The potential application of metallocene complexes into the cancer research was established by the pioneer work of Köpf-Maeir and Köpf in the late 1970s. The combination of organometallic chemistry and biochemistry created a new research area: bioorganometallic chemistry. Bioorganometallic chemistry has developed rapidly in the last thirty years leading to ...

Editorial: Flow chemistry has now found its way into research and development, not only in academic institutions, but also in industry. This special issue of ChemSusChem is dedicated to flow chemistry, and the contributions showcase the diverse state-of-the-art of flow methodology in chemistry and the potential it certainly holds for ...

Bali cattle still represents 27% of the total cattle population in Indonesia, and it is considered the pillar breed for small farmers. Moreover, it is a breed of evolutionary importance regarding its direct ancestry from Banteng. However, there is a need for the establishment of a rational system for the ...

Many animals are toxic or unpalatable and signal this to predators with warning signals (aposematism). Aposematic appearance has long been a classical system to study predator-prey interactions, communication and signalling, and animal behaviour and learning. The area has received considerable empirical and theoretical investigation. However, most research has centred on ...

The aim of the present study was to evaluate the behavioural and physiological responses to environmental disturbances (live and recorded dynamite explosions) in laboratory non-human primates in preparation for a future tunnel construction underneath our animal facility. In a pilot study (A) on 20 female Macaca fascicularis, a day of ...

Presents Ronald F. Levant as the 2011 winner of the American Psychological Association Award for Distinguished Professional Contributions to Applied Research. "Ronald F. Levant is one of the world's leading authorities on the psychology of men and masculinity. Through his pioneering research, he helped define gender role strain theory, fostered ...

Measurement of the impact and influence of medical⁄scientific journals, and of individual researchers has become more widely practiced in recent decades. This is driven, in part, by the increased availability of data regarding citations of research articles, and by increased competition for research funding. Digestive disease research has been identified ...

To determine the knowledge, attitude, and ethical concerns of medical students and graduates with regard to Embryonic Stem Cell (ESC) research. This questionnaire based descriptive study was conducted at the Civil Hospital Karachi (CHK), Pakistan from February to July 2008. A well structured questionnaire was administered to medical students and ...

The biochemical composition of seminal plasma (SP) is very complex and variable among species. Advances in reproductive technologies reveal SP as a nutritive-protective medium for sperm cells suspended in it and some of SP components are very important for sperm metabolism, as well as, sperm function, survival and transport in ...

The purpose of this position paper is to present a critical analysis of the challenges and limitations of the most widely used fluorescent probes for detecting and measuring reactive oxygen and nitrogen species. Where feasible, we have made recommendations for the use of alternate probes and appropriate analytical techniques that ...

We asked seven senior and accomplished investigators from around the world to share their experiences conducting research in reproductive medicine.

Many laboratories are conducting research using songbirds as their animal model. In particular, songbirds are widely used for studying the behavioural and neural mechanisms underlying vocal learning. Many researchers use wild-caught birds to conduct this research, although few studies of behaviour have been conducted to determine the effects of captive ...

PURPOSE OF REVIEW: A time-related negative trend in male reproductive function has been suggested. It has been hypothesized that this is due to exposure to chemicals interfering with the action of sex hormones. Also a negative effect of phytoestrogens on male fertility has been postulated. This review aimed to review ...

Purpose Trends in the authorship of original research articles by female U.S. pharmacists in three peer-reviewed pharmacy journals over the period 1989-2009 were evaluated. Methods The sex distribution of the authors of all original research articles published in 1989, 1999, and 2009 in three prominent pharmacy journals (American Journal of ...

[Formula: see text] [ Males of the striped mouse can follow alternative reproductive tactics, the fitness consequences of which might differ greatly between generations. Image by Ivana Schoepf. ] Schradin, C. & Lindholm, A. (2011) Relative fitness of alternative male reproductive tactics in a mammal varies between years. Journal of ...

In the current study the author examined whether ethnocultural empathy affects people's beliefs and expectations regarding athletes, hypothesizing that (1) individuals demonstrating a high level of ethnocultural empathy would be less likely to endorse stereotypes toward athletes, (2) females would be less likely to stereotype toward athletes than would males, ...

Analysis of 36 records of the rarely encountered moray Gymnothorax polyuranodon indicate that juveniles and adults inhabit fresh and mildly brackish habitats (salinity < 5) in streams of the Australian Wet Tropics Eighty-one per cent of these records were from freshwater streams and collectively demonstrate that this species inhabits fresh ...

The advent of in vitro fertilization and its augmentation with intracytoplasmic sperm injection (ICSI) has allowed a large number of couples suffering from moderate to severe male infertility, and also presenting with female pathologies, to achieve their reproductive dreams. Notwithstanding the existence of fundamental questions about the pathophysiological mechanisms leading ...

The current status of toxicological tests performed with Brazilian native species was evaluated through a survey of the scientific data available in the literature. The information gathered was processed and an electronic toxicology database () was generated. This database provides valuable information for researchers to select sensitive and tolerant aquatic ...

Previous research has shown that prototypes of familiar categories are preferred over novel exemplars of familiar and unfamiliar categories. The present research demonstrates a reversal of this effect by simply inducing an exploratory mindset. Specifically, participants were asked to judge the attractiveness of dot patterns that represented prototypes of familiar ...

To report the conclusions of the Think Tank on mechanisms of incontinence and surgical cure in female and male SUI: surgical research initiatives during the ICI-RS meeting in 2010. The sub-group considered five areas for future research in stress urinary incontinence (SUI); (i) epidemiology and public health efforts in SUI, ...

The health and well-being of all individuals, independent of race, ethnicity, or gender, is a significant public health concern. Despite many improvements in the status of minority health, African American males continue to have the highest age-adjusted mortality rate of any race-sex group in the United States. Such disparities are ...

(Headache 2011;51:839-842) Significant sex differences exist in migraine and other headache disorders. Several hypotheses have been proposed to explain these differences, including fluctuations in sex hormones and receptor binding, genetic factors, differences in exposure to environmental stressors, as well as differences in response to stress and pain perception; but how ...

Recent advances in assisted reproductive technology (ART) have made it possible to circumvent many causes of male and female infertility. The right to have a child by ART has been respected for infertile couples. However, there are currently no legal regulations concerning ART in Japan, and this has resulted in ...

Xiphophorus fishes are well-established models for biomedical research of spontaneous or induced tumors, and their use in research dates back to the 1930s. Currently, 58 well-pedigreed lines exist among 24 Xiphophorus species housed as live animals at the Xiphophorus Genetic Stock Center. The technique of sperm cryopreservation has been applied ...

The observation of biofilm formation is not a new phenomenon. The prevalence and significance of biofilm and aggregate formation in various processes have encouraged extensive research in this field for more than 40 years. In this review, we highlight techniques from different disciplines that have been used to successfully describe the ...

We study a model of the research process in which the true effect size, the replication jitter due to changes in experimental procedure, and the statistical error of effect size measurement are all normally distributed random variables. Within this model, we analyze the probability of successfully replicating an initial experimental ...

A meeting concerned with UK science and technology investment was held at Chatham House, London, in November 2010. The UK science and technology research budget has been preserved at a fixed cash level whereas other areas of government face significant reductions in their financial support. This is in marked contrast ...

A convenient laboratory experiment is described in which NMR magnetization transfer by inversion recovery is used to measure the kinetics and thermochemistry of amide bond rotation. The experiment utilizes Varian spectrometers with the VNMRJ 2.3 software, but can be easily adapted to any NMR platform. The procedures and sample data ...

This article traces the foundation of the study between sport and physical cultures and masculinities and sexualities principally by examining the homophobic zeitgeist by which the academic discipline was formed. I show that the intense homophobia of the mid-1980s waned throughout the 1990s, and that during the new millennia, researchers ...

OBJECTIVE:: The study reviewed all the published instruments used for the assessment, diagnosis, screening, and outcomes monitoring/evaluation of behavioral disturbances associated with dementia (BDAD) to recommend a set of psychometrically valid measures for clinicians and researchers to use, across a range of different practice settings. METHODS:: The study involved a ...

The Thoracic Surgery Foundation for Research and Education (TSFRE) was formed in 1991 with the primary goals of generating new knowledge and nurturing the development of surgeon-scientists. The purpose of this article is to determine how effective the TSFRE has been in achieving these goals. A survey instrument was sent ...

Scientists are taking advantage of the Internet and collaborative web technology to accelerate discovery in a massively connected, participative environment--a phenomenon referred to by some as Science 2.0. As a new way of doing science, this phenomenon has the potential to push science forward in a more efficient manner than ...

ABSTRACT: BACKGROUND: Prospective meta-analysis (PMA) is a collaborative research design in which individual sites perform randomized controlled trials (RCTs) and pool the data for meta-analysis. Members of the PMA collaboration agree upon specific research interventions and outcome measures, ideally before initiation but at least prior to any individual trial publishing ...

ABSTRACT: Information and communications technologies (ICTs) in healthcare are often introduced with expectations of higher-quality, more efficient, and safer care. Many fail to meet these expectations. We argue here that the well-documented failures of ICTs in healthcare are partly attributable to the philosophical foundations of much health informatics research. Positivistic ...

Helms, Henze, Sass, and Mifsud (2006) defined good practices for internal consistency reporting, interpretation, and analysis consistent with an alpha-as-data perspective. Their viewpoint (a) expands on previous arguments that reliability coefficients are group-level summary statistics of samples' responses rather than stable properties of scales or measures and (b) encourages researchers ...

The interpretation of forensic fingerprint evidence relies on the expertise of latent print examiners. The National Research Council of the National Academies and the legal and forensic sciences communities have called for research to measure the accuracy and reliability of latent print examiners' decisions, a challenging and complex problem in ...

Theoretical and empirical research in bioethics frequently focuses on ethical dilemmas or problems. This paper draws on anthropological and phenomenological sources to develop an alternative framework for bioethical enquiry that allows examination of a broader range of how the moral is experienced in the everyday lives of individuals and groups. ...

This investigation analyzed the methods used over the past 35years to study emotion regulation (ER) in children. Articles published from 1975 through 2010 were identified in 42 child clinical, developmental, and emotion psychology journals. Overall, 61.1% of published ER articles relied on one method and 23.6% used two methods. Analyses ...

Aims:  Few studies have been conducted on the rationales for using interpretive guidelines for effect size, and most of the previous statistical power surveys have covered broad research domains. The present study aimed to estimate the statistical power and to obtain realistic target effect sizes of depression research in Japan. ...

Physical conditions of prisons have been at the center of long-standing debates in correctional policy and research. Many argue prisons should be unpleasant to deter future offending and motivate prosocial change among inmates. Others believe harsh conditions inhibit effective treatment and, perhaps, make offenders worse. Little progress in these debates ...

Objective: Current diagnostic criteria specify that ADHD involves difficulties with inattention and/or hyperactivity/impulsivity. Researchers using factor analysis have consistently found support for an inattention factor in both children and adults. Findings have been mixed regarding whether hyperactivity and impulsivity reflect one or two dimensions. To date, no study has examined ...

OBJECTIVE: Dynamic p-technique (DPT) is a potentially useful statistical method for examining relationships among dynamic constructs in a single individual or small group of individuals over time. The purpose of this article is to offer a nontechnical introduction to DPT. METHOD: An overview of DPT analysis, with an emphasis on ...

Abstract Numerous recent studies have examined the impact of video gaming on various dependent variables, including the players' affective reactions, positive as well as detrimental cognitive effects, and real-world aggression. These target variables are typically analyzed as a function of game characteristics and player attributes-especially gender. However, findings on the ...

Motor overflow is involuntary overt movement or covert muscle activity that cooccurs with voluntary movement. Overflow is present in several pathological conditions, as well as in neurologically healthy children and older adults, and can be induced in healthy young adults under effortful conditions. This motor phenomenon may provide insight into ...

Abstract Interviews were conducted with 17 individuals who had intellectual disability to expand our understanding of the impact of self-determination in their life. Themes emerging from the interviews were grouped into three categories: meaning of self-determination, learning about self-determination, and dreams for the future. Participants described self-determination as being able ...

No definitive or gold standard outcome measure exists to test the efficacy of the mental disorder treatments examined within randomized controlled trials. As a result, researchers often evaluate efficacy via multiple outcome measures administered within a single controlled trial. This practice commonly yields inconsistent findings as to a treatment's efficacy. ...

Lovastatin exhibits higher thermal stability and lower degradation rate than simvastatin. However, the amount of research studying a lovastatin delivery device has been far less than similar research on simvastatin. As a consequence, a high lovastatin release rate system has not been developed. We hypothesized that highly efficient release of ...

The emerging field of bioinformatics in proteomics is introducing new algorithms in order to handle large and heterogeneous datasets and improve the knowledge-discovery process. Management systems, software construction and application, database population and leverage, as well as computed prediction, have crafted bioinformatics into a valuable tool for basic research. Human ...

The presence of researchers, ecotourists or rangers inside protected areas is generally assumed to provide a protective effect for wildlife populations, mainly by reducing poaching pressure. However, this assumption has rarely been empirically tested. Here, we evaluate and quantify the conservation benefits of the presence of a long-term research area ...