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Ehler Edvard E Department of Neurology, Regional Hospital and University of Pardubice, Kyjevská 44, CZ 532 03, Czech Republic. Electronic address: - - 2014
Miller Fisher syndrome is defined by a triad of symptoms, namely areflexia, ataxia, and ophthalmoparesis. The ophthalmoparesis is mostly severe, undulating weakness of eye movements with ptosis and increased fatigability resembling a neuromuscular transmission disorder. We present a 52-year-old man with severe Miller Fisher syndrome with a high level of ...
Ayad Micheal M Division of Vascular and Endovascular Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA - - 2014
Tarsal tunnel syndrome is a compressive neuropathy of the posterior tibial nerve within the tarsal tunnel. Its etiology varies, including space occupying lesions, trauma, inflammation, anatomic deformity, iatrogenic injury, and idiopathic and systemic causes. Herein, we describe a 46-year-old man who presented with left foot pain. Work up revealed a ...
Seo Seok Kyo SK Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Women's Life Medical Science, Seoul, Republic of - - 2014
Several studies have suggested that increased iron storage may promote the development of atherosclerotic coronary heart disease. In the present study, we aimed to investigate the association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women. We examined 280 postmenopausal women who visited the health ...
Lin I-Ching - - 2014
To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population. We conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population. The ...
Mehran Ladan L Research Institute for Endocrine Sciences, Endocrine Research Center , No 24, Yaman St, Parvaneh St, Velenjak , Tehran, Iran , Tehran, Iran, Islamic Republic of , 1985717413 , +982122432500 ; - - 2014
 Context: The association between thyroid hormones within the euthyroid range and the metabolic syndrome is not clear. Aim: This study evaluated the relationship between thyroid hormones and metabolic syndrome and its components in euthyroid subjects. Design and setting: This is a cross-sectional population based study conducted within the framework of ...
Timar Romulus R Department of Internal Medicine II, "Victor Babes" University of Medicine and Pharmacy, Timisoara, - - 2014
To assess the prevalence of metabolic syndrome and evaluate proinflammatory status in patients with type 1 diabetes, and to analyse the relationship between inflammation, metabolic control and insulin resistance in these patients. Patients with type 1 diabetes were stratified according to the presence or absence of metabolic syndrome. Serum adiponectin, ...
Manjunath Dinaker D 1 GYD Diagnostics and Reference Laboratories (P) Ltd. , Secunderabad, India - - 2014
Abstract Background: We estimated the prevalence of metabolic syndrome among urban Indian young adults (18-25 years) as defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), Internation Diabetes Federation (IDF), and Indian consensus statement criteria. Method: We included 473 urban young adults through simple random ...
Madias John E JE Icahn School of Medicine at Mount Sinai, New York, NY, United States; Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, United States. Electronic address: - - 2014
This viewpoint pertains to the still elusive pathophysiology of the Takotsubo syndrome (TTS), maintaining the position that this affliction is not the result of coronary vasospasm (CV) involving one or more coronary arteries. Although CV has been rarely encountered in the acute stage of TTS, or elicited via provocative testing ...
Chen Fang-Pei FP School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, - - 2014
Background/Aims: The links between the metabolic syndrome and homocysteine in relation to the risk of colorectal polyps are not understood. The purpose of this study was to investigate the association between the metabolic syndrome and homocysteine and further analyze the relationship between these two factors and the risk of colorectal ...
Libby Peter P From the Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.L.); Department of Medicine, Columbia University Medical Center, New York, NY (I.T.); and Division of Cardiology, Department of Medicine, New York University School of Medicine (E.A.F.). - - 2014
Inflammation contributes to many of the characteristics of plaques implicated in the pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only regulate the properties of plaques that precipitate acute coronary syndromes but also modulate the clinical consequences of the thrombotic complications of atherosclerosis. This synthesis will provide an update ...
Duman Nilay N Department of Dermatology, Afyonkarahisar Government Hospital, Afyonkarahisar, Turkey - - 2014
Cholesterol embolisation syndrome (CES) is a rare but serious disease with high mortality caused by the formation of an embolus made up of cholesterol crystals from atherosclerotic plaques. Its clinical presentation is usually initially insidious and it often remains unrecognised because of its non-specific clinical presentation, which can cause delays ...
Voils Stacy A SA Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, 1225 Center Drive, HPNP Building, Room 3315, P.O. Box 100486, Gainesville, FL 32610-0486, United States. Electronic address: - - 2014
Metabolic syndrome and elevated high-sensitivity (hs) C-reactive protein (CRP) have been associated with an increase in risk of coronary artery disease, stroke, and diabetes but the relationship between the two is unclear. The purpose of this study is to identify any association between metabolic syndrome and hs-CRP concentrations. Subjects 20 ...
Chen Xinpu X Department of Pathology & Immunology, Baylor College of Medicine , and Texas Children's Hospital, Houston, - - 2014
Abstract Background: The metabolic syndrome is a highly prevalent state affecting one in three US adults and comprises a cluster of cardiometabolic risk factors. While metabolic syndrome is a proinflammatory state, there is a paucity of studies examining monocyte/macrophage phenotype in metabolic syndrome subjects. This was the aim of this ...
Yamamura Kenichiro K Department of Pediatrics and Department of Perinatal and Pediatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
Objective. Chronic inflammation plays a key role in the development of atherosclerosis. Early progression of atherosclerosis has been reported in patients with RA. Cryopyrin-associated periodic syndromes (CAPS) are autosomal dominant autoinflammatory disorders caused by heterozygous NLRP3 gene mutations. Chronic infantile neurological cutaneous and articular (CINCA) syndrome is the most severe ...
Vuillaume Marie-Laure ML CHU Bordeaux, Service de Génétique Médicale, Bordeaux, France; Univ. Bordeaux, Maladies Rares : Génétique et Métabolisme (MRGM), EA 4576, Bordeaux, - - 2014
Syndromic obesity is defined by the association of obesity with one or more feature(s) including developmental delay, dysmorphic traits, and/or congenital malformations. Over 25 syndromic forms of obesity have been identified. However, most cases remain of unknown etiology. The aim of this study was to identify new candidate loci associated ...
Mehta Rajendra H RH Duke Clinical Research Institute, Durham, NC. Electronic address: - - 2014
The relationship of metabolic syndrome and its individual components (obesity, hypertension, glucose intolerance, high triglycerides, and low high-density lipoprotein cholesterol) with 1-year mortality in non-ST-segment elevation acute coronary syndromes (NSTE ACS) patients is not known. The association of metabolic syndrome (and its individual components) with all-cause mortality within 1 year ...
Hladunewich Michelle A MA Division of Nephrology, University of Toronto for the Toronto Glomerulonephritis Registry, Toronto, ON, - - 2014
H.P. Acthar® Gel is currently the only Food and Drug Administration therapy approved for the treatment of nephrotic syndrome. Active drug ingredients include structurally related melanocortin peptides that bind to cell surface G-protein-coupled receptors known as melanocortin receptors, which are expressed in glomerular podocytes. In animal models of membranous nephropathy, ...
Lincoff A Michael AM Director, C5 Research (Cleveland Clinic Coordinating Center for Clinical Research); Vice Chairman for Clinical Research, Lerner Research Institute; Vice Chairman of Cardiovascular Medicine, Cleveland Clinic; Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, - - 2014
In managing acute coronary syndromes, physicians can draw on a large body of evidence from clinical trials. This article reviews clinical trials that inform current standards of practice regarding reperfusion, aggressive vs conservative initial approaches, and the appropriate use of aspirin, dual antiplatelet therapy, glycoprotein IIb/IIIa antagonists, anticoagulants, and statins.
Setianto Budi Y BY Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Gadjah Mada-Sardjito Hospital, Yogyakarta, - - 2014
Aim: to determine the difference in serum matrix metalloproteinase-9 (MMP-9) levels among acute coronary syndrome patients with and without hyperglycemia. Methods: this study was a cross-sectional study on patients with acute coronary syndrome admitted to ICCU of Dr.Sardjito Hospital Yogyakarta Indonesia. Measurements of blood glucose level were performed on hospital ...
Rerksuppaphol Lakkana L Faculty, Department of Preventive Medicine, Srinakharinwirot University , Thailand - - 2014
Metabolic syndrome in children has become the focus of many research projects in recent years. The main goal of this study is to evaluate the prevalence of metabolic syndrome in Thai children and its correlation with overweight and obesity. A cross-sectional study of 348 children enrolled in grade 1 to ...
Vernon Hilary J HJ Division of Metabolism, Kennedy Krieger Institute, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: - - 2014
Barth Syndrome is a rare X-linked disorder characterized principally by dilated cardiomyopathy, skeletal myopathy and neutropenia and caused by defects in tafazzin, an enzyme responsible for modifying the acyl chain moieties of cardiolipin. While several comprehensive clinical studies of Barth Syndrome have been published detailing cardiac and hematologic features, descriptions ...
Kim Chun-Ja CJ College of Nursing, Ajou University, Suwon, South - - 2014
This study examined the prevalence of metabolic syndrome and the risk level of cardiovascular disease (CVD) in a vulnerable population of 407 subjects in Korea. This descriptive study was a part of the Tailed Health Visiting Service Program, using baseline data from public health centres in Suwon, Korea. The definition ...
Ayaz Teslime T 1 Department of Internal Medicine, Faculty of Medicine, Recep Tayyip Erdogan University , Rize, Turkey - - 2014
Abstract Objective: Insulin resistance appears to be the most likely underlying mechanism in metabolic syndrome. Acanthosis nigricans (AN) is an easily identifiable skin lesion and associated with insulin resistance. We aimed to determine the prevalence of metabolic syndrome and AN in overweight and obese women and the association between AN ...
Cheserek Maureen Jepkorir MJ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, - - 2014
Both hyperthyroidism and overt hypothyroidism are associated with increased prevalence of metabolic syndrome and its components, while data on subclinical hypothyroidism is currently limited especially in working populations. The aim of this study was to examine the association between subclinical hypothyroidism and metabolic syndrome components in workers; and to evaluate ...
Basel-Vanagaite Lina L Raphael Recanati Genetic Institute and Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, 49100, Petah Tikva, Israel, - - 2014
Biallelic mutations of UBE3B have recently been shown to cause Kaufman oculocerebrofacial syndrome (also reported as blepharophimosis-ptosis-intellectual disability syndrome), an autosomal recessive condition characterized by hypotonia, developmental delay, intellectual disability, congenital anomalies, characteristic facial dysmorphic features, and low cholesterol levels. To date, six patients with either missense mutations affecting the ...
Kiritsi Dimitra - - 2014
Inherited ichthyoses or Mendelian disorders of cornification (MeDOC) are clinically heterogeneous disorders with high unmet therapeutic needs, which are characterized by skin hyperkeratosis and scaling. Some MeDOC types are associated with defects of the epidermal lipid metabolism, resulting in perturbed barrier permeability and subsequent epidermal hyperplasia, hyperkeratosis and inflammation. An ...
Nakashima Yoshikazu Y Department of Immunology and Rheumatology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , - - 2014
A 63-year-old man with enlargement of the bilateral submandibular glands visited with elevated serum IgG4. A biopsy specimen showed plasma cell infiltration with more than 50% IgG4/IgG staining, suggesting the existence of IgG4-related disease (IgG4-RD). Positive anti-SS-A/Ro antibody and the labial salivary gland's biopsy suggested existence of primary Sjögren's syndrome ...
Maciel Gustavo A Rosa GA Faculdade de Medicina, Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), São PauloSP, Brazil, Faculdade de Medicina da Universidade de São Paulo, Laboratório de Ginecologia Estrutural e Molecular (LIM/58), Disciplina de Ginecologia, São Paulo/SP, - - 2014
We aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. ...
Pignalosa O O U.O.C. Immunohaematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT); Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, 1st School of Medicine, Second University of - - 2014
In the last few years, therapeutic apheresis (TA) has emerged as a valuable treatment option for certain life-threatening cardiovascular diseases (CVDs) and for all the cardiac dysfunctions caused by autoimmune or metabolic disorders. Besides the well-established indications for apheresis treatment, such as familial hypercholesterolaemia, hyperviscosity syndrome and thrombotic thrombocytopenic purpura ...
Abate Michele M Department of Medicine and Science of Aging, University G. d'Annunzio, Chieti-Pescara, Via dei Vestini 31, 66013, Chieti Scalo, CH, Italy, - - 2014
Enthesopathies are frequently found in rheumatic inflammatory diseases, but can be observed also in absence of systemic inflammation. Aging, overuse, and microtraumas can be responsible for enthesis-degenerative phenomena. Despite that Achilles enthesis is the more frequently affected, no systematic study on the risk factors associated to this enthesopathy has been ...
Muso Eri E Center of nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan, - - 2014
LDL-apheresis is a method to correct dyslipidemia rapidly. It is expected to alleviate the tissue toxicity of persistent dyslipidemia in not only primary, but also in secondary dyslipidemia associated with refractory nephrotic syndrome, and to have a protective effect against glomerular and tubular injury as expected in atherosclerosis. In addition, ...
Sparks S E SE Clinical Genetics, Department of Pediatrics, Carolinas Medical Center, Charlotte, NC, - - 2014
Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive, multiple congenital anomaly syndrome with cognitive impairment and a distinct behavioral phenotype that includes autistic features. SLOS is caused by a defect in 3β-hydroxysterol Δ(7)-reductase which leads to decreased cholesterol levels and elevated cholesterol precursors, specifically 7- and 8-dehydrocholesterol. However, the pathological processes ...
Blagg Ross R Division of Plastic Surgery, University of Utah Health Sciences Center, Salt Lake City, - - 2014
Descriptions of ganglion cysts date back to 400 BC. Ganglions causing peripheral nerve compression have been described most notably at the wrist. Ganglion compression of the median nerve at the elbow is rare. We report a case of a palmar elbow ganglion causing median nerve compression and the clinical presentation ...
Rodrigues Marcio H MH Department of Gynecology and Obstetrics, Botucatu Medical School-Sao Paulo State University , Botucatu, Sao Paulo , Brazil - - 2014
Abstract Nonalcoholic fatty liver disease (NAFLD) is considered the most common cause of chronic liver disease in the Western countries. NAFLD includes a spectrum ranging from a simple steatosis to a nonalcoholic steatohepatitis (NASH) which is defined by the presence of inflammatory infiltrate, cellular necrosis, hepatocyte ballooning, and fibrosis and ...
Sheikhbahaei Sara S 1 Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran - - 2014
Abstract Background: Serum uric acid (SUA) has been suggested as a potentially modifiable mediator associated with the metabolic syndrome. Hyperuricemia and metabolic syndrome were both associated with adverse renal outcome. However, epidemiologic data are limited regarding this relationship in patients with type 2 diabetes mellitus (T2DM). This study aims to ...
Jung Kyong Yeun KY Division of Hepatology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South - - 2014
Nonalcoholic steatohepatitis (NASH) is a hepatic manifestation of metabolic syndrome. We aimed to assess the relationship of metabolic syndrome-associated NASH and insulin resistance (IR), and to define the correlation of chemicometabolic components with different degree of liver histology in NASH subjects. Ninety-four subjects with NASH (mean age, 38±14 y; 77% ...
Gold Daniel A DA Department of Dermatology, Henry Ford Medical Center, Detroit, - - 2014
Metabolic syndrome is a multifaceted disorder strongly associated with increased risk for development of cardiovascular disease. Chronic inflammatory diseases have been associated with metabolic syndrome. Hidradenitis suppurativa is a chronic inflammatory skin disease with significant physical and emotional sequelae. We sought to investigate a possible association between hidradenitis suppurativa and ...
Clearfield Michael M Touro University College of Osteopathic Medicine, Vallejo, CA, USA, - - 2014
Despite population-based improvements in cardiovascular risk factors, such as blood pressure, cholesterol and smoking, cardiovascular disease still remains the number-one cause of mortality in the United States. In 1989, Kaplan coined the term "Deadly Quartet" to represent a combination of risk factors that included upper body obesity, glucose intolerance, hypertriglyceridemia ...
Mansour Mahmoud M Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, - - 2014
The epidemic of obesity and its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia, collectively known as the metabolic syndrome or syndrome X, is one of the most challenging health problems facing industrialized countries. The nuclear receptors, peroxisome proliferator-activated receptors (PPARs alpha (α), beta (β) also known as delta ...
Suriyaprom Kanjana K Faculty of Medical Technology, Rangsit University, Paholyothin Road, Pathumthani 12000, Thailand. - - 2014
Metabolic syndrome is a cluster of metabolic risk factors including dyslipidemia, impaired glucose tolerance, hypertension and central obesity. BDNF (Brain-derived neurotrophic factor) and leptin have been implied in the energy homeostasis. The purposes of this study were to examine concentrations of leptin, BDNF and biochemical parameters in metabolic-syndrome subjects and ...
Vu Anh - - 2014
Dysregulation of omentin-1, a beneficial adipokine, is thought to play a role in the development of type 2 diabetes and cardiovascular disease. The objective of this study was to evaluate the relationship between circulating omentin-1 concentrations and components of the metabolic syndrome in adults without type 2 diabetes or cardiovascular ...
Hu Huiyuan - - 2014
We applied our new method, maturity-dependent fractionation of bone marrow-derived neutrophil progenitors, to a study of gene expression profiles during granulopoiesis in myelodysplastic syndromes. CD34+ cells with low density [F1], CD11b-/CD16- [F2], CD11b+/CD16- [F3] and CD11b+/CD16low [F4] with intermediate density, CD11b+/CD16int [F5] and CD11b+/CD16high [F6] with high density were isolated ...
Song Kun K Health Management Center, Tianjin Medical University General Hospital, Tianjin, - - 2014
Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome. Immunoglobulin M is reactive to multiple autoantigens and is inferred to be important for autoimmunity, implying that immunoglobulin M may be a potential ...
Suriyaprom Kanjana K Faculty of Medical Technology, Rangsit University, Paholyothin Road, Pathumthani 12000, Thailand. - - 2014
The metabolic syndrome is related to increased risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is an adipocyte-secreted protein with insulin-sensitizing and anti-atherogenic properties. The aims of this study were to evaluate adiponectin levels and biochemical parameters in metabolic-syndrome subjects and healthy controls. The study also sought to ...
Sá Emmanuela Quental Callou de EQ Universidade Federal do Ceará, Barbalha, Ceará, - - 2014
Metabolic syndrome consists of a set of factors that imply increased risk of cardiovascular diseases. The objective here was to evaluate the association between sex hormone-binding globulin (SHBG), sex hormones and metabolic syndrome among men. Retrospective analysis on data from the study "Endogenous oestradiol but not testosterone is related to ...
Mendy Vincent L VL Department of Epidemiology and Biostatistics, School of Health Sciences, College of Public Service, Jackson State University, Jackson, Mississippi, United States of - - 2014
Approximately 26.3 million people in the United States have chronic kidney disease and many more are at risk of developing the condition. The association between specific metabolic syndrome components and chronic kidney disease in African American individuals is uncertain. Baseline data from 4,933 participants of the Jackson Heart Study were ...
Boctor Fouad N FN Department of Pathology and Laboratory Medicine, Geisinger Medical Center, Danville, PA, USA - - 2014
The Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive condition that is characterized by a mutation in the DHCR7 encoding the 7-dehydrocholesterol-Δ7 reductase, the enzyme that catalyzes the last step in cholesterol biosynthesis. The syndrome occurs in 1:20,000 newborns with an estimated gene carrier frequency in US Caucasian population of 1 ...
Savinova Olga V OV Cardiovascular Health Research Center, Sanford Research USD, Sioux Falls, South Dakota, United States of - - 2014
The purpose of this study was to compare the apolipoprotein composition of the three major lipoprotein classes in patients with metabolic syndrome to healthy controls. Very low density (VLDL), intermediate/low density (IDL/LDL, hereafter LDL), and high density lipoproteins (HDL) fractions were isolated from plasma of 56 metabolic syndrome subjects and ...
da Silva Felipe Freire FF Escola Bahiana de Medicina e Saúde Pública, 40290-000 Salvador, BA, - - 2014
A major cause of morbidity and mortality in the context of the antiphospholipid syndrome (APS) is the occurrence of thrombotic events. Besides the pathogenic roles of antiphospholipid antibodies (aPL), other risk factors and medical conditions, which are conditions for traditional risk of an individual without the APS, can coexist in ...
Tokunaga Makoto M Department of Neurology, Kumamoto Kinoh Hospital, - - 2014
We herein report the case of an 81-year-old woman with midbrain infarction causing pupil-sparing oculomotor nerve palsy with ipsilateral cerebellar ataxia. The lesion was located at the rostral end of the decussation of the superior cerebellar peduncle touching the dorsal side, further caudal and dorsal to causal lesions of Claude's ...
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