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Gerhard I - - 1986
In an unselected obstetric population of 869 women serial determinations of estriol in serum and urine were performed from the 28th week of pregnancy until delivery. Clinical management was based on ultrasound and nonstress/contraction stress tests only. Data on the development of the infants were available after 1 year in ...
Burton B K - - 1986
Maternal serum alpha-fetoprotein screening will soon be a routine component of prenatal care. The benefits of MSAFP screening have far exceeded early expectations. This technology not only provides an efficient and cost effective method of screening for fetal neural tube defects that is applicable to all pregnancies but also provides ...
Tommerup N - - 1986
The expression of the fragile X in 9 pregnant women (4 obligate carriers and 5 carriers at risk) was not significantly different from the expression observed either before or after pregnancy in the same individuals. Hence, carrier diagnosis during pregnancy seems to be as reliable as in non-pregnant women.
Niman H L - - 1985
Antisera to a number of synthetic peptides predicted from nucleic acid sequences of oncogenes have been used to screen 483 urine samples of cancer patients, pregnant women, and normal controls for the presence of immunologically related proteins. Increased levels of oncogene-related proteins are found during neoplasia and pregnancy. The differential ...
Jaffe R - - 1985
The diagnosis of appendicitis in pregnancy is complex because of altered maternal physiology and anatomy, and definitive therapy is often delayed. Ultrasonic screening is important in either diagnosing or excluding many pathologic conditions that complicate pregnancy and present a clinical picture similar to that of appendicitis. Reported here is a ...
Murday V - - 1985
The suggested strategies for a screening programme for Down's syndrome by maternal serum alpha fetoprotein concentration were examined and tested on the experience of the North East Thames Regional. Screening by maternal serum alpha fetoprotein concentration may be used to identify pregnancies at increased risk, but this is useful only ...
Burton B K - - 1985
The purpose of this study was to assess the psychological impact of maternal serum alpha-fetoprotein screening on pregnant women with normal results and their male partners. Assessments of anxiety (as measured by the state-trait anxiety inventory) and attitudes toward pregnancy (as measured by the maternal attitude to pregnancy instrument) were ...
Harper P S - - 1985
A deoxyribonucleic acid marker linked to the locus for Huntington's chorea exists, but its possible use in the prediction of this disorder depends on the pedigree structure of individual families. Analysis of data from a population register for Huntington's chorea in south Wales showed that only a minority of subjects ...
Hankins G D - - 1985
Routine screening for pregnancy ASB followed by adequate therapy and urine culture surveillance are important preventative measures which should be practiced by all obstetric physicians. The considerable maternal morbidity associated with the development of acute pyelonephritis more than justifies the effort and expense necessary to implement screening methods for the ...
Jovanovic L - - 1985
Because of the morbidity associated with undiagnosed gestational diabetes (GDM), screening programs are advocated in all pregnancy clinics. The purpose of this study was to elucidate the optimum time to test for diabetes during gestation, the indication for retesting, and the predictive value of a positive screening test for a ...
Mossman K L - - 1985
There are 4 options available to the referring physician in considering radiodiagnostic examinations of patients with uncertain pregnancy status. In the first option, the referring physician in consultation with the radiologist may elect to perform a complete or modified examination, based on a complete evaluation of the risks and benefits ...
Easmon C S - - 1985
Twenty-eight per cent of women investigated during pregnancy were carriers of group B streptococci (GBS). The use of broth enrichment was the most significant factor in determining GBS carriage rates. GBS carriage decreased during pregnancy. Transmission of GBS from mother to baby was related to vaginal carriage but rectal carriage ...
Nielsen P V - - 1985
An obstetric population was screened 'blind' by measuring unconjugated estriol (ucE3) and total estriol (tE3) in serum. The purpose was firstly to ascertain the predictive values of ucE3 for the prediction of low birth weight and distressed neonates (perinatal deaths included), and secondly to compare the predictive values of ucE3 ...
Davison J M - - 1984
Schoolgirls shown to have covert bacteriuria (CB) by a screening programme and followed up for 5 years to assess whether chemotherapy had any beneficial effect, underwent a further assessment of renal function at the age of 18 years and during subsequent pregnancies. At age 18, glomerular filtration rate (GFR) and ...
Bakketeig L S - - 1984
510 of 1009 pregnant women in the Trondheim area (Norway) were randomly selected for ultrasound examination at the 19th and 32nd weeks of pregnancy in addition to routine antenatal care. Among the screened women, twins were diagnosed earlier and there were slightly fewer post-term inductions (2.8% versus 4.0%) and fewer ...
Christie A D - - 1984
Since 1975, the primary method of antenatal diagnosis of structural defects has been by ultrasound visualisation. Improvements in equipment and operator experience have progressively increased the confidence and reliability of this technique which in 1982 provided a 100% detection rate. (Alternative methods are relatively costly and in our opinion, unsatisfactory). ...
Sturgess J M - - 1984
Normal infants from 32 to 54 weeks post-conceptional age show a clear pathway of development in the exocrine pancreas, involving differentiation of acinar tissue, reflected by increased acinar to connective tissue volumes. In contrast, an abnormal pattern of development has been found in cystic fibrosis. Early signs of a deficiency ...
Cario G M - - 1984
Eighty patients with prolonged pregnancy were managed conservatively using outpatient non-stress testing as the only form of fetal monitoring; there was no excess perinatal mortality or morbidity. The 'at risk' fetus appeared to be predominantly within the 'postmature' group who pass meconium. Non-stress testing using this rigid regimen was an ...
Geelhoed G W - - 1983
The surgical endocrinology of the pregnant patient is special with respect to the additional hazards of maternal and fetal loss under the stress of pregnancy, labor, and delivery. The added threat of drug, radiation, radioisotope, anesthetic, and surgical management requires extra precaution in diagnostic and therapeutic manipulation, and limitations are ...
Palmer J - - 1983
As more patients with cystic fibrosis reach adulthood, questions arise about the potential hazards of pregnancy. We reviewed the medical records of eight women with cystic fibrosis who had a total of 11 completed pregnancies and had been evaluated within 1 year before conception. In five women (Group 1), the ...
Verp M S - - 1983
After observing abnormal offspring following artificial insemination by donor, several authors recently have proposed intensive genetic screening of donors. The screening would be beyond that practiced by most infertility specialists. To determine the necessity for formal genetic investigation of donors, the authors analyzed the outcome of artificial insemination pregnancies in ...
Fay R A - - 1983
Massive feto-maternal haemorrhage is a cause of significant fetal morbidity and mortality, but is often overlooked because screening for fetal erythrocytes in the maternal circulation has not been a routine procedure in stillbirths, fetal distress or neonatal anaemia; there are few recognized clinical symptoms or signs, or histopathological features. This ...
Sadovnick A D - - 1983
Population screening for neural tube defects is possible by measuring maternal serum alphafetoprotein levels with appropriate follow-up as required. British Columbia has approximately 39 000 births annually and the incidence of neural tube defects is 1.55 per 1000 births (0.94 per 1000 livebirths). Results from a cost-benefit analysis suggest that ...
Aickin D R - - 1983
Urine and plasma oestriol, plasma progesterone, human placental lactogen, beta 1-glycoprotein and serum cystyl aminopeptidase were measured at intervals during 608 pregnancies. The predictive accuracy of low values for identification of pregnancies with low birthweight outcomes was assessed for each test at various gestations. Data were analysed to obtain 10th-90th ...
Coulombe J T - - 1983
We describe a prospective study of histidinaemia. Probands and siblings (n = 21) with typical histidinaemia in 16 families were ascertained by newborn screening; diagnosis was confirmed by appropriate investigations in each subject; none had been treated by low histidine diet. The median age of subjects with histidinaemia was 9.5 ...
Vest Nielsen P - - 1983
One thousand six hundred and sixty pregnancies were recorded in this investigation. In 1 042 women with singleton pregnancies and known term, measurements of the total serum estriol (E3) were made exclusively for the present study. The study was prospective, and the clinicians had no knowledge of the E3 values. ...
Ratnam A V - - 1982
Because of the high incidence of congenital syphilis at the University Teaching Hospital, Lusaka, Zambia, the potential risks of congenital infection and fetal loss due to syphilis were assessed by screening 202 antenatal patients, 340 pregnant women admitted to the hospital whose pregnancies ended in either spontaneous abortion or stillbirth, ...
Slomiany B L - - 1982
The submandibular saliva of patients with cystic fibrosis was found to contain about 66% more lipids/100 ml of saliva than that of normal individuals and exhibited elevated levels of neutral lipids, phospholipids, and glycolipids. No significant differences were noted in the proportions of individual neutral lipid and phospholipid components present ...
Smith R V - - 1982
The potential of selected microorganisms to O-dealkylate alkyl aryl ethers in a manner analogous to mammalian systems has been studied. A total of 45 fungi and actinomycetes were screened for their ability to O-demethylate 4-methoxybiphenyl. Of the 20 organisms found to actively metabolize this substrate, 5 were chosen for additional ...
Fairweather D V - - 1982
Screening programmes and techniques for antenatal diagnosis of a large number of congenital malformations and genetic disorders are now available. Most techniques requiring samples of fetal material for analysis carry some degree of risk to the pregnancy. These risks must be weighed against the degree of risk that a particular ...
De Salvia D - - 1982
Plain films of the abdomen taken during pregnancy at term from 1971 to 1981 at the Radiology Service of the Obstetric and Gynecological Clinic of the University of Padua are summarized and analysed. The average frequency of X-ray investigation is 0.5%, ranging from 0.06% (in 1980) to 2.11% (in 1977), ...
Collins E - - 1981
Salicylates have been the most widely studied of the nonnarcotic analgesics in pregnancy, and in the last 20 years evidence has accumulated indicating that their ingestion in pregnancy may have adverse effects on the mother and her child. Salicylates have been found to reduce the mean birth weight of the ...
Chapman M G - - 1981
A serum assay was performed on 605 women for pregnancy-specific beta 1-glycoprotein (SP-1) between 31 and 34 weeks' gestation. SP-1 was also estimated for 255 of these women between 15 and 20 weeks' gestation, coincidental with maternal serum alpha-fetoprotein (AFP) screening. A clinical classification of pregnancy outcome was constructed for ...
Dancygier H - - 1981
Current endoscopic measurements of gastrointestinal ulcer area using forceps or graduated probes are associated with a high degree of inaccuracy. Based on a computer-assisted, semiautomatic device for stereological analyses, we have developed a new method for the endoscopic determination of ulcer size. The basic elements are a graphical measuring tablet ...
Russell J G - - 1981
Ultrasonic screening to identify fetuses suffering from intrauterine placental insufficiency will diagnose this condition, but will also produce a large number of false positives. The fetal subcutaneous fat is visible on an antenatal radiograph and is severely reduced with fetal starvation. A method of quantifying the fetal fat is described ...
Corkey C W - - 1981
Pregnancy in patients with cystic fibrosis is likely to become a more common occurrence as a result of improving survival rates in females with this condition. Eleven pregnancies in seven patients with cystic fibrosis are presented. Despite previous reports on the hazards of pregnancy in women with cystic fibrosis, only ...
Ott W J - - 1981
Results of 686 nonstress tests with fetal monitoring were analyzed and compared to neonatal outcome. The use of an antepartum cardiotachometry screening (ACS) protocol seems to have reduced the perinatal mortality and morbidity in a high-risk group of patients to that of a low-risk group who did not undergo ACS.
Lewin E B - - 1981
Seven hundred twenty-two pregnancies were studied in a private-practice setting to determine the natural history of colonization by group B streptococcus (GBS) over time. The colonization rate remained constant at 7% to 8% in each trimester, with 19% of the women colonized at some time during pregnancy. The organism was ...
Zlotogora J - - 1980
A very high incidence of late infantile metachromatic leukodystrophy (MLD) (1/75 live births) was found in the Jewish Habbanite community which constitutes a genetic isolate of about 1,000-1,200 individuals. Screening in this population for aryl sulfatase A (ASA) levels in married adults revealed a carrier frequency for MLD of 17% ...
Scott T M - - 1980
During a screening programme of 10000 pregnant women by the Guthrie test, a previously unrecognised phenylketonuric woman was detected. A low phenylalanine diet introduced from the 16th week of gestation failed to prevent fetal abnormality and mental retardation. Maternal phenylketonuria requires earlier diagnosis than can be achieved at the initial ...
Morrison I - - 1980
To determine the role of hPL radioimmunoassays in screening for fetal assessment in normal and hypertensive pregnancies the results of 148 pregnancies were examined by measuring the specificity and sensitivity of the test for prospectively defined fetal conditions. Values of hPL were considered abnormal if they were below the tenth ...
Heinecke H - - 1980
Experiences with the three step teratological screening test for selection of teratogenic side effects are described. Step I: The prenatal examination of the foetuses may give indications of embryotoxicity, growth retardation and teratogenicity. Step II: The peri- and postnatal examination includes the duration of pregnancy, the delivery, the viability, the ...
Neri A - - 1980
A case of a cystic fibrosis patient with two pregnancies that ended in deliveries at 30 and 29 weeks' gestation, respectively, is presented. The author suggests that the increased life expectancy of cystic fibrosis patients because of therapeutic advances will increase the need to examine the association and effects of ...
Brennan R E - - 1979
A booklet, "Assessment of Maternal Nutrition," has been published by the American College of Obstetricians and Gynecologists in cooperation with The American Dietetic Association as a useful guide for physicians, nurses, dietitians, and nutritionists. Nutritional risks during pregnancy are clearly outlined. Clinical, dietary, and biochemical factors, as well as medical, ...
Alger L S - - 1979
A thalassemia screening program was implemented at our institution using the finding of a mean corpuscular volume less than 80 fl as the index of abnormality. Further evaluation using hemoglobin (Hb) electrophoresis and serum iron studies was carried out according to the scheme detailed below. A diagnosis of thalassemia was ...
Wald N J - - 1979
Between May 1975 and the end of 1977, 6443 antenatal patients were screened mainly between 16 and 22 weeks of pregnancy for neural tube defects (NTDs) at the John Radcliffe Hospital, Oxford, by maternal serum alpha-fetoprotein (AFP) measurement; a take-up of 72 per cent. Seventeen out of 18 (94 per ...
Smith M B - - 1978
Cord blood from 6578 neonates of Mediterranean origin born at The Royal Women's Hospital, Melbourne, over a five-year period was screened for alpha-thalassaemia by haemoglobin electrophoresis for haemoglobin Bart's (Hb Bart's), and 47 cases of the abnormal haemoglobin were detected (an over-all incidence of 0.71%). Hb Bart's was detected in ...
Hedges J R - - 1978
The use of the direct pharyngeal Gram stain for diagnosis of group A beta-hemolytic streptococcal pharyngitis was evaluated. Seventy-five consecutive out-patients presented with pharyngitis (or high fever in infants) were studied with pharyngeal cultures and Gram stains. Gram stains were read as either positive, negative, or indeterminate for streptococcal pharyngitis. ...
Jirkovsky I - - 1977
A series of novel 1,3,4,9-tetrahydro-1-methyl-thiopyrano-[3,4-b]indole-1-ethanamines has been synthesized and examined for effects on reserpine-induced ptosis and reserpine-induced hypothermia in mice. One member of the series, the 9-ethyl-N,N-dimethyl derivative V (tandamine), was selected for further studies in regard to its possible use as an antidepressant agent. Tandamine has been resolved, and ...
Hyánek J - - 1977
The report discusses the first results obtained by chromatographic screening of the blood amino acids in pregnant women at the outset of pregnancy. Typical cases of maternal phenylketonuria and maternal hyperphenylalaninaemia found among 2,000 women examined are described in detail, giving a concise metabolic, clinical and genetic picture. The biochemical ...
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