The symptoms of the fetal alcohol syndrome and their frequency of appearance are described based on 41 reports in the literature and on own observations. Experimental evidence is presented proving the lack of cytotoxicity, mutagenicity and teratogenicity of alcohol itself and the intensive cytotoxicity, mutagenicity and teratogenicity of acetaldehyde. Responsibility ...

His bundle electrograms and atrial pacing are reported in a 10 1/2-year-old boy and a 12-year-old girl, both of whom underwent Mustard repair for complete d-transposition of the great arteries. Each patient had progressive evidence of sick sinus syndrome culminating in syncope. Improvement occurred after insertion of a demand pacemaker.

Delirium tremens in a common feature in the alcoholic population. The Fat Embolism Syndrome (FES) is characterized by fever, encephalopathy, respiratory failure and skin petechiae. Fat embolism has been associated with alcoholics but the diagnosis was apparent only at autopsy. We present an alcoholic male who developed delirium tremens unresponsive ...

Twenty nine patients with sick sinus syndrome were treated from November, 1972 through July, 1976. Six cases had sinus bradycardia, 14 cases had sinoatrial block/sinus arrest and 9 cases had bradycardia-tachycardia syndrome. Twenty five patients received the implantation pacemaker with good result. There was found that an adequate pacing of ...

A brother and sister and described with malformations and handicaps consistent with both the Klippel-Feil Anomalad and the Fetal Alcohol Syndrome. The mother was known to be a chronic alcholic throughout both pregnancies. It is suggested that these anomalies are not purely fortuitous but rather that maternal alcoholism may cause ...

A case is described of a newborn infant, small for gestational age, with the features of the "fetal alcohol syndrome", who presented a murmur within the first few days of life, and died at age 7 days in heart failure. Autopsy revealed interruption of the aortic arch, type A, an ...

Four cases of sinus tarsi syndrome are presented. They were studied by means of arthrography of the posterior subtalar joint and histological examination of sinus tarsi soft tissue. The obliteration of synovial recesses on posterior subtalar joint arthrography can be explained by synovial hyperplasia and by cicatricial remodelling of ligament ...

Six infants with dysmorphic features of the fetal alcohol syndrome presented with symptoms of withdrawal from alcohol similar to those observed in adults and animals. Symptoms were characterized by irritability, tremors, spontaneous seizures, opisthotonos, and abdominal distention. A comparison of symptoms is made to animal and withdrawal from ethanol and ...

Subjective and physiological manifestations of the narcotic withdrawal syndrome were produced as a conditioned response. Withdrawal reactions precipitated by the narcotic antagonist naloxone in methadone-dependent volunteers were the unconditioned response. These data support clinical anecdotes of withdrawal symptoms occurring in former addicts when they return to their drug-related environment.

Intracerebroventricular administration of methionine-enkephalin or morphine sulfate immediately prior to naloxone administration inhibited the precipitated withdrawal jumping response in mice rendered dependent on morphine by the pellet implantation method. Both methionine-enkephalin and morphine sulfate failed to inhibit withdrawal defecation and rearing behavior. Morphine sulfate was found to be four times ...

The following neuropsychiatric disorders have been briefly described: alcohol withdrawal syndrome, delirium tremens, alcohol hallucinosis, Wernicke-Korsakow syndrome, seizures, tremor, Marchiafava-Bignami disease, central pontine myelinolysis, alcoholic amblyopia, alcoholic cerebellar degeneration cerebral atrophy, alterations of personality in chronic alcoholics, alcoholic polyneuropathy. The pathogenetical aspects as well as the pathological findings have been ...

Myofascial pain syndrome of the TMJ region is not uncommon. It is important to realize that these patients often have a history of TMJ trauma, frequently have positive physical findings of the TMJ, and often have positive roentgenographic findings which continue following successful therapy of myofascial pain syndrome mimicking pain ...

Since alcoholism is not only widespread but often cryptic, the index of suspicion for the withdrawal syndrome in an unfamiliar patient should be high, particularly since failure to diagnose it is common and can eventuate fatally. Yet the signs and symptoms are consistent. A staged approach to the diagnosis is ...

Neurologic complications may appear before the primary disease, alcoholism, is recognized. The common syndromes are polyneuropathy, the withdrawal syndrome and the combination of Wernicke's encephalopathy and Korsakoff's psychosis. Other conspicuous clinical pictures include ataxia of cerebellar origin, convulsions, acute hallucinosis, myopathy and coma. Rarer disorders are Marchiafava-Bignami disease and central ...

In one year, the "fetal alcohol syndrome" (FAS) was recognized in seven newborn and older infants, bringing the total in the current literature to 26 cases. This recently rediscovered disorder consists of severe prenatal and postnatal growth failure, mental deficiency, and characteristic hypoplasia of the middle face and orbits with ...

Drowsiness is one of the cardinal symptoms of motion sickness; therefore, a symptom-complex centering around "drowsiness" has been identified which, for convenience, has been termed the sopite syndrome. Generally, the symptoms characterizing this syndrome are interwoven with other symptoms but under two circumstances the sopite syndrome comprises the main or ...

Symptomatic bradycardia-tachycardia is often a feature of sick sinus syndrome. However, when alternating brady-tachycardia results from excessive use of digitalis preparations or electrolyte imbalance, it is iatrogenic and therefore not considered to be SSS per se. Sick sinus syndrome is applied to the following arrhythmias providing they are not iatrogenically ...

Five cases of carotid sinus syndrome are presented. The syndrome is defined by spontaneous attacks of dizziness and fainting which can be reproduced by graded pressure on one carotid sinus. Three forms of the clinical syndrome, cardioinhibitory, vasodepressor, and cerebral, are discussed. The hyperactive carotid sinsu reflex, in which there ...

The levo and dextro isomers of 2,5-dimethyl-2'-hydroxy-9alpha- and -9beta-propyl-6,7-benzomorphans have been prepared. The analgesic potency and physical dependence capacity of the optical isomers and their racemic parents were determined. The 9alpha-propyl levo isomer was analgesically equipotent with morphine; the 9beta-propyl levo isomer was considerably more potent subcutaneously and equipotent orally. ...

A pair of fraternal twins with stigmata of the fetal alcohol syndrome are described. Apparently differences in susceptibility to the dysmorphogenic influence of ethanol caused one twin to be more severely affected than the other one. Both infants are growing poorly postnatally, and both are at risk for retarded development. ...

Alternate-beat Wenckebach, an uncommon dysrhythmia, usually is attributed to block within the His bundle or bundle branches (or in both). A patient with features of the "sick sinus" syndrome demonstrated A-V nodal (supra-His) alternate-beat Wenckebach during atrial pacing and His bundle electrocardiography. Electrophysiologic mechanisms are proposed.

A boy born to a known alcoholic mother demonstrated the fetal alcohol syndrome. Although considerably postterm, he weighed less than 1.5 kg (3 lb) at birth and has failed to catch up at 2 1/2 years of age. In addition to continuing prenatal and postnatal growth and developmental deficits, he ...

"Sick sinus syndrome" is characterized by alternating tachyarrhythmias and bradyarrhythmias, diverse origin, generalized conduction abnormalities, and symptoms of heart failure, systemic embolization, and syncope. Proper treatment requires demand atrial or ventricular pacing. A patient with this syndrome was treated with a new transvenous atrial electrode catheter which has successfully controlled ...

Following the description of the alcohol withdrawal syndrome in man, efforts have been made to use the nonhuman primate as an animal model for studying the development of physical dependence upon alcohol. There is now general agreement regarding the qualitative description of the withdrawal reaction in the rhesus monkey, and ...

Out of a pacemaker clinic population of 182 patients 21 (11.5%) were found to have the sick sinus syndrome. Their ages ranged from 30 to 80 years and averaged 62. Ischaemic heart disease was more commonly an aetiological factor than in patients with chronic atrioventricular heart block. Other aetiologies were ...

The influence of retrograde conduction of the artificial pacemaker impulse from the right ventricle to the atria exerted upon the occurrence of rapid supraventricular rythms was investigated in patients with sick sinus syndrome. The bouts of tachycardia occurred in cases with fixed V-A retrograde block or coincided with temporary V-A ...

According to a recently proposed hypothesis, physical dependence upon alcohol is due to the formation of an endogenous opiate. We tested the hypothesis by determining whether or not ethanol-dependent mice would show typical opiate-dependent behavior (withdrawal jumping syndrome) when challenged with the opiate antagonist naloxone. Our results do not support ...

Six patients with tangential missile wounds of the vertex of the skull presented symptoms of limb paresis which were more marked proximally in the arms and distally in the legs where there was also sensory loss of a cortical type. Carotid cerebral angiography and operative treatment showed patency of the ...

Thesis (Ph. D.)--University of Kentucky, 2005.

Euthyroid sick syndrome, characterized by low serum 3,5,3′-triiodothyronine (T3) with normal L-thyroxine levels, is associated with a wide variety of disorders including sepsis, malignancy, and AIDS. The degree of low T3 in circulation has been shown to correlate with the severity of the underlying disorders and with the prognosis. Elevated ...

<l type="ord"><li> All recovered alcoholics have varying degrees of hypoglycaemia whether hereditary or acquired. Many of these will yield a history consistent with, and similar to their present endocrine status, which can be traced back to early life before the onset of alcoholism. Some spouses, of drinking alcoholics, succumb to ...

There is growing awareness of sick sinus syndrome (SSS) and related arrhythmias as treatable causes of epilepsy, syncope, dizziness, confusion and some psychoses, as well as non-neurological symptoms such as episodic congestive heart failure, pulmonary edema and palpitations. Six cases are presented which occurred in family practice in a period ...

Three males with an XXYY sex chromosome complex are described. These patients, together with five XXYY subjects recorded in the literature, show the clinical features of Klinefelter's syndrome. Taking into consideration the findings in XYY and XXXYY individuals, it appears that the addition of a Y chromosome to XY, XXY ...