A consecutive series of 43 pyogenic granulomata in the oral cavity is presented. Most were located to the marginal vestibular gingivae and only a minority (12%) of these had a history of trauma whereas 70% in extragingival locations had a previous history of injury. On the basis of an evaluation ...

A new method for the preparation of 3-ketoacyl-CoA thioesters (from malonylsemialdehyde to long-chain and phenylpropanoic 3-keto derivatives) is described. It utilizes the facile, thermodynamically very favorable, hydration of 2-alkynoyl-CoA thioesters by enoyl-CoA hydratase. The method is simple and avoids laborious organic syntheses or the use of multicomponent enzymatic methods.

L-654,284 [(2R, 12bS)-N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]-furo[2,3-a] quinolizine-2-yl)-N-methyl-2-hydroxyethanesulfonamide) was tested in several in vitro and in vivo models for alpha 2-adrenoceptor antagonist activity and compared to several reference agents. In vitro L-654,284 completed for the binding of 3H-clonidine or 3H-rauwolscine (Ki's 0.8 nM, 1.1 nM) and blocked the presynaptic effects of clonidine in the ...

A case of oral penicillin anaphylaxis is described, and the terminology, occurrence, clinical manifestations, pathogenesis, prevention, and treatment of anaphylaxis are reviewed. Emergency physicians should be aware of oral penicillin anaphylaxis in order to prevent its occurrence by prescribing the antibiotic judiciously and knowledgeably and to offer optimal medical therapy ...

Trimethoprim (TMP) 10 mg.kg-1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 micrograms.kg-1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced ...

Only small amounts of unconjugated dothiepin (unchanged drug) and northiaden were excreted in urine over a 72 hr period. More than 10% of the dose was excreted as conjugated dothiepin and less than 0.8% of the dose as conjugated northiaden. Conjugated dothiepin was thus found to be an important metabolite ...

Allopurinol has been shown to decrease the gastro-intestinal and bone marrow toxicity of 5-fluorouracil. In an attempt to diminish mucositis resulting from 5-fluorouracil administration, whilst not affecting its systemic anti-tumour activity, an allopurinol mouthwash has been used. In six patients who experienced mucositis when treated initially with 5-fluorouracil, the use ...

Oral contraceptives are in widespread use, and are commonly prescribed for contraception in patients taking other medications. An example of this is the concomitant use of oral contraceptives and anticonvulsants in epileptic patients. This combination creates a potential for drug interactions which may alter the efficacy of both medications. An ...

Brain heart infusion cysteine broth, with and without Panmede (a papain digest of ox liver) and Fastidious Anaerobe Broth, with and without Liquoid, were compared by inoculating the broths with blood collected from each of 51 patients, 2 min after dental extraction. Bacteraemia caused by viridans streptococci or oral non-sporing ...

The efficacy of rifampicin in treating a Bacteroides fragilis infection was investigated and compared to clindamycin and metronidazole in an experimental model of intra-abdominal abscess in mice. Rifampicin, when given subcutaneously, showed activity superior to that of clindamycin in reducing the incidence of abscess formation as well as the number ...

In vitro studies showed that sodium pentosan polysulphate (SPP) is an active inhibitor of calcium oxalate (CaOx) crystal growth and agglomeration and that it acts by increasing the negative zeta potential on the surface of CaOx crystals. Oral administration of SPP to control subjects, recurrent stone formers and patients with ...

The concomitant use of antibiotics and oral contraceptives should be included in the assessment of contraceptive failure. A case of unwanted adolescent pregnancy during the use of a semisynthetic penicillin and an oral contraceptive is presented and discussed. Advising a different contraceptive method or an additional contraceptive modality may be ...

A 50-year-old man, a "mainline" heroin abuser for 25 years, with a five-year history of x-ray findings compatible with asbestosis is presented. Multiple open biopsies failed to prove a diagnosis of asbestosis. The microscopic analyses of tissues revealed the presence of granulomatosis, secondary to talc from chronic intravenous heroin abuse. ...

Two new preparations of spironolactone tablets containing 25 and 100 mg of spironolactone have been characterized by their disintegration time, tablet spironolactone content, dissolution profile and bioavailability in comparison with two known spironolactone preparations as reference material. The preparations were found to possess almost identical characteristics, assuring a proper clinical ...

A direct titrimetric method has been developed for the determination of thiocarbonate in the presence of sulphite, thiosulphate and thiocyanate, by titration with o-hydroxymercuribenzoate, with sodium nitroprusside as indicator.

Paraquat is a broad spectrum herbicide known to be highly lethal to man and animals. Its toxicity is characterized by acute lung injury. Paraquat produces such toxic effects through the generation of the superoxide anion according to one proposed mechanism. The present experiment, methemoglobin formation was demonstrated after incubation of ...

Physicians are asked with increasing frequency to prepare individuals for travel in Africa. This paper presents an organized approach which includes medical screening, vaccination protocol, and malaria prophylaxis, as well as a discussion of personal hygiene for the tropics. African travel can be safe and enjoyable if the traveler is ...

The effects of an oral enteric-coated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Enteric-coated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric- coated form were later than ...

An isoflavonoid phytoalexin produced by the fungus-inoculated leaflets of MEDICAGO RUGOSA D ESR. has been formulated as (+/-)-7,4'-dimethoxy-2'-hydroxyisoflavanone (isosativanone). This compound cooccurs with the known isoflavonoid fungitoxins, (-)-medicarpin, (-)-vestitol, (-)-isosativanand(+/-)-vestitone.

Twenty asthmatic children who had daily wheezing requiring constant medication as outpatients were given oral metaproterenol or oral theophylline in a randomized double-blind crossover study. Each medication was given for four weeks, after the theophylline dosage necessary to give a therapeutic level was established. Pulmonary function parameters, daily peak-flow measurements ...

Synthesis of two omega-aldehydoalkyl 1-thioglycosides of D-glucopyranose and of D-galactopyranose is described. 3-Oxopropyl and 2-oxoethyl 1-thioglycosides were prepared by treating a tetra-O-acetyl-1-thioaldose with either acrolein or 2-bromo-acetaldehyde, followed by O-deacetylation under mild conditions. These omega-aldehydoalkyl 1-thioglycosides were successfully attached to bovine serum albumin (BSA) by reductive alkylation as described previously. ...

To obtain information on the attitudes and practices concerning oral rehydration therapy in the United States and Canada, a questionnaire was sent to the chairmen of departments of pediatrics of 142 medical colleges. Some form of oral fluid therapy for treatment of diarrheal dehydration is used by the institutions of ...

A patient with narcoleptic attacks and isolated thyrotropin deficiency is presented. Substitution with l-thyroxine did not relieve his narcoleptic attacks. Deficiency, in the central nervous system, of the ergotropic substance thyrotropin-releasing hormone (TRH) might have caused the thyrotropin deficiency and contributed to the narcoleptic attacks. However, prolonged oral medication with ...

The purification and crystallization of T17, a toxin from Ptychodiscus brevis, is reported. The toxicity of this compound and a second toxin known as T34 are compared by i.v., i.p. and oral administration in mice. Both toxins produce symptoms characteristic of muscarnic stimulants; hypersalivation, rhinorrhea and excessive urination and defecation ...

A new one-day medication schedule for single-visit oral cholecystography is described, using both Telepaque (iopanoic acid) tablets and Oragrafin Sodium (sodium ipodate) capsules. A definitive report is rendered at the first sitting; no repeat studies are performed. Preliminary results in 45 patients demonstrate the accuracy of this technique. One-day medication ...

A double-blind crossover comparison of sustained release indomethacin capsules and indomethacin suppositories showed no efficacy advantage to either preparation. In other respects the two preparations were found to be comparable. More patients preferred the convenience of the oral route of medication when given the choice after the study was concluded.

The decomposition of N-hydroxyacetaminophen (N-acetyl-N-hydroxy-p-aminophenol, 2), a postulated toxic metabolite of acetaminophen (N-acetyl-p-aminophenol, 1) in aqueous solution is quantitatively accounted for by the appearance of equimolar amounts of p-nitrosophenol and acetaminophen. The rate of decomposition depends on initial concentration and varies with pH. Antioxidants decrease the rate of decomposition and ...

The oral administration of cyclacillin, a semisynthetic aminoalicyclic penicillin, results in the elimination of the lactobacilli from the gastrointestinal tract of mice. Although cyclacillin has a broad spectrum of activity similar to that of ampicillin, it does not, like ampicillin, affect the other flora of the gastrointestinal tract. Cyclacillin, unlike ...

The efficacy of transdermally administered scopolamine was compared with the efficacy of oral dimenhydrinate and placebo therapy in the prevention of motion-induced mausea in a vertical oscillator; medications were administered on a double-blind cross-over basis, with the order of treatments counterbalanced. Thirty-five subjects known to be susceptible to the stimulus ...

Cadmium has been determined by dual-wavelength spectrophotometry with cadion, p-nitrobenzenediazoaminobenzene-p-azobenzene, and a non-ionic surfactant, Triton X-100. Cadion and its cadmium chelate are dissolved in a micellar solution of the surfactant. The absorbance difference at the wavelength of maximum absorption of the cadmium chelate (477 nm) and that of cadion (566 ...

In 1932, Kosawa visited Freud at 19 Berggasse, and submitted to him a paper entitled: 'Two kinds of guilt feelings, the Ajase complex. In his paper, Kosawa expounded his theory of the Ajase complex, rooted in Buddhist thought. He discussed the psychological peculiarity of the Japanese as evidenced by the ...

Ferredoxin immobilized on Sepharose 4B was prepared by reaction of CNBr-Sepharose 4B with spinach ferredoxin. The ferredoxin-Sepharose 4B conjugated ferredoxin-NADP+ reductase (NADPH: ferredoxin oxidoreductase, [EC 1.6.7.1]) in dilute buffer solution and released it in high salt concentrations. A novel method of preparation for the reductase was established by a combination ...

There is little physiologic data concerning the possible toxicity of nasal decongestants on respiratory cilia. Consequently, a chicken embryo tracheal organ culture system was employed to study the effect on ciliary activity of various preparations and concentrations of the following medications: tetrahydrozoline hydrochloride (Tyzine), xylometazoline hydrochloride (Otrivin), Dristan, Sinex, NTZ ...

The blanching activities and hence bioavailabilities of the cream, ointment and fatty ointment preparations of Nerisone and Temetex (diflucortolone valerate 0.1%) were evaluated using an occluded and unoccluded blanching assay. These products were compared to Synalar ointment and cream (fluocinolone acetonide 0.025%), established topical corticosteroid preparations. Statistical analysis showed no ...

Chlorhexidine has been widely used in medical practice since its introduction on to the marked in the early 1950s. Primarily it has been used for topical antisepsis, e.g. pre-surgery skin preparation, burns prophylaxis, and prior to obstetrical/gynaecological procedures. This extensive experience has demonstrated the virtual absence of sensitization and a ...

Newer medicated IUDs, such as the copper or progesterone-releasing devices, are more effective, better tolerated and have fewer side effects than nonmedicated IUDs. Major complications are rare if adequate precautions are taken. The IUD is an ideal contraceptive for patients with contraindications to oral contraception and for those who have ...

1. A patient with hereditary tyrosinemia (tyrosinosis) was given oral loads of p-tyramine and tyrosine with and without medication (neomycin) to investigate the respective roles of intestinal bacteria and tissues in accounting for the origin of urinary p-tyramine. 2. The excretion of a high circulating level of p-tyramine following an ...

A 12-week-old white male infant with ulcerative colitis and toxic megacolon is described. His diarrhea and rectal bleeding responded to prednisone. He subsequently developed toxic dilatation of the transverse colon while on salicylazosulfapyridine and one week after discontinuation of prednisone. His toxic megacolon disappeared during close medical observation, readministration of ...

The induction of glycogen deposition as subnuclear vacuoles was found to be a better method in estimating progestational potency of individual progestins than the delay of menses assay. Norgestrel was the most potent progestin in all assays. The progestational potency of oral contraceptives was estimated by multiply potency of individual ...

The denticles of the sublinguae of Galago crassicaudatus and G. senegalensis are studied histologically. There are, at the oral end of the sublingua, main or primary denticles which bear on their surface the much smaller secondary denticles. Spine-like small denticles occur on the surface of the ventromedian keel also. The ...

Out of 210 women seen at the Middlesex Hospital with secondary amenorrhoea the 63 who developed it after stopping oral contraceptives were fully investigated. Five had organic disease sufficient to account for the amenorrhoea (one had severe diabetes, one a pituitary tumour, and three premature ovarian failure); two patients had ...

The second International Reference Preparation of Lymecycline was established. Nine laboratories in 8 countries collaborated in assaying its potency in terms of the first International Reference Preparation, of which stocks had become exhausted. The best estimate of potency was taken to be 948 IU/mg, which was the unweighted geometric mean ...

This is the home page of the 'Preparing an Oral Presentation' website. The site has been provided and is maintained by Jeff Radel from the Department of Occupational Therapy Education, School of Allied Health at the University of Kansas Medical Centre in the United States. Content of the site, which ...

One in a series of dental health patient information leaflets produced by the British Dental Health Foundation as part of their 'Tell me about...' collection. This document focuses on medical conditions and oral health and is in a Q&A format. Issues covered include filling in a medical history form, patient ...

Two carbamates and one organophosphorus insecticide were evaluated in a village-scale trial in Nigeria by the WHO Insecticide Testing Unit. Toxicological studies on exposed spraymen and villagers included clinical observations, determination of plasma cholinesterase activity and-in the case of the carbamates-determination of metabolites in urine. While a village-scale trial can ...

Histamine stimulated the isolated auricles and heart of the guinea-pig. The effect was best seen in auricles which had been previously depressed by treatment with reserpine. Ganglionic blocking drugs (hexamethonium and pempidine), applied to auricles which had been previously treated with reserpine, abolished the diphasic effect of nicotine, but did ...