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Radhakrishnan Rupa R Department of Radiology, Cincinnati Children's Hospital Medical Center, MLC 5031, 3333 Burnet Ave., Cincinnati, OH, 45229-3039, - - 2014
Down syndrome, or trisomy 21, is the most common chromosomal anomaly and is characterized by intellectual disability and a typical facies. People with Down syndrome can have abnormalities of multiple organ systems. Cardiac and respiratory system involvement is the most common cause of morbidity and mortality, although every organ system ...
Cabrera-Benitez Nuria E NE From the Keenan Research Centre in Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada (N.E.C.-B., J.G.L., J.V., H.Z., A.S.S.); CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain (N.E.C.-B., J.V.); Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain (N.E.C.-B., J.V.); Departments of Anesthesia and Physiology, University of Toronto, Toronto, Ontario, Canada (J.G.L., H.Z.); Department of Medicine, Unit of Anesthesiology and Intensive Care, Medical School, University of Padua, Azienda Ospedaliera di Padova, Padua, Italy (M.P.); Department of Anesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany (P.M.S.); and Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (H.Z., - - 2014
One of the most challenging problems in critical care medicine is the management of patients with the acute respiratory distress syndrome. Increasing evidence from experimental and clinical studies suggests that mechanical ventilation, which is necessary for life support in patients with acute respiratory distress syndrome, can cause lung fibrosis, which ...
Reilly John P JP University of Pennsylvania, Perelman School of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Philadelphia, Pennsylvania, United States, University of Pennsylvania, Perelman School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania, United States ; - - 2014
Rationale: The acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that can develop at various times after major trauma. Objective: To identify and characterize distinct phenotypes of ARDS after trauma based on timing of syndrome onset. Methods: Latent class analyses were used to identify patterns of ARDS onset in ...
Boyle Andrew James AJ Queen's University Belfast, Centre for Infection and Immunity , Belfast , UK - - 2014
Introduction: The acute respiratory distress syndrome (ARDS) is characterised by life-threatening respiratory failure requiring mechanical ventilation, and multiple organ failure. It has a mortality of up to 30 - 45% and causes a long-term reduction in quality of life for survivors, with only approximately 50% of survivors able to return ...
Grasso Salvatore S 1Dipartimento dell'Emergenza e Trapianti d'Organo, Sezione di Anestesiologia e Rianimazione, Università degli Studi Aldo Moro, Bari, Italy. 2Intensive Care, Ospedale Di venere, Bari, Italy. 3Dipartimento dell'Emergenza e Trapianti d'Organo, Sezione di Chirurgia Veterinaria, Università degli Studi Aldo Moro, Bari, Italy. 4Dottorato in Scienze Chirurgiche Sperimentali e Terapie Cellulari, Università degli Studi Aldo Moro, Bari, Italy. 5Center for Anesthesiology, Emergency and Intensive Care Medicine, University Medical Center Göttingen, Göttingen, Germany. 6Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Università degli Studi Aldo Moro, Bari, - - 2014
The Acute Respiratory Distress Syndrome Network protocol recommends limiting tidal volume and plateau pressure; it also recommends increasing respiratory rate to prevent hypercapnia. We tested a strategy that combines the low tidal volume with lower respiratory rates and minimally invasive CO2 removal. Ten lung-damaged pigs (instilled hydrochloride). Two conditions randomly ...
Hurst Jonathan J Department of Ophthalmology, Queen's University , Kingston , - - 2014
Abstract Introduction: Orbital compartment syndrome may rarely occur in the setting of burns where therapy includes aggressive fluid resuscitation. Case: We report a case of bilateral orbital compartment syndrome in a 13-year-old male, with superficial facial burns secondary to hydrobromic acid, who did not receive aggressive fluid resuscitation. The patient ...
Khan Arif O AO Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Electronic address: - - 2014
Early-onset severe retinal dystrophy can be isolated (Leber congenital amaurosis) or the first sign of an underlying systemic ciliopathy, such as Bardet-Biedl syndrome. Early recognition of those children with underlying systemic ciliopathy minimizes morbidity and mortality from later extraocular manifestations, the most common of which is renal disease. We report ...
Alfaifi A A - - 2014
In this paper we describe a clinical scenario of high grade fever, jaundice, hypotension and multi-organ dysfunction syndrome in a 30-year-old homeless male without radiological biliary obstruction. He was brought to our hospital by the emergency medical service of Saudi Arabia (Red Crescent) from the street. After an initial resuscitation ...
Ghonim Sarah S Specialist Registrar in - - 2014
A middle-aged women presented with severe sepsis resulting in a transient apical ballooning of the left ventricle (takotsubo syndrome).
Ooi Yinn K YK 1 Department of Pediatrics, Division of Cardiology, Children's National Health System, The George Washington University School of Medicine, Washington, District of Columbia, United States of - - 2014
Background: Of the children with Down syndrome 40-50% have cardiac defects and the majority of these cardiac defects are amenable to biventricular repair. The outcome of single ventricle palliation is improving; nonetheless, there are limited data on Down syndrome patients with associated high-risk factors undergoing single ventricle palliation. Our aim ...
Sanz Miguel A MA University Hospital La Fe and Department of Medicine of the University of Valencia, Valencia, - - 2014
Differentiation syndrome (DS), formerly known as retinoic acid syndrome, is a relatively common and potentially severe complication seen in patients with acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). The full-blown syndrome consists of unexplained fever, weight gain, dyspnea with pulmonary infiltrates, pleuropericardial effusion, ...
Chowdhury Fazle Rabbi - - 2014
Organophosphate (OP) poisoning is the most common cause (27.64%) and has the highest death rate (13.88%) of poisoning in Bangladesh. It leads to three main syndromes notably acute cholinergic syndrome, intermediate syndrome, and delayed polyneuropathy. It rarely causes cardiac arrhythmia, pancreatitis and hepatic dysfunction. We present the case of a ...
Taupin Daniel D 1New York University School of Medicine, New York, NY. 2Department of Medicine, New York University Langone Medical Center, New York, - - 2014
Transarterial chemoembolization is a widely used therapy for the treatment of hepatocellular carcinoma. A rare adverse event is acute respiratory distress syndrome from pulmonary embolization of Lipiodol, an iodinated oil commonly used during the procedure. The objective of this report is to describe an atypical case of acute respiratory distress ...
Büyükçelik Mithat M Gaziantep University Faculty of Medicine, Department of Pediatric Endocrinology and Metabolism, Gaziantep, Turkey. E-mail: - - 2014
Autoimmune polyglandular syndrome (APS) is a disorder which is associated with multiple endocrine gland insufficiency and also with non-endocrine manifestations. The pathophysiology of APS is poorly understood, but the hallmark evidence of APS is development of autoantibodies against multiple endocrine and non-endocrine organs. These autoantibodies are responsible for the dysfunction ...
Milne-Price Shauna S Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, - - 2014
On September 20, 2012, a Saudi Arabian physician reported the isolation of a novel coronavirus from a patient with pneumonia on ProMED-mail. Within a few days the same virus was detected in a Qatari patient receiving intensive care in a London hospital, a situation reminiscent of the role air travel ...
Palmer William C WC Department of Gastroenterology and Hepatology, Mayo Clinic , Jacksonville, Florida , - - 2014
Abstract Type II autoimmune polyglandular syndrome (APS), a relatively common endocrine disorder, includes primary adrenal insufficiency coupled with type 1 diabetes mellitus and/or autoimmune primary hypothyroidism. Autoimmune serositis, an associated disease, may present as symptomatic pericardial effusion. We present a case of a 54-year old male with APS who developed ...
Gupta Nishant N Nishant Gupta is an assistant professor and Dennis McGraw is an associate professor in the Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio. Stephen M. Kralovic is an associate professor in the Division of Infectious Diseases, Department of Internal Medicine, University of - - 2014
Lemierre syndrome is a rare and life-threatening illness. Often referred to as "the forgotten disease," its incidence is reported to be as low as 1 in a million. The microorganism responsible for Lemierre syndrome is typically Fusobacterium necrophorum. The bacterium starts in the pharynx and peritonsillar tissue, then disseminates through ...
Fettah Nurdan N From the Division of Neonatology, Dr Sami Ulus Maternity and Children Training and Research Hospital, Ankara, - - 2014
Near drowning is the term for survival after suffocation caused by submersion in water or another fluid. Pulmonary insufficiency may develop insidiously or suddenly because of near drowning. We want to present a newborn case of acute respiratory distress syndrome caused by near drowning. A 26-day-old boy was brought to ...
Dzierba Amy L - - 2014
Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are conditions associated with an estimated mortality of 40–50%. The use of inhaled vasodilators can help to improve oxygenation without hemodynamic effects. This article reviews relevant studies addressing the safety and efficacy of inhaled nitric oxide (iNO) and aerosolized epoprostenol ...
Chang Youjin Y Department of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, - - 2014
Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). This case history is reported of a 59-yr-old man who was treated with MSCs in the course of ARDS and subsequent pulmonary fibrosis. He received ...
Jiří Zurek Z University Children's Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno 62500, Czech Republic; Masaryk University, Černopolní 9, Brno 62500, Czech Republic. Electronic address: - - 2014
Pancreatic stone protein (PSP)/regenerating protein 1-alpha (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill pediatric patients is unknown. The aim of this pilot study was to evaluate PSP/reg in children with systemic inflammatory response syndrome or sepsis. Prospective observational study, ...
Tonni Gabriele G Department of Obstetrics & Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, - - 2014
Prenatal diagnosis of thanatophoric dysplasia (TD) type II presenting in the first trimester with increased nuchal translucency (NT) and cloverleaf skull (Kleeblattschaedel) have been scantly reported in the medical record. Abnormal choroid plexus has been seen in association with fetal anomalies. Here we described a case of increased NT associated ...
Assir Muhammad Zaman Khan MZ From the Department of Medicine, Allama Iqbal Medical College/Jinnah Hospital , Lahore , - - 2014
Objective: We conducted this study to review deaths due to dengue fever (DF) during a large outbreak of DF in Lahore, Pakistan. Methods: We reviewed deaths due to DF at Jinnah Hospital Lahore between August and November 2011. Clinical and laboratory data were abstracted. The 2011 World Health Organization Regional ...
Leshnower Bradley G BG Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia. Electronic address: - - 2014
Acute DeBakey type 1 aortic dissection presenting with mesenteric malperfusion is a lethal variant of all dissection-related malperfusion syndromes with reported mortality rates of 38% to 75%. Conventional surgical treatment involves proximal aortic replacement to restore true lumen perfusion, followed by mesenteric revascularization if malperfusion persists. In an attempt to ...
Huang L L Department of Internal Medicine, Ikazia Hospital Rotterdam, Rotterdam, the - - 2014
Bartter syndrome consists a group of rare autosomalrecessive renal tubulopathies characterised by renal salt wasting, hypokalaemic metabolic alkalosis, hypercalciuria and hyperreninaemic hyperaldosteronism. It is classified into five types. Mutations in the KCNJ1 gene (classified as type II) usually cause the neonatal form of Bartter syndrome. We describe an adult patient ...
Cha Yong Sung YS Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Republic of - - 2014
The myeloperoxidase index (MPXI) is elevated in infection. We ascertained whether MPXI might be useful in differentiation of sepsis versus non-infectious systemic inflammatory response syndrome (SIRS) in emergency department (ED). After exclusion of patients with an age of <18 years, trauma, haematological disease and on anticancer chemotherapy, 444 consecutive cases ...
Gargano Giancarlo G Neonatologic Unit, Obstetric and Paediatric Department, Istituto di Ricovero e Cura a Carattere Scientifico, S. Maria Nuova Hospital, Reggio Emilia, - - 2014
Fetal hydrops is a condition resulting from interstitial fluid accumulation in fetal compartments secondary to increased capillary permeability and characterized by high rates of perinatal mortality and morbidity. Clinical features include skin edema, hydrothorax, pericardial effusion, ascites with or without polyhydramnios, and placental edema. While it may occur as associated ...
Fuller Brian M BM Department of Anesthesiology Division of Critical Care Division of Emergency Medicine Washington University School of Medicine in St. Louis Department of Emergency Medicine Department of Anesthesiology Division of Critical Care Roy J. and Lucille A. Carver College of Medicine University of Iowa Department of Anesthesiology Division of Critical Care Washington University School of Medicine in St. Louis Department of Medicine Division of Pulmonary and Critical Care Medicine Washington University School of Medicine in St. - - 2014
The mortality for acute respiratory distress syndrome (ARDS) remains unacceptably high. Success in clinical trials has been limited, resulting in a lack of effective therapies to treat the syndrome. The projected increase in mechanically ventilated patients and global need for critical care services suggests that the clinical and research landscape ...
Zebuhr Carleen C Pediatrics, Section of Critical Care, Children's Hospital Colorado, 13121 E 17th Ave, MS 8414, Aurora, CO 80045. Electronic address: - - 2014
Decreased intensive care unit (ICU) mortality has led to an increase in ICU morbidity. ICU-induced immobilization plays a major role in this morbidity. Recently, ICU mobility has been shown to be safe and effective in adolescent and adult patients. We report the successful rehabilitation of an 8-year-old boy with severe ...
Rai Birendra B Department of Pediatrics, Midland Regional Hospital, Mullingar, Ireland, - - 2014
Cayler cardiofacial syndrome is characterised by congenital unilateral hypoplasia of the depressor anguli oris muscle (DAOM) in association with congenital cardiac defects. Hypoplasia of this muscle causes inability to move one corner of the mouth downward and outward while crying or grimacing, giving rise to an 'asymmetric crying face' appearance. ...
Santos Natacha N Allergy and Clinical Immunology Division, Centro Hospitalar São João, EPE: Alameda Professor Hernâni Monteiro, 4202-451 Porto, Portugal. - - 2014
The most frequent causes of adult-onset recurrent infections are human immunodeficiency virus infection, malignancy, and autoimmune diseases, while acquired non-surgical hyposplenism is rare. Although acquired asplenia/hyposplenism have been described in association with celiac disease and, less frequently, with autoimmune diseases such as Sjögren's syndrome, the manifestations in this context are ...
El-Haj Nura N Trinity College, Dublin, - - 2014
Hemophagocytic syndrome (HPS) is an extremely rare condition arising from the overactivation of one's own immune system. It results in excessive inflammation and tissue destruction. Prompt initiation of treatment is warranted in either scenario in order to decrease mortality. Most cases are triggered by infectious agents, malignancy, or drugs. We ...
Du Hong H Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, - - 2014
The aim of this study was to investigate the clinical characteristics and outcomes of critical patients with hemorrhagic fever with renal syndrome (HFRS) complicated by acute respiratory distress syndrome (ARDS). To observe the demographic, epidemiological and clinical characteristics, and to explore the predictive effects for prognosis in laboratory findings, we ...
Lin Yun-Ho YH Division of Infection, Taiwan Landseed - - 2014
A 34-year-old woman presented with septic shock, disseminated intravascular coagulation (DIC), and multiorgan dysfunction with a 1-week history of fever, abdominal pain in the right upper quadrant, and dull pain in the right flank. Physical and laboratory data showed cytopenia (thrombocytopenia and anemia), splenomegaly, hyperferritinemia, hypofibrinogenemia, and an elevated level ...
Faridi Mohammad Shazib MS Department of Surgery, University College of Medical Sciences & Guru Tegh Bahadur Hospital, Dilshad Garden, Delhi, 110095, - - 2014
We report a case of Mirizzi syndrome type II associated with biliary enteric fistula. It is important to identify this combination early, as it is associated with high morbidity. In our case, intraoperative findings were cholecystoduodenal fistula and communication of Hartmann's pouch with common bile duct (CBD). A subtotal cholecystectomy ...
Narula Deepali D Department of Physiotherapy, Fortis Hospital, Vasant Kunj, New Delhi, - - 2014
A 26-year-old, 14 week pregnant woman was admitted to our hospital with pneumonia with acute respiratory distress syndrome in an intubated and mechanically ventilated state. She was diagnosed to have polymicrobial infection and left-sided pneumothorax and was put on a ventilator for 2 weeks. Postextubation, she found it difficult to ...
Namas Rajaie R 0000-0003-0353-895X Department of Internal Medicine, Division of Rheumatology, Wayne State University, Detroit, MI 48201, - - 2014
Case. A 34-year-old African-American female with a history of adult-onset Still's disease presented to an outside hospital with oligoarthritis. She experienced a generalized tonic-clonic seizure en route via ambulance, was intubated upon arrival, and transferred to the intensive care unit for treatment of suspected pneumonia and sepsis. She subsequently developed ...
Contrafouris Constantinos A CA Department of Paediatric and Congenital Heart Surgery, Onassis Cardiac Surgery Centre, 356 Syngrou Avenue, Kallithea, 17674 Athens, - - 2014
Supravalvar aortic stenosis (SVAS) in patients with Williams' syndrome is often accompanied by coronary, pulmonary, and even myocardial lesions and therefore associated with increased perioperative morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) provides reliable short-term mechanical circulatory support to patients, especially young, in acute postoperative cardiac failure when conventional means ...
Arnaoutakis Dean J DJ Division of Vascular Surgery and Endovascular Therapy, The Johns Hopkins Hospital, Baltimore, - - 2013
Metabolic syndrome, having risen to epidemic proportions in the United States, is associated with future cardiovascular disease and mortality, as well as increased postoperative complication rates. However, the impact of metabolic syndrome on outcomes after infrainguinal bypass remains poorly defined. Using the American College of Surgeons-National Surgical Quality Improvement Program ...
Langer Thomas T 1Comprehensive Intensive Care Research Task Area, United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX. 2Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy. 3National Research Council, National Academies, Washington, DC. 4School of Medicine, Università degli Studi di Milano, Milan, Italy. 5Department of Surgery, San Antonio Military Medical Center, San Antonio, TX. 6Uniformed Services University of the Health Sciences, Bethesda, MD. 7Dipartimento di Anestesia, Rianimazione (Intensiva e Sub-intensiva) e Terapia del Dolore, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, - - 2013
Venovenous extracorporeal gas exchange is increasingly used in awake, spontaneously breathing patients as a bridge to lung transplantation. Limited data are available on a similar use of extracorporeal gas exchange in patients with acute respiratory distress syndrome. The aim of this study was to investigate the use of extracorporeal gas ...
Witczak Agnieszka A Department of Internal Diseases, Medical University, Lublin, - - 2013
ARDS is defined as an acute inflammatory syndrome characterized with bilateral parenchymal lung infiltrates on chest radiograph and PaO2/FiO2 ratio<200 resulting from causes other than acute left ventricular dysfunction. Inflammatory lung lesions may be induced by different disorders, with sepsis being the leading cause of ARDS. Other causes include infectious ...
Goffi Alberto A aInterdepartmental Division of Critical Care Medicine bUniversity Health Network cDepartment of Medicine dDepartment of Physiology, University of Toronto eMount Sinai Hospital, Toronto, Ontario, - - 2013
High-frequency oscillatory ventilation (HFOV) has been considered a potentially ideal mode of lung-protective ventilation. A recent meta-analysis suggested improved oxygenation and reduced mortality in adults and children with acute respiratory distress syndrome (ARDS), but the use of outdated control strategies and small numbers of patients in many of the studies ...
Torbati Sam S SS Department of Emergency Medicine, Cedars-Sinai Medical Center, Los Angeles, - - 2013
Transfusion medicine is a common practice in the emergency department (ED) and other outpatient settings, and may be complicated by a low rate of potentially fatal transfusion-related reactions. This article presents a case of transfusion-related acute lung injury (TRALI) diagnosed and treated in the ED and reviews the differential diagnosis ...
Güldner Andreas A aPulmonary Engineering Group, Department of Anesthesiology and Intensive Care Therapy, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany bDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, - - 2013
This review summarizes the most recent clinical and experimental data on the impact of spontaneous breathing in acute respiratory distress syndrome (ARDS). Spontaneous breathing during assisted as well as nonassisted modes of mechanical ventilation improves lung function and reduces lung damage in mild and moderate ARDS. New modes of assisted ...
Terragni Pierpaolo - - 2013
To examine the role of extracorporeal membrane oxygenation (ECMO) as potential therapeutic option for severe cases of acute respiratory distress syndrome (ARDS). The use of ECMO to treat acute respiratory failure dramatically increased. Factors that may explain this increase in the use of ECMO are H1N1 pandemic influenza, results of ...
Villar Jesús - - 2013
The purpose of this review is to examine and discuss the incidence and outcome of patients with the acute respiratory distress syndrome (ARDS). This is a challenging task, as there is no specific clinical sign or diagnostic test that accurately identifies and adequately defines this syndrome. This review will focus ...
Krishna Vidya - - 2013
Streptococcal Toxic Shock syndrome (STSS) is a serious complication caused by exotoxins of Group A Streptococcus (GAS). It presents with fulminant shock and rash, is rapidly progressive with Multi-Organ Dysfunction Syndrome (MODS) and requires aggressive therapy with fluids, antibiotics and source control.
Mansini Adrián P - - 2013
Patients with Down's Syndrome have a higher risk of developing acute megakaryoblastic leukemia (AML). Ten per cent of newborn infants with this syndrome have transient abnormal myelopoiesis (TAM), indistinguishable from AML, which generally remits spontaneously. A high incidence of GATA-1 gene mutations was described in both groups of patients. Fourteen ...
Araz C - - 2013
Posterior reversible encephalopathy syndrome (PRES) is a neurological disturbance that occurs due to different reasons and presents with different clinical symptoms. It can be a devastating situation, but, timely treatment may lead to complete recovery. We report 2 cases of PRES, which developed and fully recovered in the early period ...
A Zochios Vasileios - - 2013
Positive pressure mechanical ventilation can lead to ventilator-associated lung injury as a result of alveolar strain and cyclic alveolar atelectasis. Risk factors for ventilator-associated lung injury in patients without acute respiratory distress syndrome include high tidal volume (>6 ml/kg predicted body weight), acidaemia, blood product transfusion and restrictive lung disease ...
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