of first trimester maternal serum screening for PE using free leptin index (fLI) and PAPP-A, where fLI = leptin/leptin soluble receptor was studied. METHODS: First trimester serum samples from 126 PE ...
Bestwick J P - - 2010
To determine whether the standard deviation of nuchal translucency (NT) measurements has decreased over time and if so to revise the estimate and assess the effect of revising the estimate of the standard deviation on the performance of antenatal screening for Down's syndrome. Data from a routine antenatal screening programme ...
Sharland G - - 2010
Congenital heart disease (CHD) is a common form of congenital malformation associated with significant morbidity and mortality. Antenatal diagnosis of life-threatening forms of CHD may help to improve survival and morbidity as well as allowing parental choice and preparation. The diagnosis of CHD during fetal life can be made with ...
Bawa Monika - - 2010
We report two cases of malrotation with extremely different outcomes based on the availability and non-availability of antenatal scanning. The first one had a single third trimester ultrasound which detected malrotation and helped in saving baby's life whereas the second baby without antenatal screening succumbed to midgut volvulus and its ...
Wang Ning - - 2010
Aneuploidy in pregnancy is known to increase with advanced maternal age (AMA) and associate with repeated implantation failure (RIF), and repeated miscarriage (RM). Preimplantation genetic screening (PGS) has been introduced into clinical practice, screening, and eliminating aneuploidy embryos, which can improve the chance of conceptions for infertility cases with poor ...
Xie Zhenwei - - 2010
OBJECTIVES: To explore the efficacy of contingent triple-screening for Down syndrome (DS), that is, performing triple-screening in pregnant women with DS risks between 1/270 and 1/1000 at routine double-screening, in a Mainland Chinese population. METHODS: Maternal serum concentrations of alpha fetoprotein (AFP), free-beta human chorionic gonadotropin (free beta-hCG), and unconjugated ...
Negrato Carlos Antonio - - 2010
There is an urgent need to find consensus on screening, diagnosing and treating all degrees of dysglycemia that may occur during pregnancies in Brazil, considering that many cases of dysglycemia in pregnant women are currently not diagnosed, leading to maternal and fetal complications. For this reason the Brazilian Diabetes Society ...
Shanks Anthony - - 2010
The definitive diagnosis of fetal chromosomal abnormalities is only accomplished through tests that sample fetal tissue. These procedures--amniocentesis, chorionic villus sampling and cordocentesis--are invasive and carry with them the risks of bleeding, rupture of membranes, and even pregnancy loss. Current recommendations from the American College of Obstetricians and Gynecologists state ...
Christiansen Michael - - 2009
BACKGROUND: Placental growth hormone (PGH) is synthesised by the placenta, and its function is modulated by growth hormone binding protein (GHBP). The potential of PGH and GHBP as maternal serum screening markers for Down syndrome (DS) was examined. MATERIALS AND METHODS: Maternal serum concentrations of PGH and GHBP were determined ...
Bunevicius Adomas - - 2009
This study aimed to evaluate how precise the Edinburgh Depression Scale (EDS) is in screening for major depressive disorder (MDD) during different periods of pregnancy. A random sample of 230 pregnant women was interviewed in the first, second, and third trimesters of pregnancy using the EDS and not-patient version of ...
Pihl Kasper - - 2009
OBJECTIVE: To establish the first trimester levels of pregnancy-specific beta-1-glycoprotein (SP1) in pregnancies with adverse outcome. Furthermore, to determine the screening performance for adverse outcome using SP1 alone and in combination with other first trimester markers including proMBP and PAPP-A. METHODS: A case-control study was conducted in a primary hospital ...
Ranta Jenni K - - 2010
BACKGROUND: Time-to-pregnancy (TTP) is a clinical tool used to measure uterine receptivity and a couples' fertility in spontaneously conceived pregnancies. The objective of this study was to examine the effects of TTP on first trimester Down's syndrome (DS) markers in spontaneous, chromosomally normal pregnancies and to compare the results to ...
Pihl Kasper - - 2009
OBJECTIVE: To establish the first trimester serum levels of the proform of eosinophil major basic protein (proMBP) in pregnancies with adverse outcome. Furthermore, to determine the screening performance using proMBP alone and in combination with other first trimester markers. METHODS: A case-control study was conducted in a primary hospital setting. ...
Bunn Mikiko Yazawa - - 2009
PURPOSE: Domestic violence is an important health concern that has been shown to have adverse effects on maternal and neonatal outcomes. The objectives of this study were to compare the prevalence of prenatal screening for domestic violence in a hospital-based resident clinic setting with screening practices in private obstetric offices ...
Driscoll Deborah A - - 2009
Maternal serum screening for neural tube defects and fetal aneuploidy in the second trimester has been incorporated into obstetrical practice over the past two decades. Now, as a result of several multicenter trials, first trimester screening between 11 and 14 weeks has been shown to be an effective and reliable ...
Peacock Ann S - - 2010
The cause of hypertension in pregnancy remains unknown and results in increased risk of complications for mother and baby. Symptoms of developing pre-eclampsia, such as an elevated blood pressure, can be vague and singular. The purpose of this literature review is to evaluate research investigating antenatal screening practices for hypertension ...
Massie John - - 2009
BACKGROUND: Cystic fibrosis (CF) is the most common inherited, life-shortening condition affecting Australian children. The carrier frequency is one per 25 and most babies with CF are born to parents with no family history. Carrier testing is possible before a couple has an affected infant. AIMS: To report the outcomes ...
Wu Qingqing - - 2009
OBJECTIVES: The purpose of this study was to evaluate the diagnostic accuracy of prenatal screening for congenital heart disease (CHD) based on a combination of the 4-chamber view and 3-vessel view in an unselected population. METHODS: A prospective study on 8025 scanned fetuses was performed. All singleton pregnancies scheduled for ...
Knutsen-Larson Siri - - 2009
The first-trimester screen combines nuchal translucency measurement and serum levels ot PAPP-A and beta-hCG between 11 and 13 weeks gestational age which can be used to calculate the risk of fetal Trisomy 21 and 18. Although these trisomies are the most common conditions detected, recognition of increased risk for several ...
Koster M P H - - 2009
OBJECTIVES: To identify new discriminative biomarkers for Down syndrome (DS) pregnancies using a bead-based multiplexed immunoassay, and to use the newly identified biomarkers to construct a prediction model for non-invasive DS screening. METHODS: Maternal serum samples of 14 DS pregnancies and 15 matched controls were analyzed with a bead-based multiplexed ...
Oztekin Ozg?r - - 2009
PURPOSE: The aim of the study was to determine the detection rate of structural abnormalities at the 11-14 week ultrasound examination as a part of two-stage screening process in low-risk pregnancies. MATERIALS AND METHODS: A total of 1085 consecutive low-risk pregnant women participated in screening by two-stage ultrasonography for the ...
Poon L C Y - - 2009
OBJECTIVES: To examine the performance of screening for hypertensive disorders in pregnancy by a combination of the maternal factor-derived a-priori risk with the uterine artery (UtA) pulsatility index (PI) and to determine whether it is best in such screening to use the mean PI of the two arteries, the highest ...
Giordano Piero C - - 2009
OBJECTIVES: This review emphasizes the need for adapted prevention strategies in areas where severe hemoglobin disorders are endemic and in non-endemic countries where large immigrant groups are living. DESIGN AND METHODS: Screening versus carrier diagnostics upon medical versus ethnic indication, ethical issues associated with carrier screening, information to multiethnic carriers ...
Paolini Cynthia I - - 2009
OBJECTIVE: To analyze the different variables that affect couples' decision-making about prenatal screening of chromosome abnormalities in a population with limited access to prenatal diagnosis and no legal termination of pregnancy (TOP). METHODS: From February through August 2004, 79 couples who requested for prenatal screening at centers from Argentina and ...
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