Much is known about the pathophysiology and pathogenesis of the polycystic ovary syndrome (PCO). The key clinical features are inappropriate gonadotropin secretion, altered production rates, binding and metabolism of steroids and androgen excess, all resulting in defeminization, anovulatory infertility, obesity and endometrial hyperplasia. Management should be based on the patient's ...

We report two patients with an ovarian mass following hysterectomy. These represent part of the spectrum of the "residual ovary syndrome." The retroperitoneal incarceration of a residual ovary and the presence of adhesions, preventing free access to the peritoneal cavity, result in an accumulation of follicular products locally and, thus, ...

The benign but socially embarrassing problem of gustatory sweating and flushing (Frey syndrome) has been studied in the past in search of a simple but effective treatment. Twenty-two patients participated in clinical trials of glycopyrrolate on an investigational basis, 17 of which have been followed up for four to five ...

The serotonin syndrome, a behavioral response produced by the activation of serotonin receptors, and 3H-serotonin binding were examined after repeated treatment of rats with different types of antidepressant drugs. The serotonin syndrome was produced by the direct-acting serotonin receptor agonists 5-methoxy-N,N-dimethyltryptamine (5-MeDMT) or d-lysergic acid diethylamide (LSD). Repeated, but not ...

A case of Stein-Leventhal syndrome is reported in a 37 year old Melanesian female. Endometrial carcinoma developed necessitating hysterectomy and bilateral salpingo-oophorectomy. The syndrome is due to disordered hormone synthesis in the ovary which results in excessive production of androstenedione and testosterone. The treatment of choice is patients wishing to ...

The authors review some pertinent features of the battered wife syndrome, including definitions, incidence, characteristics of wives, injury profiles, setting of the violence, psychodynamics, role of alcohol, family backgrounds, characteristics of husbands, coping responses of wives, seeking help, social support systems, recognition of the battering syndrome, prevention and treatment, and ...

Marked improvement in the severe hypertension (250/150 mmHg) and hirsutism of a patient suffering from polycystic ovary syndrome was quickly achieved by the use of spironolactone 200 mg per day. Substitution of spironolactone with bromocriptine induced further amelioration of these symptoms and renewal of ovulatory cycles. These drugs may afford ...

Polycystic ovaries are usually manifest on an ultrasound study as symmetrically enlarged ovaries containing numerous tiny cysts. The cysts are difficult to detect with conventional contact B-scanners but are readily detected with high-resolution, real-time sector scanners. The cysts range in diameter form 2 to 6 mm and may be arranged ...

The authors discuss the borderline syndrome of childhood, review the pertinent literature, and present three case histories demonstrating the salient features of the clinical syndrome. Each patient failed to benefit from intensive hospital treatment until imipramine (5 mg/kg/day) was added to the treatment regimen. One child was treated in a ...

In a 38-year-old women, suffering from the Bonnet-Blanc/Wyburn-Mason syndrome, a very disfiguring, pulsating 'angioma', situated left frontally, was successfully extirpated after gelfoam embolisation of the supplying external carotid artery. The patient, suffering from this syndrome which until recently was hardly amenable to treatment, could thus, thanks to modern embolisation technique ...

A patient with the resistant ovary syndrome is reported. It is suggested that lack of synchronization between steroidogenesis in the granulosa and theca cells is responsible for the (acquired) occurrence of this syndrome. Feedback inhibition of pituitary gonadotrophin secretion was achieved by exogenously administered ovarian steroid hormones. All protein and ...

The second case of virilism as a late manifestation of Bardet-Biedl syndrome (BBS) is described, with endocrine and histological evaluation. Both cases manifested ovulatory cycles and developed virilism in adulthood. Elevated plasma testosterone and 17-OH-progesterone were not suppressed by dexamethasone but were suppressed by medroxyprogesterone acetate. Peripheral and ovarian venous ...

A young patient with secondary amenorrhea and primary infertility is described. After a gynecological-endocrinological exploration including laparoscopy, the diagnosis indicates secondary hypergonadotropic, hypo-estrogenic normo-androgenic amenorrhea. The anatomopathological examination of an ovarian biopsy revealed an intact follicular apparatus, thus disproving the suspected diagnosis of climacterium praecox. Since very high gonadotropin doses ...

A 60-year-old white female with oat-cell carcinoma of the lung presents with a recurrent pulmonary nodule and Cushing syndrome. The tumor is uncontrollable with MeCCNU and cyclophosphamide (Cytoxan), consequently the symptoms of Cushing disease become severe. Cushing syndrome is documented by laboratory examinations. Aminoglutethimide, an anticonvulsant, is used to reverse ...

A case of the unilateral streaked ovary syndrome is presented with documentation by cytologic, chromosomal, laparoscopic and hormonal studies. This, the Slotnick-Goldfarb′s syndrome, is characterized by oligomenorrhoea progressing into secondary amenorrhoea in a normal phenotypic female with a streaked ovary in one adnexa and an hypoplastic ovary in the other. ...

The sound patterns produced by tooth contact were recorded in 24 subjects with myofascial pain-dysfunction (MPD) syndrome prior to and following treatment using an Occlusograph. Recordings also were obtained on 12 control subjects. Evaluation of the sound patterns showed a close correlation between the improvement in symptoms of MPD syndrome ...

A patient with secondary amenorrhea with the gonadotropin-resistant ovary syndrome is described. The physiopathology of the syndrome is investigated and discussed. Ovulation could not be induced by using very high doses of gonadotropins. The presence of a hormone abnormality or of an inhibitor preventing hormone action could not be substantiated. ...

A 12-year-old girl was examined for growth retardation and a few very discrete dysmorphologic stigmata of Turner's syndrome; the genitalia were infantile yet both ovaries possessed functioning follicles. R- and C-banding techniques and Brdu treatment demonstrated a 45,X formula in 95% of lymphocytes, with 5% presenting a 46,X,dic(X) formula. Cytogenetic ...

Although the pathogenesis of the PCO syndrome remains obscure, several endocrine aberrations are clinically measurable in this syndrome. It has been shown that this syndrome is associated with inappropriate gonadotropin secretion and elevated serum LH, A and T levels. Various levels of E2 and E1 have been noted. The evaluation ...

An account of the response to biological treatment of 20 patients with the syndrome of doubles (syndrome of Capgras, syndrome of Frégoli, syndrome of Intermetamorphosis, syndrome of subjective doubles) is presented. Our observations indicate that: a) the syndrome of doubles may respond to various biological treatment methods; b) in the ...

5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did ...

The polycystic ovary has the capacity to produce excessive androgens (delta4-androstenedione, dehydroepiandrosterone, and testosterone). Whether this disorder is caused by constant pituitary priming of the ovaries due to hypothalamic-pituitary derangement or an ovarian enzyme defect, the end result is the same, i.e., abnormal androgen production. In an effort to explain ...

The external sphincter spasticity syndrome is described with regard to diagnosis, etiology, pathophysiology and treatment. Use of urodynamic techniques (especially urethral pressure profile and diagnostic pudendal blocks) and adrenolytic agents and diazepam in the treatment of the dysfunction is discussed. We consider this clinical entity to be much more common ...

A case of unilateral streaked ovary (Slotnick-Goldfarb's syndrome) is reported and documented with hormonal, chromosomal, laparoscopic, and histologic studied. It is postulated that viral oophoritis associated with mumps might explain the coexistence of a streaked ovary of a congenital origin with a hypoplastic ovary, tbat would be the expression of ...

There are unknown all laws which determine the growth of the skull in the case of a hydrocephalic syndrom. Many factors depend certainly on the pathomechanism of the proper hydrocephalus. There is individual difference. Particularly is very uneasy to explain the definitive type of the skull after the treatment of ...

Three patients with oligomenorrhoea and hirsutism thought to have the polycystic ovary syndrome were found to have only one ovarian cyst. Endocrine findings were similar to those found in the polycystic syndrome, but apart from the single cyst the ovaries were histologically normal; a biopsy specimen of a cyst showed ...

When ovarian mitochondria from a patient with polycystic ovary syndrome (POS) were incubated with [7-3H]17alpha-hydroxypregnenolone and [4-14C]17alpha-hydroxyprogesterone, 11beta-hydroxylated metabolites were obtained. When the same mitochondrial preparation was incubated with [7-3H]17alpha-hydroxypregnenolone and [4-14C]11-deoxycortisol no 11beta-hydroxylated derivatives of 11-deoxycortisol were found. These results are compatible with and support the conclusion that the ...

A family with hirsutism in five generations in which polycystic or bilaterally enlarged ovaries were documented in three different sibships of two generations is described. Two brothers of one of the women with polycystic ovaries had a low or low-normal plasma follicle-stimulating hormone level and one of these had oligospermia ...

150 women with serious climacteric complaints were continuously treated from January, 1970, up to April, 1972, with Ovestin¿, an orally effective preparation containing 1 mg of oestriol per tablet. After one month of treatment subjective complaints were already considerably improved. Oestrogenic activity was markedly increased, according to vaginal smears and ...

Destruction of the septum leads to a well known hyperirritability syndrome. However, the intensity of this syndrome is modifiable by certain presurgical treatments. Injections, prior to surgery of para-chlorophenylalanine (PCPA) for two days or insulin for five days has no effect on septal rage. However, injections of PCPA five days ...

Thirty-four patients with painful shoulder syndrome (PSS) were psychologically assessed and the results compared with those from a control group presenting other musculoskeletal disorders. A significantly greater prevalence of depression was found in the former group. Fifty-six patients with PSS were treated with only lithium and amitriptyline for four months; ...

Thesis (M.A.)--Northern Kentucky University, 2006.

Abrupt termination of the treatment of humans with benzodiazepines (BDZs) leads to a rapid onset of discontinuation syndrome characterized by anxiety, muscle spasms, and occasionally convulsions. For this reason, it is recommended in clinical practice to reduce the dose of the BDZs gradually at the end of treatment. Nevertheless, many ...

Introduction: To report the results of a large series of patients undergoing treatment for Duane’s syndrome.

The Life Fertility Programme promotes and supports reproductive health and fertility, and offers evaluation and treatment to couples seeking help with infertility problems. The Life Fertility Programme is provided through the Life Hospital Trust, a UK based charity. The Programme provides a fee-paying reproductive and fertility service and information is ...

There has been much confusion in the literature over the definition, diagnosis and treatment of premenstrual syndrome (PMS). This article discusses definitions of PMS, incidence, etiology and symptomatology. Diagnosis depends on the timing of symptoms rather than the type. Symptoms commonly occur during the late premenstruum; at ovulation and during ...

An integrated ebook of answers to FAQs on women's health including infertility, IVF, polycystic ovary syndrome, recurrent miscarriage, contraception, pelvic pain, heavy periods, hysterectomy, premenstrual syndrome, menopause, HRT, and cancer. The book is directed mainly at women who want to discover the background to treatment options, but may also be ...

Polycystic ovaries were found in a 16-year-old female with congenital absence of vagina, male-like external genitalia, and congenital adrenal hyperplasia. Masculinization was sufficiently severe to cause the patient to be reared as a male. Biochemical studies of ovarian tissue revealed hyperactivity and an imbalance of enzyme systems concerned with steroid-hormone ...