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Teramo Kari A KA Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland. - - 2009
Tissue hypoxia is the major stimulus of erythropoietin (EPO) synthesis in fetuses and adults. Since EPO does not cross the placenta and is not stored, fetal plasma and amniotic fluid levels indicate EPO synthesis and elimination. Acutely, the rate and magnitude of the increase in plasma EPO levels correlate with ...
Chow Sharon S W - - 2008
The amniotic fluid cytokine profile has been shown to be indicative of various disease states, and changes may be associated with preterm labor or infection. Anti-inflammatory cytokine profiles may be essential for successful normal pregnancy. However, there are currently few normative data on the concentration of cytokines in amniotic fluids ...
Harman Christopher R - - 2008
The complex nature of amniotic fluid reflects contributions from many fetal systems, many functional roles, and multiple interactions with fetal maturation, obstetric, and maternal factors. Simple ultrasound measurement, probably done best with the maximum vertical pocket method, has a clinical role in fetal surveillance, substantiated by extensive level II and ...
Cebesoy Fatma Bahar - - 2009
OBJECTIVE: The objective was to determine whether pregnancy loss after amniocentesis is related to the amount of amniotic fluid obtained during the procedure. STUDY DESIGN: The study enrolled 2,400 women, all in their sixteenth to twentieth week of pregnancy. A 22G spinal needle was inserted for amniocentesis. The amount of ...
Huang Po-Chin - - 2009
Phthalates are developmental and reproductive toxicants for the fetus in pregnant rodents, and the ability of phthalates to penetrate the placenta have been reported. The aims of this study were to evaluate the association between maternal urine excretion, the exposure of fetus to phthalates in amniotic fluid, and the health ...
Bay Katrine - - 2008
BACKGROUND: According to animal studies, the testicular Leydig cell hormone insulin-like factor 3 (Insl3) exerts a fundamental role in abdominal testis translocation, which occurs in the beginning of the second trimester in humans. Despite this, human prenatal INSL3 production has been poorly investigated. METHODS: Amniotic fluid from 91 pregnant women ...
Chauhan Suneet P - - 2008
BACKGROUND: Intrauterine growth restriction (IUGR) is a complex problem in modern obstetrics. The presence of oligohydramnios is reported as an important diagnostic and prognostic factor in the management of a pregnancy complicated by IUGR. AIM: To determine the predictive accuracy of sonographic and actual amniotic fluid volume (AFV) to identify ...
Simsek Adnan - - 2008
OBJECTIVE: We sought to determine whether meconium-stained amniotic fluid is based on chronic hypoxia or not? In case of chronic hypoxia, higher red blood cell (Rbc) count and/or total hemoglobin levels (Hgb) and/or higher fetal hemoglobin (HbF) and/or lower adult hemoglobin (HbA) levels were expected when compared with controls. DESIGN: ...
Touboul Cyril - - 2008
OBJECTIVE: The aim of this study was to assess hourly fetal urine production rates (HFUPRs) and establish a nomogram by measuring bladder volumes with 3-dimensional ultrasound. STUDY DESIGN: Fetal urine bladder volume was estimated in 167 normal singleton pregnancies with neither oligohydramnios nor polyhydramnios, at a gestational age of 20-41 ...
Makrydimas George - - 2008
OBJECTIVE: To examine the distribution of placental growth factor (PlGF), vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sFlt-1) in maternal and embryonic fluid compartments in early pregnancy. METHOD: The concentrations of PlGF, VEGF and sFlt-1 were measured in coelomic fluid and maternal serum from 16 singleton pregnancies at ...
Anand-Ivell Ravinder - - 2008
BACKGROUND: Rodent studies suggest that the peptide hormone insulin-like factor 3 (Insl3) made by the fetal testis is responsible for the first transabdominal phase of testicular descent, and may be affected by xenobiotics to disrupt male reproductive tract development. To date, there is very little information on the production of ...
Stupin Jens H JH Department of Obstetrics, Charité-Universitätsmedizin, Berlin, Germany. - - 2008
The objective of the study is to compare outcomes after conservative management alone versus conservative management with cerclage in the treatment of amniotic sac prolapse in the second trimester. Retrospective, comparative study at a university hospital/tertiary referral centre. The medical data was provided by the files of 182 women who ...
Velez Digna R - - 2008
Spontaneous preterm birth (PTB-gestational age <37 weeks) occurs in approximately 450 000 births annually in the United States and is one of the leading causes of neonatal morbidity and mortality. Risk of PTB is affected by complex gene-environment interactions that are not well understood. We examined the PTB candidate gene, ...
Zhang Yao - - 2008
BACKGROUND: Methylmalonic aciduria (MMA) is the most frequent disease of organic aciduria in China. Various biochemical strategies are followed for the prenatal diagnosis of MMA. However, since fetuses affected by MMA have decreased excretion of methylmalonic acid, the difficulties of prenatal biochemical diagnosis are obvious. Gas chromatography mass spectrometry (GC/MS) ...
Mato Jampierre - - 2008
Amniotic fluid embolism (AFE), also referred to as anaphylactoid syndrome of pregnancy, is a rare obstetric emergency that may manifest itself at any time during pregnancy. AFE is believed to occur when the constituents of amniotic fluid enter the maternal circulation, leading to varying degrees of multiorgan compromise. AFE was ...
Buhimschi Irina A IA Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA. - - 2008
To estimate the relationship between histologic chorioamnionitis and four amniotic fluid proteomic biomarkers characteristic of inflammation (defensins 2 and 1, calgranulins C and A). One hundred fifty-eight women with singleton pregnancies had a clinically indicated amniocentesis to rule out inflammation and infection in the context of preterm labor or preterm ...
Das S - - 2008
Defensins are cytotoxic peptides and have a well-defined role in host defense. Human alpha defensins 1-3 (HNP1-3) are primarily produced by peripheral neutrophils and constitute about 50% of the azurphil granule protein. Studies have suggested that peripheral neutrophils and the resident neutrophils in the ovary enhance the release of IL-8 ...
Papaioannou Vasilios E - - 2008
Respiratory failure may develop during the later stages of pregnancy and is usually associated with tocolysis or other co-existing conditions such as pneumonia, sepsis, pre-eclampsia or amniotic fluid embolism syndrome. We present the case of a 34-year-old healthy woman with a twin pregnancy at 31 weeks and 6 days who ...
Pedreira D A L - - 2008
OBJECTIVE: To develop a new endoscopic approach to the correction of a myelomeningocele-like defect in fetal sheep. METHODS: The fetuses of 9 pregnant ewes, with an average gestational age of 115 days, were subjected to a 3.0 x 2.0 cm removal of the skin over the lumbar spine, performed through ...
Sago Haruhiko - - 2008
Anterior urethral valves are a rare congenital anomaly associated with distal urethral obstruction, which can result in a poor prognosis. We report on the endoscopic creation of a fetal urethrotomy for obstructive uropathy resulting from anterior urethral valves. A 33-year-old woman was evaluated at 17 weeks gestation due to fetal ...
Adama van Scheltema P N - - 2008
OBJECTIVE: To evaluate which of the commercially available solutions is best suited for amnioinfusion during fetoscopy, based on resemblance with the biochemical properties of amniotic fluid. MATERIALS AND METHODS: Amniotic fluid samples from 10 pregnancies were studied. Specimens were obtained from 5 pathologic pregnancies (of which 3 were complicated by ...
Nabhan Ashraf F - - 2008
Amniotic fluid volume is an important parameter in the assessment of fetal well-being. Oligohydramnios occurs in many high-risk conditions and is associated with poor perinatal outcomes. Many caregivers practice planned delivery by induction of labor or caesarean section after diagnosis of decreased amniotic fluid volume at term. There is no ...
Lee Si Eun SE Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of - - 2008
The purpose of this study was to determine if: 1) insulin-like growth factor binding protein-1 (IGFBP-1) in amniotic fluid (AF) exhibited proteolytic cleavage in cases of intra-amniotic inflammation; and 2) if the matrix metalloproteinases (MMP-3, MMP-8, MMP-9) in AF are associated with the degradation of IGFBP-1 in AF. AF samples ...
van de Beek Cornelieke - - 2009
Testosterone, estradiol, and progesterone levels were measured in the second trimester of pregnancy in maternal serum and amniotic fluid, and related to direct observations of gender-related play behavior in 63 male and 63 female offspring at age 13 months. During a structured play session, sex differences in toy preference were ...
Holst Rose-Marie - - 2007
OBJECTIVE: To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM). STUDY DESIGN: Cervical and amniotic fluid interleukin (IL)-6, IL-8, IL-18, monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 from ...
Lozano Jaime - - 2007
In recent years, the evaluation of in utero exposure to drugs of abuse has been achieved by testing biological matrices coming from the fetus or newborn (eg, meconium, fetal hair, cord blood, neonatal urine), the pregnant or nursing mother (eg, hair, blood, oral fluid, sweat, urine, breast milk), or from ...
Peitsidou A - - 2008
BACKGROUND: AFE (amniotic fluid embolism) is widely known as a disastrous rapid-progressing clinical entity. The incident ranges from 1:800 to 1:8,000. The mortality rate reaches 61-86%. Neonatal survival is reported at 70%. METHODS: We describe the case of a healthy 29-year old primigravida developing amniotic fluid embolism during labour. Acute ...
Tachi Masahiro - - 2008
Mass spectrometry (MS) with chemical ionization was found to be a useful tool for characterizing epidermal cholesterol esters (CE) and wax esters (WE), and was applied to analyse them in the epidermis of fetal, adult and keloidal human skin. Increases in the concentrations of CE and WE had occurred by ...
Cobo Tere - - 2007
OBJECTIVE: To assess the amniopatch procedure when premature rupture of membranes occurs after first-trimester chorionic villus sampling (CVS). STUDY DESIGN: From May 2001 to June 2004, the amniopatch procedure was offered in cases of premature rupture of membranes after CVS when severe oligohydramnios was present (largest vertical pocket < 2 ...
Nakatani Satoru - - 2007
PURPOSE: To evaluate the contribution of stem cell factor (SCF) to the pathogenesis of vernal keratoconjunctivitis (VKC), we determined levels of soluble SCF in the tear fluid of VKC patients. METHODS: Samples of tear fluid were obtained from 38 VKC patients and 13 normal controls after we received informed consent ...
Magann Everett F - - 2007
This study assessed whether the amniotic fluid index (AFI) or the single deepest pocket (SDP) is the best technique to estimate amniotic fluid volume. The AFI and SDP were compared to a dye-determined or directly measured amniotic fluid volume. A PUBMED search from 1990 to 2006 was conducted using the ...
Lu Szu-Ching - - 2007
OBJECTIVE: Amniotic fluid index (AFI) is a very useful index for assessing fetal well-being. In 1998, a study of AFI in mainland China showed that AFI values in normal pregnancies were less than those in Western populations. Therefore, we attempt to investigate whether fetal AFI in our population is less ...
Lee S M - - 2007
OBJECTIVES: Measurement of fetal urine production may provide a means of evaluating amniotic fluid volume, which is difficult to measure directly, and predicting fetal hypoxia. Although there have been some reports on fetal urine production, most of these have used two-dimensional (2D) ultrasonography to measure bladder volume. Three-dimensional (3D) ultrasonography ...
González Carmen - - 2007
Vasoconstriction and defective placental angiogenesis are key factors in the etiology of preeclampsia. Prolactin levels are elevated in maternal blood throughout pregnancy and the human decidua produces prolactin that is transported to the amniotic fluid. Prolactin is cleaved to yield vasoinhibins, a family of peptides that inhibit angiogenesis and nitric ...
Johnson Julie M - - 2007
OBJECTIVE: The objective of the study was to ascertain the diagnostic accuracy of 3 criteria of oligohydramnios in identifying 4 peripartum complications. STUDY DESIGN: The 3 definitions of oligohydramnios were amniotic fluid index (AFI) 5.0 cm or less and AFI <5% for gestational age (GA) using nomograms by Moore and ...
Harnett Erica L - - 2007
OBJECTIVE: This study determined whether a lipopolysaccharide (LPS) dose-dependent increase in fetal brain injury occurs to further characterize the relationship between maternal inflammation and fetal brain injury. STUDY DESIGN: Pregnant guinea pigs (n = 59) at 70% gestation were injected intraperitoneally with 1, 5, 25, 50, 100, 200, or 300 ...
Hong Joon Seok - - 2007
The aims of this study were to determine whether sonographically measured cervical length is of value in the identification of microbial invasion of the amniotic cavity in women with preterm premature rupture of membranes (PPROM) and to compare its performance with maternal blood C-reactive protein (CRP), white blood cell count ...
Sarkar P - - 2007
INTRODUCTION: Foetal exposure to testosterone is increasingly implicated in the programming of future reproductive and non-reproductive behaviour. Some outcomes associated with prenatal exposure to testosterone may be predicted from exposure to prenatal stress, suggesting a link between them. The peak serum levels of testosterone in the foetus are thought to ...
Hayashi Masatoshi - - 2007
PROBLEM: Macrophage colony-stimulating factor (M-CSF) promotes placental growth and maintenance. We evaluated whether amniotic fluid M-CSF levels were altered in normotensive pregnancies that produced small-for-gestational-age (SGA) infants arising from unknown factors. METHOD OF STUDY: This study enrolled 68 Japanese women experiencing normotensive pregnancies with single fetuses. Of these pregnancies, 22 ...
Bromley Bryann - - 2007
PURPOSE: To examine whether the third-trimester fetus can be assessed sonographically using 3-dimensional (3D) volume data sets. METHODS: Twenty-seven consecutive third-trimester fetuses were evaluated. Fetuses were scanned using 2-dimensional (2D) imaging followed by 5 3D volume acquisitions. The initial scan was interpreted and reported based on the 2D images. The ...
Umber Aneela - - 2007
OBJECTIVE: To determine the affect of acute intravenous maternal hydration on amniotic fluid volume in patients with third trimester oligohydramnios. STUDY DESIGN: Quasi experimental study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Gynaecology Unit III, Sir Ganga Ram Hospital, Lahore, from May 2001 to April 2002. PATIENTS AND ...
Augoustides-Savvopoulou P - - 2007
The prenatal diagnosis of two subsequent pregnancies of the mother of a patient homozygous for a mutation in the L-2-hydroxyglutarate dehydrogenase gene is described. In the first pregnancy, measurement of L-2-hydroxyglutaric acid in amniotic fluid revealed an affected fetus. This pregnancy was terminated. In the prenatal diagnosis of the second ...
Deering Shad H - - 2007
OBJECTIVE: Preterm premature rupture of membranes (PPROM) has been associated with an increased rate of fetal growth restriction (FGR). It is unknown whether impairment of fetal growth is mediated through external compression from decreased amniotic fluid volume or (an)other mechanism(s). METHODS: Over a three-year period all patients with singleton pregnancies ...
Sarkar P - - 2007
OBJECTIVE: There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship between cortisol in maternal plasma ...
Ellingsen Christian Lycke - - 2007
Amniotic fluid embolism (AFE) is a rare, but potentially fatal complication of pregnancy, with an incidence between 1 in 8000 and 1 in 80,000 pregnancies. The pathogenesis is not fully understood, but the generally accepted belief is that amniotic fluid enters the mother's circulation, most commonly via tears in the ...
Orsi Nicolas M - - 2007
Murine pregnancy is characterised by marked increases in serum cytokine profiles with advancing gestation, but whether these changes reflect concentrations in amniotic fluid is unknown. This study therefore profiled 23 cytokines by fluid-phase multiplex immunoassay of amniotic fluid and serum collected from naturally mated mice during mid- and late pregnancy ...
Barrilleaux P Scott - - 2007
OBJECTIVE: To evaluate the prognostic value of an amniotic fluid index (AFI) < or = 5 cm for an adverse perinatal outcome in pregnancies with the syndrome of hemolysis, elevated liver enzymes and low platelets (HELLP syndrome). STUDY DESIGN: A prospective, observational study of patients with the HELLP syndrome. An ...
Hackmon Rinat - - 2007
OBJECTIVE: To evaluate combined analysis with amniotic fluid index (AFI) and estimated fetal weight (EFW) for prediction of severe macrosomia at birth. STUDY DESIGN: In this retrospective case-control study, 50 term severe macrosomic newborns (birthweight [BW] > or = 97th percentile) were included in the study group and 100 appropriate ...
Riding George A - - 2008
In order to determine the variability inherent in conceptus-related measurements in first trimester bovine pregnancies, conceptus and fetometric parameters from beef cattle pregnancies (n=103) estimated to be between Days 36 and 103 of gestation were examined. During this period, the protein concentration of amniotic fluid ranged between 0.181 and 0.501mg/mL. ...
Chhabra S - - 2007
OBJECTIVE: To determine the usefulness of antepartum transabdominal amnioinfusion (APTA) in reducing perinatal morbidity and mortality due to oligohydramnios. METHODS: In this case-control study of 100 pregnant women with oligohydramnios, 50 received APTA and 50 were treated conservatively. These controls were matched for age, parity, and pregnancy duration with the ...
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