Pfiesteria piscicida (Pp) is an estuarine dinoflagellate that has been associated with fish kill events in estuaries along the eastern seaboard and possibly with human health effects. CDC, in collaboration with other federal, state, and local government agencies and academic institutions, is conducting multistate surveillance, epidemiologic studies, and laboratory research ...

Cogan's syndrome is a rare clinical entity defined by the association of a nonsyphilitic interstitial keratitis and vestibuloauditory dysfunction, typically Menière's disease-like; the condition has been reported in association with a variety of cutaneous diseases. We now report a case of pyoderma gangrenosum complicating Cogan's syndrome in a 57-year-old woman, ...

A 16-year-old girl had fully manifested Coffin-Lowry syndrome and drop episodes. Her drop episodes were precipitated by sudden unexpected tactile or auditory stimuli associated with the electrostatic circumstances in her leg muscles immediately after the stimuli. Studies revealed that her drop episode symptom was an unusual type of startle response ...

The neglect syndrome is a cluster of neurologic symptoms commonly found after right hemisphere damage. This study investigates the degree of association between the main components in a representative sample of 69 patients at 2 to 3 days poststroke. Despite evidence of statistically significant associations between components, many dissociations were ...

We describe a 52-year-old woman with panniculitis and blind loop syndrome. She had undergone a gastrectomy for peptic ulcer 4 years before. Tender erythematous nodules on her palms and soles were associated with diarrhea and weight loss. A biopsy specimen revealed septal and lobular panniculitis. A glucose hydrogen breath test ...

We report two cases of Vohwinkel's syndrome in son and mother presenting with a progressive palmoplantar keratoderma with 'honeycomb' appearance associated with constricting bands encircling digits of hands and feet along with keratotic plaques on dorsum of hands and feet. Both had associated sensorineural deafness.

The association of a human herpesvirus 6 primary infection with a fatal case of hemophagocytic syndrome in a 3 month old baby is described. The trigger mechanism of the virus for the clinical syndrome is discussed.

Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are ...

BACKGROUND: Systemic acetazolamide treatment has been reported in association with Stevens-Johnson syndrome (SJS). This is the first report of this syndrome associated with methazolamide treatment. The association is reported in two Japanese-American women. METHOD AND RESULTS: Two patients with SJS, which developed during treatment with methazolamide, are described. Other potential ...

OBJECTIVE: To highlight the association of colobomatous microphthalmos with blepharophimosis syndrome. RESULT: We present a case of blepharophimosis syndrome associated with bilateral optic disc, retinochoroidal and iris colobomas, and microphthalmos, in a Caucasian boy. Inheritance in this case was autosomal dominant from the maternal side. CONCLUSION: Colobomatous microphthalmos is an ...

A case is presented of a male with Kallmann's syndrome who at the age of 27 developed central diabetes insipidus. Previously, Kallmann's syndrome has been found to be associated with an altered osmotic threshold for vasopressin release and impaired thirst sensation, but to our knowledge, this is the first reported ...

We report a male with cerebellar ataxia, hypogonadism and chorioretinopathy. The age of onset was 12. The parents were first cousins. Endocrinologic studies demonstrated hypogonadotropic hypogonadism due to pituitary dysfunction. The ocular disorder involved the choriocapillaris and the retina. The association may represent a separate syndrome, seldom recognized in the ...

New species associated with Coleoptera are described: Sandrophela hugoni from Sumatra, S. sophiae from India, S. amarae from Java and Sumatra, Dicanestrinia huberti, Photia adolfinae both from Poland, Scarabiphotia vigoni from unknown locality, Beeriphotia volkeri, Canestrinia paavoi and C. ramoni, all from China. There are created two new genera: Beeriphotia ...

Melanocytic nevi have been reported in association with several congenital syndromes. This review describes the clinical and cutaneous manifestations of six syndromes associated with congenital melanocytic nevi, two associated with acquired nevi, and six associated with melanocytic nevi in which insufficient evidence exists to classify them as congenital or acquired. ...

Headache syndromes are known to occur in association with sleep. Both the clinical and the polysomnographic abnormalities occurring in association with various headache syndromes have been described. We report the occurrence of transient recurrent situational insomnia that occurred in association with chronic cluster headaches and was reversible after the headache ...

The association between agnathia and holoprosencephaly is well documented (Pauli et al., 1981). Pauli et al. described two female sibs with agnathia and holoprosencephaly who were subsequently shown to carry an unbalanced 46,XX, der 18,t(6;18)(pter p24.1) karyotype (Pauli et al., 1983; Krassikoff and Sekhon, 1989). All other cases have been ...

Wilms tumor can occur in association with a number of recognizable patterns of malformation, as first described by Miller et al. in 1964. This paper represents a synthesis of the current state of knowledge regarding recognizable phenotypes associated with Wilms tumor. Specific disorders discussed include the Beckwith-Wiedemann syndrome, which has ...

Protrusio acetabuli (PA) in neurofibromatosis is not well documented in the literature. Two forms of PA, a nondysplastic and dysplastic type, are noted. Twenty-one percent of hips (13 patients) in neurofibromatosis were found to have some form of acetabular protrusion abnormality. In the control group (83 patients) without stigmata of ...

An 11-year-old Japanese female having acanthosis nigricans associated with Crouzon syndrome is reported. Crouzon syndrome is a craniostenotic craniofacial malformation associated with premature closure of selective calvarial sutures, exophthalmos, maxillary hypoplasia, and a beak-shaped nose. It is an autosomal dominant inherited disorder. Crouzon syndrome is one of the syndromes which ...

We present clinical and laboratory data from a patient with Waardenburg's syndrome type II comprising iris heterochromia and deafness, complicated by Hirschsprung's disease--a known association--and an unusual demyelinating peripheral neuropathy--a unique association. The neuropathy is characterised by excessive focal folding of myelin sheaths. It is our view that, although both ...

Uterine leiomyoma associated with ascites and hydrothorax was apparently cured by total hysterectomy. This is believed to be the 15th recorded case of this type of Pseudo-Meigs' syndrome and the first in a patient with severe curvature of the spine and dorsolumbar scoliosis. The association with ascites and hydrothorax was ...

Hypomelanosis of Ito is an uncommon syndrome where bizarre, systematized hypopigmentation is often associated with neurological and other non-cutaneous abnormalities. We report two cases, one which was associated with laryngomalacia and sudden death (in which the parents were consanguineous), and one which was associated with episodes of loss of consciousness.

The acne conglobata (AC)-, acne fulminans (AF)-, and isotretinoin-associated musculoskeletal syndromes are three distinct clinical entities. The AC-associated musculoskeletal syndrome occurs primarily in black men over the age of 22, who develop sacroilitis with or without a peripheral arthropathy. In contrast, the AF-associated musculoskeletal syndrome is found almost exclusively in ...

Several cutaneous disorders have been associated with Down syndrome. An increased frequency of syringomas and of elastosis perforans serpinginosa, a transepidermal elimination disorder, have been described. We report the first case of the simultaneous occurrence of transepidermal elimination of calcium associated with syringomas in a patient with Down syndrome who ...

DQ A and DX A RFLPs were studied in DR4-positive rheumatoid arthritis, Felty's syndrome, and in DR4-positive control subjects, and in the light of the previously documented association between Felty's syndrome and the DQ B 3.1 allele (3b RFLP). In these DR4-positive subjects there were no preferential associations between DQ ...

The smallest free-living, self-replicating organisms known, the mycoplasmas have been the subject of intense research. Of the 12 species that have been found in association with humans, Mycoplasma pneumoniae, M. hominis, and Ureaplasma urealyticum have been clearly shown to have pathogenic properties. The newly described M. genitalium may also have ...

Osteogenesis imperfecta is a disease of bone formation subdivided into two types, congenita and tarda. It is associated with bony fragility, blue sclerae and abnormality of tooth dentin. Rarely the tarda form is associated with basilar invagination or infolding of the foramen magnum and upper cervical segments into the posterior ...

Thyrotoxic periodic paralysis is an uncommon neuromuscular disorder frequently associated with severe hypokalemia. We describe a patient with hypophosphatemia occurring in the setting of hypokalemic thyrotoxic periodic paralysis, an association reported only once previously. A review of the literature indicates that this combined biochemical derangement may not be uncommon and ...

This study included 625 patients with Bell's palsy and 124 patients with Ramsay Hunt syndrome. Seven percent of the cases of Bell's palsy and 1.6% of the cases of Ramsay Hunt syndrome were associated with diabetes mellitus, while 14.1% of the cases of Bell's palsy and 10.4% of the cases ...

Nonimmune hydrops fetalis may be associated with an elevated amniotic fluid delta OD450. Cases of I-cell disease (mucolipidosis II), lethal multiple pterygium syndrome, and alpha-thalassemia are presented, each associated with nonimmune hydrops fetalis and an elevated delta OD450. An elevated delta OD450 does not always indicate isoimmunization, and may be ...

Keratocysts of the solitary type were histologically and histometrically compared with those associated with the nevoid basal cell carcinoma syndrome (NBS). It was observed that parakeratinization, intramural epithelial remnants and satellite cysts were a more frequent finding among NBS keratocysts than among solitary keratocysts. Conversely, it was also found that ...

Three patients showing Sjögren's syndrome in association with macrocytic anemia due to vitamin B(12) deficiency are described. Antibodies to parietal cells, intrinsic factor and salivary protein were investigated; positive test results were obtained in different combinations. Addisonian pernicious anemia as well as vitamin B(12)-malabsorption because of anti-intrinsic factor antibodies in ...

A case of focal palmoplantar keratoderma with associated sensorineural deafness is reported. The palmoplantar keratoderma was sharply marginated by geometric borders, spared the plantar arch and was accompanied by marked hyperkeratosis of palmar flexural creases. This syndrome, consisting of a very particular type of palmoplantar keratoderma associated with sensorineural deafness, ...

Twenty-two Michigan dairy herds participating in a computerized herd-health program were studied to determine the incidence and epidemiologic characteristics of repeat-breeder syndrome. A cow with repeat-breeder syndrome was defined as having been inseminated three or more times within the same lactation. Repeat-breeder syndrome was observed in 24% of 3,309 lactations. ...

A 10-year-old male Lhasa Apso was examined because of pyrexia, vomiting, weight loss, lethargy, and disorientation. The clinical and laboratory findings were supportive of a diagnosis of serum hyperviscosity syndrome associated with an Ehrlichia canis infection. After tetracycline therapy the serum hyperviscosity syndrome and E. canis infection were successfully resolved.

A severe case of supine hypotensive syndrome associated with a bicornuate uterus is presented. It is suggested that failure of left lateral tilt to prevent the syndrome was associated with anatomical displacement of the uterus to the right. The importance of trying right lateral tilt, if response to left tilt ...

Two patients are described with polyclonal IgG cryoglobulinaemia and necrotizing arteritis who developed severe lymphadenopathy which clinically mimicked malignant lymphoma. Histological studies demonstrated that the lymphadenopathy resulted from a pseudolymphomatous reaction associated with vascular damage.

Maffucci's syndrome (association of multiple enchondromatosis and multiple hemangiomata) is rarely associated with other ectodermal tumors. The present case is the second in literature in which the Maffucci's syndrome is associated with the parathyroid adenoma resulting in primary hyperparathyroidism. Although the cystic lesions of the bone and the ectopic calcifications ...

The authors describe a case of the catatonia syndrome associated with disulfiram therapy. Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia. The authors note that catatonia is a clinical syndrome ...

In recent years, there have been major advances in knowledge of Vibrio species and related organisms that are responsible for diarrhoeal diseases, particularly V. cholerae O-Group 1 (epidemic strains), atypical V. cholerae O-Group 1, non-O-Group 1 V. cholerae (non-epidemic strains), V. parahaemolyticus, V. alginolyticus, and "Group F vibrios". This article ...

Senile and involutional entropion is occasionally associated with a marked relaxation of the canthal tendons. A simple adjunctive procedure to the imbrication of the lower lid retractors for the correction of senile entropion is described. This adjunctive procedure--the lateral canthal tendon tuck--should further reduce the remarkably low recurrence rate associated ...

The first case of Sézary's syndrome associated with generalized plane xanthoma is reported, thereby extending the association of lymphoreticular proliferative disorders with plane xanthomatosis. The association of Sézary's syndrome with plane xanthomatosis may be an in vivo example of defective cell regulation involving the major cellular components of the immune ...

A case is reported in which features of pseudohypoparathyroidism were found in association with the cri du chat syndrome. This association may throw some light on the localization of the chromosomal abberration which underlies pseudohypoparathyroidism, since deletion of the short arm of chromosome 5 has been clearly established in the ...

The Robin anomalad, once thought to constitute a specific syndrome, is now known to occur with several genetic syndromes, a few drug-induced syndromes, and some loosely associated anomalies. The mode of inheritance in genetic syndromes with the Robin anomalad is that of the particular syndrome with which the anomalad is ...

Immune complexes play an important role in the pathogenesis of malaria-associated nephropathies. Two main types of lesion are demonstrable: (a) acute (transient-reversible) lesions typical of falciparum infections in man, with mild clinical symptoms developing a week or two after infection. Renal biopsies at that time show deposits of immunoglobulins, complement, ...

A rigorous theory for the analysis of an associating system involving two different monomer units, which may also undergo self-association, has been developed. In the present paper the application of the theory to actual data is demonstrated for the first time. The model system chosen is the interaction of inosine ...

An adult (21 year old) male is described who developed Reye's syndrome in association with dengue type 1 infection.

Vesicles have been identified within the cartilage matrix of the upper tibial epiphyseal plate of normal mice. They were seen at all levels within the plate and usually did not appear to be in contact with cartilage cells. Vesicles were concentrated within the matrix of the longitudinal septa from the ...

Three patients experienced a rheumatic-fever-like illness with painful limitation of joint movements. The illnesses were due to infection with Mycoplasma pneumoniae. Joint symptoms have not been previously described in cases of M. pneumoniae infection.

1. Mice of A and C(57)BL/6 Ks strains, thymectomized at birth acquire wasting disease in 84.1% (A) and 77.1% (C(57)BL/6 Ks) of the cases. There is no sex predelection. 2. Anemia in these animals is characterized by shortened red cell survival and increased fragility to hypotonic salt solutions. Among thymectomized ...