Four patients with Gregg's syndrome (congenital rubella) are described. They were all deaf mutes but with clear lenses and good vision though they had marked hypoplasia of the iris stroma and rubella retinopathy. Three of the four had a high rise in intra ocular pressure which was destructive of vision ...

We reviewed the records of 74 patients with exfoliation syndrome. Patients with exfoliation syndrome represented 12% of the current Glaucoma Clinic population. There were 40 unilateral and 34 bilateral cases. Thirteen percent of the patients who originally had unilateral exfoliation later developed exfoliation in the fellow eye. Forty percent of ...

In a patient with the clinical features of the iris nevus syndrome who was treated for glaucoma a cataract developed later. The sector of iris removed during cataract extraction was examined by electron microscopy and was found to be covered by ectopic corneal endothelium with an underlying atypical Descemet's membrane. ...

Sixteen cases of essential iris atrophy and two of iris nevus (Cogan-Reese) syndrome were reviewed retrospectively by light and electron microscopy. Varying degrees of corneal endothelial proliferation onto the trabecular meshwork and anterior iris were seen in all cases. The demonstration of an endothelial-abnormal basement membrane complex on the anterior ...

A 2-week-old premature child with congenital glaucoma secondary to anterior cleavage syndrome was treated with timolol maleate and cyclocryotherapy. The patient had apneic spells of up to 30 seconds that stopped soon after timolol maleate therapy was discontinued. No apnea was seen before timolol maleate administration, and no further spells ...

An eye from an adult with Sturge-Weber syndrome and glaucoma is described histologically following enucleation for massive choroidal hemorrhage. The specimen is noted to contain hemangiomas of the episclera and choroid as well as a partial angle cleavage abnormality. Histologic evidence reviewed herein supports the concept that infantile glaucoma associated ...

We present the history and treatment of a woman who had benign symmetrical lipomatosis and hypothyroidism. We suggest full thyroid investigation of future patients. We also suggest shortening the name of the disorder to symmetrical lipodystrophy, since the syndrome seems to be related to fat deposit growth rather than lipoma, ...

Anterior ectopic anus is increasingly being recognized as a cause of constipation in infancy. Experience is reported with surgical treatment of 20 patients with anterior ectopic anus. This form of anal ectopia is associated with a syndrome of constipation that begins at birth, straining on defecation, and anterior displacement of ...

Corneal and iris tissue were examined from a 72-year-old woman with Chandler's syndrome. Light and electron microscopy showed posterior, corneal, collagenous-layer production by metaplastic corneal endothelium. In areas of iridocorneal contact, there were several layers of metaplastic endothelial cells that covered iris stroma and melanocytes, which were directly subjacent to ...

We found that the spectrum of essential iris atrophy (progressive essential iris atrophy, Chandler's syndrome, and the Cogan-Reese syndrome) began as a corneal endothelial degeneration, which, with ectopic endothelial membrane overgrowth over an open angle, followed by contraction of this membrane and further growth onto the iris, accounted for all ...

A 14-year-old girl with typical oculodentodigital syndrome had been treated for chronic glaucoma for seven years. She had corneas measuring R.E.: 10 mm; L.E.: 9 mm, with narrow angles open on the right, but almost entirely closed on the left. Gonioscopic examination of the right iris revealed that the root ...

An update on the percentage of my patients showing the UGH syndrome associated with the Mark VIII anterior chamber lens implant as manufactured by Surgidev is given. Of seven patients having the syndrome sufficiently severe to warrant removal of the offending lens, six have now been reimplanted, two each with ...

According to our material the exfoliation glaucoma can be regarded as the result of an interplay of at least two different pathologic conditions: a primary genetic goniodysgenesis creating a relative block to the outflow, and a probable vasculopathy in the iris. Subsequent degeneration of the iris will lead to a ...

A family is described with hypoplasia of the anterior iris stroma, no angle anomalies, and no glaucoma. The pedigree is suggestive of an autosomal dominant mode of inheritance. This is compared to the main peripheral malformations of the anterior chamber cleavage syndrome and other disease entities with similar iris changes. ...

Nine trabeculectomy samples, five iridectomy samples and one lens of an exfoliation syndrom were examined. Next to typical exfoliation syndrome fibrils, the alteration of endothelial membranes and similar structures has been pointed out. Concerning the glaucoma genesis, it is being discussed whether a participation of the trabecular network in the ...

The syndrome of anterior segment ischemia occurred in three patients as a complication of cyclocryotherapy for hemorrhagic glaucoma. Cryotherapy was applied with a retinal probe (2.5 mm in diameter) for 12 one-minute applications (-60 degrees or -80 degrees C) over the entire 360-degree circumference at the globe. The pathogenesis for ...

Measurement of the corrosion rates of three distinctive amalgam alloys (lathe-cut, spherical and dispersed-phase) when immersed in three different electrolytes, including saliva, is reported. The results indicate that the dispersed phase alloy amalgam exhibits a lower corrosion rate than a conventional lathe-cut alloy amalgam but is somewhat inferior to a ...

The pigment dispersion syndrome was noted in 10% of white and black subjects with and without glaucoma. This suggested pigment dispersion was not a high risk factor in the development of glaucoma. The HLA-B7 antigen was less prevalent and HLA-B13 and Bw17 antigens were significantly more prevalent in individuals with ...

Eight cases of the plateau iris syndrome are presented. The "plateau iris syndrome" should be differentiated from the "plateau iris configuration." The "configuration" refers to a preoperative condition in which gonioscopically confirmed angle-closure glaucoma occurs, but the iris plane is flat and the anterior chamber is not shallow axially. In ...

A specific type of optic disc damage and visual field loss has been emphasized. The changes occur acutely at the inferotemporal disc margin and do not seem to progress. Such patients have normal intraocular pressures. We have termed this entity "acute inferotemporal prelaminar optic disc infarction syndrome" in an effort ...

Late failure of a filtering cicatrix occurred in a patient who had had surgery to control the glaucoma associated with the iris nevus syndrome (Cogan-Reese). The internal surface of the filtration site, as well as the anterior chamber angle, proved to be lined by corneal endothelium that had laid down ...

A clinical and ultramicroscopic review, including discussion of both scanning and transmission microscopy of the exfoliation syndrome, suggests that the term pseudoexfoliation be replaced by exfoliation syndrome. Involvement of the lens epithelium and, particularly, the pigment epithelium of the iris and the ciliary body epithelium are emphasized as being the ...

Two patients with adolescent onset glaucoma associated with Sturge-Weber Syndrome have been presented. Both patients were successfully treated with ab externo trabeculectomy. This procedure is suggested as an additional means for controlling the late onset glaucoma associated with the syndrome without provoking additional complications or deterioration. Early treatment is emphasized ...

Bilateral eyelid edema, chemosis, conjunctival injection and hemorrhages, shallowing of the anterior chamber with transitory myopia, and acute glaucoma were observed in three patients with hemorrhagic fever with renal syndrome (nephropathia epidemica). One patient had anterior uveitis with posterior synechiae. Two patients had congestion of retinal venules and retinal edema, ...

Slit-lamp examination and stereoscopic fundus photography were found to be helpful in differentiating between physiological and glaucomatous cupping of the disc. Vertical ovalness of any cup in the disc should raise the suspicion of glaucoma, and the magnitude of the vertical cup: disc ratio is of particular significance.

Iris tissue and trabecular meshwork, obtained at time of trabeculectomy, was studied using the light and electron microscope in a 54-year-old woman with pigmentary dispersion syndrome with glaucoma. The specific defect was a loss of the outer epithelial cells of the iris with marked thinning of the remaining outer layers ...

Fourteen patients (ten women, four men) with iris nevus (Cogan-Reese) syndrome, all having unilateral glaucoma, were studied clinically. Many had corneal edema, and all had changes in the iris consisting of one or more of the following: iris whorls or nodules or both, atrophy of iris stroma, heterochromia (the darker ...

A case of postpartum amenorrhea and galactorrhea is reported, with several additional features leading to the diagnosis of primary hypothyroidism. Resolution of the amenorrhea and galactorrhea was noted coincident with adequate thyroid hormone therapy. The interrelationships of the many organ systems involved are discussed, and speculations advanced regarding the mechanisms ...

Seventy-nine patients with hypothyroidism and autoimmune thyroid disease were studied, and allotted to one of four categories on the basis of clinical and biochemical features. Firstly, patients with overt hypothyroidism had obvious clinical features of hypothyroidism and abnormal results from routine tests of thyroid function. Secondly, those with mild hypothyroidism, ...

A prospective study of bowel frequency in patients with thyroid disease showed increased frequency of bowel action in thyrotoxicosis and decreased frequency in myxoedema. The contrary findings of previous studies may be due to the use of inexact criteria in interrogation of the patients.

We report 6 patients with binasal visual field defects; two had been followed as cases of primary open angle glaucoma, one with normal tension glaucoma, and three with ocular ischemic syndrome. The 6 patients underwent magnetic resonance imaging to rule out neurological disorders, and all cases were found to have ...

The purpose of the technique described was to combine the advantages of a cleanedged Graefe-knife incision with those of safety and near-perfect apposition offered by preplaced sutures: a preliminary to cataract extraction. Uncuttable preplaced 2-mm. stainless steel sutures were finally replaced after completion of the incision by attached braided silk ...

The absorption of quanta by rhodopsin leads to the contraction of frog iris muscle. The contractions reach a maximum after about 8 sec. in the light. When the light is turned off the irises relax exponentially with a half-time of about 6 sec. Membrane polarization is not necessary for the ...