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Tessier Daniel R DR Department of Biology, University of Ottawa, Ottawa, ON, Canada; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, - - 2014
The process of uterine spiral artery remodeling in the first trimester of human pregnancy is an essential part of establishing adequate blood perfusion of the placenta that will allow optimal nutrient/waste exchange to meet fetal demands during later development. Key regulators of spiral artery remodeling are the uterine natural killer ...
Arck Petra Clara - - 2014
During pregnancy, the maternal immune and endocrine systems undergo significant adaptations in order to maintain immune tolerance towards the semi-allogeneic fetus. Pregnancy related hormones, such as estradiol, progesterone and glucocorticoids soar, and leukocyte subsets of the innate and adaptive immune response systems functionally engage in ensuring successful implantation of the ...
Wallace Alison E AE Institute of Cardiovascular and Cell Sciences, St George's University of London, United Kingdom; - - 2014
During pregnancy, a specialized type of NK cell accumulates in the lining of the uterus (decidua) and interacts with semiallogeneic fetal trophoblast cells. dNK cells are functionally and phenotypically distinct from PB NK and are implicated in regulation of trophoblast transformation of the uterine spiral arteries, which if inadequately performed, ...
Komine-Aizawa S S Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Ohyaguchikamicho, Itabashi-ku, Tokyo, Japan. Electronic address: - - 2014
Periodontitis is a chronic infectious disease associated with Gram-negative subgingival microflora. In pregnant women, periodontitis is thought to be associated with adverse pregnancy outcomes, although the pathophysiology is unknown. Additionally, smoking is an established risk factor for adverse pregnancy outcomes. In the present study, we examined the direct effects of ...
Mikhailova V A VA Laboratory of Immunology, D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, - - 2014
Microparticles are microvesicles forming during cell activation and as a result of apoptotic cell death. Normal pregnancy is associated with apoptosis induction in active immune system cells, present in the decidual tissue. Preeclampsia is associated with activation of the peripheral blood leukocytes and more intense apoptosis of the trophoblast cells. ...
Vanders Rebecca L RL Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: - - 2014
Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the ...
Kharche Suresh Dinkar SD Central Institute for Research on Goats, Makhdoom, PO Farah, 281122, Mathura, UP, India, - - 2014
The aim of this study is to generate parthenogenetic embryos from chemically activated in vitro matured caprine oocytes and to study the in vivo developmental potency of such embryos. The parthenogenetic embryos (2-8 and 16 cells to morula stage) were surgically transferred in 26 recipients. Pregnancy in recipients following embryo ...
Kay Alexander W AW Departments of Pediatrics, cblish@stanford.edu mmdavis@stanford.edu - - 2014
Pregnant women experience increased morbidity and mortality after influenza infection, for reasons that are not understood. Although some data suggest that natural killer (NK)- and T-cell responses are suppressed during pregnancy, influenza-specific responses have not been previously evaluated. Thus, we analyzed the responses of women that were pregnant (n = ...
Muzzio Damián O - - 2014
Pregnancy hides an immunological riddle combining two antagonistic characteristics of immunology: the existence of a tolerance that allows the gestation of a semi-allogeneic fetus, and the proper protection against pathogens threatening health of the immunocompromised mother. Despite the fundamental role that B cells play in orchestrating an immune response, their ...
Knott Jason J J Knott, Department of Animal Science, Michigan State University, East Lansing, United - - 2014
Mammalian reproduction is critically dependent on the trophoblast cell lineage, which assures proper establishment of maternal-fetal interactions during pregnancy. Specification of trophoblast cell lineage begins with the development of the trophectoderm (TE) in preimplantation embryos. Subsequently, other trophoblast cell types arise with progression of pregnancy. Studies with transgenic animal models ...
Liu Beiyu B Department of Reproductive Medicine, University of Sheffield, Sheffield Teaching Hospitals, Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK; Reproductive Medicine Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of - - 2014
Histological dating has been used for decades to evaluate the histological maturation of the endometrium. Uterine natural killer cells are thought to play a significant role in pregnancy. While several studies have shown an increased number of uNK cells in women with recurrent reproductive failure, its prognostic value of pregnancy ...
Blackburn Daniel G DG Department of Biology and, Electron Microscopy Center, Trinity College, Hartford, Connecticut, - - 2014
Phylogenetic analyses indicate that viviparity (live-bearing reproduction) has originated independently in more than 150 vertebrate lineages, including a minimum of 115 clades of extant squamate reptiles. Other evolutionary origins of viviparity include 13 origins among bony fishes, nine among chondrichthyans, eight in amphibians, one in Paleozoic placoderms, six among extinct ...
Ruocco Maria Grazia MG Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , - - 2014
In this review, we first revisit the original concept of "suppressor T-cells" in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of "regulatory T-cells" (Tregs) in pregnancy. We review the evidence for a major role of ...
Zhang Jinping J Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing 312000, Zhejiang, - - 2014
To study the expression and roles of Connexin43 (Cx43) and Paired-box3 (Pax3) proteins in the human Chorionic villi and decidua during early pregnancy, Cx43 and Pax3 protein expression in the human placental villi and decidua at 5-7 weeks of early pregnancy was studied by immunohistochemistry (SABC). Integrated optical density (IOD) ...
Choi Jacqueline J - - 2013
A placental site nodule is a benign proliferation of intermediate trophoblasts from a previous gestation that failed to completely involute. It is a rare entity that is often asymptomatic and is usually found incidentally weeks or even years after the pregnancy. The most common location for placental site nodules is ...
Carter Anthony M AM Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense DK-5000, Denmark; email: - - 2013
Epitheliochorial placentation is a derived condition and has evolved separately in strepsirrhine primates and laurasiatherians (pangolins, whales, and hoofed mammals). Usually it is associated with a long gestation period, small litters, and precocial young. Oxygen transfer is facilitated by indenting of the uterine and trophoblast epithelia by maternal and fetal ...
Saso S - - 2012
Please cite this paper as: Saso S, Chatterjee J, Yazbek J, Thum Y, Keefe K, Abdallah Y, Naji O, Lindsay I, Savage P, Seckl M, Smith J. A case of pregnancy following a modified Strassman procedure applied to treat a placental site trophoblastic tumour. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03501.x.
Miller Keith - - 2012
Abstract The incidence of maternal cancer during pregnancy is low and metastatic disease involving the placenta is rare. We present a case of rapidly progressive and fatal gastric carcinoma presenting during pregnancy, with spread to the maternal blood space within the placenta but no chorionic villous invasion, and no evidence ...
Boyd Casey A - - 2012
Neoplasms of the pancreas during pregnancy are rare, with less than 25 cases of benign and malignant tumors reported in the literature. We present three unique cases of pancreatic tumors occurring during pregnancy--one mucinous cystic neoplasm and two adenocarcinomas. We review the literature regarding pancreatic neoplasms during pregnancy and discuss ...
Papadakis Efstathios P - - 2011
Acute pancreatitis is rare in pregnancy but it is associated with increased incidence of maternal and fetal mortality. It should be considered in the differential diagnosis of upper quadrant abdominal pain with or without nausea and vomiting. The commonest identified causes of acute pancreatitis in pregnancy are gallstones, alcohol and ...
Stimac Davor - - 2011
Acute pancreatitis in pregnancy is a rare condition estimated to occur in 1 per 1000 to 1 per 12 000 pregnancies. The most frequent etiology in pregnancy is biliary, followed by hyperlipidemia and/or alcohol abuse. Abdominal ultrasound and endoscopic ultrasound are ideal imaging techniques for diagnosing disease because they have ...
Vianna Priscila - - 2011
Psychological stress may affect up to 18% of all pregnant women, altering the function of both neuroendocrine and immune systems. Distress conditions may directly change the hypothalamic-pituitary-adrenal (HPA) axis, leading to increased cortisol levels and associated changes in cellular immunity. Psychological events such as high stress levels, anxiety or depression ...
D'Anna-Hernandez Kimberly L KL University of Colorado Denver, School of Medicine, Department of Psychiatry, Aurora, CO 80045, USA. - - 2011
Maternal stress during pregnancy is associated with negative maternal/child outcomes. One potential biomarker of the maternal stress response is cortisol, a product of activity of the hypothalamic-pituitary-adrenal axis. This study evaluated cortisol levels in hair throughout pregnancy as a marker of total cortisol release. Cortisol levels in hair have been ...
Tong Xiao-Mei - - 2011
OBJECTIVE: To report two successful pregnancies after frozen-thawed ET in discontinued hormone replacement treatment cycles. DESIGN: Case report. SETTING: University hospital. PATIENT(S): Two infertile patients. INTERVENTION(S): Hormone replacement treatment for endometrial preparation and frozen-thawed ET. MAIN OUTCOME MEASURE(S): Ovarian ultrasonography, serial hormone measurements of serum E(2) and P, successful pregnancy, ...
Jornayvaz François R - - 2011
Context: Pituitary surgery is the first line of treatment for Cushing's disease; when surgery fails, bilateral adrenalectomy may be proposed, particularly for women with a desire for pregnancy. Little is known about the impact of pregnancy on corticotroph tumor progression after bilateral adrenalectomy. Objective: The aim was to evaluate the ...
Haydardedeoglu Bulent - - 2011
We compared the retrieval efficiency of single- (direct follicular aspiration) and double-lumen-needle (attained with follicular flushing) procedures in normal-responder IVF-intracytoplasmic sperm injection cycles. This prospective randomized study did not demonstrate a beneficial effect of double-lumen needle retrieval compared with single-needle retrieval in normal-responder IVF-intracytoplasmic sperm injection cycles in terms of ...
Cift Tayfur T Department of Gynecology and Obstetrics, Cerrahpa┼ča Medical School, Istanbul University, 34303 Istanbul, - - 2011
We report a rare case of gastric cancer in pregnancy. A 26-year-old woman presented at the 20th week of pregnancy complaining of nausea and vomiting. Although the patient considered the condition to be related with pregnancy and underestimated its importance, her complaints persisted over the following weeks and she was ...
Youssef Mohamed Afm MA Obstetrics & Gynaecology, Faculty of Medicine - Cairo University, Cairo, Egypt, - - 2011
Gonadotropin-releasing hormone (GnRH) antagonist protocols for pituitary down regulation in in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) allow the use of GnRH agonists for triggering final oocyte maturation. Currently, human chorionic gonadotropin (HCG) is still the standard medication for this purpose. The effectiveness of triggering with a GnRH ...
An L - - 2010
The present study was performed to test fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm under field conditions. Some parameters, including the dosage, deposition site and timing, were assessed with the pregnancy rates after artificial insemination (AI). Moreover, the use of oestrus synchronization in ...
Shamsa Ali - - 2010
Varicocele is still an enigma. Its effects on semen analysis, fertility and, more re-cently, early ejaculation and spontaneous abortion in spouses are not yet fully understood. In this retrospective study, we evaluated these four parameters (semen analysis, fertility, early ejacu-lation and spontaneous abortion among spouses) in relation to varicocele and ...
Liu Feng - - 2011
This goal of this study was to compare the outcomes of conventional intracytoplasmic sperm injection (ICSI; control group, n = 53 couples) and a modified ICSI technique using zona pellucida (ZP)-bound sperm for injection of oocytes (test group, n = 53 couples). The proportion of high-quality embryos (grades 1 and ...
Walsh A P H - - 2011
Couples presenting with male factor infertility comprise an important proportion of clinical reproductive endocrinology consultations. Indeed, a problem with the male is the only cause, or a contributing cause, of infertility in ~40% of infertility evaluations. Here we present the first published deliveries obtained from IVF utilising surgically retrieved sperm ...
Nijs Martine - - 2010
The sperm-hyaluronan binding assay (HBA) is a diagnostic kit for assessing sperm maturity, function and fertility. The aim of this prospective cohort pilot study was to evaluate the relationship between HBA and WHO sperm parameters (motility, concentration and detailed morphology) and possible influence of sperm processing on hyaluronic acid binding. ...
Noels Johanna E - - 2011
Hepatocellular adenoma in pregnant women requires special considerations because of the risk of hormone induced growth and rupture. To prevent these potential lethal complications, pregnancy is either often discouraged or the surgical resection of large adenomas is recommended. It may be questioned whether it is justified to deny a young ...
Esteves Sandro C - - 2010
PURPOSE: We evaluated the impact of varicocelectomy on intracytoplasmic sperm injection outcomes in infertile men with clinical varicocele. MATERIALS AND METHODS: We studied 242 infertile men with a history of clinical varicocele who underwent intracytoplasmic sperm injection. Of the men 80 underwent prior subinguinal microsurgical varicocelectomy (treated group 1) and ...
Keltz Julia - - 2010
To evaluate if elevated male body mass influences success after assisted reproductive technologies Retrospective study of 290 cycles. Male body mass index greater than 25.0 kg/m² was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the ...
Spencer Karl W - - 2010
There are advantages for use of frozen-thawed boar sperm (FTS) as a tool for preservation and transfer of valuable genetic material, despite its practical limitations. It was hypothesized that increasing the number of motile FTS and number of fixed-time artificial inseminations (AI) would improve pregnancy rate and litter size. Semen ...
Souza Setti Amanda - - 2010
The development of a modified intracytoplasmic sperm injection (ICSI), called intracytoplasmic morphologically selected sperm injection (IMSI), demonstrated that a profound morphological investigation of the spermatozoon, under the magnification of 6600 x, enables outcome improvement. The aim of this study was to compare ICSI outcome with IMSI outcome. The meta-analysis results ...
Lazaros Leandros - - 2011
To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. Prospective study. Patients referred to the IVF Unit of Ioannina ...
Speyer B E - - 2010
There is considerable uncertainty as to the significance of a high sperm DNA fragmentation index (DFI) for achieving a successful pregnancy. The sperm DFI of 124 patients undergoing 192 IVF cycles and of 96 patients undergoing 155 ICSI cycles was determined using the sperm chromatin structure assay on neat sperm. ...
Oweini Houssam - - 2011
Dasatinib is a highly potent Bcr-Abl inhibitor that is approved for the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia (CML). The potential effects of dasatinib on sperm counts, sperm function, and fertility have not been studied yet. There is only one report in the medical literature of successful pregnancies ...
Irmak M Kemal - - 2010
Chimeras are the result of fusion of two zygotes to form a single embryo, producing an individual with genetically different kinds of tissue. If the fused zygotes are of different sex, the individual develops both ovarian and testicular tissues. The majority of these people are best reared as females and ...
Gambera Laura - - 2010
To describe a case of successful triplet pregnancy after testicular sperm extraction (TESE) from a man with AZFc deletion and intracytoplasmic sperm injection (ICSI). Case report. University hospital. A 38-year-old man affected by complete AZFc deletion and azoospermia. Spermiogram, Y-chromosome microdeletion screening, TESE for sperm recovery from testicular tissue on ...
Engels M A J - - 2010
OBJECTIVE: To evaluate marker distribution of free beta-human chorionic gonadotrophin (fbeta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in singleton pregnancies conceived by assisted reproduction techniques (ART). METHODS: In vitro fertilization (IVF) (n = 203) and intracytoplasmic sperm injection (ICSI) (n = 192) cases from a database of 14 645 first-trimester combined ...
Vujkovic Marijana - - 2010
To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers of the homocysteine pathway. Observational prospective study. A tertiary referral fertility clinic at the Erasmus University Medical Centre, Rotterdam, The Netherlands. One hundred sixty-one couples undergoing IVF/ICSI treatment. No interventions other than the Dutch ...
Underwood S L - - 2010
The use of sex-sorted sperm by the dairy industry is often limited by the geographical distance between potential sires and the sex-sorting facility. One method that may be used to overcome this limitation is sex-sorting sperm that have been previously frozen, or transported to the sorting facility as cooled liquid ...
Casas I - - 2010
This study compared the field fertility outcomes in frozen-thawed (FT) sperm from boar ejaculates with different freezability (good, GFE/poor, PFE) while testing the reliability of the post-cervical artificial insemination (post-CAI) in FT sperm. The assay was conducted over eight months with 86 weaned sows being inseminated by post-CAI. Every ejaculate ...
Kamal Ahmed - - 2010
To compare the outcomes of intracytoplasmic sperm injection (ICSI) for men with obstructive azoospermia and normal spermatogenesis, according to the use of epididymal or testicular spermatozoa and the cause of obstruction. Retrospective study. Private infertility center. A detailed chart review of a cohort of 1,121 men with obstructive azoospermia who ...
Brackett Nancy L - - 2010
Most men with spinal cord injury (SCI) are infertile. Erectile dysfunction, ejaculatory dysfunction and semen abnormalities contribute to the problem. Treatments for erectile dysfunction include phosphodiesterase type 5 inhibitors, intracavernous injections of alprostadil, penile prostheses, and vacuum constriction devices. In anejaculatory patients who wish to father children, semen retrieval is ...
Polak de Fried Ester - - 2010
OBJECTIVE: To treat couples with intracytoplasmic sperm injection (ICSI) after annexin V sperm sorting. DESIGN: Two case reports. SETTING: Department of Reproductive Medicine at a private medical institute. PATIENT(S): Couples on infertility treatment, donor oocytes. INTERVENTION(S): Sperm sorted with annexin V magnetic microbeads before ICSI, day 3 embryo transfer; case ...
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