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Roberts Devender D Obstetrics Directorate, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, Merseyside, UK, L8 - - 2014
Twin-twin transfusion syndrome, a condition affecting monochorionic twin pregnancies, is associated with a high risk of perinatal mortality and morbidity. A number of treatments have been introduced to treat the condition but it is unclear which intervention improves maternal and fetal outcome. The objective of this review was to evaluate ...
Negro Roberto R Division of Endocrinology, "V. Fazzi" Hospital, Lecce, - - 2014
Objective: To evaluate the peer-reviewed literature on hypothyroidism, hyperthyroidism, and thyroid autoimmunity in pregnancy.Methods: We review published studies on thyroid autoimmunity and dysfunction in pregnancy, the impact of thyroid disease on pregnancy, and discuss implications for screening.Results: Overt hyperthyroidism and hypothyroidism are responsible for adverse obstetrical and neonatal events. Several ...
Arija Victoria - - 2014
Currently, there is no consensus regarding iron supplementation dose that is most beneficial for maternal and offspring health during gestation. Recommended iron supplementation dose does not preempt anemia in around 20% of the pregnancies, nor the risk of hemoconcentration in 15%. This deficit, or excess, of iron prejudices the mother-child ...
Levy Delphine P DP Laboratoire HRA Pharma, Paris, - - 2014
To describe the safety of ulipristal acetate in emergency contraception. Postmarketing pharmacovigilance data collection. A total of 553 women experienced 1049 adverse drug reactions. The most frequent (n,%) were pregnancies (282, 6.8%); nausea, abdominal pain and vomiting (139, 13.3%); headache, dizziness (67, 6.4%); and metrorrhagia, menses delay and breast symptoms ...
Hamel Maureen S MS Warren Alpert Medical School of Brown University, Women & Infants Hospital, Department of Obstetrics & Gynecology, Providence, RI. Electronic address: - - 2014
Maternal oxygen is often given to laboring women to improve fetal metabolic status or in an attempt to alleviate non-reassuring fetal heart rate patterns. However, the only two randomized trials investigating the use of maternal oxygen supplementation in laboring women do not support that such supplementation is likely to be ...
Grzeskowiak Luke E - - 2014
Pregnancy presents a unique situation for the management of asthma as it can alter the course of asthma severity and its treatment, which in turn can affect pregnancy outcomes. Despite awareness of the substantial adverse effects associated with asthma during pregnancy, little has been done to improve its management and ...
Holst Lone L Department of Global Public Health and Primary Care and Centre for Pharmacy, Faculty of Medicine and Dentistry, University of Bergen Bergen, - - 2014
This review evaluates the safety of echinacea and elderberry in pregnancy. Both herbs are commonly used to prevent or treat upper respiratory tract infections (URTIs) and surveys have shown that they are also used by pregnant women. The electronic databases PubMed, ISI Web of Science, AMED, EMBASE, Natural Medicines Comprehensive ...
Zarei Afsoon A Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2014
The direct effect of hCG on the human endometrium was studied several times. The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET). In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing ...
Kelekci Sefa S Eagen Maternity and Gynaecology Education and Research Hospital, Izmir, Turkey; Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: - - 2013
To evaluate a new trial of short-term clomiphene citrate (CC) in high responder women with polycystic ovary syndrome (PCOS). This case series was conducted in the infertility outpatient clinics of two centres. Ovulation induction was performed with CC 50-100mg a day in six high-responder women with PCOS who had a ...
Kaandorp J J JJ Department of Perinatology, University Medical Centre, , Utrecht, The - - 2013
Perinatal hypoxia-induced free radical formation is an important cause of hypoxic-ischaemic encephalopathy and subsequent neurodevelopmental disabilities. Allopurinol reduces the formation of free radicals, which potentially limits hypoxia-induced brain damage. We investigated placental transfer and safety of allopurinol after maternal allopurinol treatment during labour to evaluate its potential role as a ...
Jiang Hong - - 2013
Evidence has suggested that periodontal disease is associated with an increased risk of various adverse pregnancy and birth outcomes. However, several large clinical randomized controlled trials failed to demonstrate periodontal therapy during pregnancy reduced the incidence of adverse pregnancy and birth outcomes. It has been suggested that the pre-conception period ...
Tan Kelvin H - - 2013
Manual fetal manipulation has been suggested to improve the efficiency of antepartum fetal heart rate testing. The objective of this review was to assess the merits or adverse effects of the use of manual fetal manipulation in conjunction with tests of fetal wellbeing. We searched the Cochrane Pregnancy and Childbirth ...
Tan Kelvin H - - 2013
Acoustic stimulation of the fetus has been suggested to improve the efficiency of antepartum fetal heart rate testing. To assess the advantages and disadvantages of the use of fetal vibroacoustic stimulation in conjunction with tests of fetal wellbeing. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September ...
Abu Hashim Hatem H Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address: - - 2013
Rescue cervical cerclage (RCC) is essentially a salvage procedure to prolong pregnancy in women with advanced cervical changes and prolapsed membranes in the second trimester. However, its effectiveness and safety remain controversial. To provide a comprehensive review of the contemporary evidence on RCC and evaluate which treatment modalities can be ...
Luo Shan - - 2013
Abstract Polycystic ovary syndrome (PCOS) patients undergoing controlled ovarian stimulation and intrauterine insemination (COS/IUI) often face the risk of premature luteinization, which may result in lower pregnancy rate and higher miscarriage rate. This review was performed to identify if adjuvant treatment with GnRH antagonist (GnRH-ant) could effectively improve the clinical ...
Wang Chi Chiu CC Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong - - 2013
Chinese medicine is a common name for a collection of Chinese Materia Medica with therapeutic properties for medical treatment and healing. Similar to Western pharmaceuticals, Chinese medicines are not free of risk, and have the potential to cause adverse pregnancy outcomes and affect embryonic and fetal development. However, most clinical ...
Earl Rachel - - 2013
Women with hyperthyroidism in pregnancy have increased risks of miscarriage, stillbirth, preterm birth, and intrauterine growth restriction; and they can develop severe pre-eclampsia or placental abruption. To identify interventions used in the management of hyperthyroidism pre-pregnancy or during pregnancy and to ascertain the impact of these interventions on important maternal, ...
Lin Yu-Hung - - 2013
Cervical stenosis can be an impediment to embryo transfer (ET) and intrauterine insemination (IUI). We propose a technique of hysteroscopic cervical resection to overcome cervical stenosis. Prospective clinical study (Canadian Task Force classification III). Private general hospital. Forty-three infertile women in whom trial ET or IUI had failed with 3 ...
Guardino Christine M CM a Department of Psychology , University of California , Los Angeles , CA , - - 2014
This randomised controlled pilot trial tested a six-week mindfulness-based intervention in a sample of pregnant women experiencing high levels of perceived stress and pregnancy anxiety. Forty-seven women enrolled between 10 and 25 weeks gestation were randomly assigned to either a series of weekly Mindful Awareness Practices classes (n = 24) ...
Nahuis Marleen J - - 2013
Clomiphene citrate (CC) is first line treatment in women with World Health Organization (WHO) type II anovulation and polycystic ovary syndrome (PCOS). Whereas 60% to 85% of these women will ovulate on CC, only about one half will have conceived after six cycles. If women do not conceive, treatment can ...
Zolghadri Jaleh - - 2013
To compare the effectiveness of the double cervical cerclage method versus the single method in women with recurrent second-trimester delivery. In this randomized clinical trial, we included 33 singleton pregnancies suffering from recurrent second-trimester pregnancy loss (≥2 consecutive fetal loss during second-trimester or with a history of unsuccessful procedures utilizing ...
Tajik Parvin - - 2013
The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT trial) showed that in women with suspected intrauterine growth restriction (IUGR) at term, there were no substantial outcome differences between induction of labour and expectant monitoring. The objective of the present analysis is to evaluate whether maternal or fetal markers could ...
Schisterman Enrique F - - 2013
Low-dose aspirin (LDA) has been proposed to improve pregnancy outcomes in couples experiencing recurrent pregnancy loss. However, results from studies of LDA on pregnancy outcomes have been inconsistent, perhaps because most studies evaluated LDA-initiated post-conception. The purpose of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was to ...
Vigil-De Gracia Paulino - - 2013
Abstract Objective: To determine the maternal and neonatal efficacy and safety with furosemide, amlodipine or aspirin in women with mild/moderate chronic hypertension during pregnancy. Methods: A pilot clinical trial was performed in a tertiary teaching hospital in Panama. Pregnant patients with mild/moderate chronic hypertension at ≤ 20 weeks of gestation ...
Maimburg Rikke D - - 2013
It has been suggested that participation in an antenatal education programme will increase the level of worry in pregnant women. This randomised controlled trial, investigated women's worries in late pregnancy as a secondary outcome depending on their attendance in an antenatal education programme. We found that women attending the education ...
Danzer Enrico - - 2013
A recently completed randomized, controlled, prospective multicenter trial, the Management of Myelomeningocele Study (MOMS), demonstrated that maternal-fetal surgery for myelomeningocele (MMC) before 26 weeks of gestation decreases the need for ventriculoperitoneal shunting, decreases hindbrain herniation, and preserves neurological function. However, the study also found that fetal MMC surgery is not ...
Nabhan Ashraf F - - 2013
To assess the effectiveness of prophylactic antibiotics compared with placebo in preventing neonatal and maternal infection-related morbidity associated with prelabor spontaneous rupture of membranes at or beyond 36weeks of pregnancy. In the present randomized controlled trial conducted during 2009-2011, 1640 women with prelabor spontaneous rupture of fetal membranes at or ...
Ezeama Chukwuemeka O CO Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, - - 2014
To compare the efficacy and adverse effects of ergometrine and oxytocin given intramuscularly for the prevention of postpartum hemorrhage during the third stage of labor. The study included women with a singleton pregnancy of at least 28weeks' gestation who had a vaginal delivery. High-risk pregnancies were excluded. Oxytocin (10IU) or ...
Pundir Jyotsna J Assisted Conception Unit, 11th Floor, Tower Wing, Guy's and St Thomas NHS Trust, London, UK. Electronic address: - - 2013
This systematic review and meta-analysis investigated the use of routine hysteroscopy prior to starting the first IVF cycle on treatment outcome in asymptomatic women. Searches were conducted on MEDLINE, EMBASE, Cochrane Library, National Research Register and ISI Conference Proceedings. The main outcome measures were clinical pregnancy and live birth rates ...
Moise Kenneth J KJ - - 2013
Amniotic fluid is typically measured by ultrasound using the amniotic fluid index (AFI) or the maximum vertical pocket (MVP). Although both parameters correlate poorly with the actual amniotic fluid volume measured with dye-dilution methods, cross-sectional studies have been used to establish gestational norms. The current acceptable definition of polyhydramnios in ...
Mahajan Nalini N Department of Reproductive Medicine, NOVA IVI Fertility, New Delhi, - - 2013
Mild stimulation protocols aim to reduce the physical, financial and emotional burden associated with the conventional IVF protocol without compromising the pregnancy rate. Such protocols help to decrease the complications and the discomfort related to the prolonged administration of agonist and large doses of gonadotrophins, by limiting the number of ...
Money Deborah D Vancouver - - 2013
To review the evidence in the literature and to provide recommendations on the management of pregnant women in labour for the prevention of early-onset neonatal group B streptococcal disease. The key revisions in this updated guideline include changed recommendations for regimens for antibiotic prophylaxis, susceptibility testing, and management of women ...
Aflatoonian Abbas A Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, - - 2013
Preterm labor (PTL) is one of the most important causes in neonatal mortality and morbidity. Late preterm labor (34-36w) includes 75% of such birth. Assisted reproductive technology (ART) pregnant women are at increased risk of PTL. The study has been undertaken to determine whether beginning and continuing 17-α hydroxy progesterone ...
Hauzman Erik E - - 2013
Both oral contraceptive pills (OCPs) and estradiol (E2) valerate have been used to schedule gonadotropin-releasing hormone (GnRH) antagonist in vitro fertilization (IVF) cycles and, consequently, laboratory activities. However, there are no studies comparing treatment outcomes directly between these two pretreatment methods. This randomized controlled trial was aimed at finding differences ...
Mattes Joerg - - 2013
Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are strongly associated with the development of childhood asthma. We conducted a follow-up study of infants born to women with asthma who completed a double-blind randomised controlled ...
Zhou Shao J - - 2013
Routine iodine supplementation during pregnancy is recommended by leading health authorities worldwide, even in countries where the iodine status of the population is sufficient. We evaluated the efficacy and safety of iodine supplementation during pregnancy or the periconceptional period on the development and growth of children. Secondary outcomes included pregnancy ...
Mok-Lin Evelyn - - 2013
Does follicular flushing during oocyte retrieval improve the number of oocytes retrieved in the poorest responders? Follicular flushing in the poorest responders does not increase the number of oocytes retrieved and may result in lower implantation and clinical pregnancy rates. Although previous studies have shown no beneficial effect of follicular ...
Attia Abdelhamid M - - 2013
Male factors leading to subfertility account for at least half of all cases of subfertility worldwide. Although some causes of male subfertility are treatable, treatment of idiopathic male factor subfertility remains empirical. Researchers have used gonadotrophins to improve sperm parameters in idiopathic male factor subfertility with the ultimate goal of ...
Girardi Guillermina - - 2013
Statins are potent inhibitors of cholesterol biosynthesis. The beneficial effects of the statins in preventing cardiovascular diseases are not entirely due to cholesterol reduction. Numerous studies suggest that the benefits observed with statins may be mediated by pleiotropic effects that are cholesterol-independent. There is now compelling evidence that statin therapy ...
Van Teeffelen Stijn - - 2013
Preterm prelabour rupture of membranes (PPROM) before 26 weeks can delay lung development and can cause pulmonary hypoplasia, as a result of oligohydramnios. Restoring the amniotic fluid volume by transabdominal amnioinfusion might prevent abnormal lung development and might have a protective effect for neurological complications, fetal deformities and neonatal sepsis. ...
Rambaldi Marianna Pina - - 2013
Thrombophilias represent an evolving story that continues to stir controversy for care providers and obstetrical patients. The predominant thrombophilic mutations include the factor V Leiden mutation, prothrombin gene mutation G20210A, methylene tetrahydrafolate reductase C667T, and deficiencies of the natural anticoagulants proteins C and S, and antithrombin. Prospective cohort studies have ...
Pandian Zabeena - - 2013
Multiple embryo transfer during in vitro fertilisation (IVF) increases multiple pregnancy rates causing maternal and perinatal morbidity. Single embryo transfer is now being seriously considered as a means of minimising the risk of multiple pregnancy. However, this needs to be balanced against the risk of jeopardising the overall live birth ...
Cheong Ying C - - 2013
Acupuncture is commonly undertaken during an assisted reproductive technology (ART) cycle although its role in improving live birth and pregnancy rates is unclear. To determine the effectiveness and safety of acupuncture as an adjunct to ART cycles for male and female subfertility. All reports which described randomised controlled trials of ...
Johnson Mark - - 2013
Cardiac disease is the most important cause of maternal mortality and despite considerable efforts by cardiologists and obstetricians alike, the numbers of deaths continue to rise. The literature on the subject is limited and almost entirely made up of case series. In this editorial we consider the need for randomized ...
Arendt Katherine W - - 2013
The association between epidural labor analgesia and maternal fever is complex and controversial. Observational, retrospective, before-and-after, and randomized controlled trials all support the association, with the most current evidence supporting the mechanistic involvement of noninfectious inflammation. Considering the clinically significant neonatal consequences that have been previously demonstrated, and the possibility ...
Ilany Jacob - - 2013
Abstract Objective: We describe calcium homeostasis during pregestation and gestation in a woman with iatrogenic hypoparathyroidism, treated with continuous subcutaneous recombinant parathyroid hormone (PTH) (1-34) infusion. Results: The requirement for PTH did not fluctuate much during pregnancy and was essential for maintaining normal calcium and phosphorus serum levels. Conclusions: This ...
Siristatidis Charalampos - - 2013
Through a non-randomized clinical trial, we examined the theoretical benefit of the coadministration of low molecular weight heparin (LMWH) and prednisolone on pregnancy outcomes in women with previously failed IVF/ICSI cycles. Fifteen women constituted the study group, and were compared with 19 women receiving LMWH alone and another 18 women ...
Taylor Peter N PN Thyroid Research Group, Institute of Molecular Medicine, Cardiff University School of Medicine, Cardiff CF14 4XN, United - - 2013
Overt thyroid disease is associated with profound adverse health outcomes; however, data are conflicting for studies of borderline/subclinical thyroid dysfunction. Many studies of subclinical thyroid disease have had low power and were prone to selection bias. In contrast, large datasets are available from community studies in healthy individuals. Studies of ...
Robles Ana - - 2013
Abstract Oocyte donation can satisfy the desire to have children in women with premature ovarian failure (POF) but little progress has been made to improve reproduction using the patients' own gametes. The aim of this study was to assess the effectiveness of alternative treatments to oocyte donation in patients with ...
Giorlandino Claudio - - 2013
to verify whether vaginally intake of docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid, would improve length of gestation and newborn birth weight in high risk pregnancies for preterm delivery. this study was a randomized, double-blind, controlled, clinical trial, including women at high risk for preterm delivery. Of ...
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