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Jeppesen Palle B PB Department of Medical Gastroenterology CA-2121, Rigshospitalet, Copenhagen, - - 2014
The approval of teduglutide, a recombinant analog of human glucagon-like peptide (GLP) 2, by the US Food and Drug Administration (Gattex) and the European Medicines Agency (Revestive) has illustrated the potential of selected gut hormones as treatments in patients with short-bowel syndrome and intestinal failure. Gut hormones may improve the ...
Uzunoglu Yener Y Yener Uzunoglu, Omer Yalkin, Guner Cakmak, Department of General Surgery, Sakarya University Research and Educational Hospital, 54100 Sakarya, - - 2014
Abdominal cocoon syndrome is a rare cause of intestinal obstruction with unknown etiology. Diagnosis of this syndrome, which can be summarized as the small intestine being surrounded by a fibrous capsule not containing the mesothelium, is difficult in the preoperative period. A 47-year-old male patient was referred to the emergency ...
Crawshaw Graham G Toronto Zoo, Toronto, Ontario, - - 2014
The endangered Puerto Rican crested toad (Peltophryne [Bufo] lemur) has been held and bred in zoos for release into protected areas in Puerto Rico since 1982. In 2004, several cases of a novel syndrome of skin changes in toads were noticed at the Toronto Zoo. A total of 21 toads ...
Coletta Riccardo R Paediatric Autologous Bowel Reconstruction and Rehabilitation Unit, Royal Manchester Children׳s Hospital, Oxford Rd, Manchester M13 9WL, UK; School of Medicine, University of Manchester, Manchester, - - 2014
The main cause of intestinal failure in children is due to short bowel syndrome (SBS) resulting from congenital or acquired intestinal lesions. From the first lengthening procedure introduced by Bianchi, the last three decades have seen lengthening procedures established as fundamental components of multidisciplinary intestinal rehabilitation programs. Debate on indications ...
Valle Raffaele Dalla RD Raffaele Dalla Valle, Maurizio Iaria, Department of Surgery, Division of General Surgery and Organ Transplantation, Parma University Hospital, 43121 Parma, - - 2014
Blind loop syndrome after side-to-side ileocolonic anastomosis is a well-recognized entity even though its incidence and complication rates are not clearly defined. The inevitable dilation of the ileal cul-de-sac leads to stasis and bacterial overgrowth which eventually leads to mucosal ulceration and even full-thickness perforation. Blind loop syndrome may be ...
Mok Yee Hui YH Children's Intensive Care Unit, KK Women's and Children's Hospital, 100 Bukit Timah Road, - - 2014
Acute respiratory distress syndrome (ARDS) is a devastating process that involves pulmonary inflammation, alveolar damage and hypoxemic respiratory failure. Although advances in management approaches over the past two decades have resulted in significantly improved outcomes, death from pediatric ARDS may still occur in up to 35% of patients. While invasive ...
Rozé H H Service d'anesthésie-réanimation II, unité de réanimation polyvalente de la Maison du Haut-Lévêque, hôpital Haut-Lévêque, CHU de Bordeaux, avenue Magellan, 33600 Pessac, France; Inserm, adaptation cardiovasculaire à l'ischémie, U1034, université Bordeaux, 33600 Pessac, France. Electronic address: - - 2014
The purpose of this review is to examine the indications of extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS). This technique of oxygenation has significantly increased worldwide with the H1N1 flu pandemic. The goal of ECMO is to maintain a safe level of oxygenation and controlled respiratory ...
Honarpisheh Hedieh H *Department of Pathology; and †Department of Dermatology and Pathology, Smilow Cancer Center, Yale School of Medicine, New Haven, - - 2014
: Purpura fulminans (PF) is associated with several infections and most commonly with meningococcemia. However, there are only a few reports of this entity in association with toxic shock syndrome toxin-1-producing Staphylococcus aureus. We report a 53-year-old man who presented with fever, progressive hemodynamic instability, multiorgan failure, and thrombocytopenia following ...
Cunha Cheston B CB Division of Infectious Disease; Rhode Island Hospital and The Miriam Hospital; Providence, RI USA; Division of Infectious Disease; Brown University Alpert School of Medicine; Providence, RI - - 2014
Coronaviruses have traditionally been associated with mild upper respiratory tract infections throughout the world. In the fall of 2002, a new coronavirus emerged in in Asia causing severe viral pneumonia, i.e., severe acute respiratory syndrome (SARS). Nearly a decade following the SARS epidemic, a new coronavirus causing severe viral pneumonia ...
Yung Evan E EE Department of Pathology, and Department of Surgery, Los Angeles County-University of Southern California Medical Center, Los Angeles, California - - 2014
Strongyloidiasis is a parasitic disease caused by Strongyloides stercoralis, a nematode predominately endemic to tropical and subtropical regions, such as Southeast Asia. Autoinfection enables the organism to infect the host for extended periods. Symptoms, when present, are non-specific and may initially lead to misdiagnosis, particularly if the patient has additional ...
Celik Gulperi G Department of Internal Medicine, Department of Internal Medicine, Division of Nephrology, Selcuk University, Konya, - - 2014
We describe herein a case of hypokalemia due to proximal renal tubular acidosis (RTA) and Fanconi's syndrome (FS) and nephrogenic diabetes insipidus with DIC - a rare complication of Sjögren's syndrome (SS) and brucellosis. The interesting feature of this case was the presentation with severe hypokalemia, causing acute flaccid quadriparesis ...
van den Berg Bianca B Department of Neurology, Erasmus MC University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, - - 2014
Guillain-Barré syndrome (GBS) is a potentially life-threatening postinfectious disease characterized by rapidly progressive, symmetrical weakness of the extremities. About 25% of patients develop respiratory insufficiency and many show signs of autonomic dysfunction. Diagnosis can usually be made on clinical grounds, but lumbar puncture and electrophysiological studies can help to substantiate ...
Poissy J J Pôle de Réanimation, Hôpital Roger Salengro, Centre Hospitalier Régional et Universitaire de Lille, Université de Lille 2, Lille Cedex, France. Electronic address: - - 2014
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus involved in severe acute respiratory distress syndrome (ARDS) and rapid renal failure. Hospital outbreak and nosocomial transmission were reported, however, several issues remain on the viral excretion course. Describe the kinetics and pattern of viral excretion in two infected patients. ...
Nadeau Pierre L PL aDepartment of Cardiology bDepartment of Pathology, Institut universitaire de cardiologie et de pneumologie de Québec, Quebec City, Quebec, - - 2014
Churg-Strauss syndrome (CSS) is a rare entity that is characterized by widespread vasculitis, which affects both small and medium-sized blood vessels of nearly all organs. More than 50% of these cases have cardiac involvement, which is the major cause of morbidity and mortality. We describe a case of a patient ...
Ezeani I U IU Department of Medicine, Federal Medical Center, Umuahia, Abia State, - - 2014
Tropical diabetic hand syndrome is a term used to describe diabetes complication of the hand affecting people in the tropics. It consists of localized cellulitis with variable swelling and ulceration of the hands, progressive, fulminant hand sepsis and gangrene in extreme cases. This syndrome is not well-recognized and is therefore ...
Kaushik Rupesh R Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, - - 2014
Acute flaccid paralysis (AFP) is a complex clinical syndrome with a broad array of potential etiologies that vary with age. We present our experience of acute onset lower motor neuron paralysis. One hundred and thirty-three consecutive adult patients presenting with weakness of duration less than four weeks over 12 months ...
Dieks Jana-Katharina JK Department of Pediatric Cardiology and Intensive Care Medicine, University Hospital, Georg-August University Göttingen, Robert-Koch Str. 40, 37075, Göttingen, Germany, - - 2014
To date, the genetic basis of Dubowitz syndrome (short stature, microcephaly, facial abnormalities, eczema) is unknown and vascular complications are not known to be associated with this syndrome. In microcephalic osteodysplastic primordial dwarfism type II (MOPD II; disproportionate short statue, microcephaly, facial abnormalities), however, cerebral aneurysms and other vascular abnormalities ...
Lloyd Isaac E IE a University of Utah, - - 2014
Abstract Scimitar syndrome is a congenital anomaly occurring in approximately 1/50,000 births, consisting of partial anomalous pulmonary venous return, right lung hypoplasia, and several associated defects. The condition generally has significant morbidity and mortality, but the underlying cause is poorly understood. In this report, we describe two autopsy cases of ...
Durvasula Venkata S P B VS Department of Pediatric Otolaryngology, Arkansas Children's Hospital, Little - - 2014
Supraglottoplasty (SGP) failure is frequently attributed to coexistent medical comorbidities, but studies specifically evaluating outcomes in these populations are lacking. To assess SGP outcomes in patients with neurologic and syndromic comorbidities and severe laryngomalacia (LM). Case series with retrospective review of medical records of 54 patients with neurologic and/or syndromic ...
Trikudanathan Guru G Division of Gastroenterology, University of Minnesota, Minneapolis, - - 2014
The association of acute pancreatitis (AP) with intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) has only recently been recognized. The detrimental effects of raised intra-abdominal pressure in cardiovascular, pulmonary and renal systems have been well established. Although IAH was associated with a higher APACHE II score and multi-organ dysfunction ...
Plaza-Benhumea L L Departamento de Genética, Hospital para el Niño IMIEM, - - 2014
Trichorhinophalangeal syndrome type II, also known as Langer-Giedion syndrome, (TRPS II, OMIM 150230) is a contiguous gene deletion syndrome (1). Depending on the size and position of the heterozygous deleted region, the genetic defect principally involves the TRPS1, RAD21, and EXT1 genes. TRPS II,, combines the clinical features of trichorhinophalageal ...
Shalaby Tamer T Health Education Kent Surrey Sussex and Maidstone Hospital, Maidstone, UK - - 2014
Toxic shock syndrome (TSS) represents a fascinating example of immune activation caused by infection resulting in a dramatic and challenging clinical syndrome. TSS is commonly associated with tampon use and still causes significant morbidity and mortality in young healthy women. A misconception is that TSS presents with a skin rash ...
Iwasa Tadashi - - 2014
Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder, characterized by episodic life-threatening hypotension, hypoalbuminemia, and hemoconcentration. A 10 year old girl presented with abdominal pain, vomiting, diarrhea, fever and developed generalized edema a day after admission. Clinical and laboratory findings were consistent with ISCLS. She received aggressive fluid ...
Athota Krishna P KP Department of Surgery, University of Cincinnati, Cincinnati, OH, - - 2014
In this article we propose a practical approach to the use of prone therapy for acute respiratory distress syndrome (ARDS). We have attempted to provide information to improve the understanding and implementation of prone therapy based on the literature available and our own experience. We review the basic physiology behind ...
Maitra Souvik S From the Department of Anaesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India (S.M., S.B., D.K.B.); and Department of Anaesthesiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India - - 2014
Despite implementation of lung-protective ventilation strategy, acute respiratory distress syndrome is associated with significant mortality, which necessitates the evaluation of ventilatory modes other than conventional lung-protective strategy. This meta-analysis of the randomized controlled trials has been undertaken to know whether high-frequency oscillatory ventilation (HFOV) provides any mortality benefit over conventional ...
Rivière Sébastien S AP-HP, Hôpital Saint Antoine, service de Médecine Interne, Paris, F-75012, France; UPMC Université Paris 06, Faculté de Médecine Pierre et Marie Curie, Paris, F-75012, France. Electronic address: - - 2014
Current knowledge in reactive hemophagocytic syndrome mainly relies on single-centre case series including a relatively small number of patients. We aimed to identify a multicenter large cohort of adult patients with reactive hemophagocytic syndrome and to describe relevant clinical and laboratory features, underlying conditions and outcome. We conducted a multicenter ...
Li Stephanie S Penn State Hershey Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, - - 2014
We report a case of Takotsubo's syndrome in a 37-year-old woman after mitral valve repair for severe mitral regurgitation triggered by a severe protamine reaction that was likely associated with immune-mediated coronary hypersensitivity (Kounis' syndrome) and made worse by resuscitation with high doses of catecholamines. The patient recovered fully after a ...
Marraro Giuseppe A GA Healthcare Accountability Lab, Departmental Section of Legal Medicine, University of Milan, - - 2014
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that lacks definitive treatment. The cornerstone of management is sound intensive care treatment and early anticipatory ventilation support. A mechanical ventilation strategy aiming at optimal alveolar recruitment, judicious use of positive end-respiratory pressure (PEEP) and low tidal volumes (VT) remains the ...
Banzal Subodh S Department of Medicine, Sri Aurobindo Medical College, Indore, Madhya Pradesh, - - 2014
Autoimmune polyendocrine syndrome Type II (APS II), also known as polyglandular autoimmune syndrome Type II or Schmidt syndrome, is constellations of multiple endocrine gland insufficiencies. It is a rare, but most common of the immunoendocrinopathy syndrome. It is characterized by the obligatory occurrence of autoimmune Addison's disease in combination with ...
Thomas Mark M 1Department of Neonatal Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, United - - 2014
Mitochondrial DNA depletion syndromes are an important cause of mitochondrial cytopathies in both children and adults. We describe a newborn with multiple congenital malformations including a right aberrant subclavian artery and a trachea-oesophageal fistula in whom mitochondrial depletion syndrome was unmasked by perioperative muscle relaxation. After vecuronium infusion, the infant ...
Osterbur K K Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, - - 2014
Multiple organ dysfunction syndrome (MODS), defined as the presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention, is a cause of high morbidity and mortality in humans and animals. Many advances have been made in understanding the pathophysiology and treatment of ...
Kongsted Hanne - - 2014
The study evaluated the effect of New Neonatal Porcine Diarrhoea Syndrome (NNPDS) on average daily gain (ADG) and mortality and described the clinical manifestations in four herds suffering from the syndrome. NNPDS is a diarrhoeic syndrome affecting piglets within the first week of life, which is not caused by enterotoxigenic ...
Deutschman Clifford S CS Department of Anesthesiology and Critical Care and Surgery and Sepsis Research Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: - - 2014
Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity and mortality worldwide. Current immunological mechanisms do not explain the basis of cellular dysfunction and organ failure, the ultimate cause of death. Here we review current dogma and argue that it is time ...
Bos Lieuwe D J LD Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
There is a need for biological markers of the acute respiratory distress syndrome (ARDS). Exhaled breath contains hundreds of metabolites in the gas phase, some of which reflect (patho)physiological processes. We aimed to determine the diagnostic accuracy of metabolites in exhaled breath as biomarkers of ARDS.Breath from ventilated intensive care ...
Radhakrishnan Rupa R Department of Radiology, Cincinnati Children's Hospital Medical Center, MLC 5031, 3333 Burnet Ave., Cincinnati, OH, 45229-3039, - - 2014
Down syndrome, or trisomy 21, is the most common chromosomal anomaly and is characterized by intellectual disability and a typical facies. People with Down syndrome can have abnormalities of multiple organ systems. Cardiac and respiratory system involvement is the most common cause of morbidity and mortality, although every organ system ...
Cabrera-Benitez Nuria E NE From the Keenan Research Centre in Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada (N.E.C.-B., J.G.L., J.V., H.Z., A.S.S.); CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain (N.E.C.-B., J.V.); Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain (N.E.C.-B., J.V.); Departments of Anesthesia and Physiology, University of Toronto, Toronto, Ontario, Canada (J.G.L., H.Z.); Department of Medicine, Unit of Anesthesiology and Intensive Care, Medical School, University of Padua, Azienda Ospedaliera di Padova, Padua, Italy (M.P.); Department of Anesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany (P.M.S.); and Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (H.Z., - - 2014
One of the most challenging problems in critical care medicine is the management of patients with the acute respiratory distress syndrome. Increasing evidence from experimental and clinical studies suggests that mechanical ventilation, which is necessary for life support in patients with acute respiratory distress syndrome, can cause lung fibrosis, which ...
Reilly John P JP University of Pennsylvania, Perelman School of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Philadelphia, Pennsylvania, United States, University of Pennsylvania, Perelman School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania, United States ; - - 2014
Rationale: The acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that can develop at various times after major trauma. Objective: To identify and characterize distinct phenotypes of ARDS after trauma based on timing of syndrome onset. Methods: Latent class analyses were used to identify patterns of ARDS onset in ...
Boyle Andrew James AJ Queen's University Belfast, Centre for Infection and Immunity , Belfast , UK - - 2014
Introduction: The acute respiratory distress syndrome (ARDS) is characterised by life-threatening respiratory failure requiring mechanical ventilation, and multiple organ failure. It has a mortality of up to 30 - 45% and causes a long-term reduction in quality of life for survivors, with only approximately 50% of survivors able to return ...
Grasso Salvatore S 1Dipartimento dell'Emergenza e Trapianti d'Organo, Sezione di Anestesiologia e Rianimazione, Università degli Studi Aldo Moro, Bari, Italy. 2Intensive Care, Ospedale Di venere, Bari, Italy. 3Dipartimento dell'Emergenza e Trapianti d'Organo, Sezione di Chirurgia Veterinaria, Università degli Studi Aldo Moro, Bari, Italy. 4Dottorato in Scienze Chirurgiche Sperimentali e Terapie Cellulari, Università degli Studi Aldo Moro, Bari, Italy. 5Center for Anesthesiology, Emergency and Intensive Care Medicine, University Medical Center Göttingen, Göttingen, Germany. 6Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Università degli Studi Aldo Moro, Bari, - - 2014
The Acute Respiratory Distress Syndrome Network protocol recommends limiting tidal volume and plateau pressure; it also recommends increasing respiratory rate to prevent hypercapnia. We tested a strategy that combines the low tidal volume with lower respiratory rates and minimally invasive CO2 removal. Ten lung-damaged pigs (instilled hydrochloride). Two conditions randomly ...
Hurst Jonathan J Department of Ophthalmology, Queen's University , Kingston , - - 2014
Abstract Introduction: Orbital compartment syndrome may rarely occur in the setting of burns where therapy includes aggressive fluid resuscitation. Case: We report a case of bilateral orbital compartment syndrome in a 13-year-old male, with superficial facial burns secondary to hydrobromic acid, who did not receive aggressive fluid resuscitation. The patient ...
Luedike Peter P Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty Heinrich-Heine-University, University Hospital Düsseldorf, Düsseldorf, - - 2014
Early identification of acute respiratory distress syndrome (ARDS) and forceful implementation of standardized therapy algorithms are the mandatory basis of an effective therapy to improve patient outcome. Recently, a new definition of ARDS was implemented, which simplified the diagnostic criteria for ARDS. Evidence-based therapies are rare, but some cornerstone interventions ...
Khan Arif O AO Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Electronic address: - - 2014
Early-onset severe retinal dystrophy can be isolated (Leber congenital amaurosis) or the first sign of an underlying systemic ciliopathy, such as Bardet-Biedl syndrome. Early recognition of those children with underlying systemic ciliopathy minimizes morbidity and mortality from later extraocular manifestations, the most common of which is renal disease. We report ...
Alfaifi A A - - 2014
In this paper we describe a clinical scenario of high grade fever, jaundice, hypotension and multi-organ dysfunction syndrome in a 30-year-old homeless male without radiological biliary obstruction. He was brought to our hospital by the emergency medical service of Saudi Arabia (Red Crescent) from the street. After an initial resuscitation ...
Ghonim Sarah S Specialist Registrar in - - 2014
A middle-aged women presented with severe sepsis resulting in a transient apical ballooning of the left ventricle (takotsubo syndrome).
Saxena Amrish A Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha District, Maharashtra, - - 2014
Guillain-Barre syndrome (GBS) is a heterogenous group of peripheral-nerve disorders with similar clinical presentation characterized by acute, self-limited, progressive, bilateral and relatively symmetric ascending flaccid paralysis, which peaks in 2-4 weeks and then subsides. The usual complications, which occur in a patient of GBS are pneumonia, sepsis, pulmonary embolism, respiratory ...
Cornejo Rodrigo R Unidade de Terapia Intensiva, Departamento de Medicina, Hospital Clínico Universidad de Chile, Santiago, - - 2014
We report the successful treatment of two patients with aneurismal subarachnoid hemorrhage complicated by severe respiratory failure and refractory septic shock using simultaneous prone position ventilation and high-volume hemofiltration. These rescue therapies allowed the patients to overcome the critical situation without associated complications and with no detrimental effects on the ...
Ooi Yinn K YK 1 Department of Pediatrics, Division of Cardiology, Children's National Health System, The George Washington University School of Medicine, Washington, District of Columbia, United States of - - 2014
Background: Of the children with Down syndrome 40-50% have cardiac defects and the majority of these cardiac defects are amenable to biventricular repair. The outcome of single ventricle palliation is improving; nonetheless, there are limited data on Down syndrome patients with associated high-risk factors undergoing single ventricle palliation. Our aim ...
Sanz Miguel A MA University Hospital La Fe and Department of Medicine of the University of Valencia, Valencia, - - 2014
Differentiation syndrome (DS), formerly known as retinoic acid syndrome, is a relatively common and potentially severe complication seen in patients with acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). The full-blown syndrome consists of unexplained fever, weight gain, dyspnea with pulmonary infiltrates, pleuropericardial effusion, ...
Chowdhury Fazle Rabbi - - 2014
Organophosphate (OP) poisoning is the most common cause (27.64%) and has the highest death rate (13.88%) of poisoning in Bangladesh. It leads to three main syndromes notably acute cholinergic syndrome, intermediate syndrome, and delayed polyneuropathy. It rarely causes cardiac arrhythmia, pancreatitis and hepatic dysfunction. We present the case of a ...
Taupin Daniel D 1New York University School of Medicine, New York, NY. 2Department of Medicine, New York University Langone Medical Center, New York, - - 2014
Transarterial chemoembolization is a widely used therapy for the treatment of hepatocellular carcinoma. A rare adverse event is acute respiratory distress syndrome from pulmonary embolization of Lipiodol, an iodinated oil commonly used during the procedure. The objective of this report is to describe an atypical case of acute respiratory distress ...
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