Musculoskeletal Ultrasonography (US) is nowadays widely used for clinical grounds and for research purposes in rheumatology. US of the hand and wrist has recently developed due to the technological improvement and use of new, high resolution transducers. US is currently improving clinical examination of the rheumatic hand and wrist and ...

T. N. Phoenix, D. S. Currle, G. Robinson and R. J. Gilbertson (2012) Neuropathology and Applied Neurobiology38, 222-227 Developmental origins of neural tumours: old idea, new approaches The recent convergence of pathology, cancer research and basic neurobiology disciplines is providing unprecedented insights to the origins of brain tumours. This new ...

We celebrate the lives of Michael and Kate Bárány in this issue of the Journal of Muscle Research and Cell Motility. Kate and Michael died within weeks of each other in 2011. Joe Chalovich has written about Michael and we write about Kate. As emphasized by Joe, Kate, and Michael ...

Academic and industrial research on nanofibres is an area of increasing global interest, as seen in the continuously multiplying number of research papers and patents and the broadening range of chemical, medical, electrical and environmental applications. This in turn expands the size of the market opportunity and is reflected in ...

Humans feel uncertain. They know when they do not know. These feelings and the responses to them ground the research literature on metacognition. It is a natural question whether animals share this cognitive capacity, and thus animal metacognition has become an influential research area within comparative psychology. Researchers have explored ...

Condorcet (1785) proposed that a majority vote drawn from individual, independent and fallible (but not totally uninformed) opinions provides near-perfect accuracy if the number of voters is adequately large. Research in social psychology has since then repeatedly demonstrated that collectives can and do fail more often than expected by Condorcet. ...

Accessible summary •  The idea for this research and practice development project emerged from the production of a recently published book of recovery narratives, written by a community of people broadly working in the mental health recovery movement. •  The research component of this project, described in this paper, sits ...

A large research literature attests to the positive influence of spirituality on a range of health outcomes. Recently, a growing literature links spirituality to improved recovery from cardiac surgery. Cardiac surgery has become an increasingly common procedure in the United States, so these results may provide a promising indication for ...

The Garnett Passe and Rodney Williams Foundation, a major medical research foundation in Melbourne, has recently acquired a hitherto unknown and uncatalogued painting by Dame Barbara Hepworth, the celebrated British sculptor and artist. It is of the Foundation's nominal patron Garnett Passe performing a tonsillectomy, probably at the London Clinic, ...

In recent years, a number of researchers have advocated extending the modern synthesis in evolutionary biology. One of the core arguments made in favour of an extension comes from work on soft inheritance systems, including transgenerational epigenetic effects, cultural transmission and niche construction. In this study, we outline this claim ...

High quality research in all surgical specialties is essential for improving patient care and outcome; neurosurgery is not an exception. Trainee collaborative networks have recently attracted considerable interest as they have a number of advantages for trainees and clinical research studies. We believe that neurosurgery represents a unique opportunity for ...

This article deals with the aims and achievements of intensive lecture and laboratory courses given in countries with very little money available for research in neurobiology.

ABSTRACT: A National Institutes of Health (NIH) workshop was convened in Bethesda, MD on September 26-27, 2011, with representative scientific leaders in the field of proteomics and its applications to clinical settings. The main purpose of this workshop was to articulate ways in which the biomedical research community can capitalize ...

In this study, I will elaborate and extend the theoretical framework of the presentational self (Komatsu, Human Development 53:208-228, 2010) that finds the self in two aspects of our interaction with others or objects. From this perspective, the self is not an internal entity, a representation that can be revealed ...

Clinical data describing the phenotypes and treatment of patients represents an underused data source that has much greater research potential than is currently realized. Mining of electronic health records (EHRs) has the potential for establishing new patient-stratification principles and for revealing unknown disease correlations. Integrating EHR data with genetic data ...

In a context of increasing international concern about public cost savings, research interest in the waste sector has gradually emerged. The literature on waste cost and inefficiency, particularly the use of parametric and non-parametric methods has increased exponentially in the last years. This paper reviews the developments, themes, objectives, concerns ...

Recent recommendations by the National Science Advisory Board for Biosecurity (NSABB) to redact key methodological details of two studies involving mammal-to-mammal transmission of the H5N1 (H5) subtype influenza viruses, has led to a temporary moratorium on all research involving live H5N1 or H5 HA reassortant viruses shown to be transmissible ...

As the use of imaging continues to increase in medical research, the Royal College of Radiologists (RCR) Research Committee and the Wellcome Trust held a joint meeting in 2010 to explore the current issues critical to training the next generation of radiology researchers. It was stated that despite an increase ...

Elevated serum ferritin, or hyperferritinemia, is a common finding on routine bloodwork and often prompts referral for further evaluation. In the following review, we outline the various causes of hyperferritinemia and point out that, in the majority of cases, this does not represent true iron overload. Despite much research interest ...

Hospitalist medicine has enjoyed a period of rapid growth over the past 10 years and research within this domain is no exception. This article will describe the initial research conducted within the world of pediatric hospital medicine, what the future of research will hold and how this will impact the ...

This month, "The AJT Report" looks at the flat growth of NIH funding in recent years, and how the presidential election may impact future funding. Also this month, the concern of several researchers over the lung allocation system's effectiveness is examined.

This perspective updates the status of the "National Plan to Address Alzheimer's Disease" and the recommendations of the NAPA Advisory Council's Sub-committee on Research. Here, we identify some of the critical issues the future reiterations of the National Plan should consider during implementation phase of the plan. The Journal invites ...

The Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences conducts fundamental and applied research towards chemistry and chemical engineering, with strong competence in the development of new technologies. The research in this special issue, containing 19 papers, features some of the DICP's best work on sustainable energy, use ...

The past three decades have seen a global wine glut. So far, well-intended but wasteful and expensive market-intervention has failed to drag the wine industry out of a chronic annual oversupply of roughly 15%. Can yeast research succeed where these approaches have failed by providing a means of improving wine ...

Well, it's my first editorial, having worked on the JWC for almost a year now. Coming from a rather eclectic background, including a curious stint as an experimental and theoretical physicist, I'm constantly impressed by the quality of the articles and studies submitted to us. However, I often feel that ...

The past decade has seen a resurgent, concerted interest in social learning research comparing human and nonhuman animals. In this special issue, we present a synthesis of work that consolidates what is currently known and provides a platform for future research. Consequently, we include both new empirical studies and novel ...

Degradation in the lysosome/vacuole is not the final step of autophagy. In particular, for starvation-induced autophagy it is necessary to release the breakdown products back into the cytosol. However, some researchers ignore this last step and simply refer to the endpoint of autophagy as degradation, or perhaps even cargo delivery. ...

ABSTRACT: The number of metabolites identified in human cerebrospinal fluid (CSF) has steadily increased over the past 5 years, and in this issue of Genome Medicine David Wishart and colleagues provide a comprehensive update that brings the number of metabolites listed in the CSF metabolome database to 476 compounds. There ...

The Expected Value of Information Framework has been proposed as a method for identifying when health care technologies should be immediately reimbursed and when any reimbursement should be withheld while awaiting more evidence. This framework assesses the value of obtaining additional evidence to inform a current reimbursement decision. This represents ...

Research articles on atherosclerosis have been well represented in The American Journal of Pathology (AJP), with more than 500 articles published since 1925. An initial focus on descriptive studies led to the proposal that atherosclerosis occurs as a response to vascular injury. With time, this was modified by a greater ...

Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation. The animal research on uterus ...

Biopharmaceuticals reflect the rapid progress achieved in modern biomedical research. This area has also become one of the main criteria for assessing the development level of biotechnology for a particular country. Although it has been only three decades since the first biopharmaceutical, recombinant human insulin, was licensed by the US ...

Text-based plagiarism, or copying language from sources, has recently become an issue of growing concern in scientific publishing. Use of CrossCheck (a computational text-matching tool) by journals has sometimes exposed an unexpected amount of textual similarity between submissions and databases of scholarly literature. In this paper I provide an overview ...

Educational outreach is a common quality improvement (QI) strategy used alone and in combination with other interventions. However, a meta-analysis of educational outreach has failed to identify reasons for variation in its impact. To better understand such variation in findings, a more comprehensive set of characteristics about educational outreach is ...

Bernhard Guggenheim is a distinguished leader in oral microbiology and immunology and a recipient of many honors. This article outlines his background and scientific career and illuminates some of his important contributions to dental research. At the age of 75, he continues to scrutinize established paradigms and unremittingly fosters demanding ...

This paper reviews the contributions of von Békésy to psychoacoustics, comparing his findings and interpretations to those that have emerged since his work. The areas covered include the perception of pitch for pure tones and complex tones, the effect of frequency on the apparent location of pure tones, estimation of ...

Body donation is important for medical education and academic research. However, it is relatively rare in Hong Kong when compared with many Western countries. Comprehensive research has been performed on the motivation for body donation in Western countries; however, there is still insufficient research on body donation in Hong Kong ...

ABSTRACT: Loss of physical mobility makes maximal participation in desired activities more difficult and in the worst case fully prevents participation. This paper surveys recent work in assistive technology to improve mobility for persons with a disability, drawing on examples observed during a tour of academic and industrial research sites ...

This paper provides a sociological account of how researchers of different disciplines become experts in translational nanomedicine. Using a case study of the Nanotechnology Characterization Laboratory (NCL) at the National Cancer Institute (NCI), the author argues that the relationship between the different disciplines involved in translational nanomedicine should be understood ...

Efforts to enhance therapy for children and adults with sickle cell disease (SCD) have proven more challenging than might have been predicted from the fact that an understanding of the underlying pathogenesis antedated that of many other diseases for which good treatments presently exist. The multi-organ injury that occurs with ...

ABSTRACT: This article is a response to Wang and Luo. See correspondence article http://www.biomedcentral.com/1741-7007/10/30 [WEBCITE] and the original research article http://www.biomedcentral.com/1741-7007/9/24 [WEBCITE].

Over the last decade, stem cell research has generated an enormous amount of public, political and bioethical debate. These debates have overwhelmingly tended to focus on two moral issues: the moral status of human embryos and the duty to care for the sick and vulnerable. This preoccupation, especially on the ...

During the latter part of the 20(th) century, the fetus became recognized as a patient separate from the mother. Powerful imaging and sampling techniques provided insight into normal fetal development and the opportunity to detect anomalies. In this overview of the rapidly evolving fetal surgery field, we describe the evolution ...

In an earlier essay in this journal I critiqued Don Marquis's well-known argument against abortion. I distinguished two versions of Marquis's argument, which I refer to as 'the essence argument' and 'the sufficient condition argument'. I presented two counterexamples showing that the essence argument was mistaken, and I argued that ...

In this article, we present a summary of the discussion from the symposium on 'what is evidence', which took place at the AMEE conference in 2011. A panel of five academics and clinicians, plus the chair, considered the nature of evidence, in particular in relation to the 'evidence' in the ...

This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understanding of pLGICs, and highlight the contributions ...

There is widespread agreement that it would be both morally and legally wrong to treat a competent patient, or to carry out research with a competent participant, without the voluntary consent of that patient or research participant. Furthermore, in medical ethics it is generally taken that that consent must be ...

PURPOSE: Citation analysis within specific journals and subject areas has become a popular method to assess the impact of a journal, article or author. To date, only a few evaluations of citation reports have been published in the field of pediatric surgery. Twenty-six years after its inception, Pediatric Surgery International ...

This manuscript summarizes the recommendations that emerged from the first Roundtable on Clinical Research in Immunoglobulin Light-chain Amyloidosis (AL), a meeting sponsored by the Amyloidosis Foundation in order to develop a consensus of experts on a modern framework for clinical trial design and drug development in AL. Recent diagnostic and ...

Optimal thromboprophylaxis following bioprosthetic aortic valve replacement (AVR) remains controversial. The main objective, which is the effective prevention of central nervous or peripheral embolic events, especially in the early postoperative period, will have to be weighed against the haemorrhagic risk that is associated with the utilization of different antithrombotic regimes. ...