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Norman Jane E JE Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK. - - 2011
The prevalence of obesity in pregnancy is rising exponentially; about 15-20% of pregnant women now enter pregnancy with a BMI which would define them as obese. This paper provides a review of the strong links between obesity and adverse pregnancy outcome which operate across a range of pregnancy complications. For ...
Illsinger Sabine - - 2011
Abstract Aim: The aim of this study was to investigate the impact of gestational age on energy metabolism in human umbilical vein endothelial cells (HUVECs) of preterm and term neonates. Methods: Activities of respiratory chain (RC) complexes I-V, citrate synthase (CS), overall mitochondrial fatty acid oxidation (FAO), carnitine palmitoyltransferase 2 ...
Van Dyke James U - - 2011
Reproductive effort has been defined as the proportion of an organism's energy budget that is allocated to reproduction over a biologically meaningful time period. Historically, studies of reproductive bioenergetics considered energy content of gametes, but not costs of gamete production. Although metabolic costs of vitellogenesis (MCV) fundamentally reflect the primary ...
Amorini Angela M - - 2011
Physiologic concentration in amniotic fluid (AF) of several metabolites has not been established with certainty. In this study, we initially assayed purines, pyrimidines, and amino compounds in 1,257 AF withdrawn between the 15th and the 20th week of gestation from actually normal pregnancies (normal gestations, normal offspring). Results allowed to ...
Alvarez-Rodríguez J - - 2011
This study evaluated the carry-over effects of ewe body reserves during early pregnancy on peri-partum adipose tissue metabolism. Forty-nine multiparous ewes were divided in three categories according to their body condition score (BCS) at day 30 of pregnancy (BCS < 3, 2.5-2.75; BCS = 3; BCS > 3, 3.25-3.5). Live-weight (LW) and BCS gains from 1st ...
Börzsönyi Balázs - - 2011
Abstract Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR). Materials and methods: We compared 101 human placentas from intrauterine growth restriction pregnancies to those of 140 normal ...
Salcedo Jennifer - - 2011
In stage V twin-twin transfusion syndrome (TTTS), up to 50% of surviving twins die or experience permanent disabilities, likely due to acute intertwin hemorrhage resulting in sudden severe anemia of the survivor. Although fetal middle cerebral artery (MCA) Doppler studies demonstrate strong correlation with fetal hemoglobin values, acute hemorrhagic events ...
Westerhuis Michelle E M H - - 2011
We sought to predict neonatal metabolic acidosis at birth using antepartum obstetric characteristics (model 1) and additional characteristics available during labor (model 2). In 5667 laboring women from a multicenter randomized trial that had a high-risk singleton pregnancy in cephalic presentation beyond 36 weeks of gestation, we predicted neonatal metabolic ...
Mandal Debasmita - - 2011
To analyze whether the obese women have an increased risk of pregnancy complications and adverse fetal outcome. The longitudinal prospective study was carried out in the Obst and Gynae department, IPGME and R, Kolkata. The study enrolled 422 pre-pregnant obese women with pregnancy as study population and equal number of ...
Heinis Ayesha M F - - 2011
Objective. To study to what extent the fetal scalp blood lactate concentration during labor correlates with fetal scalp pH and base deficit, and metabolic acidosis at birth, and to suggest lactate cut-off values to serve as indicators for either reassurance or immediate intervention. Design. A retrospective observational study. Setting. Labor ...
Wallace Jacqueline M - - 2011
Both high and low maternal dietary intakes adversely affect fetal nutrient supply in adolescent sheep pregnancies. Aims were: (a) to assess the impact of prenatal nutrition on pregnancy outcome, offspring growth and offspring glucose metabolism and (b) to determine whether the offspring metabolic phenotype could then be altered by modifying ...
Giuffrè Mario - - 2011
Intestinal atresia in both twins from the same pregnancy is very rare. Only seven pairs of twins have been described. The authors report on two cases of monozygotic twins with different types of intestinal atresia and clinical evolution. Both pairs of observed twins turned out to be concordant for the ...
Mace H S - - 2011
Obesity is increasing in the population as a whole, and especially in the obstetric population, among whom pregnancy-induced physiological changes impact on those already present due to obesity. In particular, changes in the cardiovascular and respiratory systems during pregnancy further alter the physiological effects and comorbidities of obesity. Obese pregnant ...
Mislanova Csilla - - 2011
Etiology and degree of clinical symptoms of preeclampsia depend on genotypic and phenotypic maternal and trophoblast factors, and elevated levels of plasma homocysteine (Hcy) are one of the pathogenetic factors of preeclampsia. To assess the impact of the folate-related metabolism, we characterized the indices of this metabolism in 40 samples ...
Horgan Richard P - - 2011
Being born small for gestational age (SGA) confers increased risks of perinatal morbidity and mortality and increases the risk of cardiovascular complications and diabetes in later life. Accumulating evidence suggests that the etiology of SGA is usually associated with poor placental vascular development in early pregnancy. We examined metabolomic profiles ...
Gallup Gordon G GG - - 2011
To compensate for the high metabolic costs of lactation, the likelihood of re-impregnation shortly after childbirth is normally reduced due to hormonal changes triggered by breast feeding during the postpartum period. Nowadays, however, bottle feeding as a substitute for breast feeding precludes such changes and leads to early postpartum reinstatement ...
Bitzer J - - 2011
The synthetic estrogen ethinylestradiol (EE)given by mouth is stable and yields satisfactory results in terms of ovulation inhibition and effects on the endometrium. It increases however the risk especially for venous thrombotic events and to a lesser degree also arterial thrombosis. Therefore research focused on diminuition of the EE dosage ...
Pantalone Kevin M - - 2011
Objective: Review the literature regarding the use of insulin glargine during pregnancy, specifically addressing the issues/concerns regarding mitogenicity, placental transfer, and maternal and fetal safety.Methods: A systematic literature search was conducted using MEDLINE and BIOSIS Previews. Additional studies were identified by hand-searching reference lists from original articles.Results: Insulin glargine does ...
Rodriguez Maria I - - 2011
The public health impact of obesity and unintended pregnancy is profound with far reaching consequences. Obese women are less likely to use contraception due to a variety of self-induced and systems-based barriers but their risk of becoming pregnant is similar to their normal weight counterparts. However, pregnancy-associated risks for obese ...
Rooney K K Discipline of Exercise and Sport Science, Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, - - 2011
Obesity now represents one of the major health care issues of the 21st century. Its prevalence has increased exponentially in both the developed and developing world during the last couple of decades. Such a rapid rise can therefore not be explained by a change in genotype, but must result from ...
Sohi Gurjeev - - 2011
Susceptibility to disease begins during fetal life, and adverse events in utero are a critical factor in determining quality of life and overall health. In fact, up to 50% of metabolic syndrome diseases can be attributed to an adverse in utero environment. However, the mechanisms linking impaired fetal development to ...
Waller Nimisha - - 2011
Increase in obesity and prevalence of diabetes has made this condition the most common and important metabolic disorder. Midwives regularly meet women at booking whose pregnancy will be or is complicated by diabetes. These women and their babies are at increased risk of morbidity not just during pregnancy and birth ...
Yarrington Christina - - 2011
Iodine is a necessary element for the production of thyroid hormone. We will review the impact of dietary iodine status on thyroid function in pregnancy. We will discuss iodine metabolism, homeostasis, and nutritional recommendations for pregnancy. We will also discuss the possible effects of environmental contaminants on iodine utilization in ...
Lamers Yvonne - - 2011
An adequate intake of folate during pregnancy, lactation, and infancy is essential for maternal and child health and normal growth. Higher folate requirements during pregnancy and lactation are difficult to meet by increased intake of folate-rich food products only. Supplementation with folic acid is recommended not only to meet the ...
Khan Yousuf A - - 2011
A conjoined twin is one of the rare congenital defects. Ischiopagus variety is even rarer. We present a case of ischiopagus-tripus conjoined twins. They were fused at the lower halves of the bodies. One of the twins was apparently normal looking, active and pink. The other twin was small, ill ...
Tzanetakou Irene P - - 2011
Fetal growth and development is primarily dependent upon the nutritional, hormonal and metabolic environment provided by the mother. A wartime famine study in Holland first showed that a low food intake reduces the glucose offered to the fetus and thus produces smaller size infants at birth. Maternal glucose regulation is ...
Forges Thierry - - 2011
To report two consecutive spontaneous pregnancies in a compound heterozygous patient with classic galactosemia and a heterozygous partner, 6 years after ovarian tissue cryopreservation. Case report. Tertiary health care center. A patient with classic galactosemia and strict adherance to a galactose-free diet. Right ovariectomy by laparoscopy and cryopreservation of cortical ...
Van Mieghem T T Division of Woman and Child, Department of Obstetrics and Gynecology, University Hospitals Leuven, B-3000 Leuven, - - 2011
The fetal and the maternal cardiovascular compartment undergo dramatic functional changes during pregnancy. In this thesis we examined the heart of fetuses with twin-to-twin transfusion syndrome (TTTS) and congenital diaphragmatic hernia (CDH) using two new ultrasound parameters of ventricular function : the myocardial performance index and speckle tracking derived myocardial ...
Walker Latoya R - - 2011
Outside of Wilson's Disease, abnormal copper metabolism is a rare condition. In pregnancy, excess copper levels can be associated with intrauterine growth restriction, preeclampsia and neurological disease. A 32 year old Gravida 4 para 2012 with an obstetrical history complicated by elevated copper levels presented for routine prenatal care. Her ...
Casella Giovanni G Division of Internal Medicine, Desio General Hospital, - - 2011
Inflammatory bowel disease (IBD) frequently affects young patients of childbearing age. Treatments for inflammatory bowel disease include immunosuppressive, cytotoxic and surgical therapies. Azathioprine is frequently used to treat patients with steroid dependent IBD. We report the case of a patient with ulcerative colitis, treated with azathioprine prior to conception and ...
Jha Sangeeta S Department of Obstetrics and Gynaecology, Good Hope Hospital, Birmingham, UK. - - 2011
The authors report the rare case of a 25-year-old female who suffered from an ovarian ectopic pregnancy. She presented at 10 weeks gestation with a 1-day history of vaginal bleeding and lower abdominal discomfort. β-human chorionic gonadotropin concentration was 8538 IU/ml. Ultrasound showed a right adnexal mass 4.0 × 3.8 ...
Van Eerden Peter - - 2011
More than one-third of U.S. women are obese, and the prevalence of obesity in childhood has increased. Excessive gestational weight gain and obesity are independent risk factors for maternal and fetal complications of pregnancy and may very well be implicated in the epidemic of childhood obesity currently seen in the ...
Ghio Alessandra - - 2011
During pregnancy, complex changes occur in lipid profiles. From the 12th week of gestation, phospholipids, cholesterol (total, LDL, HDL), and triglycerides (TG) increase in response to estrogen stimulation and insulin resistance. Transition to a catabolic state favors maternal tissue lipid use as energy sources, thus sparing glucose and amino acids ...
Aggarwal Pakhee - - 2011
Ovarian tumours in pregnancy are a diagnostic and management challenge that is increasingly being faced by the clinician. While most masses are benign and resolve spontaneously, there are others that persist and indicate the need for surgical management. Ultrasound not only detects asymptomatic masses but also helps to guide their ...
Greve Tine - - 2010
Cryopreservation of ovarian tissue is a promising new technique for fertility preservation in patients facing gonadotoxic treatment. Ovarian tissue is extracted and cryo-stored at low temperature prior to treatment. If the woman becomes menopausal, the tissue can be transplanted and a few months later the woman will start to ovulate ...
Papanikolaou Evangelos G - - 2010
Ovarian hyperstimulation syndrome (OHSS), an iatrogenic complication of ovarian stimulation for assisted reproduction, is a potentially life-threatening condition. Exogenous human chorionic gonadotropin (hCG) administered for final oocyte maturation and endogenous hCG produced by a developing pregnancy are fundamental in the development of the disease. Vascular endothelial growth factor is the ...
Coakley Fergus V - - 2010
To investigate the MRI findings of massive ovarian edema in pregnancy. Asymmetric ovarian enlargement with a teardrop configuration and T2 hyperintensity with or without T1 hyperintensity appear characteristic of massive ovarian edema in pregnancy, potentially facilitating nonoperative diagnosis and expectant management. These findings support the concept that massive ovarian edema ...
Mavromatidis G - - 2010
A large (165 × 235 × 250 mm) solitary, unilocular cyst with a thin, smooth wall and homogeneous anechoic content was detected during a routine ultrasound scan at 24 weeks of gestation in an asymptomatic 39-year-old woman with a singleton pregnancy. The cyst was aseptate, lacked mural blood flow and ...
Benjapibal Mongkol - - 2010
Pregnancy complicated by endodermal sinus tumor of the ovary is a very rare event. We present a case report of a pregnant woman with a ruptured primary endodermal sinus tumor of the ovary that was diagnosed at 13 weeks of gestation. After right salpingo-oophorectomy had been performed the patient received ...
Cao Dong-yan - - 2010
To summarize the clinicopathological features and prognosis of malignant ovarian neoplasmas complicating pregnancy and explore the rational treatment. The clinical data of 38 patients with malignant ovarian neoplasmas complicating pregnancy were retrospectively analyzed,and the intra-surgical pathological sections were reviewed. International Federation of Gynecology and Obstetrics (FIGO) staging system (1988) was ...
Zhao M - - 2010
The objective of this study was to investigate the correlation between the concentrations of vascular endothelial cell growth factor (VEGF), nitric oxide (NO), or endothelin-1 (ET-1) in follicular fluid with antral follicle counts (AFCs) or ovarian volume in order to predict the outcome of in vitro fertilization (IVF). One hundred ...
Graham Dorothy F - - 2010
This case report describes the onset of hypertension and virilisation during pregnancy due to a Brenner tumour.
Riggs Ryan - - 2011
The objective of this retrospective cross-sectional study was to evaluate the value of basal serum anti-Müllerian hormone (AMH) levels as a predictor of ovarian response and pregnancy outcome in a donor egg program. The study showed that AMH was superior to other biomarkers of ovarian reserve in predicting low and ...
Smaldone Gina M Mantia - - 2010
HYPOTHESIS: Conservative surgical management of ovarian neoplasms can result in favorable oncologic and obstetric outcomes. METHODS: All reproductive-age women (18-45 years old) with stage IA to stage IIC ovarian neoplasms (N = 161) were retrospectively identified from a single institution's tumor registry between 1990 and 2007. Operative, pathological, outpatient, and ...
Sztein Jorge - - 2010
Here we describe a new technique for cryopreserving mouse ovaries by using 0.5-mL straws. One advantage of this method is that it uses the same controlled-rate freezer and programming routinely used for the cryopreservation of mouse embryos. Using a 0.5-mL French straw loaded in the same way as for embryo ...
Mourali Mechaal - - 2010
BACKGROUND: Composing of less than 1% of all ovarian cancers, immature teratoma is a malignancy that mainly affects the young. Immature teratoma of the ovary together with pregnancy is rare. To our knowledge, this association was reported only in twelve cases. AIM: We Report two cases of immature teratoma of ...
Altinbas Sadiman Kiykac - - 2010
We report a case of ovarian cystic teratoma with an important growth during pregnancy and the sonographic appearance of intracystic multiple, mobile, polygonal structures called intracystic "fat balls." Due to the rapid growth of the lesion, which exceeded 15 cm in diameter, a right oophorectomy was performed. Histopathologic diagnosis confirmed ...
Ben-Aharon Irit - - 2010
The rate of chemotherapy-induced ovarian failure (CIOF) has been reported as 14-100% and is age- and agent-dependent. The role of GnRH analogs (GnRHa) and oral contraceptives (OC) in the prevention of CIOF is questionable. We performed a systematic review and a meta-analysis of studies assessing the efficacy of hormonal interventions ...
Yu Hsing-Tse - - 2010
To assess whether the laparoscopist's experience can affect ovarian reserve and pregnancy outcome in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) patients who previously underwent laparoscopic conservative treatment for ovarian endometriomas. One hundred and forty-nine IVF-ICSI cycles with infertile patients who previously underwent laparoscopic conservative treatment for ovarian endometriomas were enrolled. There ...
Chang Eun Mi - - 2010
To evaluate the safety, feasibility, and pregnancy outcomes of adnexal detorsion using simple aspiration following ovarian hyperstimulation in pregnancy. Retrospective review of eight pregnant women who underwent ultrasound (US)-guided transvaginal aspiration to induce natural reduction of ovarian torsion following ovarian hyperstimulation. Six of the eight patients were successfully treated with ...
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