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Govindan Morgen L - - 2014
Hepatopulmonary syndrome is a clinical syndrome that can affect patients of all ages with liver disease and is more common in children with biliary atresia. Contrast echocardiography is the test of choice to diagnose the presence of intrapulmonary vascular dilatation. The established treatment for hepatopulmonary syndrome is liver transplantation. We ...
Schulert Grant S GS Divisions of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
Objectives: Mevalonate kinase deficiency (MKD) is a metabolic autoinflammatory syndrome encompassing Hyper Immunoglubulinemia D and periodic fever Syndrome (HIDS) and mevalonic aciduria (MA). Although inflammatory episodes often include abdominal pain and hepatomegaly, severe liver dysfunction is uncommon. There are also rare reports of children with MKD developing macrophage activation syndrome ...
Abdin Amany A a Department of Pharmacology, Faculty of Medicine, Tanta University, Al-Geish Street, Postal No. 31527, - - 2014
This study was designed to investigate whether resveratrol could provide protection against Reye's syndrome induced by 4-pentenoic acid in Wistar albino rats. Compared with rats with untreated Reye's syndrome, 1 h pretreatment by low dose resveratrol (10 mg/kg by oral gavage) resulted in marked amelioration in liver functions in the ...
Roales-Gómez V - - 2014
Acute liver failure has a high mortality and its most frequent cause in Spain is viral infection. In this article, we present a case of fulminant liver failure. The failure is secondary to an idiosyncratic reaction to ibuprofen, an entity included in the DRESS syndrome. This syndrome plays a key ...
Feillet-Coudray Christine - - 2014
Abstract The prevalence of metabolic syndrome components including obesity, dyslipidemia, insulin resistance and hepatic steatosis is rapidly increasing in wealthy societies. It is accepted that inflammation/oxidative stress are involved in the initiation/evolution of the metabolic syndrome features. The present work was designed to evaluate the effects of three major cellular ...
Misiołek Aleksandra A Psychological Practice, Barcelona, Spain. - - 2014
Burnout syndrome is a psychological response to chronic work-related stress characterized by low enthusiasm towards the job, high psychological exhaustion, indolence and guilt. Being a medical doctor, both in Poland and in other countries, is one of the most stressful occupations and anaesthesiology is considered one of the most stressful ...
Chu Po-Ching PC National Taiwan University College of Medicine, Taipei, TaiwanNational Taiwan University Hospital, Taipei, - - 2014
Some of cardiovascular diseases, like stroke and acute coronary syndrome (ACS), are compensable diseases in Taiwan as well as Japan and Korea. The number of compensated cases in the disease has increased from 13 in 2006 to 92 in 2012. The information on workplace risk factors before onset of disease ...
Aghilinejad Mashaallah M Occupational Medicine Research Center, Iran University of Medical Sciences, Tehran, IR - - 2014
Occupation is one of the major parts of our daily lives that might cause a great amount of stress. Stress and job burnout are linked together. The association between musculoskeletal disorders (MSD) and burnout syndrome as a psychosocial factor was investigated previously. The aim of this study was to identify ...
Fitzpatrick Therese A - - 2014
Women are often reluctant to apply for promotions even when they are well deserved, simply believing good job performance will naturally lead to rewards. This phenomenon of advancement reticence has led to such labels as "tiara syndrome," "girl disease", and "imposter syndrome". Women often undervalue their skills and are less ...
Hintsa Taina T University of Helsinki, - - 2014
We examined whether long QT syndrome status moderates the association between stressful life events and depressive symptoms. Participants were 562 (n = 246 symptomatic) long QT syndrome mutation carriers. Depressive symptoms were measured with a modified version of the Beck's Depression Inventory. There was an interaction between long QT syndrome ...
Bianchi Renzo R University of Franche-Comté, Besançon, - - 2014
Within the field-dominating, multidimensional theory of burnout, burnout is viewed as a work-specific condition. As a consequence, the burnout syndrome cannot be investigated outside of the occupational domain. In the present paper, this restrictive view of burnout's scope is criticized and a rationale to decide between a work-specific and a ...
Pelliccia F F Department 'Attilio Reale', Sapienza University, Rome, Italy. Electronic address: - - 2014
Takotsubo Syndrome is a relatively frequent clinical entity presenting typically as an acute coronary syndrome in the absence of obstructive coronary artery disease and characterized angiographically by transient left ventricular systolic dysfunction sparing the basal segments of the left ventricle ("apical ballooning"). Takotsubo Syndrome characteristically affects peri- or post-menopausal women, ...
Chattopadhyay Sayan S Department of Oral Medicine & Radiology, Awadh Dental College, Jamshedpur, - - 2014
Rett Syndrome (RS) is a chromosome X-linked genetic neurological disorder characterized by developmental regression, particularly in relation to expressive language and use of the hands. It is also associated with profound mental retardation and almost exclusively affects females. A four and a half year old girl reported to our dental ...
Mazzeo A T AT Department of Anaesthesia and Intensive Care, University of Torino, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Presidio Molinette, Corso Dogliotti 14, 10126 Torino, - - 2014
Neurogenic stress cardiomyopathy (NSC) is a well-known syndrome complicating the early phase after an acute brain injury, potentially affecting outcomes. This article is a review of recent data on the putative role of localization and lateralization of brain lesions in NSC, cardiac innervation abnormalities, and new polymorphisms and other genetic ...
Hejazi Reza A RA Department of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, - - 2014
: Rumination is a normal and common phenomenon among ruminant animals; but in humans, it is always regarded as symptom indicative of abnormal function of the upper gastrointestinal tract, and understanding of the mechanisms explaining this event are still evolving. Learning-based theories, organic factors such as gastroesophageal reflux disease and ...
Jiao Yang Y Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, - - 2014
To analyze the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease (CHD). This prospective cohort study investigated and collected the clinical information of patients with stable CHD and observed the syndrome type at the baseline and 6-month at follow-up, as well as ...
Crane Denis I DI The Eskitis Institute for Drug Discovery, and School of Biomolecular and Physical Sciences, Griffith University, Queensland, Australia. Electronic address: - - 2014
Zellweger syndrome (ZS) is a neonatal-lethal genetic disease that affects all tissues, and features neuropathology that involves primary developmental defects as well as neurodegeneration. Neuropathological changes include abnormal neuronal migration affecting the cerebral hemispheres, cerebellum and inferior olivary complex, abnormal Purkinje cell arborisation, demyelination and post-developmental neuronal degeneration. ZS is ...
Seco-Cervera Marta M CIBERER. Centro de Investigación Biomédica en Red de Enfermedades Raras, Valencia, - - 2014
Werner Syndrome (WS, ICD-10 E34.8, ORPHA902) and Atypical Werner Syndrome (AWS, ICD-10 E34.8, ORPHA79474) are very rare inherited syndromes characterized by premature aging. While approximately 90% of WS individuals have any of a range of mutations in theWRN gene, there exists a clinical subgroup in which the mutation occurs in ...
Buse Judith J Department of Child and Adolescent Psychiatry, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, - - 2014
Accumulating data indicate a common occurrence of tic exacerbations and periods of psychosocial stress. Patients with Tourette's syndrome (TS) also exhibit aberrant markers of hypothalamic-pituitary-adrenal (HPA) axis activation. Based on these findings, a functional relationship between stress and tic disorders has been suggested, but the underlying mechanism of how stress ...
Martynenko A Yu AY Department of Infectious Diseases and Epidemiology, Khabarovsk, - - 2014
Activation of proliferative processes (Ki-67 proliferation index) and local oxidative stress was found in biopsy material from the mucosa of the large intestine of patients at the early stages of hemorrhagic fever with renal syndrome on days 5-10 after disease onset. Analysis of data of rectosigmoidoscopy and clinical examination refl ...
Zhang Pei P 0000-0003-0608-5677 Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China ; Key Laboratory of Neurological Diseases, Ministry of Education, Wuhan, Hubei 430030, - - 2014
Metabolic syndrome is becoming commoner due to a rise in obesity rates among adults. Generally speaking, a person with metabolic syndrome is twice as likely to develop cardiovascular disease and five times as likely to develop diabetes as someone without metabolic syndrome. Increasing oxidative stress in metabolic syndrome and Parkinson's ...
Soto María Elena ME Immunology Department, National Institute of Cardiology "Ignacio Chavez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 Mexico City, DF, - - 2014
The role of oxidative stress in different aortopathies is evaluated. Thirty-two tissue samples from 18 men and 14 women were divided into: 4 control (C) subjects, 11 patients with systemic arterial hypertension (SAH), 4 with variants of Marfan's syndrome (MV), 9 with Marfan's syndrome (M), 2 with Turner's syndrome, and ...
Sharma Brij B Department of Gastroenterology, Indira Gandhi Medical College, Shimla, Himachal Pradesh 171001, - - 2014
Autoimmune cholangitis (AIC) or autoimmune cholangiopathy is a chronic inflammation of liver and a variant syndrome of autoimmune hepatitis (AIH). We present a case of an adult female who had biochemical features of cholestasis and transaminasemia but aminotransferases were not in the hepatitis range and had histological evidence of bile ...
Popescu Gabriel-Adrian GA "Matei Bals" Infectious Diseases Institute, Bucharest, Romania. - - 2014
Liver abscess was diagnosed in a man presenting with fever, chills and severe myopathy. The K. pneumoniae isolated from blood cultures belonged to the K1 serotype. The patient responded favourably to percutaneous drainage of the abscess and antibiotics. This is the first documented report of Klebsiella pneumoniae liver abscess syndrome ...
Määttänen Ilmari I University of Helsinki, - - 2013
To study emotional distress in symptomatic and asymptomatic long QT syndrome mutation carriers who had experienced a recent stressful life event. The participants were 209 symptomatic and 279 asymptomatic long QT syndrome mutation carriers. Emotional distress was assessed with the Cope questionnaire and stressful life events with the Social Readjustment ...
Magnavita Nicola - - 2013
Scientific data have amply demonstrated that work stress increases the risk of cardiovascular disease. However, less attention has been given to the association between stress and metabolic syndrome. In this study, our aim was to investigate the relationship between work stress and metabolic syndrome in a population of radiologists. Radiologists ...
Djamshidian Atbin - - 2013
In this manuscript we summarize the role of chronic stress as a potential trigger factor for Parkinson's disease. Underlying mechanisms and stress-induced changes to the neuronal networks have been highlighted. Examples of stress induced reversible symptoms that resemble parkinsonism in humans and in animal models raise the question whether emotional ...
Glaubach Taly - - 2013
The inherited bone marrow failure syndromes, like severe congenital neutropenia (SCN) and Shwachman-Diamond syndrome (SDS), provide unique insights into normal and impaired myelopoiesis. The inherited neutropenias are heterogeneous in both clinical presentation and genetic associations, and their causative mechanisms are not well established. SCN, for example, is a genetically heterogeneous ...
Gyawali Prajwal - - 2013
Erythrocyte aggregation has been consistently associated with insulin resistance, central obesity and hypertension in the literature. Oxidative stress and chronic inflammation are almost always present in metabolic syndrome (MetS). Prooxidants and adipocytokines generated in MetS alter erythrocyte morphology, decrease erythrocyte deformability and increase whole blood viscosity (WBV). Increased WBV has ...
Brownlee-Bouboulis Sarah A SA 1  Department of Biology, Bucknell University, 1 Dent Drive, Lewisburg, Pennsylvania 17837, - - 2013
Abstract White-nose syndrome (WNS) is an emerging infectious disease of hibernating bats linked to the death of an estimated 5.7 million or more bats in the northeastern United States and Canada. White-nose syndrome is caused by the cold-loving fungus Pseudogymnoascus destructans (Pd), which invades the skin of the muzzles, ears, ...
Kim Soung Min - - 2013
Abnormal elongation of the styloid process, or Eagle syndrome, can be painful, and is associated with differential diagnoses including cranio-facial malformations and vasculo-neurological disturbances. The precise molecular mechanism leading to styloid process elongation is unknown. In this study, elongated styloid processes with periosteal fibrous ligament tissue were obtained from three ...
Delmiro Aitor - - 2013
We describe a West syndrome (WS) patient with unidentified etiology that evolved to Lennox-Gastaut syndrome (LGS). The mitochondrial respiratory chain of the patient showed a simple complex I deficiency in fibroblasts. Whole-exome sequencing (WES) uncovered two heterozygous mutations in NDUFV2 gene that were reassigned to a pseudogene. With the WES ...
Adams Madeleine M Department of Paediatric Oncology, Children's Hospital for Wales, University Hospital, Cardiff CF14 4XW, United - - 2013
Bloom syndrome (BS) is an inherited genomic instability disorder caused by disruption of the BLM helicase and confers an extreme cancer predisposition. Here we report on a girl with BS who developed acute lymphoblastic leukaemia (ALL) at age nine, and treatment-related acute myeloid leukaemia (t-AML) aged 12. She was compound ...
Foley Sue - - 2013
Caring for young infants can be stressful. Non-accidental brain or head injury (shaken baby syndrome) is a result of parental stress, and a lack of knowledge of how to respond to a crying infant and the dangers of shaking a child. This article demonstrates the value of international collaboration in ...
Ciammella Patrizia - - 2013
Few data exist about the prevalence of burnout syndrome among young radiation oncologists. A national survey to assess its prevalence among junior members (under 40 yrs of age) of the Italian Society of Radiation Oncology was conducted. One hundred and twelve young radiation oncologists completed the questionnaire: the prevalence of ...
Elnakish Mohammad T - - 2013
Oxidative stress is a term defining states of elevated reactive oxygen species (ROS) levels. Normally, ROS control several physiological processes such as host defense, biosynthesis of hormones, fertilization, and cellular signaling. However, oxidative stress has been involved in different pathologies including metabolic syndrome and numerous cardiovascular diseases. A major source ...
Tikarová Jana - - 2013
Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase in concentrations of asymmetric dimethylarginine (0.84 +/- 0.32 mumol/L, p = 0.0022) and malondialdehyde ...
- - 2013
By operational criteria, burnout appears to be a multifaceted behavioral syndrome consisting of maladaptive individual responses subsequent to prolonged stressful situations. Given the intense physical and cognitive demands of providing high quality healthcare to a wide spectrum of patients, healthcare professionals are particularly susceptible to developing burnout syndrome, a notable ...
Samela P C - - 2013
Nevoid basal cell carcinoma (BCC) syndrome, or Gorlin syndrome, is a rare autosomal dominant disorder associated with mutations in the patched 1 gene, PTCH1. It is characterized by the presence of multiple BCCs in association with disorders affecting the bones, the skin, the eyes, and the nervous system. We describe ...
Fikree Asma - - 2013
Although perceived as a rare condition, joint hypermobility syndrome is common. Its prevalence in rheumatology clinics is extremely high. Early estimates suggest that it may be the most common of all rheumatologic conditions. The problem lies in the general lack of awareness of the syndrome, its means of recognition, and ...
Gharbi Hakam - - 2013
Signaling through the hypoxia-inducible factor hif-1 controls longevity, metabolism and stress resistance in C. elegans. HIF protein levels are regulated through an evolutionarily conserved ubiquitin ligase complex. Mutations in the VHL gene, encoding a core component of this complex, cause a multi-tumor syndrome and renal cell carcinoma in humans. In ...
Singh Ankur - - 2013
The phenotypic description of SHORT syndrome (OMIM- 269880) is expanding since its initial description in 1975. There have been 26 case reports till date but the genetic locus of this syndrome is elusive. Involvement of PITX2 gene initially envisaged is probably is not the only gene involved but has an ...
Harizanova Stanislava N - - 2013
Correctional facilities present unique work places--the employees there work in tough, demanding and hazardous working conditions, in real life-threatening environment, subjected to physical and mental fatigue, risk of infectious diseases, work in shifts, with inadequate pay, etc. The aim of this study was to find the prevalence and level of ...
Barrera M J - - 2013
The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with the hope of developing drugs that reduce inflammation. However, there is increasing recognition that understanding the immunobiology of target tissues ...
Brooks Ka - - 2013
Running, or any aerobic training in moderation, has a positive effect on health. There is a point of diminishing returns, where chronic stress from overtraining, which is common in runners, may be linked to problems in the adrenal gland. Overtraining Syndrome (OS) has been linked with adrenal insufficiency. There is ...
Sticova Eva E Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 14021 Prague 4, Czech Republic. - - 2013
Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress. Dubin-Johnson syndrome is a rare, autosomal recessive, inherited disorder characterized by biphasic, predominantly conjugated hyperbilirubinemia with no progression to end-stage liver disease. The molecular basis in Dubin-Johnson syndrome is absence or deficiency of ...
Bornholdt Dorothea - - 2013
Missense mutations affecting membrane-bound transcription factor protease, site 2 (MBTPS2) have been associated with IFAP syndrome with or without BRESHECK syndrome, with keratosis follicularis spinulosa decalvans, and Olmsted syndrome. This metalloprotease activates, by intramembranous trimming in conjunction with the protease MBTPS1, regulatory factors involved in sterol control of transcription and ...
Acquaviva Rosaria - - 2013
Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennial climbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic and antilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may represent an important pathogenic mechanism in obesity-associated metabolic syndrome. ...
Navarro-Zarza José Eduardo - - 2012
The contents of this review may appear odd. After a brief description of the coxofemoral joint, the entities discussed include ilioinguinal neuropathy within the context of the nerves that may be damaged during lower abdominal surgery, meralgia paresthetica, piriformis syndrome with the appropriate caveats, trochanteric syndrome, "ischial bursitis" and trochanteric ...
Lindgren Peter - - 2012
We enjoyed reading the Editorial by Jan Deprests' group from Leuven in Belgium on laser treatment for TTTS. Although we agree on most of their statements, and that there is an obvious room for further improvements, we would like to stress that an inherent problem, when comparing results from different ...
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