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Agarwala Anandita A Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, One Baylor Plaza, Houston, TX, 77030, USA, - - 2015
Antisense oligonucleotide therapy is a promising approach for the treatment of a broad variety of medical conditions. It functions at the cellular level by interfering with RNA function, often leading to degradation of specifically targeted abnormal gene products implicated in the disease process. Mipomersen is a novel antisense oligonucleotide directed ...
Saunders Nick N PHE Microbiology Services Colindale, 61 Colindale Avenue, London, NW9 5EQ, - - 2015
This chapter describes the process of validating in-house molecular assays although the principles described are equally relevant to all diagnostic assays. The best practice principles described below are based on the In Vitro Diagnostic Medical Devices Directive (IVDD) and associated documentation. Although compliance with these regulations is not required for ...
Plakiotis Christos C Department of Psychiatry, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia, - - 2015
There is widespread concern in Australia and internationally at the high prevalence of psychotropic medication use in residential aged care facilities. It is difficult for nurses and general practitioners in aged care facilities to cease new residents' psychotropic medications when they often have no information about why residents were started ...
Yu Mark Shipeng MS Department of Medicine, University of Toledo, 3000 Arlington Ave, Toledo, OH, 43614, USA, - - 2014
The diagnosis of renal artery stenosis (RAS) has become increasingly common in part due to greater awareness of ischemic renal disease and increased use of diagnostic techniques. Over 90 % of RAS cases are caused by atherosclerotic renovascular disease (ARVD). Patients with ARVD are at high risk for fatal and nonfatal ...
Zelante A A Gastroenterology Unit, Department of Medicine University Hospital "Sant'Anna", Ferrara, - - 2014
Inflammatory bowel diseases (IBD) are a group of chronic intestinal conditions characterized by unpredictable course, with periods of flare-ups and remissions suggesting poor adherence to medical therapy. On the other hand adherence is one of the most common reason of failure in the treatment of chronic disease. We have analyzed ...
Goldstein Jennifer N JN *Department of Medicine, Christiana Hospital, Newark, DE †Philadelphia VA Medical Center ‡Department of Medicine, University of Pennsylvania Philadelphia, PA §University of Illinois, Urbana-Champaign, Urbana, IL ∥Philadelphia VA Medical Center, Center for Health Equity and Promotion ¶Department of Family and Community Medicine, University of Pennsylvania, Philadelphia, - - 2014
Vitamins and supplements are the most commonly used form of complementary and alternative medicine in the United States. Growing research suggests that patients substitute vitamins and supplements for their prescription medications. The reasons might include cost of prescription medications and discordant patient and doctor health belief systems. To investigate the ...
Giladi Aviram M AM Ann Arbor, Mich.; and Atlanta, Ga. From the Department of Surgery, Section of Plastic Surgery, University of Michigan Health System; and private - - 2014
Shared medical appointments combine individual patient-physician encounters with a group educational segment. This allows for patients' needs to be addressed individually and for patients to benefit from shared learning. Shared medical appointments enhance knowledge, understanding, and management of disease by providing a variety of perspectives and experiences. In addition, physician-patient ...
Stothard J Russell JR Department of Parasitology,Liverpool School of Tropical Medicine,Liverpool L3 - - 2014
SUMMARY There are many reasons why detection of parasites of medical and veterinary importance is vital and where novel diagnostic and surveillance tools are required. From a medical perspective alone, these originate from a desire for better clinical management and rational use of medications. Diagnosis can be at the individual-level, ...
Jabbal Abhimanyu A Medical student, University of Edinburgh, - - 2014
Currently, medical students are not given specific guidance on how to dress, which allows them to wear what they interpret as being appropriate, which may not always be optimal. Many studies have shown that a doctor's attire can greatly affect the consultation; however, no studies have been carried out for ...
Shorter Daryl D Michael E. DeBakey VA Medical Center, Research Service Line , 2002 Holcombe Blvd, Bldg 121, Office 121-137, Houston, TX 77030 , USA +1 713 791 1414 Ext. 24643 ; - - 2014
Introduction: Cocaine use is a global public health concern of significant magnitude, negatively impacting both the individual as well as larger society. Despite numerous trials, the discovery of an effective medication for treatment of cocaine use disorder remains elusive. Areas covered: This article reviews the emerging pharmacotherapies for treatment of ...
Abdul-Sattar Amal B AB Department of Rheumatology and Rehabilitation, Zagazig University, 16 El-Emam Ali St. Villat el Jamaa, Zagazig, Egypt, - - 2014
The aim of the study was to identify the determinants of adherence to medication among Egyptian patients with SLE. A single-center cross-sectional study was conducted among Egyptian patients with SLE. Adherence to medication was measured via The Compliance Questionnaire for Rheumatology-19, and the patients were classified as non-adherers if they ...
Wöber Christian - - 2014
In this letter, we present the Austrian proposal for diagnostic criteria of refractory chronic migraine and we discuss the consensensus statement of the European Headache Feaderation. We focus in particular on the definition of adequate prophylactic treatment, the management of medication overuse and the requirement for CSF analyses in patients ...
Eaton Cyd K CK University of Georgia, Boston Children's Hospital/Harvard Medical School, Rutgers Cancer Institute of New Jersey, and Children's Healthcare of Atlanta/Emory University School of Medicine - - 2014
 The current study used multiple statistical methods to determine empirically derived and clinically relevant cutoff scores on the Adolescent Medication Barriers Scale (AMBS) and Parent Medication Barriers Scale (PMBS) to detect adolescents and young adults with solid organ transplants who experienced medication nonadherence or negative medical outcomes.  METHODS:  Participants included ...
Swatzyna Ronald J RJ The Tarnow Center for Self-Management, Houston, TX, USA - - 2014
Pharmaco-electroencephalography (Pharmaco-EEG) studies using clinical EEG and quantitative EEG (qEEG) technologies have existed for more than 4 decades. This is a promising area that could improve psychotropic intervention using neurological data. One of the objectives in our clinical practice has been to collect EEG and quantitative EEG (qEEG) data. In ...
Wehmeier Peter M PM Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany, - - 2014
Although the efficacy and tolerability of ADHD medications have been investigated fairly extensively, there are very few data comparing the different types of medication (e.g. psychostimulants, non-stimulants) in terms of medication adherence. The primary research objective of the COMPLY observational study was to evaluate medication adherence (i.e. compliance) over 1 year ...
Mooe Thomas T Unit of Medicine, Department of Public Health and Clinical Medicine Umeå University , Umeå , - - 2014
Abstract Background: The prevalence of COPD among individuals with acute coronary syndrome (ACS) is estimated at 5% to 18%, and COPD appears to be a predictor of poor outcome. Diagnosis of COPD has mostly been based on medical records without spirometry. As COPD is largely undiagnosed and misdiagnosed, the prevalence ...
McGowan Bernie B The North Western Rheumatology Unit, Our Lady's Hospital, Manorhamilton, Co. Leitrim, Ireland, - - 2014
To identify adherence and persistence levels with urate-lowering therapies using the national administrative pharmacy claim database. This was a retrospective, pharmacy claims-based analysis of dispensed anti-gout medications on the Irish national HSE-PCRS scheme database between January 2008 and December 2012. Adherence is defined by the medication possession ratio (MPR), and ...
Nieuwlaat Robby R Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton General Hospital campus, Room C3-107, 237 Barton Street East, Hamilton, ON, Canada, L8L - - 2014
People who are prescribed self administered medications typically take only about half their prescribed doses. Efforts to assist patients with adherence to medications might improve the benefits of prescribed medications. The primary objective of this review is to assess the effects of interventions intended to enhance patient adherence to prescribed ...
Strassnig Martin T MT 1Department of Psychiatry,University of - - 2014
Treatment resistance, along with its sibling partial response, remains a common phenomenon in schizophrenia, complicating the disability burden inherent in the disease. Antipsychotic medications are the mainstay of treatment, and treatment resistance has mainly been defined in terms of poor response to antipsychotic medication. At the same time, clozapine, the ...
Mathern Gary W GW Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine, The Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles, California, - - 2014
From May 20 to September 1 2014, Epilepsia conducted an online survey seeking opinions about the use of medical marijuana and cannabidiol (CBD) for people with epilepsy. This study reports the findings of that poll. The survey consisted of eight questions. Four questions asked if there were sufficient safety and ...
N Diaye Dieynaba S - - 2014
BackgroundTétanos Quick Stick® (TQS) is a test for tetanus immunity screening for wounded patients in emergency departments (EDs), but represents additional costs compared with a medical interview on vaccination history. The study objective was to assess the effectiveness and cost of the TQS in French EDs.MethodsWe performed a model-based analysis ...
Spanos Constantine P - - 2014
Benign anorectal conditions are fairly common. Physicians of various specialties usually see patients with these conditions before being referred to colorectal specialists, frequently with an incorrect diagnosis.We sought to evaluate the effect of attending an outpatient colorectal clinic by medical students on the diagnostic accuracy of these conditions. Over a ...
Wilens Timothy T Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Bay Cove Human Services, Andrew House Detoxification Center, Quincy, - - 2014
Opioid related morbidity and mortality is heightened in context to the concomitant use of psychotropic medications. The aim of this project was to examine the extent to which opioid dependent patients seeking detoxification are using and misusing specific psychotropic agents. As part of a quality assurance/improvement project, we systematically assessed ...
Laba Tracey-Lea TL The George Institute for Global Health, University of Sydney, Camperdown, NSW, 2010, Australia, - - 2014
Nonadherence is a global problem undermining the cost-effectiveness of evidence-based medications. Aligning treatment choices with patient preferences may promote adherent behaviour: eliciting patient treatment preferences may help resolve the problem of nonadherence. As there is no reliable measure of nonadherent behaviour that can be used to derive preferences, stated-preference techniques ...
Walsh Kathleen E KE Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati School of Medicine, Cincinnati, Ohio; Departments of Pediatrics, and Meyers Primary Care Institute, Worcester, Massachusetts; - - 2014
Describe rates of adherence for sickle cell disease (SCD) medications, identify patient and medication characteristics associated with nonadherence, and determine the effect of nonadherence and moderate adherence (defined as taking 60%-80% of doses) on clinical outcomes. In February 2012 we systematically searched 6 databases for peer-reviewed articles published after 1940. ...
Goodman Sam S Weymouth House, The Media School, Bournemouth University, BH12 5BB, Fern Barrow, Poole, Dorset, UK, - - 2014
This article examines J. G. Farrell's depictions of colonial medicine as a means of analysing the historical reception of the further past and argues that the end-of-Empire context of the 1970s in which Farrell was writing informed his reappraisal of Imperial authority with particular regard to the limits of medical ...
Schaarschmidt Marthe-Lisa ML Department of Dermatology, University Medical Center Mannheim, Heidelberg University, Mannheim, - - 2014
Evidence on preferences for specific medications is scarce. Here we assessed treatment satisfaction of 200 participants with moderate-to-severe psoriasis from a German University hospital with a 5-point scale and the Treatment Satisfaction Questionnaire for Medication (TSQM) and determined sociodemographic and disease-related influence factors. Participants obtaining biologicals and traditional systemic medications ...
Hsu Clarissa - - 2014
BackgroundIn the United States, more than 25 million people have diabetes. Medication adherence is known to be important for disease control. However, factors that consistently predict medication adherence are unclear and the literature lacks patient perspectives on how health care systems affect adherence to oral hypoglycemic agents (OHAs). This study ...
Scheuner Maren T MT 1] Division of Medical Genetics, Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA [2] Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, - - 2014
Purpose:The aim of this study was to survey American College of Medical Genetics and Genomics members about secondary findings from clinical genome-scale sequencing.Methods:A Web-based survey was mailed to 1,687 members of the American College of Medical Genetics and Genomics. Exploratory factor analysis identified underlying factors assessed by survey items. Linear ...
Jones David S DS Department of the History of Science, Harvard University, Cambridge, Massachusetts - - 2014
Historians of medicine have struggled for centuries to make the case for history in medical education. They have developed many arguments about the value of historical perspective, but their efforts have faced persistent obstacles, from limited resources to curricular time constraints and skepticism about whether history actually is essential for ...
Binney Nicholas N EGENIS: Centre for the Life Sciences, University of Exeter, Exeter, - - 2014
Medics may consider worrying about their metaphysics and ontology to be a waste of time. I will argue here that this is not the case. Promiscuous realism is a metaphysical position which holds that multiple, equally valid, classification schemes should be applied to objects (such as patients) to capture different ...
Zhou Qi Q *The Children's Hospital of Soochow University †Collaborative Innovation Center of Hematology, Soochow University, Suzhou, - - 2014
In this study, we have analyzed both administrative and clinical data from our hospital during 2002 to 2012 to evaluate the influence of government medical policies on reducing abandonment treatment in pediatric patients with acute lymphoblastic leukemia. Two policies funding for the catastrophic diseases and the new rural cooperative medical ...
Placzek Hilary E D HE Industry Sponsored Research, HealthCore, Inc., Andover, Massachusetts, - - 2014
To determine prior authorization (PA) impact on healthcare utilization, costs, and pharmacologic treatment patterns for painful diabetic peripheral neuropathy (pDPN) and fibromyalgia (FM). This retrospective, observational, longitudinal cohort study used medical and pharmacy claims data. Newly diagnosed patients treated for FM or pDPN between 7/1/2007 and 12/31/2011 were included. PA ...
Reeve Emily E University of South Australia, Adelaide, South Australia, Australia Royal Adelaide Hospital, Adelaide, South Australia, Australia - - 2014
Proton pump inhibitors (PPIs) are inappropriately prescribed in up to 50% of users. Systematic medication review and cessation of inappropriate medications or deprescribing may improve patient outcomes and reduce costs. The aim of this study was to assess the feasibility of a patient-centered deprescribing process in a population of adults ...
Zellweger Ueli - - 2014
Prevalence estimates of chronic medical conditions and their multiples (multimorbidity) in the general population are scarce and often rather speculative in Switzerland. Using complementary data sources, we assessed estimates validity of population-based prevalence rates of four common chronic medical conditions with high impact on cardiovascular health (diabetes mellitus, hypertension, dyslipidemia, ...
Leblanc Richard R Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; - - 2014
William Howard Feindel (1918-2014) was one of the world's most distinguished neurosurgeons and a brilliant neuroscientist. As the Montreal Neurological Institute's third director, having succeeded Theodore Rasmussen and Wilder Penfield, he proved to be a visionary medical and scientific administrator. His keen interests in epilepsy and brain imaging were enhanced ...
Mathern Gary W GW Departments of Neurosurgery and Psychiatry & BioBehavioral Medicine, The Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, - - 2014
From March 19 to June 30, 2014, Epilepsia conducted an open access online survey asking directed questions related to the 2014 Operational Definition of Epilepsy. This study reports the findings of that poll. The survey consisted of seven questions. Three questions addressed: (1) Criteria for when a person could be ...
de Castro J J Oncology Department, La Paz University Hospital, Paseo de la Castellana, 261, 28046, Madrid, Spain, - - 2014
The last decade has seen substantial progress in the diagnostic and therapeutic approach to lung cancer, thus meaning that its prognosis has improved. The Spanish Society of Medical Radiology and the Spanish Society of Medical Oncology have therefore produced a national consensus statement to make recommendations for radiological diagnosis and ...
Choi Sharon S SS Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, - - 2014
Atherosclerotic renovascular disease is the most common cause of secondary hypertension. The patients with renovascular disease are at increased risk for adverse cardiac outcomes. Recent trials comparing medical therapy alone to medical therapy with stenting are flawed, but lay to rest any existing debate that unselected revascularization is unwarranted; however, ...
Willmott Lindy L Australian Centre for Health Law Research, Faculty of Law, Queensland University of Technology, Brisbane, QLD, Australia. - - 2014
Intractable disputes about withholding and withdrawing life-sustaining treatment from adults who lack capacity are rare but challenging. Judicial resolution may be needed in some of these cases. A central concept for judicial (and clinical) decision making in this area is a patient's "best interests". Yet what this term means is ...
Morgan Daniel J DJ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore2Department of Hospital Epidemiology, Veterans Affairs Maryland Health Care System, - - 2014
Overuse of medical care, consisting primarily of overdiagnosis and overtreatment, is a common clinical problem. To identify and highlight the most significant clinical articles published in 2013 related to medical overuse. A systematic review of English-language articles published in 2013 that related to medical overuse in adults. We reviewed 478 ...
Kimura Michio M Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu, - - 2014
In the present study, medication adherence and factors affecting adherence were examined in patients taking oral anticancer agents. In June 2013, 172 outpatients who had been prescribed oral anticancer agents by Ogaki Municipal Hospital (Ogaki, Gifu, Japan) completed a questionnaire survey, with answers rated on a five-point Likert scale. The ...
Magura Stephen S The Evaluation Center, Western Michigan University, Kalamazoo MI 49008 - - 2014
Medication non-adherence among psychiatric patients is known to be associated with poorer treatment outcomes. The study examined a comprehensive set of modifiable risk factors for non-adherence in a theoretical framework among a diverse, high risk sample of psychiatric patients with substance misuse histories (N=299). Medication side effects and excessive alcohol ...
Merkx Maarten J M MJ Department of Psychiatry, Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands, Jellinek Substance Abuse Treatment Center, Amsterdam, the - - 2014
ABSTRACT. Little is known about the incremental effects of medically assisted detoxification on outpatient treatment for alcohol use disorders. The objective of this study was to compare drinking outcomes in a psychosocial treatment program between two groups of heavy drinking patients who had an alcohol use disorder: (a) one group ...
Gelatic Randee R Randee Gelatic is a pharmacist at North Country HealthCare in Flagstaff, Ariz. The author has disclosed no potential conflicts of interest, financial or - - 2014
Recent guidelines on hypertension management offer conflicting recommendations. This article describes the JNC 8 and ASH/ISH guidelines and the four medications recommended for controlling BP in various patient populations.
Levin Jennifer B JB *Department of Psychiatry, Case Western Reserve University School of Medicine; †Neurological and Behavioral Outcomes Center, University Hospitals Case Medical Center; and ‡Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, - - 2014
This analysis compared medication attitudes and reasons for nonadherence in three distinct groups of patients with serious mental illness (SMI). Cohort 1 had 43 patients with bipolar disorder (BD) treated in a community mental health setting, cohort 2 had 43 patients with BD taking an atypical antipsychotic and treated in ...
Mottillo Salvatore - - 2014
Clinical questionWhat is the effect of family presence during cardiopulmonary resuscitation on family members and the medical team?Article chosenJabre P, Belpomme V, Azoulay E, et al. Family presence during cardiopulmonary resuscitation. N Engl J Med 2013;368:1008-18.ObjectiveThe authors sought to determine whether systematically offering relatives the option to be present during ...
Crowley Matthew J MJ Center for Health Services Research in Primary Care, Durham VA Medical Center, HSR&D (152), 508 Fulton Street, Durham, NC, 27705, USA, - - 2014
Medication non-adherence is a major impediment to the management of cardiovascular disease risk factors. A better understanding of the modifying factors underlying medication non-adherence among individuals with known cardiovascular disease may inform approaches for addressing non-adherence. The purpose of this study was to identify demographic and patient characteristics, medical comorbidities, ...
Johnson Björn B a Senior Lecturer, Department of Social Work , Malmö University , Malmö ,, - - 2014
Abstract Opioid substitution treatment (OST) is still controversial, despite positive results. The issue of diversion to the illicit drug market is a cornerstone in the criticism typically voiced against the treatment. Little research is available concerning how professionals who work in OST view the issue of diversion. In this article, ...
Spencer A A Department of General Medicine, Christchurch Hospital, Christchurch, New - - 2014
Prevention of venous thromboembolism (VTE) in medical patients is controversial. In contrast to surgical patients, the evidence supporting the use of heparin-based treatment for prevention of VTE (HVTEp) may not justify current guidelines. This study aims to determine whether current clinical guidelines for HVTEp are appropriate for medical patients. We ...
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