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Maloney Kelly W KW Center for Cancer & Blood Disorders, Children's Hospital Colorado, 13123 East 16th Avenue, B115, Aurora, CO 80045, - - 2015
Children with Down syndrome (DS) and acute leukemias acute have unique biological, cytogenetic, and intrinsic factors that affect their treatment and outcome. Myeloid leukemia of Down syndrome (ML-DS) is associated with high event-free survival (EFS) rates and frequently preceded by a preleukemia condition, the transient abnormal hematopoiesis (TAM) present at ...
Monti Giacomo G Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, - - 2015
Sepsis is one of the oldest and most elusive syndromes in medicine. With the confirmation of germ theory by Semmelweis, Pasteur, and others, sepsis was considered as a systemic infection by a pathogenic organism. Although the germ is probably the beginning of the syndrome and one of the major enemies ...
Miloslavsky Eli M EM Rheumatology Unit, Massachusetts General Hospital, Yawkey 2, 55 Fruit Street, Boston, MA 02114, - - 2015
The need to distinguish true primary systemic vasculitis from its multiple potential mimickers is one of the most challenging diagnostic conundrums in clinical medicine. This article reviews 9 challenging vasculitis mimickers: fibromuscular dysplasia, calciphylaxis, segmental arterial mediolysis, antiphospholipid syndrome, hypereosinophilic syndrome, lymphomatoid granulomatosis, malignant atrophic papulosis, livedoid vasculopathy, and immunoglobulin ...
Kuan Edward C EC Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, CHS 62-132, Los Angeles, CA, 90095-1624, USA, - - 2015
Empty nose syndrome (ENS) is a rare, late complication of turbinate surgery. The most common clinical symptoms are paradoxical nasal obstruction, nasal dryness and crusting, and a persistent feeling of dyspnea. Little is known about the pathogenesis of ENS, though it is speculated that anatomical changes leading to alterations in ...
Moroni Gabriella G Division of Nephrology, Fondazione Ca' Granda Ospedale Maggiore IRCCS, Via Della Commenda 15-20122 Milano, - - 2014
The term refractory lupus nephritis is generally used to indicate cases that do not respond to traditional treatment. However, the clinical presentation of lupus nephritis is variable and the time to response depends on the typology of the underlying renal syndrome. The criteria and the time for response are different ...
Karashima Takashi - - 2014
BackgroundWe report a case of a 33-year-old man who presented with immunoglobulin (Ig)G4-related disease (IgG4-RD) forming a pseudotumor in the left paratesticular region during oral administration of corticosteroid for Wells syndrome, which involves cellulitis with eosinophilia.Case presentationThe patient was introduced to our institution from a private hospital with a 3-month ...
Jin Xue-Li XL Xue-Li Jin, Xi-Bin Xiao, Lian-Sheng Huang, Xiao-Ying Zhao, Department of Hematology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, - - 2014
Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations and hemangiomas in the skin and visceral organs. The lesions often involve the cutaneous and gastrointestinal systems. Other organs can also be involved, such as the central nervous system, liver, and muscles. The most common ...
Schrock Lauren E LE Department of Neurology, University of Utah, Salt Lake City, Utah, - - 2014
Deep brain stimulation (DBS) may improve disabling tics in severely affected medication and behaviorally resistant Tourette syndrome (TS). Here we review all reported cases of TS DBS and provide updated recommendations for selection, assessment, and management of potential TS DBS cases based on the literature and implantation experience. Candidates should ...
Min Seung Yeon - - 2014
Multiple organ infarctions combined with Leriche syndrome due to embolic particles of myxoma are very rare. There is no definite guideline for immediate medical treatment. A 36-year-old married female was referred to the emergency department (ED) with severe pain of both lower extremities and gradual decreased mental status. Brain magnetic ...
Ryu Seunghyong S From the *Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center; †Center of Clinical Research, Samsung Biomedical Research Institute, Seoul; ‡Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-Do; §Seoul National Hospital; and ∥Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of - - 2014
This study investigates the clinical nature, prevalence rates, and associated factors of second-generation antipsychotic (SGA)-related tardive dyskinesia and tardive dystonia. To date, these subjects have not been thoroughly investigated.The subjects were 80 non-elderly schizophrenic patients who received SGAs for more than 1 year without any previous exposure to first-generation antipsychotics. ...
Li Chunyan C Department of Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301, Yanchang Road, Shanghai, - - 2015
The results from the published studies on whether the risk of metabolic syndrome is high among hematologic malignancies survivors are conflicting. The aims of this study are to conduct a systematic search and assess the literature to determine the available evidence on the association between metabolic syndrome and hematologic malignancies. ...
Besik Josef J Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech - - 2014
A 53-year-old female with idiopathic hypereosinophilic syndrome underwent recurrent tricuspid valve replacement for Löffler's endocarditis. We review the literature on tricuspid valve surgery in patients with this uncommon disorder.
Mazzoccoli Gianluigi G Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy, - - 2014
Behçet syndrome is a chronic disease hallmarked by inflammation of the blood vessels that is related to an autoimmune reaction caused by inherited susceptibility due to specific genes and environmental factors, probably components of infectious microorganisms, which turn on or get going the disease in genetically susceptible subjects. The more ...
Rosa Salazar Vladimir V Unidad de Corta Estancia/Trombosis, Servicio de Medicina Interna, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España. Electronic address: - - 2014
Paget-Schroetter syndrome (PSS) in the context of upper extremity deep venous thrombosis (DVT) is an uncommon but potentially very serious condition affecting young, healthy adults, in which secondary post-thrombotic syndrome (PTS) can be a complication with major implications. The best treatment option remains controversial, with current guidelines recommending anticoagulation for ...
Scharf Sebastian H SH Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, - - 2014
Fragile X syndrome (FXS) is the most common monogenic form of inherited mental retardation caused by a trinucleotid repeat expansion and transcriptional shutdown of the FMR1 gene. FXS patients present a complex and often severe neuropsychiatric phenotype yet have mild somatic symptoms, normal life expectancies, and no indications of neurodegeneration. ...
Jang Sung Ho SH Department of Physical Medicine and Rehabilitation, , College of Medicine, Yeungnam University , Seoul, Republic of - - 2014
Objective: Serotonin syndrome is a potentially life-threatening condition that can be caused by administration of agents that increase serotonergic activity in the brain. We report here on 2 stroke patients who presented with serotonin syndrome following administration of dopaminergic agents. Case report: Two stroke patients were administered ropinirole (patient 1) ...
Zhao Defeng D Department of Hematology, Navy General Hospital, Beijing 100048, P.R. - - 2014
Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome, is an aggressive hyperinflammatory condition characterized by prolonged fever, cytopenias and hepatosplenomegaly, as well as hemophagocytosis by activated, morphologically benign macrophages. HLH may be characterized into two forms, familial and secondary HLH. Familial HLH usually manifests in children with genetic abnormalities associated ...
Donovan Summer S Pediatric Infectious Diseases Fellow, Virginia Commonwealth University Health System, VCU Sanger Hall 12-041, P.O. Box 980163, Richmond, VA, 23298-0163, USA, - - 2014
Intravenous immunoglobulin (IVIG) has been suggested for the treatment of many ailments due to its ability to modulate the immune system and to provide passive immunity to commonly circulating pathogens. Its use as primary and adjunctive therapy for the treatment of conditions affecting critically ill patients is an attractive option, ...
Hidlay Douglas T DT Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, P.O. Box 980631, Richmond, VA 23298 - - 2014
Thoracic outlet syndrome is an uncommon cause of upper extremity neuropathy resulting from either neurogenic or vascular compromise in the thoracic outlet. Congenital anomalies as the cause of this disease process represent a minority of cases, and the literature regarding their surgical management is still evolving. A 42-year-old female without ...
Vigneri Simone S *Department of Neuroscience/Rehabilitation, Neurophysiology Unit, Arcispedale Sant'Anna, University of Ferrara, Ferrara, Italy; and †Department of Morphology, Surgery and Experimental Medicine, Anaesthesia and Intensive Care Unit, Arcispedale Sant'Anna, University of Ferrara, Ferrara, - - 2014
A 69-year-old white man was admitted because of a clinical history of persistent cough and fever. Chest x-rays showed bilateral lung infiltrates with air bronchograms, whereas the urine antigen test resulted positive for Legionella pneumophila. The next day, he was transferred to the intensive care unit and intubated because of ...
Walsh Christopher J CJ Department of Medicine, Institute of Medical Sciences, Keenan Centre for Biomedical Science, Li Ka Shing Knowledge institute, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, - - 2014
Survivors of acute respiratory distress syndrome often sustain muscle wasting and functional impairment related to intensive care unit (ICU)-acquired weakness (ICUAW) and this disability may persist for years after ICU discharge. Early diagnosis in cooperative patients by physical examination is recommended to identify patients at risk for weaning failure and ...
Hough Catherine L CL Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Mailstop 359762, Seattle, WA 98104, USA. Electronic address: - - 2014
The development and severity of acute respiratory distress syndrome (ARDS) are closely related to dysregulated inflammation, and the duration of ARDS and eventual outcomes are related to persistent inflammation and abnormal fibroproliferation. Corticosteroids are potent modulators of inflammation and inhibitors of fibrosis that have been used since the first description ...
Curley Gerard F GF Department of Anesthesia, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, 30, Bond Street, Toronto, Ontario M5B 1W8, - - 2014
Our ability to define appropriate molecular targets for preclinical development and develop better methods needs to be improved, to determine the clinical value of novel acute respiratory distress syndrome (ARDS) agents. Clinical trials must have realistic sample sizes and meaningful end points and use the available observation and meta-analytical data ...
Sanchez Juan F JF Pulmonary and Critical Care Medicine Division, Baylor Scott and White Healthcare, 2401 South 31st street, Temple, TX 76508, - - 2014
Immunosuppression predisposes the host to development of pulmonary infections, which can lead to respiratory failure and the development of acute respiratory distress syndrome (ARDS). There are multiple mechanisms by which a host can be immunosuppressed and each is associated with specific infectious pathogens. Early invasive diagnostic modalities such as fiber-optic ...
Moazed Farzad F Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, M1097 Box 0111, San Francisco, CA 94143-0111, - - 2014
Acute respiratory distress syndrome (ARDS) remains a major cause of morbidity and mortality in critically ill patients. Over the past several decades, alcohol abuse and cigarette smoke exposure have been identified as risk factors for the development of ARDS. The mechanisms underlying these relationships are complex and remain under investigation ...
Sweatt Andrew J AJ Division of Pulmonary and Critical Care Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, - - 2014
This article reviews the evolving definitions and epidemiology of the acute respiratory distress syndrome (ARDS) and highlights current efforts to improve identification of high-risk patients, thus to target prevention and early treatment before progression to ARDS. This information will be important for general practitioners and intensivists interested in improving the ...
de Leon Jose J 1University of Kentucky Mental Health Research Center at Eastern State - - 2014
Personalised medicine has finally been featured in psychiatric journals, but psychiatrists have mainly focused on the promise of using disease mechanisms to personalise treatment. Psychiatric disorders such as schizophrenia and depression are not diseases, in the medical sense, and are probably more like syndromes. Instead of spending much time and ...
Castelo-Branco Camil C Gynaecologic Endocrinology Unit, Clinic Institute of Gynaecology, Obstetrics and Neonatology - Hospital Clinic, Faculty of Medicine, University of Barcelona, IDIBAPS, Spain. Electronic address: - - 2014
To describe in practical terms the clinical management in adult life of patients with Turner syndrome. Systematic review of the literature and practical issues. An evaluation of clinical trials, meta-analysis, case reports and reviews assessing the management of different conditions related to Turner syndrome was done using the following data ...
Jordan Barry D - - 2014
Growing public health concern exists over the incidence of chronic traumatic brain injury (TBI) in athletes participating in contact sports. Chronic TBI represents a spectrum of disorders associated with long-term consequences of single or repetitive TBI and includes chronic traumatic encephalopathy (CTE), chronic postconcussion syndrome, and chronic neurocognitive impairment. Neurologists ...
Liew Felicity F Medical Student in the School of Medicine, University College London, - - 2014
Acute respiratory distress syndrome is a life-threatening condition that is common in critically ill patients. Historically, diagnosis has been difficult and prognosis has been poor, but the Berlin definition and developments in medical therapies provide promise that we can improve outcomes for these patients in the future.
Bhattacharya Kaustuv - - 2014
BackgroundMorquio A syndrome is an autosomal recessive lysosomal storage disease often resulting in life-threatening complications. Early recognition and proficient diagnosis is imperative to facilitate prompt treatment and prevention of clinical complications.MethodsExperts in Asia Pacific reviewed medical records focusing on presenting signs and symptoms leading to a diagnosis of Morquio A ...
Rupa-Matysek Joanna J Department of Haematology, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569, Poznan, Poland, - - 2014
Acquired von Willebrand syndrome (AVWS) is an acquired bleeding disorder with clinical and laboratory features similar to those of the inherited form of the disease. AVWS is reported in many disorders, most frequently in myeloproliferative neoplasms and in, among others, essential thrombocythemia (ET). Interestingly, ET is associated with both the ...
Szeredi L L Veterinary Diagnostic Directorate, National Food Chain Safety Office, Budapest, - - 2014
Cases of acute tracheal oedema and haemorrhage with fibrinonecrotic tracheitis have been described in Hungarian pig herds. Clinical signs and gross and microscopical tracheal lesions bore resemblance to those of bovine 'honker syndrome'. Diagnostic examination of affected tracheas and corresponding lungs revealed the presence of a variety of agents; however, ...
Abu-Assi Emad E Emad Abu-Assi, Sergio Raposeiras-Roubín, José María García-Acuña, José Ramón González-Juanatey, Department of Cardiology, University Clinical Hospital of Santiago de Compostela, 15071 Santiago de Compostela, - - 2014
Major bleeding is currently one of the most common non-cardiac complications observed in the treatment of patients with acute coronary syndrome (ACS). Hemorrhagic complications occur with a frequency of 1% to 10% during treatment for ACS. In fact, bleeding events are the most common extrinsic complication associated with ACS therapy. ...
Merritt Wyndell H WH Division of Plastic & Reconstructive Surgery, Virginia Commonwealth University, 830 East Main Street, Richmond, VA 23298, USA; Department of Plastic & Maxillofacial Surgery, University of Virginia, 1215 Lee Street, Charlottesville, VA 22903, USA. Electronic address: - - 2015
There is no consensus regarding etiology or best surgical technique for severe Raynaud syndrome in patients with connective tissue disease. Observations after 30 years' experience in more than 100 cases led to the conclusion that an extended periarterial sympathectomy (with or without vein-graft reconstruction) and adjunctive use of Botox topically will ...
Braga-Mele Rosa R From the University of Toronto, Toronto, Canada (Braga-Mele); University of California, San Francisco, San Francisco, CA (Chang); Tufts University School of Medicine, Boston, MA (Henderson); Moran Eye Centre, University of Utah, Salt Lake City, UT (Mamalis); Northwest Eye Surgeons, Seattle, WA (Talley-Rostov); Raghudeep Eye Clinic, Ahmedabad, India (Vasavada). Electronic address: - - 2014
Endophthalmitis is a rare but potentially devastating complication of cataract surgery. This article presents an overview of endophthalmitis prophylaxis and the use of intracameral antibiotics. It highlights available intracameral antibiotics with respect to pharmacology, spectrum of activity, dosage and preparation, safety, and efficacy profiles, as well as toxic anterior segment ...
Desai M J MJ International Spine, Pain & Performance Center, Washington DC, USA. Electronic address: - - 2014
Failed back surgery syndrome (FBSS) constitutes a constellation of symptoms grouped together and attributed to prior surgical intervention. Clinicians often poorly understand the heterogeneity of this condition combined with the etiological factors responsible for its development. Therefore, it would follow that an algorithmic treatment approach to patients diagnosed with this ...
Trikudanathan Subbulaxmi S Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medical Center, 4245 Roosevelt Way Northeast, Seattle, WA 98105, USA. Electronic address: - - 2015
Polycystic ovarian syndrome (PCOS) is a complex and phenotypically heterogeneous endocrine disorder that typically presents in reproductive-aged women. Key clinical components include hyperandrogenism, menstrual irregularities, infertility, and cardiometabolic abnormalities. Definition of PCOS has been confusing and controversial because of the lack of consistent diagnostic criteria. Management choices in women with ...
Tawfik Hatem A HA *Department of Ophthalmology, Ain Shams University, Cairo, Egypt; and †Ain Shams University, Cairo, - - 2014
To review the recent literature and describe the authors' experience with congenital upper eyelid coloboma. In this review, we will summarize the embryologic and etiopathogenetic bases of congenital upper eyelid coloboma, and study the published clinical reports. We will also attempt to briefly shed some light on the rarer syndromic ...
Chaudhry Priyanka P Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, - - 2014
To report a case series of hiccup as a migraine aura. Hiccup is a syndrome of inappropriate muscle contraction. To our knowledge, hiccup as a migraine aura has not been reported. We describe series of patients who presented with hiccups as their migraine aura symptom. Hiccups can present as a ...
Giannetti Paolo P 1 Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK - - 2014
The most accurate predictor of the subsequent development of multiple sclerosis in clinically isolated syndrome is the presence of lesions at magnetic resonance imaging. We used in vivo positron emission tomography with (11)C-(R)-PK11195, a biomarker of activated microglia, to investigate the normal-appearing white matter and grey matter of subjects with ...
Bunchorntavakul Chalermrat C Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Ratchathewi, Bangkok 10400, - - 2015
Overlapping features between autoimmune hepatitis (AIH) and cholestatic disorders (primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), or indeterminate cholestasis), so-called overlap syndromes, usually have a progressive course toward cirrhosis and liver failure without adequate treatment. The diagnosis of overlap syndrome requires the prominent features of classic AIH and secondary ...
Siddiqui Nauman N 1Department of Medicine, University of Toledo Medical Center, Toledo, OH; and 2Division of Hematology and Oncology, Department of Pathology, University of Toledo Medical Center, Toledo, - - 2014
Evan syndrome (ES) is a rare hematological disorder that involves 2 or more immune cytopenias. It usually includes autoimmune hemolytic anemia and autoimmune thrombocytopenia. Although occasionally associated with immune neutropenia, its association with disseminated intravascular coagulation (DIC) is rare. And, early diagnosis with appropriate intervention is important because mortality from ...
Spiri Daniele - - 2014
ImportanceMigraine is a common disorder and a frequent cause of medical consultation in children. Many childhood episodic syndromes have been described as common precursors of migraine.ObjectiveTo review current knowledge on migraine and childhood episodic syndromes, and to discuss future directions for research and clinical practice.FindingsFor most children it is difficult ...
O'Neill S S School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, - - 2014
Obesity is reaching epidemic proportions with recent worldwide figures estimated at 1.4 billion and rising year-on-year. Obesity affects all socioeconomic backgrounds and ethnicities and is a pre-requisite for metabolic syndrome. Metabolic syndrome is a clustering of risk factors, such as central obesity, insulin resistance, dyslipidaemia and hypertension that together culminate ...
Halcox Julian J 1 University of Swansea , Singleton Park, Swansea, United Kingdom - - 2014
Abstract Individuals with mixed atherogenic dyslipidemia, type 2 diabetes mellitus (T2DM), and metabolic syndrome are at high risk of developing cardiovascular disease (CVD) and can often benefit greatly from preventive lifestyle and medical interventions. These conditions typically co-exist in an individual, and the lipid profiles associated with them have several ...
Hanna Elias B EB Department of Medicine, Cardiovascular Section, Louisiana State University, New Orleans, - - 2014
Congestion and acute renal dysfunction are at the center of acute heart failure (HF) syndromes. Acute cardiorenal syndrome, which refers to worsening of renal function in a patient with acute HF syndrome, is partly related to venous congestion and high renal afterload. Aggressive decongestion improves renal and myocardial flow and ...
González-Martín-Moro J J Servicio de Oftalmología, Hospital Universitario del Henares, Madrid, España. Electronic address: - - 2014
To determine the incidence and the risk factors involved in the development of the three main postoperative capsular complications: posterior capsule opacification (PCO), capsular bag distension syndrome (CBDS), and anterior capsular phimosis syndrome (ACP). A retrospective cohort study was conducted on 801 patients submitted to cataract surgery in the ophthalmology ...
Costa Luisa L Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, via S. Pansini 5, 80131, Naples, Italy, - - 2014
The aim of the study was to evaluate the influence of metabolic syndrome (MetS) on achieving minimal disease activity (MDA) in psoriatic arthritis (PsA) patients treated with anti-tumor necrosis factor (TNF)-α with a follow-up period of 24 months. A cohort of PsA patients was assessed at the University Federico II of ...
Ganzetti G G Dermatological Clinic, Department of Clinical and Molecular Medicine, Polytechnic MarcheUniversity, Ancona, Italy - - - 2014
Toxic epidermal necrolysis (TEN), also known as Lyell syndrome, is a potential life--threatening muco--cutaneous disease with important systemic implications. It affects the skin and mucous membranes, with involvement of more than 30% of body surface and it is mostly caused by drugs. Although the pathogenesis is not fully elucidated, it ...
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